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Aliases for LY6G6F Gene

Aliases for LY6G6F Gene

  • Lymphocyte Antigen 6 Complex, Locus G6F 2 3 5
  • C6orf21 3 4
  • LY6G6D 3 4
  • NG32 3 4
  • G6f 3 4
  • Lymphocyte Antigen 6 Complex Locus Protein G6f 3
  • Lymphocyte Antigen 6 Complex, Locus G6D 3
  • Chromosome 6 Open Reading Frame 21 2

External Ids for LY6G6F Gene

Previous HGNC Symbols for LY6G6F Gene

  • LY6G6D
  • C6orf21

Previous GeneCards Identifiers for LY6G6F Gene

  • GC06P031784
  • GC06P031674
  • GC06P031460

Summaries for LY6G6F Gene

Entrez Gene Summary for LY6G6F Gene

  • The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LY6G6F Gene

LY6G6F (Lymphocyte Antigen 6 Complex, Locus G6F) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is ENSG00000250641.

UniProtKB/Swiss-Prot for LY6G6F Gene

  • May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY6G6F Gene

Genomics for LY6G6F Gene

Regulatory Elements for LY6G6F Gene

Genomic Location for LY6G6F Gene

31,706,885 bp from pter
31,710,595 bp from pter
3,711 bases
Plus strand

Genomic View for LY6G6F Gene

Genes around LY6G6F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY6G6F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY6G6F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for LY6G6F Gene

  • Protein details for LY6G6F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lymphocyte antigen 6 complex locus protein G6f
    Protein Accession:
    Secondary Accessions:
    • B0UXB7
    • O95869
    • Q7Z5H2
    • Q96QC7
    • Q9NZJ1

    Protein attributes for LY6G6F Gene

    297 amino acids
    Molecular mass:
    32465 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a phosphorylation-dependent manner.
    • Sequence=AAD18078.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB63382.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LY6G6F Gene


neXtProt entry for LY6G6F Gene

Post-translational modifications for LY6G6F Gene

Other Protein References for LY6G6F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LY6G6F Gene

Domains & Families for LY6G6F Gene

Protein Domains for LY6G6F Gene

Suggested Antigen Peptide Sequences for LY6G6F Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with LY6G6F: view

Function for LY6G6F Gene

Molecular function for LY6G6F Gene

UniProtKB/Swiss-Prot Function:
May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.

Phenotypes for LY6G6F Gene

GenomeRNAi human phenotypes for LY6G6F:
genes like me logo Genes that share phenotypes with LY6G6F: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LY6G6F

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6G6F Gene

Localization for LY6G6F Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY6G6F Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LY6G6F Gene COMPARTMENTS Subcellular localization image for LY6G6F gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LY6G6F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LY6G6F: view

Pathways & Interactions for LY6G6F Gene

genes like me logo Genes that share pathways with LY6G6F: view

Gene Ontology (GO) - Biological Process for LY6G6F Gene


No data available for SIGNOR curated interactions for LY6G6F Gene

Transcripts for LY6G6F Gene

mRNA/cDNA for LY6G6F Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LY6G6F Gene

Lymphocyte antigen 6 complex, locus G6F:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LY6G6F Gene

No ASD Table

Relevant External Links for LY6G6F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LY6G6F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LY6G6F Gene

mRNA differential expression in normal tissues according to GTEx for LY6G6F Gene

This gene is overexpressed in Whole Blood (x45.1).

Protein differential expression in normal tissues from HIPED for LY6G6F Gene

This gene is overexpressed in Platelet (32.0), Peripheral blood mononuclear cells (23.1), and Serum (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LY6G6F Gene

Protein tissue co-expression partners for LY6G6F Gene

NURSA nuclear receptor signaling pathways regulating expression of LY6G6F Gene:


SOURCE GeneReport for Unigene cluster for LY6G6F Gene:

genes like me logo Genes that share expression patterns with LY6G6F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LY6G6F Gene

Orthologs for LY6G6F Gene

This gene was present in the common ancestor of chordates.

Orthologs for LY6G6F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LY6G6F 34
  • 99.55 (n)
-- 35
  • 87 (a)
(Canis familiaris)
Mammalia LY6G6F 34
  • 83.39 (n)
-- 35
  • 81 (a)
(Bos Taurus)
Mammalia LY6G6F 34
  • 83.16 (n)
(Mus musculus)
Mammalia Ly6g6f 34 16
  • 77.55 (n)
(Rattus norvegicus)
Mammalia Ly6g6f 34
  • 75.15 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
Species where no ortholog for LY6G6F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY6G6F Gene

Gene Tree for LY6G6F (if available)
Gene Tree for LY6G6F (if available)

Paralogs for LY6G6F Gene

Paralogs for LY6G6F Gene

(1) SIMAP similar genes for LY6G6F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LY6G6F: view

Variants for LY6G6F Gene

Sequence variations from dbSNP and Humsavar for LY6G6F Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111697685 -- 31,710,753(+) GGTGG(A/G)GGACT downstream-variant-500B
rs113873577 -- 31,710,285(+) GGGGG(C/T)GAGGA intron-variant
rs115639191 -- 31,706,862(+) TCCCT(A/G)GGGAC upstream-variant-2KB
rs11575846 -- 31,710,296(+) ACACG(C/G)CTCTA intron-variant
rs115819005 -- 31,708,071(+) GGAGC(C/T)GAAGA reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for LY6G6F Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780

Variation tolerance for LY6G6F Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.42; 90.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LY6G6F Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6G6F Gene

Disorders for LY6G6F Gene

Relevant External Links for LY6G6F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LY6G6F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LY6G6F Gene

Publications for LY6G6F Gene

  1. Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC. (PMID: 12852788) De Vet E.C.J.M. … Campbell R.D. (Biochem. J. 2003) 2 3 4 22 64
  2. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  4. Regulation of expression of two LY-6 family genes by intron retention and transcription induced chimerism. (PMID: 18817541) Calvanese V. … Aguado B. (BMC Mol. Biol. 2008) 22 64
  5. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay I.C. … Ouwehand W.H. (Blood 2007) 3 64

Products for LY6G6F Gene

Sources for LY6G6F Gene

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