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Aliases for LY6H Gene

Aliases for LY6H Gene

  • Lymphocyte Antigen 6 Family Member H 2 3 5
  • Lymphocyte Antigen 6 Complex, Locus H 2 3
  • Ly-6H 3 4
  • Lymphocyte Antigen 6H 3
  • NMLY6 3

External Ids for LY6H Gene

Previous GeneCards Identifiers for LY6H Gene

  • GC08U990047
  • GC08M144462
  • GC08M144014
  • GC08M144344
  • GC08M144310
  • GC08M139492
  • GC08M144239

Summaries for LY6H Gene

GeneCards Summary for LY6H Gene

LY6H (Lymphocyte Antigen 6 Family Member H) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for LY6H Gene

  • Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons.

Additional gene information for LY6H Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY6H Gene

Genomics for LY6H Gene

Regulatory Elements for LY6H Gene

Enhancers for LY6H Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H143263 1.3 Ensembl ENCODE dbSUPER 10.6 -103.8 -103813 1 PKNOX1 ATF1 FOXA2 SAP130 JUN ZNF175 FOSL1 ZNF316 FOXK2 ZNF584 MINCR ZNF696 LY6H FAM83H-AS1 PIR58179 GLI4
GH08H143333 1.1 ENCODE 10.3 -174.0 -174024 2 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 YY1 TCF12 ZNF766 GLIS2 TOP1MT RHPN1 ENSG00000253931 MAFA-AS1 LY6H MINCR GC08M143337 ENSG00000272172
GH08H143136 0.8 Ensembl ENCODE 12.7 +24.3 24282 0 ZFHX2 NR2F1 ELF1 RCOR1 RUNX3 SPI1 EGR2 LY6H SLURP1 LY6L
GH08H143029 1 ENCODE dbSUPER 10.1 +131.3 131253 0 CTCF PKNOX1 SAP130 SIN3A RAD21 FOXK2 SMC3 ZNF143 ZNF207 DEK LOC100133669 ENSG00000253715 LY6D LY6H SLURP1 GC08P143031 PIR51584
GH08H143131 0.8 ENCODE 12.2 +29.5 29503 0 GTF2F1 CTCF PKNOX1 RB1 SIN3A ZBTB7B RAD21 RFX5 CC2D1A CTBP1 LY6H ZFP41 LY6L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LY6H on UCSC Golden Path with GeneCards custom track

Genomic Location for LY6H Gene

Chromosome:
8
Start:
143,157,914 bp from pter
End:
143,160,711 bp from pter
Size:
2,798 bases
Orientation:
Minus strand

Genomic View for LY6H Gene

Genes around LY6H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY6H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY6H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY6H Gene

Proteins for LY6H Gene

  • Protein details for LY6H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94772-LY6H_HUMAN
    Recommended name:
    Lymphocyte antigen 6H
    Protein Accession:
    O94772
    Secondary Accessions:
    • B2RAD2
    • J3KQI0
    • Q6IAX0

    Protein attributes for LY6H Gene

    Size:
    140 amino acids
    Molecular mass:
    14669 Da
    Quaternary structure:
    • Interacts with CHRNA4 and CHRNA7.

    Alternative splice isoforms for LY6H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LY6H Gene

Post-translational modifications for LY6H Gene

  • Glycosylation at Asn36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LY6H Gene

Domains & Families for LY6H Gene

Gene Families for LY6H Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for LY6H Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LY6H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LY6H: view

No data available for UniProtKB/Swiss-Prot for LY6H Gene

Function for LY6H Gene

Molecular function for LY6H Gene

GENATLAS Biochemistry:
lymphocyte antigen complex,member E,homolog with the murine LY-6 family members of small cysteine-rich proteins,expressed in the central nervous system and in acute lymphoblastic leukemia cells
UniProtKB/Swiss-Prot Function:
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons.

Gene Ontology (GO) - Molecular Function for LY6H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LY6H: view
genes like me logo Genes that share phenotypes with LY6H: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LY6H

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LY6H
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6H Gene

Localization for LY6H Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY6H Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LY6H gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for LY6H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with LY6H: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LY6H Gene

Pathways & Interactions for LY6H Gene

genes like me logo Genes that share pathways with LY6H: view

Interacting Proteins for LY6H Gene

Gene Ontology (GO) - Biological Process for LY6H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007399 nervous system development TAS 9799603
GO:0009887 animal organ morphogenesis TAS 9799603
genes like me logo Genes that share ontologies with LY6H: view

No data available for SIGNOR curated interactions for LY6H Gene

Drugs & Compounds for LY6H Gene

No Compound Related Data Available

Transcripts for LY6H Gene

Unigene Clusters for LY6H Gene

Lymphocyte antigen 6 complex, locus H:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LY6H
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LY6H Gene

No ASD Table

Relevant External Links for LY6H Gene

GeneLoc Exon Structure for
LY6H
ECgene alternative splicing isoforms for
LY6H

Expression for LY6H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LY6H Gene

mRNA differential expression in normal tissues according to GTEx for LY6H Gene

This gene is overexpressed in Brain - Hippocampus (x8.9), Brain - Hypothalamus (x6.9), Brain - Amygdala (x6.2), Brain - Anterior cingulate cortex (BA24) (x6.1), Brain - Cortex (x5.6), and Brain - Frontal Cortex (BA9) (x5.0).

Protein differential expression in normal tissues from HIPED for LY6H Gene

This gene is overexpressed in Brain (36.0), Cerebrospinal fluid (16.7), and Fetal Brain (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LY6H Gene



Protein tissue co-expression partners for LY6H Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LY6H Gene:

LY6H

SOURCE GeneReport for Unigene cluster for LY6H Gene:

Hs.159590

mRNA Expression by UniProt/SwissProt for LY6H Gene:

O94772-LY6H_HUMAN
Tissue specificity: Highly expressed in brain (cerebral cortex, amygdala, hippocampus and subthalamic nucleus) and in acute human leukemic cell line MOLT-3. Also found in lower levels in testis, pancreas, small intestine and colon.

Evidence on tissue expression from TISSUES for LY6H Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with LY6H: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LY6H Gene

Orthologs for LY6H Gene

This gene was present in the common ancestor of mammals.

Orthologs for LY6H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LY6H 33 34
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia LY6H 33 34
  • 91.43 (n)
rat
(Rattus norvegicus)
Mammalia Ly6h 33
  • 89.69 (n)
mouse
(Mus musculus)
Mammalia Ly6h 33 16 34
  • 88.33 (n)
dog
(Canis familiaris)
Mammalia LY6H 33 34
  • 87.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
OneToMany
-- 34
  • 39 (a)
OneToMany
Species where no ortholog for LY6H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY6H Gene

ENSEMBL:
Gene Tree for LY6H (if available)
TreeFam:
Gene Tree for LY6H (if available)

Paralogs for LY6H Gene

No data available for Paralogs for LY6H Gene

Variants for LY6H Gene

Sequence variations from dbSNP and Humsavar for LY6H Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000033925 -- 143,157,424(+) CACGT(C/G)CACTG downstream-variant-500B
rs1000058936 -- 143,159,450(+) AGGGG(C/T)CCCGG intron-variant
rs1000515074 -- 143,159,247(+) ATATC(A/C)CCCCC intron-variant
rs1001145186 -- 143,160,403(+) GGGCG(C/G)GGGGC intron-variant, upstream-variant-2KB
rs1001312920 -- 143,160,864(+) CAGGG(A/G)CTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LY6H Gene

Variant ID Type Subtype PubMed ID
nsv1137626 CNV deletion 24896259
nsv612726 CNV loss 21841781
nsv824760 CNV gain 20364138
nsv950006 CNV deletion 24416366

Variation tolerance for LY6H Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LY6H Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LY6H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6H Gene

Disorders for LY6H Gene

Relevant External Links for LY6H

Human Genome Epidemiology (HuGE) Navigator
LY6H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LY6H

No disorders were found for LY6H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LY6H Gene

Publications for LY6H Gene

  1. Isolation and characterization of a new member of the human Ly6 gene family (LY6H). (PMID: 9799603) Horie M … Takahashi E (Genomics 1998) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 60
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60

Products for LY6H Gene

Sources for LY6H Gene

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