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Aliases for LY6E Gene

Aliases for LY6E Gene

  • Lymphocyte Antigen 6 Complex, Locus E 2 3 5
  • Retinoic Acid-Induced Gene E Protein 3 4
  • Retinoic Acid Induced Gene E 2 3
  • Thymic Shared Antigen 1 3 4
  • Stem Cell Antigen 2 3 4
  • Ly-6E 3 4
  • RIG-E 3 4
  • SCA-2 3 4
  • TSA-1 3 4
  • SCA2 3 4
  • RIGE 3 4
  • 9804 4
  • TSA1 4

External Ids for LY6E Gene

Previous GeneCards Identifiers for LY6E Gene

  • GC08P142338
  • GC08P144322
  • GC08P143874
  • GC08P144205
  • GC08P144171
  • GC08P139353
  • GC08P144099

Summaries for LY6E Gene

GeneCards Summary for LY6E Gene

LY6E (Lymphocyte Antigen 6 Complex, Locus E) is a Protein Coding gene. Diseases associated with LY6E include leukemia, acute promyelocytic, somatic and subvalvular aortic stenosis. Among its related pathways are Akt Signaling and Chks in Checkpoint Regulation.

Gene Wiki entry for LY6E Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY6E Gene

Genomics for LY6E Gene

Regulatory Elements for LY6E Gene

Promoters for LY6E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LY6E on UCSC Golden Path with GeneCards custom track

Genomic Location for LY6E Gene

Chromosome:
8
Start:
143,017,982 bp from pter
End:
143,023,832 bp from pter
Size:
5,851 bases
Orientation:
Plus strand

Genomic View for LY6E Gene

Genes around LY6E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LY6E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LY6E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY6E Gene

Proteins for LY6E Gene

  • Protein details for LY6E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16553-LY6E_HUMAN
    Recommended name:
    Lymphocyte antigen 6E
    Protein Accession:
    Q16553
    Secondary Accessions:
    • B2R4X5
    • D3DWJ2
    • Q0VDE5

    Protein attributes for LY6E Gene

    Size:
    131 amino acids
    Molecular mass:
    13507 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LY6E Gene

Proteomics data for LY6E Gene at MOPED

Post-translational modifications for LY6E Gene

  • Glycosylation at Asn 99
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LY6E Gene

Domains & Families for LY6E Gene

Gene Families for LY6E Gene

Protein Domains for LY6E Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LY6E Gene

Graphical View of Domain Structure for InterPro Entry

Q16553

UniProtKB/Swiss-Prot:

LY6E_HUMAN :
  • Contains 1 UPAR/Ly6 domain.
Domain:
  • Contains 1 UPAR/Ly6 domain.
genes like me logo Genes that share domains with LY6E: view

Function for LY6E Gene

Molecular function for LY6E Gene

GENATLAS Biochemistry:
lymphocyte antigen 6 complex,member E,homolog with the murine LY-6 family members of small cysteine-rich proteins,involved in signal transduction
UniProtKB/Swiss-Prot Induction:
By retinoic acid; in promyelocytic leukemia NB4 and in myeloblast HL-60 cell lines. Activated by IFN-alpha in monocytic cell line U-937 and in peripheral blood monocyte cells.
genes like me logo Genes that share phenotypes with LY6E: view

Animal Models for LY6E Gene

MGI Knock Outs for LY6E:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LY6E Gene

Localization for LY6E Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY6E Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LY6E Gene COMPARTMENTS Subcellular localization image for LY6E gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for LY6E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8650192
genes like me logo Genes that share ontologies with LY6E: view

Pathways & Interactions for LY6E Gene

genes like me logo Genes that share pathways with LY6E: view

Pathways by source for LY6E Gene

2 Qiagen pathways for LY6E Gene

Interacting Proteins for LY6E Gene

Gene Ontology (GO) - Biological Process for LY6E Gene

None

No data available for SIGNOR curated interactions for LY6E Gene

Drugs & Compounds for LY6E Gene

(1) Additional Compounds for LY6E Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LY6E: view

Transcripts for LY6E Gene

Unigene Clusters for LY6E Gene

Lymphocyte antigen 6 complex, locus E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LY6E Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l · 7m ^ 8
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - - -
SP14: - - - - - - - - - - - - - - - -
SP15: - -
SP16: - - -

Relevant External Links for LY6E Gene

GeneLoc Exon Structure for
LY6E
ECgene alternative splicing isoforms for
LY6E

Expression for LY6E Gene

mRNA expression in normal human tissues for LY6E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LY6E Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LY6E Gene



SOURCE GeneReport for Unigene cluster for LY6E Gene Hs.521903

mRNA Expression by UniProt/SwissProt for LY6E Gene

Q16553-LY6E_HUMAN
Tissue specificity: Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.
genes like me logo Genes that share expression patterns with LY6E: view

Protein tissue co-expression partners for LY6E Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LY6E Gene

Orthologs for LY6E Gene

This gene was present in the common ancestor of chordates.

Orthologs for LY6E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LY6E 35
  • 73.33 (n)
  • 70.77 (a)
LY6E 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LY6E 35
  • 77.57 (n)
  • 75.7 (a)
LY6E 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ly6e 35
  • 68.18 (n)
  • 60 (a)
Ly6e 16
Ly6e 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LY6E 35
  • 98.98 (n)
  • 100 (a)
LY6E 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ly6e 35
  • 68.48 (n)
  • 61.82 (a)
chicken
(Gallus gallus)
Aves LY6E 35
  • 56.8 (n)
  • 51.02 (a)
-- 36
  • 33 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
LY6E 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
Species with no ortholog for LY6E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY6E Gene

ENSEMBL:
Gene Tree for LY6E (if available)
TreeFam:
Gene Tree for LY6E (if available)

Paralogs for LY6E Gene

(1) SIMAP similar genes for LY6E Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LY6E: view

No data available for Paralogs for LY6E Gene

Variants for LY6E Gene

Sequence variations from dbSNP and Humsavar for LY6E Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1131075 -- 143,022,295(+) GGTTT(C/T)TGCCA utr-variant-3-prime
rs1131088 -- 143,022,310(+) CGGGT(C/T)TAGGC utr-variant-3-prime
rs1802886 -- 143,022,220(+) TGGAG(A/G)GCCTC utr-variant-3-prime
rs4483135 -- 143,022,771(+) GAGGG(C/T)ACAAA downstream-variant-500B
rs4483136 -- 143,022,896(+) TGCAG(C/T)GCTGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LY6E Gene

Variant ID Type Subtype PubMed ID
nsv465991 CNV Loss 19166990

Variation tolerance for LY6E Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LY6E Gene

HapMap Linkage Disequilibrium report
LY6E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY6E Gene

Disorders for LY6E Gene

MalaCards: The human disease database

(2) MalaCards diseases for LY6E Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
subvalvular aortic stenosis
  • aortic stenosis, subvalvular
- elite association - COSMIC cancer census association via MalaCards
Search LY6E in MalaCards View complete list of genes associated with diseases

Relevant External Links for LY6E

Genetic Association Database (GAD)
LY6E
Human Genome Epidemiology (HuGE) Navigator
LY6E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LY6E
genes like me logo Genes that share disorders with LY6E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LY6E Gene

Publications for LY6E Gene

  1. RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell. (PMID: 8650192) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen. (PMID: 11576217) Ding L. … Shevach E.M. (Immunology 2001) 3 23
  3. Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex. (PMID: 9575182) Kosugi A. … Hamaoka T. (J. Biol. Chem. 1998) 3 23
  4. Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2: a new member of the human Ly-6 family. (PMID: 8757598) Capone M.C. … Zlotnik A. (J. Immunol. 1996) 2 3
  5. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. (PMID: 25344775) Feng X. … Sun L. (Clin. Rheumatol. 2015) 3

Products for LY6E Gene

Sources for LY6E Gene

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