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Aliases for LUZP2 Gene

Aliases for LUZP2 Gene

  • Leucine Zipper Protein 2 2 3 5
  • KFSP2566 3
  • PRO6246 3

External Ids for LUZP2 Gene

Previous GeneCards Identifiers for LUZP2 Gene

  • GC00U913333
  • GC11U900589
  • GC11P024475
  • GC11P024205

Summaries for LUZP2 Gene

Entrez Gene Summary for LUZP2 Gene

  • This gene encodes a leucine zipper protein. This protein is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for LUZP2 Gene

LUZP2 (Leucine Zipper Protein 2) is a Protein Coding gene. Diseases associated with LUZP2 include wagr syndrome and aniridia.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUZP2 Gene

Genomics for LUZP2 Gene

Regulatory Elements for LUZP2 Gene

Promoters for LUZP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LUZP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LUZP2 Gene

24,496,488 bp from pter
25,082,640 bp from pter
586,153 bases
Plus strand

Genomic View for LUZP2 Gene

Genes around LUZP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUZP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUZP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUZP2 Gene

Proteins for LUZP2 Gene

  • Protein details for LUZP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine zipper protein 2
    Protein Accession:
    Secondary Accessions:
    • A2RUB8
    • E9PN53
    • Q6UXE7
    • Q6ZS65

    Protein attributes for LUZP2 Gene

    346 amino acids
    Molecular mass:
    38958 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD90000.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LUZP2 Gene


neXtProt entry for LUZP2 Gene

Proteomics data for LUZP2 Gene at MOPED

Post-translational modifications for LUZP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LUZP2 Gene

No data available for DME Specific Peptides for LUZP2 Gene

Domains & Families for LUZP2 Gene

Protein Domains for LUZP2 Gene


Suggested Antigen Peptide Sequences for LUZP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LUZP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LUZP2 Gene

Function for LUZP2 Gene

Phenotypes for LUZP2 Gene

genes like me logo Genes that share phenotypes with LUZP2: view

Animal Models for LUZP2 Gene

MGI Knock Outs for LUZP2:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LUZP2 Gene

Localization for LUZP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUZP2 Gene


Subcellular locations from

Jensen Localization Image for LUZP2 Gene COMPARTMENTS Subcellular localization image for LUZP2 gene
Compartment Confidence
extracellular 4
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LUZP2 Gene

Pathways & Interactions for LUZP2 Gene

SuperPathways for LUZP2 Gene

No Data Available

Interacting Proteins for LUZP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q86TE4-LUZP2_HUMAN ENSP00000336817 for LUZP2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for LUZP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LUZP2 Gene

Drugs & Compounds for LUZP2 Gene

No Compound Related Data Available

Transcripts for LUZP2 Gene

Unigene Clusters for LUZP2 Gene

Leucine zipper protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LUZP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -

Relevant External Links for LUZP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LUZP2 Gene

mRNA expression in normal human tissues for LUZP2 Gene

mRNA differential expression in normal tissues according to GTEx for LUZP2 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.7), Brain - Substantia nigra (x6.1), Brain - Amygdala (x5.7), Brain - Spinal cord (cervical c-1) (x5.5), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for LUZP2 Gene

This gene is overexpressed in Serum (62.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LUZP2 Gene

SOURCE GeneReport for Unigene cluster for LUZP2 Gene Hs.144138

genes like me logo Genes that share expression patterns with LUZP2: view

Protein tissue co-expression partners for LUZP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LUZP2 Gene

Orthologs for LUZP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LUZP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC612193 35
  • 83.54 (n)
  • 76.06 (a)
LUZP2 36
  • 82 (a)
(Mus musculus)
Mammalia Luzp2 35
  • 84.15 (n)
  • 83.19 (a)
Luzp2 16
Luzp2 36
  • 83 (a)
(Pan troglodytes)
Mammalia LUZP2 35
  • 99.42 (n)
  • 99.13 (a)
LUZP2 36
  • 99 (a)
(Bos Taurus)
Mammalia MGC157332 36
  • 65 (a)
(Monodelphis domestica)
Mammalia LUZP2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia LUZP2 36
  • 72 (a)
(Gallus gallus)
Aves LUZP2 35
  • 72.74 (n)
  • 70.15 (a)
LUZP2 36
  • 67 (a)
(Anolis carolinensis)
Reptilia LUZP2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia luzp2 35
  • 65.11 (n)
  • 59.48 (a)
(Danio rerio)
Actinopterygii si:dkeyp-86e4.1 35
  • 69.09 (n)
  • 68.38 (a)
luzp2 36
  • 51 (a)
Species with no ortholog for LUZP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LUZP2 Gene

Gene Tree for LUZP2 (if available)
Gene Tree for LUZP2 (if available)

Paralogs for LUZP2 Gene

No data available for Paralogs for LUZP2 Gene

Variants for LUZP2 Gene

Sequence variations from dbSNP and Humsavar for LUZP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7930185 - 25,077,392(+) AAACC(A/C/G)AGCCT reference, missense
rs17050 -- 25,080,785(-) CTTTC(C/T)ATAGG utr-variant-3-prime
rs3598 -- 24,892,447(-) TAAAT(G/T)TTGAA intron-variant
rs749149 -- 24,884,859(+) CCATT(C/G)CCAGA intron-variant
rs749150 -- 24,884,969(+) AACCT(A/G)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LUZP2 Gene

Variant ID Type Subtype PubMed ID
nsv467755 CNV Loss 19166990
nsv897088 CNV Gain 21882294
nsv897089 CNV Loss 21882294
nsv469945 CNV Gain 18288195
dgv1044n71 CNV Gain 21882294
esv270297 CNV Insertion 20981092
esv274904 CNV Loss 21479260
esv2744240 CNV Deletion 23290073
esv2744242 CNV Deletion 23290073
nsv897092 CNV Gain 21882294
dgv60n21 CNV Loss 19592680
nsv522581 CNV Loss 19592680
nsv436133 CNV Deletion 17901297
esv2657586 CNV Deletion 23128226
esv24619 CNV Loss 19812545
nsv897093 CNV Gain 21882294
nsv7714 CNV Insertion 18451855
esv990306 CNV Deletion 20482838
nsv897094 CNV Loss 21882294
dgv1045n71 CNV Loss 21882294
nsv897096 CNV Gain+Loss 21882294
nsv523280 CNV Gain 19592680
dgv1046n71 CNV Loss 21882294
nsv467756 CNV Loss 19166990
nsv469946 CNV Loss 18288195
nsv467757 CNV Loss 19166990
nsv515848 CNV Gain 19592680
nsv818804 CNV Loss 17921354
nsv818805 CNV Gain 17921354
esv274032 CNV Insertion 20981092
esv269929 CNV Insertion 20981092
dgv2e49 CNV Loss 18971310
esv22649 CNV Loss 19812545
esv2744243 CNV Deletion 23290073
nsv507585 CNV Insertion 20534489
esv2672146 CNV Deletion 23128226
esv2676862 CNV Deletion 23128226
esv2640552 OTHER Inversion 19546169
dgv1047n71 CNV Loss 21882294
nsv897104 CNV Gain 21882294
dgv1048n71 CNV Loss 21882294
esv1095740 CNV Insertion 17803354
nsv467758 CNV Loss 19166990
dgv1049n71 CNV Loss 21882294
esv2422339 CNV Deletion 17116639
dgv1050n71 CNV Loss 21882294
nsv832089 CNV Gain 17160897
nsv897116 CNV Gain 21882294
esv2658856 CNV Deletion 23128226
nsv897117 CNV Loss 21882294
esv2661725 CNV Deletion 23128226
esv2157154 CNV Deletion 18987734
nsv897118 CNV Loss 21882294
dgv1051n71 CNV Loss 21882294
nsv897121 CNV Loss 21882294
esv2744244 CNV Deletion 23290073
esv1927907 CNV Deletion 18987734
esv2744245 CNV Deletion 23290073
esv270545 CNV Insertion 20981092
nsv513690 OTHER Inversion 21212237
esv2657334 CNV Deletion 23128226
nsv520070 CNV Loss 19592680
nsv518374 CNV Loss 19592680
nsv513691 OTHER Inversion 21212237
nsv511487 CNV Gain 21212237
esv27550 CNV Gain 19812545
nsv512214 CNV Loss 21212237
esv2744246 CNV Deletion 23290073
esv2671494 CNV Deletion 23128226
nsv511472 CNV Loss 21212237
esv28433 CNV Loss 19812545
nsv442222 CNV CNV 18776908
dgv354e1 CNV Complex 17122850
esv2744247 CNV Deletion 23290073
esv2744248 CNV Deletion 23290073

Variation tolerance for LUZP2 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.84; 89.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUZP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUZP2 Gene

Disorders for LUZP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LUZP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wagr syndrome
  • 11p partial monosomy syndrome
  • cataract with late-onset corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search LUZP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LUZP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LUZP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LUZP2 Gene

Publications for LUZP2 Gene

  1. Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14. (PMID: 12856284) Wu M. … Johnson D.K. (Mamm. Genome 2003) 2 3 23 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. Genome-wide association study of intelligence: additive effects of novel brain expressed genes. (PMID: 22449649) Loo S.K. … Nelson S.F. (J Am Acad Child Adolesc Psychiatry 2012) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. (PMID: 22881374) Cummings A.C. … Haines J.L. (Ann. Hum. Genet. 2012) 3

Products for LUZP2 Gene

Sources for LUZP2 Gene

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