Aliases for LUZP2 Gene
External Ids for LUZP2 Gene
- HGNC: 23206
- Entrez Gene: 338645
- Ensembl: ENSG00000187398
- OMIM: 608178
- UniProtKB: Q86TE4
Previous GeneCards Identifiers for LUZP2 Gene
- GC00U913333
- GC11U900589
- GC11P024475
- GC11P024205
Summaries for LUZP2 Gene
-
This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
GeneCards Summary for LUZP2 Gene
LUZP2 (Leucine Zipper Protein 2) is a Protein Coding gene. Diseases associated with LUZP2 include Aniridia and Wagr Syndrome.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUZP2 Gene
Genomics for LUZP2 Gene
Regulatory Elements for LUZP2 Gene
Enhancers for LUZP2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11F023987 | 0.6 | ENCODE | 6.1 | -507.8 | -507842 | 1.7 | ZNF316 MAFF JUND MAFG EMSY MAFK | LUZP2 GC11M023947 GC11M023953 |
| GH11F023975 | 0.2 | ENCODE | 7.6 | -519.5 | -519517 | 2.3 | LUZP2 GC11M023953 GC11M023947 | |
| GH11F024496 | 0.6 | ENCODE | 0.8 | +0.6 | 578 | 1.0 | CTCF JUND SUZ12 CBX2 CTBP2 RAD21 ZBTB26 | LUZP2 GC11P024521 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around LUZP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for LUZP2 Gene
- Chromosome:
- 11
- Start:
- 24,496,488 bp from pter
- End:
- 25,082,640 bp from pter
- Size:
- 586,153 bases
- Orientation:
- Plus strand
Genomic View for LUZP2 Gene
Genes around LUZP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p14.3 by Ensembl
- 11p14.3 by Entrez Gene
- 11p14.3 by HGNC
LUZP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LUZP2 Gene
Proteins for LUZP2 Gene
-
Protein details for LUZP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86TE4-LUZP2_HUMAN
- Recommended name:
- Leucine zipper protein 2
- Protein Accession:
- Q86TE4
- A2RUB8
- E9PN53
- Q6UXE7
- Q6ZS65
Protein attributes for LUZP2 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 38958 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAD90000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for LUZP2 Gene
Post-translational modifications for LUZP2 Gene
Other Protein References for LUZP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LUZP2
- Invitrogen Antibodies for LUZP2
- antibodies-online Antibodies for LUZP2: See all 18
- GeneTex LUZP2 antibody for LUZP2
Protein Products
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OriGene Purified Proteins for LUZP2
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- Novus Biologicals proteins for LUZP2
- antibodies-online Proteins for LUZP2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for LUZP2
Assay Products
No data available for DME Specific Peptides for LUZP2 Gene
Domains & Families for LUZP2 Gene
Suggested Antigen Peptide Sequences for LUZP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for LUZP2 Gene
Function for LUZP2 Gene
Phenotypes for LUZP2 Gene
- MGI mutant phenotypes for LUZP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LUZP2:
Animal Models for LUZP2 Gene
- MGI Knock Outs for LUZP2:
-
- Luzp2 tm1Dkj
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for LUZP2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for LUZP2
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miRNA for LUZP2 Gene
- miRTarBase miRNAs that target LUZP2
-
- hsa-mir-653-5p (MIRT549810)
- hsa-mir-5585-3p (MIRT549811)
- hsa-mir-374b-5p (MIRT549812)
- hsa-mir-374a-5p (MIRT549813)
- hsa-mir-205-3p (MIRT549814)
- hsa-mir-5692c (MIRT549815)
- hsa-mir-5692b (MIRT549816)
- hsa-mir-369-3p (MIRT549817)
- hsa-mir-5590-3p (MIRT549818)
- hsa-mir-142-5p (MIRT549819)
- hsa-mir-652-5p (MIRT549820)
- hsa-mir-4796-3p (MIRT549821)
- hsa-mir-93-5p (MIRT549822)
- hsa-mir-526b-3p (MIRT549823)
- hsa-mir-519d-3p (MIRT549824)
- hsa-mir-20b-5p (MIRT549825)
- hsa-mir-20a-5p (MIRT549826)
- hsa-mir-17-5p (MIRT549827)
- hsa-mir-106b-5p (MIRT549828)
- hsa-mir-106a-5p (MIRT549829)
- hsa-mir-548ah-5p (MIRT549830)
- hsa-mir-3609 (MIRT549831)
- hsa-mir-548s (MIRT690005)
- hsa-mir-3165 (MIRT690006)
- hsa-mir-3926 (MIRT690007)
- hsa-mir-4786-5p (MIRT690008)
- hsa-mir-3190-5p (MIRT690009)
- hsa-mir-7162-3p (MIRT690010)
- hsa-mir-6078 (MIRT690011)
- hsa-mir-544b (MIRT690012)
- hsa-mir-6849-3p (MIRT690013)
- hsa-mir-4433a-3p (MIRT690014)
- hsa-mir-4459 (MIRT690015)
- hsa-mir-4768-3p (MIRT690016)
miRNA Products
- Search ViGene Biosciences for LUZP2
Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for LUZP2
-
ViGene Biosciences adenoviral particle packaged cDNA for LUZP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LUZP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LUZP2 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LUZP2 Gene
Localization for LUZP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LUZP2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| mitochondrion | 1 |
| nucleus | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
Pathways & Interactions for LUZP2 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for LUZP2 Gene
Transcripts for LUZP2 Gene
mRNA/cDNA for LUZP2 Gene
- (8) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (20) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LUZP2 Gene
- Leucine zipper protein 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LUZP2
- GenScript: Design CRISPR guide RNA sequences for LUZP2
miRNA Products
- Search ViGene Biosciences for LUZP2
Inhibitory RNA Products
- Origene RNAi, siRNA, shRNA, and mouse_rna products in human, mouse, rat for LUZP2
- Browse OriGene Inhibitory RNA Products For LUZP2
-
ViGene Biosciences ready-to-package AAV shRNAs for LUZP2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for LUZP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LUZP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: |
Expression for LUZP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
- Neural Tube (Nervous System)
- Spinal Cord (Nervous System)
- Glial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for LUZP2 Gene
This gene is overexpressed in Brain - Hypothalamus (x6.7), Brain - Substantia nigra (x6.1), Brain - Amygdala (x5.7), Brain - Spinal cord (cervical c-1) (x5.5), and Brain - Anterior cingulate cortex (BA24) (x4.2).
This gene is overexpressed in Serum (62.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LUZP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of LUZP2 Gene:
LUZP2SOURCE GeneReport for Unigene cluster for LUZP2 Gene:
Hs.144138Primer Products
-
OriGene qPCR primer pairs for LUZP2
No data available for mRNA Expression by UniProt/SwissProt for LUZP2 Gene
Orthologs for LUZP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LUZP2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Luzp2 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC612193 34 |
|
||
| LUZP2 35 |
|
OneToOne | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LUZP2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LUZP2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MGC157332 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LUZP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | LUZP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | luzp2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkeyp-86e4.1 34 |
|
||
| luzp2 35 |
|
OneToOne |
- Species where no ortholog for LUZP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for LUZP2 Gene
No data available for Paralogs for LUZP2 Gene
Variants for LUZP2 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1007719 | -- | 24,772,778(+) | ATGTC(A/G)CTCTT | intron-variant | |
| rs1007720 | -- | 24,772,963(+) | GCAAA(G/T)AACTT | intron-variant | |
| rs10082638 | -- | 24,896,400(+) | ggcga(C/T)gccag | intron-variant | |
| rs10082639 | -- | 24,896,432(+) | gcacc(C/T)gggcc | intron-variant | |
| rs10128728 | -- | 24,655,433(+) | CATTT(C/G)GGAAA | intron-variant |
Residual Variation Intolerance Score:
56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.84;
89.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for LUZP2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUZP2 Gene
Disorders for LUZP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| aniridia |
|
|
| wagr syndrome |
|
|
Search LUZP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for LUZP2
No data available for UniProtKB/Swiss-Prot and Genatlas for LUZP2 Gene
Publications for LUZP2 Gene
- Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14. (PMID: 12856284) Wu M. … Johnson D.K. (Mamm. Genome 2003) 2 3 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PMID: 20700443) Meyer T.E. … . (PLoS Genet. 2010) 3 46 64
- Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B. … Visscher P.M. (Am. J. Hum. Genet. 2009) 3 46 64
- Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 64
Products for LUZP2 Gene
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- VectorBuilder custom plasmid, inducible vectors for LUZP2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for LUZP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
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- (98) BioGPS
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- (100) COMPARTMENTS
- (101) HOMER
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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