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Aliases for LURAP1 Gene

Aliases for LURAP1 Gene

  • Leucine Rich Adaptor Protein 1 2 3 5
  • Leucine Repeat Adaptor Protein 35a 2 3
  • Leucine Repeat Adapter Protein 35A 3 4
  • C1orf190 3 4
  • LRAP35a 3 4
  • LRP35A 3 4
  • Chromosome 1 Open Reading Frame 190 2
  • NF-Kappa-B Activator C1orf190 3

External Ids for LURAP1 Gene

Previous HGNC Symbols for LURAP1 Gene

  • C1orf190

Previous GeneCards Identifiers for LURAP1 Gene

  • GC01P046671

Summaries for LURAP1 Gene

GeneCards Summary for LURAP1 Gene

LURAP1 (Leucine Rich Adaptor Protein 1) is a Protein Coding gene. An important paralog of this gene is LURAP1L.

UniProtKB/Swiss-Prot for LURAP1 Gene

  • Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).

Additional gene information for LURAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LURAP1 Gene

Genomics for LURAP1 Gene

Regulatory Elements for LURAP1 Gene

Enhancers for LURAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H046196 1.3 ENCODE dbSUPER 36.5 -5.1 -5089 2 HDGF ARNT SIN3A DMAP1 TCF12 ELK1 ZNF143 ATF7 RUNX3 SP3 LURAP1 TOE1 GPBP1L1 LRRC41 POMGNT1 TSPAN1 PIK3R3 LOC110117498 RAD54L RPL7AP16
GH01H046202 1 ENCODE 42.7 +1.4 1405 4 ATF1 ARNT ZNF2 ZNF121 GLIS2 ZNF143 KLF7 ATF7 SP3 ZNF518A LURAP1 NSUN4 ZSWIM5 RAD54L PIK3R3 TSPAN1 LOC110117498 MUTYH POMGNT1
GH01H046178 1.6 Ensembl ENCODE dbSUPER 23 -20.9 -20850 6 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B FEZF1 DMAP1 YBX1 ZNF2 GPBP1L1 TOE1 RPL7AP16 LRRC41 EFCAB14-AS1 LURAP1 RPS15AP10 CCDC163 CCDC17 NSUN4
GH01H046299 1.4 ENCODE dbSUPER 22.6 +99.4 99445 5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 LRRC41 GPBP1L1 LURAP1 TOE1 RPL7AP16 EFCAB14-AS1 NASP RPS15AP10 MOB3C EFCAB14
GH01H046338 1.4 ENCODE dbSUPER 15.2 +138.2 138215 5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D NSUN4 LRRC41 GPBP1L1 LURAP1 UQCRH EFCAB14-AS1 CYP4B1 RPL7AP16 FAAH PIR34500
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LURAP1 on UCSC Golden Path with GeneCards custom track

Promoters for LURAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005936 166 1401 ARNT FEZF1 ZNF2 GLIS2 ZNF143 KLF7 ATF7 SP3 ZNF610 SMARCA4

Genomic Location for LURAP1 Gene

Chromosome:
1
Start:
46,203,334 bp from pter
End:
46,221,261 bp from pter
Size:
17,928 bases
Orientation:
Plus strand

Genomic View for LURAP1 Gene

Genes around LURAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LURAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LURAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LURAP1 Gene

Proteins for LURAP1 Gene

  • Protein details for LURAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LR2-LURA1_HUMAN
    Recommended name:
    Leucine rich adaptor protein 1
    Protein Accession:
    Q96LR2

    Protein attributes for LURAP1 Gene

    Size:
    239 amino acids
    Molecular mass:
    25806 Da
    Quaternary structure:
    • Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation.

neXtProt entry for LURAP1 Gene

Post-translational modifications for LURAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LURAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LURAP1 Gene

Domains & Families for LURAP1 Gene

Gene Families for LURAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LURAP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LURAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LURAP1: view

No data available for UniProtKB/Swiss-Prot for LURAP1 Gene

Function for LURAP1 Gene

Molecular function for LURAP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).

Phenotypes From GWAS Catalog for LURAP1 Gene

Gene Ontology (GO) - Molecular Function for LURAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LURAP1: view
genes like me logo Genes that share phenotypes with LURAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LURAP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LURAP1 Gene

Localization for LURAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LURAP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LURAP1 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LURAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 21048106
GO:0042641 actomyosin IEA --
genes like me logo Genes that share ontologies with LURAP1: view

Pathways & Interactions for LURAP1 Gene

SuperPathways for LURAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LURAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 21048106
GO:0016477 cell migration IEA --
GO:0031032 actomyosin structure organization IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 21048106
genes like me logo Genes that share ontologies with LURAP1: view

No data available for Pathways by source and SIGNOR curated interactions for LURAP1 Gene

Drugs & Compounds for LURAP1 Gene

No Compound Related Data Available

Transcripts for LURAP1 Gene

mRNA/cDNA for LURAP1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LURAP1 Gene

Leucine rich adaptor protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LURAP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LURAP1 Gene

No ASD Table

Relevant External Links for LURAP1 Gene

GeneLoc Exon Structure for
LURAP1
ECgene alternative splicing isoforms for
LURAP1

Expression for LURAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LURAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LURAP1 Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for LURAP1 Gene

This gene is overexpressed in Frontal cortex (27.6), CD4 Tcells (15.2), Fetal ovary (12.6), and CD8 Tcells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LURAP1 Gene



Protein tissue co-expression partners for LURAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LURAP1 Gene:

LURAP1

SOURCE GeneReport for Unigene cluster for LURAP1 Gene:

Hs.568642

Evidence on tissue expression from TISSUES for LURAP1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LURAP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LURAP1 Gene

Orthologs for LURAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LURAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LURAP1 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia LURAP1 33 34
  • 89.68 (n)
cow
(Bos Taurus)
Mammalia LURAP1 33 34
  • 87.5 (n)
rat
(Rattus norvegicus)
Mammalia Lurap1 33
  • 86.75 (n)
mouse
(Mus musculus)
Mammalia Lurap1 33 16 34
  • 85.91 (n)
oppossum
(Monodelphis domestica)
Mammalia LURAP1 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF190 33
  • 63.95 (n)
LURAP1 34
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LURAP1 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lurap1 33
  • 62 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171930 33
  • 58.63 (n)
LURAP1 34
  • 39 (a)
OneToOne
Species where no ortholog for LURAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LURAP1 Gene

ENSEMBL:
Gene Tree for LURAP1 (if available)
TreeFam:
Gene Tree for LURAP1 (if available)

Paralogs for LURAP1 Gene

Paralogs for LURAP1 Gene

(1) SIMAP similar genes for LURAP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LURAP1: view

Variants for LURAP1 Gene

Sequence variations from dbSNP and Humsavar for LURAP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000070305 -- 46,221,276(+) ACTTC(C/G)TCTGT intron-variant, upstream-variant-2KB
rs1000324694 -- 46,201,559(+) TCGGG(C/T)ATGGT intron-variant, upstream-variant-2KB
rs1000684728 -- 46,220,558(+) CCCCA(C/T)AGTTA upstream-variant-2KB, utr-variant-3-prime
rs1000923988 -- 46,201,534(+) TCTCT(A/T)CTAAA intron-variant, upstream-variant-2KB
rs1000965083 -- 46,213,860(+) TCAAG(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LURAP1 Gene

Variant ID Type Subtype PubMed ID
esv1137837 CNV insertion 17803354
esv2761743 CNV gain 21179565
esv3306122 CNV mobile element insertion 20981092
esv3326121 CNV insertion 20981092
nsv470711 CNV gain 18288195

Variation tolerance for LURAP1 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LURAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LURAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LURAP1 Gene

Disorders for LURAP1 Gene

Relevant External Links for LURAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LURAP1

No disorders were found for LURAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LURAP1 Gene

Publications for LURAP1 Gene

  1. Chromosome 1 open reading frame 190 promotes activation of NF-κB canonical pathway and resistance of dendritic cells to tumor-associated inhibition in vitro. (PMID: 21048106) Jing Z … Yang R (Journal of immunology (Baltimore, Md. : 1950) 2010) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for LURAP1 Gene

Sources for LURAP1 Gene

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