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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LXN Gene

protein-coding   GIFtS: 52
GCID: GC03M158366

latexin
 Explore 4 diseases affiliated with
LXN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LXN    

Aliases
for LXN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Latexin1     Tissue Carboxypeptidase Inhibitor2 3
ECI2 3 5     MUM2
TCI2 3 5     Protein MUM3
Endogenous Carboxypeptidase Inhibitor2 3     

External Ids:    HGNC: 133471   Entrez Gene: 569252   Ensembl: ENSG000000792577   OMIM: 6093055   UniProtKB: Q9BS403   

Export aliases for LXN gene to outside databases

Previous GC identifers: GC03M155644 GC03M159331 GC03M159645 GC03M159705 GC03M159866 GC03M155780


Summaries
for LXN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LXN:
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. (provided by RefSeq, Oct
2008)

UniProtKB/Swiss-Prot: LXN_HUMAN, Q9BS40
Function: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in
inflammation




Genomic Views
for LXN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LXN gene promoter:
         Max1   AML1a   Nkx2-5   HNF-3beta   IRF-2   FOXO4   SEF-1 (1)   FOXO1a   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LXN promoter sequence
   Search SABiosciences Chromatin IP Primers for LXN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LXN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.32   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25.32

LXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LXN gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M158366:  view genomic region     (about GC identifiers)

Start:
 158,363,611 bp from pter      End:
 158,390,482 bp from pter
Size:
 26,872 bases      Orientation:
 minus strand

Proteins
for LXN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LXN_HUMAN, Q9BS40 (See protein sequence)
Recommended Name: Latexin  
Size: 222 amino acids; 25750 Da
Subcellular location: Cytoplasm (Probable)
1 PDB 3D structure from and Proteopedia for LXN:
2BO9 (3D)    
Secondary accessions: Q96PN2 Q9NQS6

Explore the universe of human proteins at neXtProt for LXN: NX_Q9BS40

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BS40

    • LXN Protein expression data from MOPED and PaxDb:    About this image 
    LXN Protein Expression
    REFSEQ proteins: NP_064554.3  
    ENSEMBL proteins: 
     ENSP00000419373   ENSP00000264265  

    Human Recombinant Protein Products for LXN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LXN (Latexin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: LXN
    OriGene Protein Over-expression Lysate: LXN
    OriGene Custom Protein Services for LXN 
    GenScript Custom Purified and Recombinant Proteins Services for LXN
    Novus Biologicals LXN Proteins
    Novus Biologicals LXN Lysates
    Sino Biological Recombinant Protein for LXN
    ProSpec Recombinant Protein for LXN
    Uscn Proteins for LXN

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    LXN for ontologies           About GeneDecksing



    LXN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for LXN 
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    GenScript Custom Assay Services for LXN
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    Uscn ELISAs and CLIAs for LXN

    Protein Domains /
    Families
    for LXN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LXN for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009684 Prot_inh_latexin

    Graphical View of Domain Structure for InterPro Entry Q9BS40

    ProtoNet protein and cluster: Q9BS40

    1 Blocks protein family: IPB009684 Proteinase inhibitor I47

    UniProtKB/Swiss-Prot: LXN_HUMAN, Q9BS40
    Similarity: Belongs to the protease inhibitor I47 (latexin) family


    Function
    for LXN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LXN_HUMAN, Q9BS40
    Function: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in
    inflammation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008191metalloendopeptidase inhibitor activity IEA--
    GO:0008201heparin binding IEA--
         
    LXN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LXN:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lxn):
     behavior/neurological  integument 

    LXN for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Lxntm1Yari for LXN
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LXN 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: LXN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LXN
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LXN:
    hsa-miR-641 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmid: LXN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LXN (see all 7)
    OriGene shRNA RFP: LXN
    OriGene siRNA: LXN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LXN
    Sirion Biotech Custom design and validation of potent shRNA sequences against LXN 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LXN
    Sirion Biotech Customized adenovirus for overexpression of LXN 
    Sirion Biotech Customized adenovirus for potent knockdown of LXN

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LXN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LXN (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LXN (NM_032242)
    Sino Biological Human cDNA Clone for LXN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LXN 

    Cell Line
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    Search LifeMap BioReagents cell lines for LXN
    Sirion Biotech Customized stable knockdown cell line services for LXN 
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    Sirion Biotech Customized stable overexpressing cell line services for LXN
    Sirion Biotech Customized inducible overexpressing cell line services for LXN

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LXN


    Pathways & Interactions
    for LXN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LXN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for LXN (Q9BS401, 3 ENSP000002642654) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIRBPQ140111, 3, ENSP000003228874EBI-1044504,EBI-538850 I2D: score=2 STRING: ENSP00000322887
    KIAA1009Q5TB801, 3, ENSP000003852154EBI-1044504,EBI-1059012 I2D: score=2 STRING: ENSP00000385215
    PPM1AP358131, 3, ENSP000003272554EBI-1044504,EBI-989143 I2D: score=2 STRING: ENSP00000327255
    THRAP3Q9Y2W11, 3, ENSP000003466344EBI-1044504,EBI-352039 I2D: score=2 STRING: ENSP00000346634
    PANK2Q9BZ231, 3, ENSP000003133774EBI-1044504,EBI-1058434 I2D: score=2 STRING: ENSP00000313377
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0050965detection of temperature stimulus involved in sensory perception of pain IEA--

    LXN for ontologies           About GeneDecksing



    Drugs & Compounds
    for LXN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LXN
    Search CenterWatch for drugs/clinical trials and news about LXN 

    Transcripts
    for LXN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LXN gene: 
    NM_020169.3  

    Unigene Cluster for LXN:

    Latexin
    Hs.478067  [show with all ESTs]
    Unigene Representative Sequence: BC005346
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482640 ENST00000264265(uc003fch.3 uc011bov.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: LXN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LXN
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LXN:
    hsa-miR-641 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmid: LXN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LXN (see all 7)
    OriGene shRNA RFP: LXN
    OriGene siRNA: LXN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LXN
    Sirion Biotech Custom design and validation of potent shRNA sequences against LXN 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LXN (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LXN (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LXN (NM_032242)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LXN 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LXN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LXN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LXN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LXN

    Additional cDNA sequence: 

    AF087851.1 AF282594.1 AF282626.1 BC005346.1 BC008438.1 

    5 DOTS entries:

    DT.99963069  DT.453576  DT.95331260  DT.97780480  DT.95331287 

    24/177 AceView cDNA sequences (see all 177):

    BG940926 BG944101 CB853033 AI638836 CD370776 BM972192 BG941720 BM994209 
    AW139793 AI630571 AA954088 CD676426 AA422079 AI092299 BX090076 BG941595 
    AL557781 CA430411 CA412913 CB306141 N55030 AI087271 CA310657 AA436375 

    GeneLoc Exon Structure


    Expression
    for LXN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LXN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTATTGATG
    LXN Expression
    About this image

    LXN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Trophoblast-like cells (Generation of tropho...)

    See LXN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LXN

    SOURCE GeneReport for Unigene cluster: Hs.478067

    UniProtKB/Swiss-Prot: LXN_HUMAN, Q9BS40
    Tissue specificity: Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other
    tissues including brain

        SABiosciences Custom PCR Arrays for LXN
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LXN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LXN

    Orthologs
    for LXN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LXN gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LXN1 latexin 65.72(n)
    56.87(a)    		   771519  XM_001233653.2  XP_001233654.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LXN6
    		 --
    		 55(a)
    		 1 ↔ 1
    		 3(14122082-14131739)
    zebrafish
    (Danio rerio)    		 Actinopterygii lxn1 latexin 48.22(n)
    38.14(a)    		   494053  NM_001008596.1  NP_001008596.1 


    ENSEMBL Gene Tree for LXN (if available)
    TreeFam Gene Tree for LXN (if available) 

    Paralogs
    for LXN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LXN gene
    RARRES12  
    1 SIMAP similar gene for LXN using alignment to 2 protein entries:     LXN_HUMAN (see all proteins):
    RARRES1

    LXN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LXN
    PGOHUM00000235441


    Genomic Variants
    for LXN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/171 NCBI SNPs in LXN are shown (see all 171)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs611070681,2
    		C,F--155779550(+) ATGTAT/CTGATA 1 -- int14Minor allele frequency- C:0.21WA CSA NA 242
    rs563212071,2
    		C,F--155780579(+) TAAAGC/AATACT 1 -- int16Minor allele frequency- A:0.17WA CSA NA EA 366
    rs176303941,2
    		C,F,H--155781642(+) TGTTGG/CATTAT 1 -- int122Minor allele frequency- C:0.09NA NS EA 2678
    rs754119411,2
    		F--155782385(+) GCAAAG/AGAGGC 1 -- int11Minor allele frequency- A:0.08WA 118
    rs613487831,2
    		C,F--155782543(+) TGACTA/GTAGGA 1 -- int14Minor allele frequency- G:0.15WA CSA 126
    rs32138451,2
    		C,H--155783004(+) AAGCAC/TAGATA 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs785368441,2
    		C,F--155784007(+) GCAGAC/TGTTAA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1128984441,2
    		C--155784568(+) GTCTCAAAG    
       AAA    /-    AAAGA     		1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1140516821,2
    		C,F--155784809(+) ATGTAA/CCATCT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs168292831,2
    		C,F,H--155784974(+) ACAGCG/ATTTAA 1 -- int113Minor allele frequency- A:0.16NA NS EA WA CSA 927

    HapMap Linkage Disequilibrium report for LXN (158363611 - 158390482 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LXN: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LXN
    DNA2.0 Custom Variant and Variant Library Synthesis for LXN

    Disorders / Diseases
    for LXN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LXN for disorders           About GeneDecksing

    OMIM gene information: 609305    OMIM disorders: --

    4 diseases for LXN:    About MalaCards
    listeriosis    endocervicitis    prostatitis    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for LXN:
    Endocervicitis     Listeriosis

    Export disorders for LXN gene to outside databases

    Publications
    for LXN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LXN gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with LXN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. (PubMed id 11455960)1, 2, 9 Liu Q.... Zhao S. (2000)
    2. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PubMed id 15738388)1, 2, 9 Pallares I.... Gomis-Rueth F.-X. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Latexin regulates the abundance of multiple cellular p roteins in hematopoietic stem cells. (PubMed id 21567403)1 Mitsunaga K....Furukawa Y. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential. (PubMed id 21466706)1 Li Y....Ke Y. (2011)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)

    External Searches for LXN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing LXN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56925 HGNC: 13347 AceView: LXN Ensembl:ENSG00000079257 euGenes: HUgn56925
    ECgene: LXN H-InvDB: LXN

    Other Databases showing LXN gene

    (According to HUGE)
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    Specialized Databases showing LXN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LXN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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