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Aliases for LUZP2 Gene

Aliases for LUZP2 Gene

  • Leucine Zipper Protein 2 2 3 5
  • KFSP2566 3
  • PRO6246 3

External Ids for LUZP2 Gene

Previous GeneCards Identifiers for LUZP2 Gene

  • GC00U913333
  • GC11U900589
  • GC11P024475
  • GC11P024205

Summaries for LUZP2 Gene

Entrez Gene Summary for LUZP2 Gene

  • This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for LUZP2 Gene

LUZP2 (Leucine Zipper Protein 2) is a Protein Coding gene. Diseases associated with LUZP2 include Aniridia and Wagr Syndrome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUZP2 Gene

Genomics for LUZP2 Gene

Regulatory Elements for LUZP2 Gene

Enhancers for LUZP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F023975 1.1 ENCODE 7.6 -519.5 -519517 2.3 LUZP2 GC11M023953 GC11M023947
GH11F023987 0.2 ENCODE 6.1 -507.8 -507842 1.7 ZNF316 MAFF JUND MAFG EMSY MAFK LUZP2 GC11M023947 GC11M023953
GH11F024496 0.4 ENCODE 0.8 +0.6 578 1.0 CTCF JUND SUZ12 CBX2 CTBP2 RAD21 ZBTB26 LUZP2 GC11P024521
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LUZP2 on UCSC Golden Path with GeneCards custom track

Promoters for LUZP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001569003 513 1199 CTCF JUND SUZ12 CBX2 CTBP2 KDM1A RAD21 ZBTB26

Genomic Location for LUZP2 Gene

Chromosome:
11
Start:
24,496,488 bp from pter
End:
25,082,640 bp from pter
Size:
586,153 bases
Orientation:
Plus strand

Genomic View for LUZP2 Gene

Genes around LUZP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUZP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUZP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUZP2 Gene

Proteins for LUZP2 Gene

  • Protein details for LUZP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TE4-LUZP2_HUMAN
    Recommended name:
    Leucine zipper protein 2
    Protein Accession:
    Q86TE4
    Secondary Accessions:
    • A2RUB8
    • E9PN53
    • Q6UXE7
    • Q6ZS65

    Protein attributes for LUZP2 Gene

    Size:
    346 amino acids
    Molecular mass:
    38958 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD90000.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LUZP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUZP2 Gene

Post-translational modifications for LUZP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LUZP2 Gene

Domains & Families for LUZP2 Gene

Protein Domains for LUZP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LUZP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LUZP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LUZP2 Gene

Function for LUZP2 Gene

Phenotypes for LUZP2 Gene

genes like me logo Genes that share phenotypes with LUZP2: view

Animal Models for LUZP2 Gene

MGI Knock Outs for LUZP2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LUZP2 Gene

Localization for LUZP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUZP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LUZP2 Gene COMPARTMENTS Subcellular localization image for LUZP2 gene
Compartment Confidence
extracellular 4
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LUZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LUZP2: view

Pathways & Interactions for LUZP2 Gene

SuperPathways for LUZP2 Gene

No Data Available

Interacting Proteins for LUZP2 Gene

Gene Ontology (GO) - Biological Process for LUZP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LUZP2 Gene

Transcripts for LUZP2 Gene

Unigene Clusters for LUZP2 Gene

Leucine zipper protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LUZP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3:
SP4:

Relevant External Links for LUZP2 Gene

GeneLoc Exon Structure for
LUZP2
ECgene alternative splicing isoforms for
LUZP2

Expression for LUZP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LUZP2 Gene

mRNA differential expression in normal tissues according to GTEx for LUZP2 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.7), Brain - Substantia nigra (x6.1), Brain - Amygdala (x5.7), Brain - Spinal cord (cervical c-1) (x5.5), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for LUZP2 Gene

This gene is overexpressed in Serum (62.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LUZP2 Gene



Protein tissue co-expression partners for LUZP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LUZP2 Gene:

LUZP2

SOURCE GeneReport for Unigene cluster for LUZP2 Gene:

Hs.144138
genes like me logo Genes that share expression patterns with LUZP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LUZP2 Gene

Orthologs for LUZP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LUZP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LUZP2 34 35
  • 99.42 (n)
mouse
(Mus musculus)
Mammalia Luzp2 34 16 35
  • 84.15 (n)
dog
(Canis familiaris)
Mammalia LOC612193 34
  • 83.54 (n)
LUZP2 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LUZP2 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LUZP2 35
  • 67 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC157332 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves LUZP2 34 35
  • 72.74 (n)
lizard
(Anolis carolinensis)
Reptilia LUZP2 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia luzp2 34
  • 65.11 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-86e4.1 34
  • 69.09 (n)
luzp2 35
  • 51 (a)
OneToOne
Species where no ortholog for LUZP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LUZP2 Gene

ENSEMBL:
Gene Tree for LUZP2 (if available)
TreeFam:
Gene Tree for LUZP2 (if available)

Paralogs for LUZP2 Gene

No data available for Paralogs for LUZP2 Gene

Variants for LUZP2 Gene

Sequence variations from dbSNP and Humsavar for LUZP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1007719 -- 24,772,778(+) ATGTC(A/G)CTCTT intron-variant
rs1007720 -- 24,772,963(+) GCAAA(G/T)AACTT intron-variant
rs10082638 -- 24,896,400(+) ggcga(C/T)gccag intron-variant
rs10082639 -- 24,896,432(+) gcacc(C/T)gggcc intron-variant
rs10128728 -- 24,655,433(+) CATTT(C/G)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LUZP2 Gene

Variant ID Type Subtype PubMed ID
dgv1076n100 CNV gain 25217958
dgv1702n54 CNV loss 21841781
dgv1709n54 CNV loss 21841781
dgv1710n54 CNV loss 21841781
dgv1711n54 CNV gain 21841781
dgv1712n54 CNV loss 21841781
dgv1713n54 CNV loss 21841781
dgv1714n54 CNV loss 21841781
dgv2e49 CNV loss 18971310
dgv598n106 CNV deletion 24896259
dgv599n106 CNV deletion 24896259
dgv60n21 CNV loss 19592680
esv1095740 CNV insertion 17803354
esv1927907 CNV deletion 18987734
esv2157154 CNV deletion 18987734
esv22649 CNV loss 19812545
esv2422339 CNV deletion 17116639
esv24619 CNV loss 19812545
esv2640552 OTHER inversion 19546169
esv2657334 CNV deletion 23128226
esv2657586 CNV deletion 23128226
esv2658856 CNV deletion 23128226
esv2661725 CNV deletion 23128226
esv2671494 CNV deletion 23128226
esv2672146 CNV deletion 23128226
esv2676862 CNV deletion 23128226
esv2744240 CNV deletion 23290073
esv2744242 CNV deletion 23290073
esv2744243 CNV deletion 23290073
esv2744244 CNV deletion 23290073
esv2744245 CNV deletion 23290073
esv2744246 CNV deletion 23290073
esv2744247 CNV deletion 23290073
esv2744248 CNV deletion 23290073
esv274904 CNV loss 21479260
esv27550 CNV gain 19812545
esv2759810 CNV gain+loss 17122850
esv28433 CNV loss 19812545
esv3147816 CNV deletion 24192839
esv3305652 CNV mobile element insertion 20981092
esv3306020 CNV mobile element insertion 20981092
esv3309760 CNV mobile element insertion 20981092
esv3397534 CNV insertion 20981092
esv3405563 CNV insertion 20981092
esv3425051 CNV insertion 20981092
esv3547468 CNV deletion 23714750
esv3579445 CNV loss 25503493
esv3579446 CNV loss 25503493
esv3625678 CNV loss 21293372
esv3625679 CNV loss 21293372
esv3625680 CNV loss 21293372
esv3625681 CNV loss 21293372
esv3625683 CNV loss 21293372
esv3625685 CNV loss 21293372
esv3625686 CNV loss 21293372
esv3625687 CNV loss 21293372
esv3625689 CNV loss 21293372
esv3625690 CNV gain 21293372
esv3625691 CNV loss 21293372
esv3891952 CNV loss 25118596
esv990306 CNV deletion 20482838
nsv1040177 CNV gain 25217958
nsv1044583 CNV gain 25217958
nsv1053055 CNV gain 25217958
nsv1122590 CNV deletion 24896259
nsv1129511 CNV tandem duplication 24896259
nsv1140468 CNV tandem duplication 24896259
nsv1142104 CNV tandem duplication 24896259
nsv436133 CNV deletion 17901297
nsv442222 CNV loss 18776908
nsv467755 CNV loss 19166990
nsv467756 CNV loss 19166990
nsv467757 CNV loss 19166990
nsv467758 CNV loss 19166990
nsv469945 CNV gain 18288195
nsv469946 CNV loss 18288195
nsv478569 CNV novel sequence insertion 20440878
nsv507585 OTHER sequence alteration 20534489
nsv511472 CNV loss 21212237
nsv511487 CNV gain 21212237
nsv512214 CNV loss 21212237
nsv513690 OTHER inversion 21212237
nsv513691 OTHER inversion 21212237
nsv515848 CNV gain 19592680
nsv518374 CNV loss 19592680
nsv520070 CNV loss 19592680
nsv522581 CNV loss 19592680
nsv523280 CNV gain 19592680
nsv553819 CNV loss 21841781
nsv553820 CNV loss 21841781
nsv553821 CNV gain 21841781
nsv553822 CNV loss 21841781
nsv553825 CNV gain+loss 21841781
nsv553826 CNV loss 21841781
nsv553827 CNV gain 21841781
nsv553828 CNV loss 21841781
nsv553834 CNV gain 21841781
nsv553840 CNV loss 21841781
nsv553852 CNV loss 21841781
nsv553853 CNV loss 21841781
nsv553854 CNV loss 21841781
nsv553855 CNV gain 21841781
nsv7714 CNV insertion 18451855
nsv818804 CNV loss 17921354
nsv818805 CNV gain 17921354
nsv832089 CNV gain 17160897
nsv957379 CNV deletion 24416366
nsv957873 CNV insertion 24416366
nsv971996 CNV duplication 23825009

Variation tolerance for LUZP2 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.84; 89.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUZP2 Gene

Human Gene Mutation Database (HGMD)
LUZP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LUZP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUZP2 Gene

Disorders for LUZP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LUZP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
aniridia
  • cataract with late-onset corneal dystrophy
wagr syndrome
  • 11p partial monosomy syndrome
- elite association - COSMIC cancer census association via MalaCards
Search LUZP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LUZP2

Genetic Association Database (GAD)
LUZP2
Human Genome Epidemiology (HuGE) Navigator
LUZP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LUZP2
genes like me logo Genes that share disorders with LUZP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LUZP2 Gene

Publications for LUZP2 Gene

  1. Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14. (PMID: 12856284) Wu M. … Johnson D.K. (Mamm. Genome 2003) 2 3 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PMID: 20700443) Meyer T.E. … . (PLoS Genet. 2010) 3 46 64
  4. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PMID: 19084217) Benyamin B. … Visscher P.M. (Am. J. Hum. Genet. 2009) 3 46 64
  5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 64

Products for LUZP2 Gene

Sources for LUZP2 Gene

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