Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LVRN Gene

Aliases for LVRN Gene

  • Laeverin 2 3 4 5
  • Aminopeptidase Q 2 3
  • CHL2 Antigen 3 4
  • AQPEP 3 4
  • AP-Q 3 4
  • APQ 3 4
  • EC 56
  • EC 56
  • EC 3.4.11.- 4
  • EC 3.4.11 56
  • TAQPEP 3

External Ids for LVRN Gene

Previous GeneCards Identifiers for LVRN Gene

  • GC05P115327

Summaries for LVRN Gene

GeneCards Summary for LVRN Gene

LVRN (Laeverin) is a Protein Coding gene. Diseases associated with LVRN include Chronic Laryngitis and Laryngeal Disease. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity. An important paralog of this gene is ANPEP.

UniProtKB/Swiss-Prot for LVRN Gene

  • Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.

Additional gene information for LVRN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LVRN Gene

Genomics for LVRN Gene

GeneHancer (GH) Regulatory Elements for LVRN Gene

Promoters and enhancers for LVRN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I115960 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 556 +7.3 7263 2.3 RNF2 SUZ12 FOXP2 RCOR1 CHD2 EZH2 LVRN ENSG00000249791 DDX43P1
GH05I115977 Enhancer 0.8 ENCODE dbSUPER 23.6 +24.0 24018 3.4 JUN MAFG CTBP1 PRDM6 ZNF316 FOS NFE2 EMSY MAFK LVRN DDX43P1 ARL14EPL
GH05I115927 Enhancer 1.1 FANTOM5 ENCODE 11.9 -24.6 -24622 4.6 ZNF473 INSM2 KLF17 TCF12 ZNF23 ZNF366 SCRT2 ZNF416 ZNF207 FOS GC05M115931 ENSG00000250015 SEMA6A-AS1 ATG12 LVRN PGGT1B GC05M115886
GH05I116076 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.9 +121.8 121815 0.6 BACH1 BATF NFATC1 ATF7 ETV6 IKZF2 RUNX3 SRF JUNB DPF2 ENSG00000272265 LVRN ATG12 AP3S1 TMED7 COMMD10 ENSG00000271918 RPS25P6
GH05I115987 Enhancer 0.4 dbSUPER 25.3 +33.9 33911 3 POLR2A ZFP36 LVRN AP3S1 DDX43P1 ARL14EPL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LVRN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LVRN gene promoter:

Genomic Locations for LVRN Gene

Genomic Locations for LVRN Gene
72,717 bases
Plus strand

Genomic View for LVRN Gene

Genes around LVRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LVRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LVRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LVRN Gene

Proteins for LVRN Gene

  • Protein details for LVRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aminopeptidase Q
    Protein Accession:
    Secondary Accessions:
    • A8K6J0
    • C9JGD2
    • Q32MR1
    • Q4G0I9
    • Q4G0V2
    • Q86XA3
    • Q8NBZ2

    Protein attributes for LVRN Gene

    990 amino acids
    Molecular mass:
    113283 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • Sequence=BAC11422.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LVRN Gene


neXtProt entry for LVRN Gene

Selected DME Specific Peptides for LVRN Gene


Post-translational modifications for LVRN Gene

  • N-glycosylated.
  • Glycosylation at isoforms=2132, posLast=168168, posLast=261261, posLast=288288, isoforms=2319, isoforms=2346, posLast=607607, and posLast=653653

Domains & Families for LVRN Gene

Gene Families for LVRN Gene

Suggested Antigen Peptide Sequences for LVRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M1 family.
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with LVRN: view

Function for LVRN Gene

Molecular function for LVRN Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=78.2 uM for Leu-4-methylcoumaryl-7-amide {ECO:0000269 PubMed:17525158}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:17525158};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by bestatin.
UniProtKB/Swiss-Prot Function:
Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.

Enzyme Numbers (IUBMB) for LVRN Gene

Phenotypes From GWAS Catalog for LVRN Gene

Gene Ontology (GO) - Molecular Function for LVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA,IBA --
GO:0016787 hydrolase activity IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with LVRN: view
genes like me logo Genes that share phenotypes with LVRN: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LVRN Gene

Localization for LVRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LVRN Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LVRN gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LVRN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LVRN Gene

Pathways & Interactions for LVRN Gene

No Data Available

Gene Ontology (GO) - Biological Process for LVRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IBA --
GO:0007165 signal transduction IBA --
GO:0007267 cell-cell signaling IBA --
GO:0008217 regulation of blood pressure IBA --
GO:0043171 peptide catabolic process IBA --
genes like me logo Genes that share ontologies with LVRN: view

No data available for Pathways by source and SIGNOR curated interactions for LVRN Gene

Drugs & Compounds for LVRN Gene

No Compound Related Data Available

Transcripts for LVRN Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LVRN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: -

Relevant External Links for LVRN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LVRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LVRN Gene

Protein differential expression in normal tissues from HIPED for LVRN Gene

This gene is overexpressed in Placenta (57.2) and Monocytes (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LVRN Gene

Protein tissue co-expression partners for LVRN Gene

NURSA nuclear receptor signaling pathways regulating expression of LVRN Gene:


mRNA Expression by UniProt/SwissProt for LVRN Gene:

Tissue specificity: Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level).
genes like me logo Genes that share expression patterns with LVRN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LVRN Gene

Orthologs for LVRN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LVRN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC462012 33
  • 99.36 (n)
-- 34
  • 99 (a)
(Canis familiaris)
Mammalia AQPEP 33
  • 86.36 (n)
-- 34
  • 80 (a)
(Bos Taurus)
Mammalia AQPEP 33 34
  • 85.56 (n)
(Rattus norvegicus)
Mammalia Aqpep 33
  • 77.68 (n)
(Mus musculus)
Mammalia 4833403I15Rik 33 34
  • 76.47 (n)
Lvrn 16
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
(Gallus gallus)
Aves LOC431649 33
  • 63.65 (n)
-- 34
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496094 33
  • 57.72 (n)
(Danio rerio)
Actinopterygii anpepa 34
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14516 34
  • 29 (a)
SP1029 34
  • 29 (a)
CG11951 34
  • 29 (a)
CG31445 34
  • 28 (a)
CG31233 34
  • 26 (a)
CG3502 34
  • 26 (a)
CG7653 34
  • 26 (a)
CG2111 34
  • 25 (a)
CG31343 34
  • 25 (a)
CG9806 34
  • 24 (a)
CG42335 34
  • 23 (a)
CG31198 34
  • 22 (a)
CG40470 34
  • 22 (a)
CG5849 34
  • 22 (a)
CG6071 34
  • 22 (a)
sda 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea R03G8.6 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 34
  • 27 (a)
APE2 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
-- 34
  • 30 (a)
-- 34
  • 28 (a)
-- 34
  • 22 (a)
Species where no ortholog for LVRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LVRN Gene

Gene Tree for LVRN (if available)
Gene Tree for LVRN (if available)

Paralogs for LVRN Gene

Paralogs for LVRN Gene

genes like me logo Genes that share paralogs with LVRN: view

Variants for LVRN Gene

Sequence variations from dbSNP and Humsavar for LVRN Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000076499 -- 116,027,023(+) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000108994 -- 115,977,602(+) T/C intron_variant
rs1000157733 -- 115,969,840(+) A/T intron_variant
rs1000174840 -- 115,987,212(+) A/G intron_variant
rs1000262658 -- 116,006,679(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LVRN Gene

Variant ID Type Subtype PubMed ID
dgv10028n54 CNV gain 21841781
dgv3156n106 OTHER inversion 24896259
dgv5789n100 CNV gain 25217958
esv2730630 CNV deletion 23290073
esv2763487 CNV gain 21179565
esv34146 CNV loss 18971310
esv3606377 CNV loss 21293372
esv7796 OTHER inversion 19470904
nsv1068317 OTHER inversion 25765185
nsv515611 CNV gain+loss 19592680

Variation tolerance for LVRN Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LVRN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LVRN Gene

Disorders for LVRN Gene

MalaCards: The human disease database

(2) MalaCards diseases for LVRN Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic laryngitis
laryngeal disease
  • laryngeal diseases
- elite association - COSMIC cancer census association via MalaCards
Search LVRN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LVRN

genes like me logo Genes that share disorders with LVRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LVRN Gene

Publications for LVRN Gene

  1. Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases. (PMID: 17525158) Maruyama M … Tsujimoto M (The Journal of biological chemistry 2007) 2 3 4 58
  2. Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases. (PMID: 14706636) Fujiwara H … Fujii S (Biochemical and biophysical research communications 2004) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Histidine 379 of human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties. (PMID: 19819873) Maruyama M … Tsujimoto M (The Journal of biological chemistry 2009) 3 22 58
  5. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. (PMID: 16804865) Haas CS … Holoshitz J (Arthritis and rheumatism 2006) 3 22 58

Products for LVRN Gene

Sources for LVRN Gene

Loading form....