Aliases for LUZP2 Gene
External Ids for LUZP2 Gene
- HGNC: 23206
- Entrez Gene: 338645
- Ensembl: ENSG00000187398
- OMIM: 608178
- UniProtKB: Q86TE4
Previous GeneCards Identifiers for LUZP2 Gene
- GC00U913333
- GC11U900589
- GC11P024475
- GC11P024205
Summaries for LUZP2 Gene
-
This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
GeneCards Summary for LUZP2 Gene
LUZP2 (Leucine Zipper Protein 2) is a Protein Coding gene. Diseases associated with LUZP2 include Wagr Syndrome and Aniridia.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUZP2 Gene
Genomics for LUZP2 Gene
Regulatory Elements for LUZP2 Gene
Enhancers for LUZP2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around LUZP2 on UCSC Golden Path with GeneCards custom track
Promoters for LUZP2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around LUZP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for LUZP2 Gene
- Chromosome:
- 11
- Start:
- 24,496,488 bp from pter
- End:
- 25,082,640 bp from pter
- Size:
- 586,153 bases
- Orientation:
- Plus strand
Genomic View for LUZP2 Gene
Genes around LUZP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p14.3 by Ensembl
- 11p14.3 by Entrez Gene
- 11p14.3 by HGNC
LUZP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LUZP2 Gene
Proteins for LUZP2 Gene
-
Protein details for LUZP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86TE4-LUZP2_HUMAN
- Recommended name:
- Leucine zipper protein 2
- Protein Accession:
- Q86TE4
- A2RUB8
- E9PN53
- Q6UXE7
- Q6ZS65
Protein attributes for LUZP2 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 38958 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAD90000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for LUZP2 Gene
Post-translational modifications for LUZP2 Gene
Other Protein References for LUZP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LUZP2
- antibodies-online Antibodies for LUZP2: See all 18
- GeneTex LUZP2 antibody for LUZP2
Protein Products
-
OriGene Purified Proteins for LUZP2
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- Novus Biologicals proteins for LUZP2
- antibodies-online Proteins for LUZP2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for LUZP2
Assay Products
No data available for DME Specific Peptides for LUZP2 Gene
Domains & Families for LUZP2 Gene
Suggested Antigen Peptide Sequences for LUZP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for LUZP2 Gene
Function for LUZP2 Gene
Phenotypes for LUZP2 Gene
- MGI mutant phenotypes for LUZP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LUZP2:
Animal Models for LUZP2 Gene
- MGI Knock Outs for LUZP2:
-
- Luzp2 tm1Dkj
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for LUZP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LUZP2 gene
- Search ViGene Biosciences for LUZP2
CRISPR Products
-
OriGene CRISPR knockouts for LUZP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LUZP2
- GenScript: Design CRISPR guide RNA sequences for LUZP2
miRNA for LUZP2 Gene
- miRTarBase miRNAs that target LUZP2
-
- hsa-mir-653-5p (MIRT549810)
- hsa-mir-5585-3p (MIRT549811)
- hsa-mir-374b-5p (MIRT549812)
- hsa-mir-374a-5p (MIRT549813)
- hsa-mir-205-3p (MIRT549814)
- hsa-mir-5692c (MIRT549815)
- hsa-mir-5692b (MIRT549816)
- hsa-mir-369-3p (MIRT549817)
- hsa-mir-5590-3p (MIRT549818)
- hsa-mir-142-5p (MIRT549819)
- hsa-mir-652-5p (MIRT549820)
- hsa-mir-4796-3p (MIRT549821)
- hsa-mir-93-5p (MIRT549822)
- hsa-mir-526b-3p (MIRT549823)
- hsa-mir-519d-3p (MIRT549824)
- hsa-mir-20b-5p (MIRT549825)
- hsa-mir-20a-5p (MIRT549826)
- hsa-mir-17-5p (MIRT549827)
- hsa-mir-106b-5p (MIRT549828)
- hsa-mir-106a-5p (MIRT549829)
- hsa-mir-548ah-5p (MIRT549830)
- hsa-mir-3609 (MIRT549831)
- hsa-mir-548s (MIRT690005)
- hsa-mir-3165 (MIRT690006)
- hsa-mir-3926 (MIRT690007)
- hsa-mir-4786-5p (MIRT690008)
- hsa-mir-3190-5p (MIRT690009)
- hsa-mir-7162-3p (MIRT690010)
- hsa-mir-6078 (MIRT690011)
- hsa-mir-544b (MIRT690012)
- hsa-mir-6849-3p (MIRT690013)
- hsa-mir-4433a-3p (MIRT690014)
- hsa-mir-4459 (MIRT690015)
- hsa-mir-4768-3p (MIRT690016)
miRNA Products
- Search ViGene Biosciences for LUZP2
Inhibitory RNA Products
- Origene mouse_rna, shRNA, siRNA, and RNAi products in human, mouse, rat for LUZP2
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-
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Clone Products
- OriGene clones in human for LUZP2
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for LUZP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LUZP2 gene
-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LUZP2 Gene
Localization for LUZP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LUZP2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| lysosome | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| vacuole | 1 |
No data available for Gene Ontology (GO) - Cellular Components for LUZP2 Gene
Pathways & Interactions for LUZP2 Gene
More details on SuperPathways for LUZP2
No Data Available
Interacting Proteins for LUZP2 Gene
No data available for Pathways by source and SIGNOR curated interactions for LUZP2 Gene
Transcripts for LUZP2 Gene
mRNA/cDNA for LUZP2 Gene
- (7) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (20) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LUZP2 Gene
- Leucine zipper protein 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LUZP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LUZP2
- GenScript: Design CRISPR guide RNA sequences for LUZP2
miRNA Products
- Search ViGene Biosciences for LUZP2
Inhibitory RNA Products
- Origene mouse_rna, shRNA, siRNA, and RNAi products in human, mouse, rat for LUZP2
- Browse OriGene Inhibitory RNA Products For LUZP2
-
ViGene Biosciences ready-to-package AAV shRNAs for LUZP2 gene
Clone Products
- OriGene clones in human for LUZP2
- OriGene ORF clones in human,mouse for LUZP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: |
Expression for LUZP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
- Neural Tube (Nervous System)
- Glial Cells (Uncategorized)
- Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for LUZP2 Gene
This gene is overexpressed in Brain - Hypothalamus (x6.7), Brain - Substantia nigra (x6.1), Brain - Amygdala (x5.7), Brain - Spinal cord (cervical c-1) (x5.5), and Brain - Anterior cingulate cortex (BA24) (x4.2).
This gene is overexpressed in Serum (62.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LUZP2 Gene
SOURCE GeneReport for Unigene cluster for LUZP2 Gene Hs.144138
Primer Products
-
OriGene qPCR primer pairs for LUZP2
No data available for mRNA Expression by UniProt/SwissProt for LUZP2 Gene
Orthologs for LUZP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | LOC612193 35 |
|
||
| LUZP2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Luzp2 35 |
|
||
| Luzp2 16 |
|
||||
| Luzp2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | LUZP2 35 |
|
||
| LUZP2 36 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | MGC157332 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LUZP2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | LUZP2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LUZP2 35 |
|
||
| LUZP2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | LUZP2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | luzp2 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkeyp-86e4.1 35 |
|
||
| luzp2 36 |
|
OneToOne |
- Species with no ortholog for LUZP2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for LUZP2 Gene
No data available for Paralogs for LUZP2 Gene
Variants for LUZP2 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7930185 | - | 25,077,392(+) | AAACC(A/C/G)AGCCT | reference, missense | |
| rs715634 | -- | 24,881,171(-) | TGAAA(C/T)AACCT | intron-variant | |
| rs720951 | -- | 24,989,433(-) | GATAT(A/C)CTAAA | intron-variant | |
| rs723139 | -- | 24,764,014(-) | CTGAT(A/T)ACTCT | intron-variant | |
| rs723140 | -- | 24,764,285(-) | CTTAT(A/G)TAAAG | intron-variant |
Residual Variation Intolerance Score:
56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.84;
89.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for LUZP2 Gene
- Human Gene Mutation Database (HGMD)
- LUZP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUZP2 Gene
Disorders for LUZP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wagr syndrome |
|
|
| aniridia |
|
|
Search LUZP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for LUZP2
No data available for UniProtKB/Swiss-Prot and Genatlas for LUZP2 Gene
Publications for LUZP2 Gene
- Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14. (PMID: 12856284) Wu M. … Johnson D.K. (Mamm. Genome 2003) 2 3 23 67
- Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
- Genome-wide association study of intelligence: additive effects of novel brain expressed genes. (PMID: 22449649) Loo S.K. … Nelson S.F. (J Am Acad Child Adolesc Psychiatry 2012) 3
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
- Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. (PMID: 22881374) Cummings A.C. … Haines J.L. (Ann. Hum. Genet. 2012) 3
Products for LUZP2 Gene
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- antibodies-online Antibodies for LUZP2: See all 18
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- antibodies-online Proteins for LUZP2: See all 5
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- GeneTex LUZP2 antibody for LUZP2
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- ViGene Biosciences adenoviral particle packaged cDNA for LUZP2 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for LUZP2 gene
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- Search ViGene Biosciences for LUZP2
- Search ViGene Biosciences for LUZP2
Sources for LUZP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon