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Aliases for LY6H Gene

Aliases for LY6H Gene

  • Lymphocyte Antigen 6 Complex, Locus H 2 3 5
  • Ly-6H 3 4
  • NMLY6 3

External Ids for LY6H Gene

Previous GeneCards Identifiers for LY6H Gene

  • GC08U990047
  • GC08M144462
  • GC08M144014
  • GC08M144344
  • GC08M144310
  • GC08M139492
  • GC08M144239

Summaries for LY6H Gene

GeneCards Summary for LY6H Gene

LY6H (Lymphocyte Antigen 6 Complex, Locus H) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY6H Gene

Genomics for LY6H Gene

Regulatory Elements for LY6H Gene

Genomic Location for LY6H Gene

Chromosome:
8
Start:
143,157,914 bp from pter
End:
143,160,711 bp from pter
Size:
2,798 bases
Orientation:
Minus strand

Genomic View for LY6H Gene

Genes around LY6H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY6H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY6H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY6H Gene

Proteins for LY6H Gene

  • Protein details for LY6H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94772-LY6H_HUMAN
    Recommended name:
    Lymphocyte antigen 6H
    Protein Accession:
    O94772
    Secondary Accessions:
    • B2RAD2
    • J3KQI0
    • Q6IAX0

    Protein attributes for LY6H Gene

    Size:
    140 amino acids
    Molecular mass:
    14669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LY6H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LY6H Gene

Proteomics data for LY6H Gene at MOPED

Post-translational modifications for LY6H Gene

  • Glycosylation at Asn 36
  • Modification sites at PhosphoSitePlus

Other Protein References for LY6H Gene

No data available for DME Specific Peptides for LY6H Gene

Domains & Families for LY6H Gene

Gene Families for LY6H Gene

Protein Domains for LY6H Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LY6H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94772

UniProtKB/Swiss-Prot:

LY6H_HUMAN :
  • Contains 1 UPAR/Ly6 domain.
Domain:
  • Contains 1 UPAR/Ly6 domain.
genes like me logo Genes that share domains with LY6H: view

Function for LY6H Gene

Molecular function for LY6H Gene

GENATLAS Biochemistry:
lymphocyte antigen complex,member E,homolog with the murine LY-6 family members of small cysteine-rich proteins,expressed in the central nervous system and in acute lymphoblastic leukemia cells
genes like me logo Genes that share phenotypes with LY6H: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6H Gene

Localization for LY6H Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY6H Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LY6H Gene COMPARTMENTS Subcellular localization image for LY6H gene
Compartment Confidence
plasma membrane 4
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for LY6H Gene

Pathways & Interactions for LY6H Gene

SuperPathways for LY6H Gene

No Data Available

Interacting Proteins for LY6H Gene

Gene Ontology (GO) - Biological Process for LY6H Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LY6H Gene

Drugs & Compounds for LY6H Gene

No Compound Related Data Available

Transcripts for LY6H Gene

Unigene Clusters for LY6H Gene

Lymphocyte antigen 6 complex, locus H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LY6H Gene

No ASD Table

Relevant External Links for LY6H Gene

GeneLoc Exon Structure for
LY6H
ECgene alternative splicing isoforms for
LY6H

Expression for LY6H Gene

mRNA expression in normal human tissues for LY6H Gene

mRNA differential expression in normal tissues according to GTEx for LY6H Gene

This gene is overexpressed in Brain - Hippocampus (x8.9), Brain - Hypothalamus (x6.9), Brain - Amygdala (x6.2), Brain - Anterior cingulate cortex (BA24) (x6.1), Brain - Cortex (x5.6), and Brain - Frontal Cortex (BA9) (x5.0).

Protein differential expression in normal tissues from HIPED for LY6H Gene

This gene is overexpressed in Brain (36.0), Cerebrospinal fluid (16.7), and Fetal Brain (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LY6H Gene



SOURCE GeneReport for Unigene cluster for LY6H Gene Hs.159590

mRNA Expression by UniProt/SwissProt for LY6H Gene

O94772-LY6H_HUMAN
Tissue specificity: Highly expressed in brain (cerebral cortex, amygdala, hippocampus and subthalamic nucleus) and in acute human leukemic cell line MOLT-3. Also found in lower levels in testis, pancreas, small intestine and colon.
genes like me logo Genes that share expression patterns with LY6H: view

Protein tissue co-expression partners for LY6H Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LY6H Gene

This gene was present in the common ancestor of mammals.

Orthologs for LY6H Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LY6H 35
  • 91.43 (n)
  • 93.57 (a)
LY6H 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LY6H 35
  • 87.88 (n)
  • 93.39 (a)
LY6H 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ly6h 35
  • 88.33 (n)
  • 90 (a)
Ly6h 16
Ly6h 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LY6H 35
  • 99.59 (n)
  • 100 (a)
LY6H 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ly6h 35
  • 89.69 (n)
  • 92.81 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
Species with no ortholog for LY6H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY6H Gene

ENSEMBL:
Gene Tree for LY6H (if available)
TreeFam:
Gene Tree for LY6H (if available)

Paralogs for LY6H Gene

No data available for Paralogs for LY6H Gene

Variants for LY6H Gene

Sequence variations from dbSNP and Humsavar for LY6H Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs6558330 -- 143,161,898(+) tgggg(A/G)tagca upstream-variant-2KB
rs7007949 -- 143,158,243(+) AAGGA(A/G)GAGAC utr-variant-3-prime
rs7835528 -- 143,161,975(+) ccccc(C/T)gcagt upstream-variant-2KB
rs7835985 -- 143,162,209(+) gcttg(C/G)aaaag upstream-variant-2KB
rs10095387 -- 143,158,513(+) GGGAC(A/C/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LY6H Gene

Variant ID Type Subtype PubMed ID
nsv891650 CNV Gain 21882294
nsv891653 CNV Loss 21882294
nsv891654 CNV Loss 21882294
dgv7920n71 CNV Loss 21882294
nsv891656 CNV Gain 21882294
nsv824760 CNV Gain 20364138

Variation tolerance for LY6H Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LY6H Gene

HapMap Linkage Disequilibrium report
LY6H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6H Gene

Disorders for LY6H Gene

Relevant External Links for LY6H

Human Genome Epidemiology (HuGE) Navigator
LY6H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LY6H

No disorders were found for LY6H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LY6H Gene

Publications for LY6H Gene

  1. Isolation and characterization of a new member of the human Ly6 gene family (LY6H). (PMID: 9799603) Horie M. … Takahashi E. (Genomics 1998) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for LY6H Gene

Sources for LY6H Gene

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