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Aliases for LY6G6C Gene

Aliases for LY6G6C Gene

  • Lymphocyte Antigen 6 Family Member G6C 2 3 5
  • Lymphocyte Antigen 6 Complex, Locus G6C 2 3
  • C6orf24 3 4
  • NG24 3 4
  • G6c 3 4
  • Lymphocyte Antigen 6 Complex Locus Protein G6c 3
  • Chromosome 6 Open Reading Frame 24 2
  • Lymphocyte Antigen-6 G6C 3

External Ids for LY6G6C Gene

Previous HGNC Symbols for LY6G6C Gene

  • C6orf24

Previous GeneCards Identifiers for LY6G6C Gene

  • GC06M031749
  • GC06M031457
  • GC06M031790
  • GC06M031794
  • GC06M031691
  • GC06M031692
  • GC06M031472
  • GC06M031699
  • GC06M031719
  • GC06M031729
  • GC06M031795
  • GC06M031833

Summaries for LY6G6C Gene

Entrez Gene Summary for LY6G6C Gene

  • LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LY6G6C Gene

LY6G6C (Lymphocyte Antigen 6 Family Member G6C) is a Protein Coding gene. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY6G6C Gene

Genomics for LY6G6C Gene

Regulatory Elements for LY6G6C Gene

Enhancers for LY6G6C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031829 1.4 ENCODE dbSUPER 24.6 -112.3 -112312 9.1 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D LSM2 LY6G5B ATF6B DDX39B SKIV2L VARS LY6G6C GTF2H4 CSNK2B BAG6
GH06G031762 1.1 Ensembl ENCODE 11.8 -41.7 -41749 1.5 HDGF ARNT NFRKB RAD21 ZNF366 SCRT2 PAF1 SMAD5 CEBPB REST LY6G6C SKIV2L SAPCD1-AS1 SAPCD1
GH06G031750 0.8 ENCODE 9.2 -28.7 -28722 0.6 ZMYM3 DMAP1 ZKSCAN1 FOSL1 GATA3 CTBP1 POLR2A STAT2 FOS NR2F6 C4A LY6G6C RNU6-850P MSH5-SAPCD1 MSH5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LY6G6C on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LY6G6C gene promoter:

Genomic Location for LY6G6C Gene

31,718,648 bp from pter
31,721,845 bp from pter
3,198 bases
Minus strand

Genomic View for LY6G6C Gene

Genes around LY6G6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY6G6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY6G6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for LY6G6C Gene

  • Protein details for LY6G6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lymphocyte antigen 6 complex locus protein G6c
    Protein Accession:
    Secondary Accessions:
    • Q5SRS8
    • Q8IY94

    Protein attributes for LY6G6C Gene

    125 amino acids
    Molecular mass:
    13821 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for LY6G6C Gene

Post-translational modifications for LY6G6C Gene

Other Protein References for LY6G6C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LY6G6C Gene

Domains & Families for LY6G6C Gene

Gene Families for LY6G6C Gene

Protein Domains for LY6G6C Gene


Suggested Antigen Peptide Sequences for LY6G6C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LY6G6C: view

No data available for UniProtKB/Swiss-Prot for LY6G6C Gene

Function for LY6G6C Gene

genes like me logo Genes that share phenotypes with LY6G6C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LY6G6C

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LY6G6C Gene

Localization for LY6G6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY6G6C Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LY6G6C gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for LY6G6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with LY6G6C: view

Pathways & Interactions for LY6G6C Gene

genes like me logo Genes that share pathways with LY6G6C: view

Interacting Proteins for LY6G6C Gene

Selected Interacting proteins: O95867-LY66C_HUMAN for LY6G6C Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for LY6G6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
genes like me logo Genes that share ontologies with LY6G6C: view

No data available for SIGNOR curated interactions for LY6G6C Gene

Drugs & Compounds for LY6G6C Gene

No Compound Related Data Available

Transcripts for LY6G6C Gene

mRNA/cDNA for LY6G6C Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LY6G6C Gene

Lymphocyte antigen 6 complex, locus G6C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LY6G6C Gene

No ASD Table

Relevant External Links for LY6G6C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LY6G6C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LY6G6C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LY6G6C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.0) and Skin - Not Sun Exposed (Suprapubic) (x21.9).

Protein differential expression in normal tissues from HIPED for LY6G6C Gene

This gene is overexpressed in Cervix (62.9) and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LY6G6C Gene

Protein tissue co-expression partners for LY6G6C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LY6G6C Gene:


SOURCE GeneReport for Unigene cluster for LY6G6C Gene:


mRNA Expression by UniProt/SwissProt for LY6G6C Gene:

Tissue specificity: Highly expressed at the leading edges of cells, on filopodia.

Evidence on tissue expression from TISSUES for LY6G6C Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with LY6G6C: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LY6G6C Gene

Orthologs for LY6G6C Gene

This gene was present in the common ancestor of mammals.

Orthologs for LY6G6C Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LY6G6C 34 35
  • 89.07 (n)
(Bos Taurus)
Mammalia LY6G6C 35 34
  • 86.93 (n)
(Rattus norvegicus)
Mammalia Ly6g6c 34
  • 85.42 (n)
(Mus musculus)
Mammalia Ly6g6c 34 16 35
  • 85.12 (n)
(Monodelphis domestica)
Mammalia LY6G6C 35
  • 57 (a)
Species where no ortholog for LY6G6C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY6G6C Gene

Gene Tree for LY6G6C (if available)
Gene Tree for LY6G6C (if available)

Paralogs for LY6G6C Gene

No data available for Paralogs for LY6G6C Gene

Variants for LY6G6C Gene

Sequence variations from dbSNP and Humsavar for LY6G6C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001126146 -- 31,722,750(+) CTCAG(A/G)AGGCT intron-variant, upstream-variant-2KB
rs1001157311 -- 31,723,065(+) GCAAC(C/T)TCGAC intron-variant, upstream-variant-2KB
rs1001185679 -- 31,720,088(+) GGGAT(A/G)TTACC intron-variant, upstream-variant-2KB
rs1001215235 -- 31,719,657(+) TCAGC(C/T)TCCCG intron-variant, upstream-variant-2KB
rs1002799794 -- 31,720,944(+) CCTGG(C/T)AAGTG intron-variant, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for LY6G6C Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259

Variation tolerance for LY6G6C Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LY6G6C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6G6C Gene

Disorders for LY6G6C Gene

Relevant External Links for LY6G6C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LY6G6C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LY6G6C Gene

Publications for LY6G6C Gene

  1. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (PMID: 12079290) Mallya M. … Aguado B. (Genomics 2002) 2 3 4 64
  2. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PMID: 10384126) Ribas G. … Campbell R.D. (J. Immunol. 1999) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for LY6G6C Gene

Sources for LY6G6C Gene

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