Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LXN Gene

Aliases for LXN Gene

  • Latexin 2 3 5
  • Endogenous Carboxypeptidase Inhibitor 3 4
  • Tissue Carboxypeptidase Inhibitor 3 4
  • ECI 3 4
  • TCI 3 4
  • Protein MUM 4
  • MUM 3

External Ids for LXN Gene

Previous GeneCards Identifiers for LXN Gene

  • GC03M155644
  • GC03M159331
  • GC03M159645
  • GC03M159705
  • GC03M159866
  • GC03M158366
  • GC03M155780

Summaries for LXN Gene

Entrez Gene Summary for LXN Gene

  • This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]

GeneCards Summary for LXN Gene

LXN (Latexin) is a Protein Coding gene. Diseases associated with LXN include endocervicitis. GO annotations related to this gene include heparin binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is RARRES1.

UniProtKB/Swiss-Prot for LXN Gene

  • Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LXN Gene

Genomics for LXN Gene

Regulatory Elements for LXN Gene

Enhancers for LXN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LXN on UCSC Golden Path with GeneCards custom track

Promoters for LXN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LXN on UCSC Golden Path with GeneCards custom track

Genomic Location for LXN Gene

Chromosome:
3
Start:
158,645,822 bp from pter
End:
158,672,693 bp from pter
Size:
26,872 bases
Orientation:
Minus strand

Genomic View for LXN Gene

Genes around LXN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LXN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LXN Gene

Proteins for LXN Gene

  • Protein details for LXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS40-LXN_HUMAN
    Recommended name:
    Latexin
    Protein Accession:
    Q9BS40
    Secondary Accessions:
    • Q96PN2
    • Q9NQS6

    Protein attributes for LXN Gene

    Size:
    222 amino acids
    Molecular mass:
    25750 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LXN Gene

neXtProt entry for LXN Gene

Proteomics data for LXN Gene at MOPED

Post-translational modifications for LXN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LXN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LXN Gene

Domains & Families for LXN Gene

Protein Domains for LXN Gene

Suggested Antigen Peptide Sequences for LXN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BS40

UniProtKB/Swiss-Prot:

LXN_HUMAN :
  • Belongs to the protease inhibitor I47 (latexin) family.
Family:
  • Belongs to the protease inhibitor I47 (latexin) family.
genes like me logo Genes that share domains with LXN: view

No data available for Gene Families for LXN Gene

Function for LXN Gene

Molecular function for LXN Gene

UniProtKB/Swiss-Prot Function:
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.

Gene Ontology (GO) - Molecular Function for LXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LXN: view
genes like me logo Genes that share phenotypes with LXN: view

Animal Models for LXN Gene

MGI Knock Outs for LXN:

Animal Model Products

miRNA for LXN Gene

miRTarBase miRNAs that target LXN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LXN Gene

Localization for LXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LXN Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LXN Gene COMPARTMENTS Subcellular localization image for LXN gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LXN: view

Pathways & Interactions for LXN Gene

SuperPathways for LXN Gene

No Data Available

Gene Ontology (GO) - Biological Process for LXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA --
genes like me logo Genes that share ontologies with LXN: view

No data available for Pathways by source and SIGNOR curated interactions for LXN Gene

Drugs & Compounds for LXN Gene

No Compound Related Data Available

Transcripts for LXN Gene

mRNA/cDNA for LXN Gene

Unigene Clusters for LXN Gene

Latexin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LXN Gene

No ASD Table

Relevant External Links for LXN Gene

GeneLoc Exon Structure for
LXN
ECgene alternative splicing isoforms for
LXN

Expression for LXN Gene

mRNA expression in normal human tissues for LXN Gene

mRNA differential expression in normal tissues according to GTEx for LXN Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for LXN Gene

This gene is overexpressed in Salivary gland (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LXN Gene



SOURCE GeneReport for Unigene cluster for LXN Gene Hs.478067

mRNA Expression by UniProt/SwissProt for LXN Gene

Q9BS40-LXN_HUMAN
Tissue specificity: Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.
genes like me logo Genes that share expression patterns with LXN: view

Protein tissue co-expression partners for LXN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LXN Gene

Orthologs for LXN Gene

This gene was present in the common ancestor of chordates.

Orthologs for LXN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LXN 35
  • 90.54 (n)
  • 85.59 (a)
LXN 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LXN 35
  • 85.14 (n)
  • 82.88 (a)
LXN 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lxn 35
  • 84.23 (n)
  • 85.14 (a)
Lxn 16
Lxn 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LXN 35
  • 99.7 (n)
  • 99.55 (a)
LXN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lxn 35
  • 84.31 (n)
  • 84.62 (a)
oppossum
(Monodelphis domestica)
Mammalia LXN 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LXN 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LXN 35
  • 65.74 (n)
  • 56.74 (a)
LXN 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LXN 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lxn 35
  • 61.75 (n)
  • 48.85 (a)
zebrafish
(Danio rerio)
Actinopterygii lxn 35
  • 48.22 (n)
  • 38.14 (a)
lxn 36
  • 28 (a)
OneToMany
Species with no ortholog for LXN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LXN Gene

ENSEMBL:
Gene Tree for LXN (if available)
TreeFam:
Gene Tree for LXN (if available)

Paralogs for LXN Gene

Paralogs for LXN Gene

(1) SIMAP similar genes for LXN Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LXN Gene

genes like me logo Genes that share paralogs with LXN: view

Variants for LXN Gene

Sequence variations from dbSNP and Humsavar for LXN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_019117 -
VAR_062139 -

Variation tolerance for LXN Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LXN Gene

HapMap Linkage Disequilibrium report
LXN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LXN Gene

Disorders for LXN Gene

MalaCards: The human disease database

(1) MalaCards diseases for LXN Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocervicitis
- elite association - COSMIC cancer census association via MalaCards
Search LXN in MalaCards View complete list of genes associated with diseases

Relevant External Links for LXN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LXN
genes like me logo Genes that share disorders with LXN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LXN Gene

Publications for LXN Gene

  1. Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. (PMID: 11455960) Liu Q. … Zhao S. (Mol. Biol. Rep. 2000) 3 4 23 67
  2. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PMID: 15738388) Pallares I. … Gomis-Rueth F.-X. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  3. Latexin exhibits tumor suppressor potential in hepatocellular carcinoma. (PMID: 24399246) Ni Q.F. … Kong L.B. (Oncol. Rep. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Latexin inhibits the proliferation of CD133+ miapaca-2 pancreatic cancer stem-like cells. (PMID: 25551472) Xue Z.X. … Cai Z.Z. (World J Surg Oncol 2014) 3

Products for LXN Gene

Sources for LXN Gene

Content