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Aliases for LVRN Gene

Aliases for LVRN Gene

  • Laeverin 2 3 4
  • Aminopeptidase Q 2 3
  • CHL2 Antigen 3 4
  • AQPEP 3 4
  • AP-Q 3 4
  • EC 3.4.24.57 64
  • EC 3.4.11.2 64
  • EC 3.4.11.- 4
  • EC 3.4.11 64
  • TAQPEP 3
  • APQ 3

External Ids for LVRN Gene

Summaries for LVRN Gene

GeneCards Summary for LVRN Gene

LVRN (Laeverin) is a Protein Coding gene. An important paralog of this gene is ERAP1.

UniProtKB/Swiss-Prot for LVRN Gene

  • Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LVRN Gene

Genomics for LVRN Gene

Genomic Location for LVRN Gene

Start:
115,962,454 bp from pter
End:
116,027,619 bp from pter
Size:
65,166 bases
Orientation:
Plus strand

Genomic View for LVRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LVRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LVRN Gene

Regulatory Elements for LVRN Gene

Proteins for LVRN Gene

  • Protein details for LVRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q4G3-AMPQ_HUMAN
    Recommended name:
    Aminopeptidase Q
    Protein Accession:
    Q6Q4G3
    Secondary Accessions:
    • A8K6J0
    • C9JGD2
    • Q32MR1
    • Q4G0I9
    • Q4G0V2
    • Q86XA3
    • Q8NBZ2

    Protein attributes for LVRN Gene

    Size:
    990 amino acids
    Molecular mass:
    113283 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAC11422.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LVRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LVRN Gene

Proteomics data for LVRN Gene at MOPED

Selected DME Specific Peptides for LVRN Gene

Post-translational modifications for LVRN Gene

Other Protein References for LVRN Gene

Domains for LVRN Gene

UniProtKB/Swiss-Prot:

AMPQ_HUMAN
Family:
  • Belongs to the peptidase M1 family.:
    • Q6Q4G3
genes like me logo Genes that share domains with LVRN: view

No data available for Gene Families for LVRN Gene

Function for LVRN Gene

Molecular function for LVRN Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=78.2 uM for Leu-4-methylcoumaryl-7-amide {ECO:0000269 PubMed:17525158}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:17525158};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by bestatin.
UniProtKB/Swiss-Prot Function: Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.

Enzyme Numbers (IUBMB) for LVRN Gene

Gene Ontology (GO) - Molecular Function for LVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LVRN: view
genes like me logo Genes that share phenotypes with LVRN: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LVRN Gene

Localization for LVRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LVRN Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for LVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LVRN: view

Pathways for LVRN Gene

SuperPathways for LVRN Gene

No Data Available

Interacting Proteins for LVRN Gene

Gene Ontology (GO) - Biological Process for LVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with LVRN: view

No data available for Pathways by source for LVRN Gene

Transcripts for LVRN Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LVRN Gene

No ASD Table

Relevant External Links for LVRN Gene

GeneLoc Exon Structure for
LVRN
ECgene alternative splicing isoforms for
LVRN

Expression for LVRN Gene

mRNA expression in normal human tissues for LVRN Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LVRN Gene

mRNA Expression by UniProt/SwissProt for LVRN Gene

Q6Q4G3-AMPQ_HUMAN
Tissue specificity: Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level).
genes like me logo Genes that share expressions with LVRN: view

Orthologs for LVRN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LVRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 99 (a)
OneToOne
LOC462012 36
  • 99.36 (n)
  • 99.19 (a)
cow
(Bos Taurus)
Mammalia AQPEP 36
  • 85.56 (n)
  • 81.17 (a)
AQPEP 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 80 (a)
OneToOne
AQPEP 36
  • 86.36 (n)
  • 80.61 (a)
mouse
(Mus musculus)
Mammalia 4833403I15Rik 36
  • 76.47 (n)
  • 67.65 (a)
4833403I15Rik 16
4833403I15Rik 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aqpep 36
  • 77.68 (n)
  • 70.22 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 52 (a)
OneToOne
LOC431649 36
  • 63.65 (n)
  • 53.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496094 36
  • 57.72 (n)
  • 47.61 (a)
zebrafish
(Danio rerio)
Actinopterygii anpepa 37
  • 31 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11951 37
  • 29 (a)
ManyToMany
CG14516 37
  • 29 (a)
ManyToMany
CG2111 37
  • 25 (a)
ManyToMany
CG31198 37
  • 22 (a)
ManyToMany
CG31233 37
  • 26 (a)
ManyToMany
CG31343 37
  • 25 (a)
ManyToMany
CG31445 37
  • 28 (a)
ManyToMany
CG3502 37
  • 26 (a)
ManyToMany
CG40470 37
  • 22 (a)
ManyToMany
CG42335 37
  • 23 (a)
ManyToMany
CG5849 37
  • 22 (a)
ManyToMany
CG6071 37
  • 22 (a)
ManyToMany
CG7653 37
  • 26 (a)
ManyToMany
CG9806 37
  • 24 (a)
ManyToMany
sda 37
  • 22 (a)
ManyToMany
SP1029 37
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R03G8.6 37
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 37
  • 27 (a)
ManyToMany
APE2 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
Species with no ortholog for LVRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LVRN Gene

ENSEMBL:
Gene Tree for LVRN (if available)
TreeFam:
Gene Tree for LVRN (if available)

Paralogs for LVRN Gene

Paralogs for LVRN Gene

genes like me logo Genes that share paralogs with LVRN: view

Variants for LVRN Gene

Sequence variations from dbSNP and Humsavar for LVRN Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs885119 -- 115,996,522(-) TCTTG(A/G)TCTCC intron-variant
rs885120 -- 115,996,478(-) AAAAC(A/C)AAGAA intron-variant
rs885121 -- 115,995,771(+) atttt(A/T)catgt intron-variant
rs885122 -- 115,995,638(+) ACGAT(A/G)ACAAC intron-variant
rs885123 -- 115,996,106(+) CTTTA(A/T)CTTCT intron-variant

Relevant External Links for LVRN Gene

HapMap Linkage Disequilibrium report
LVRN

No data available for Structural Variations from Database of Genomic Variants (DGV) for LVRN Gene

Disorders for LVRN Gene

Relevant External Links for LVRN

Genetic Association Database (GAD)
LVRN
genes like me logo Genes that share disorders with LVRN: view

No data available for UniProtKB/Swiss-Prot for LVRN Gene

Publications for LVRN Gene

  1. Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases. (PMID: 14706636) Fujiwara H. … Fujii S. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases. (PMID: 17525158) Maruyama M. … Tsujimoto M. (J. Biol. Chem. 2007) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Regulation of human extravillous trophoblast function by membrane-bound peptidases. (PMID: 15897020) Fujiwara H. … Maeda M. (Biochim. Biophys. Acta 2005) 3 23
  5. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. (PMID: 16804865) Haas C.S. … Holoshitz J. (Arthritis Rheum. 2006) 3 23

Products for LVRN Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate LVRN
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for LVRN
    • Block miRNA regulation of LVRN using miScript Target Protectors

    Sources for LVRN Gene

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