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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LUM Gene

protein-coding   GIFtS: 66
GCID: GC12M091430

lumican


(Previous symbol: LDC)
 Explore 23 diseases affiliated with
LUM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LUM    

Aliases
for LUM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lumican1
LDC1 2 3 5
SLRR2D1 2 3
Keratan Sulfate Proteoglycan Lumican2 3
KSPG Lumican2 3
Lumican Proteoglycan2

External Ids:    HGNC: 67241   Entrez Gene: 40602   Ensembl: ENSG000001393297   OMIM: 6006165   UniProtKB: P518843   

Export aliases for LUM gene to outside databases

Previous GC identifers: GC12M090819 GC12M091944 GC12M089999 GC12M088565


Summaries
for LUM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LUM:
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan,
fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds
collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is
the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices
throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal
transparency, and epithelial cell migration and tissue repair. (provided by RefSeq, Jul 2008)

Gene Wiki entry for LUM


Genomic Views
for LUM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LUM gene promoter:
         NF-YB   PPAR-gamma1   CBF-B   AML1a   NF-YA   Meis-1a   PPAR-gamma2   NF-Y   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LUM promoter sequence
   Search SABiosciences Chromatin IP Primers for LUM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LUM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.3-q22   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21.3-q22

LUM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LUM gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M091430:  view genomic region     (about GC identifiers)

Start:
 91,496,406 bp from pter      End:
 91,505,608 bp from pter
Size:
 9,203 bases      Orientation:
 minus strand

Proteins
for LUM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LUM_HUMAN, P51884 (See protein sequence)
Recommended Name: Lumican precursor  
Size: 338 amino acids; 38429 Da
Subunit: Binds to laminin (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Developmental stage: Present in the extracellular matrix of human articular cartilage at all ages, although its
abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form
lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan
Secondary accessions: B2R6R5 Q96QM7

Explore the universe of human proteins at neXtProt for LUM: NX_P51884

Post-translational modifications:

  • Sulfated on tyrosine residue(s)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51884

    • LUM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002336.1  
    ENSEMBL proteins: 
     ENSP00000266718  
    Reactome Protein details: P51884
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LUM (Lumican)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: LUM
    OriGene Protein Over-expression Lysate: LUM
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    Novus Biologicals LUM Protein
    Novus Biologicals LUM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LUM

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix TAS7665616
    GO:0005583fibrillar collagen IDA10734230
    GO:0005615extracellular space IDA--
    GO:0005796Golgi lumen TAS--


    LUM for ontologies           About GeneDecksing



    LUM Antibody Products: 
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    R&D Systems Antibodies for LUM (Lumican)
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    ThermoFisher Antibodies for LUM

    Assay Products for LUM: 
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    Uscn ELISAs and CLIAs for LUM

    Protein Domains /
    Families
    for LUM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LUM for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR027219 Lumican
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P51884

    ProtoNet protein and cluster: P51884

    2 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: LUM_HUMAN, P51884
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    Function
    for LUM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for LUM:
    lumican,keratan sulfate proteoglycan one of the three major constituents of the corneal stroma,playing a role in the
    regulation of collagen assembly into fibrils in various connective tissues,small-leucine-rich proteoglycans family

    miRNA
    Products:            		 OriGene 3'-UTR Clone: LUM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LUM
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate LUM:
    hsa-miR-33a* hsa-miR-4307 hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmid: LUM 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LUM (see all 7)
    OriGene shRNA RFP: LUM
    OriGene siRNA: LUM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LUM

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LUM

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LUM (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LUM (NM_002345)
    Sino Biological Human cDNA Clone for LUM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LUM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LUM 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LUM
    LifeMap BioReagents: cell line associated with LUM: PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LUM

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent NAS10892350
    GO:0005518collagen binding IDA10892350


    LUM for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for LUM:
     Decreased viability with carbo 

    Animal Models:
         Mouse knock-outs for LUM: Lumtm1Chak Lumtm1Wwk
         14 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lum):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     muscle  reproductive system  skeleton  vision/eye 

    LUM for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LUM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS I - Hurler syndrome1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		Mucopolysaccharidoses1.00
    		MPS IX - Natowicz syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		MPS II - Hunter syndrome1.00
    2Extracellular KSPG translocates to the lysosome for degradation
    		Extracellular KSPG translocates to the lysosome for degradation1.00
    		Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase1.00
    		KSPG is secreted from the cell1.00
    		Keratan sulfate degradation0.58
    3Keratan sulfate biosynthesis
    		Keratan sulfate biosynthesis1.00
    		Keratan sulfate/keratin metabolism0.84
    4Disease
    		Disease1.00
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for LUM
        Metalloproteases in connective tissue degradation


    5/22        Reactome Pathways for LUM (see all 22)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    MPS IIIA - Sanfilippo syndrome A



    LUM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LUM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/29 Interacting proteins for LUM (P518842, 3 ENSP000002667184) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP14P502813, ENSP000003082084I2D: score=2 STRING: ENSP00000308208
    TRA2BP629953, ENSP000004169594I2D: score=2 STRING: ENSP00000416959
    COL1A2P081233, ENSP000002972684I2D: score=2 STRING: ENSP00000297268
    CXCL2P198753I2D: score=1 
    WNK1Q9H4A33I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007601visual perception TAS10802664
    GO:0014070response to organic cyclic compound IEA--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030199collagen fibril organization NAS10892350


    LUM for ontologies           About GeneDecksing



    Drugs & Compounds
    for LUM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LUM
    Search CenterWatch for drugs/clinical trials and news about LUM 

    Transcripts
    for LUM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LUM gene: 
    NM_002345.3  

    Unigene Cluster for LUM:

    Lumican
    Hs.406475  [show with all ESTs]
    Unigene Representative Sequence: BG114678
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266718(uc001tbm.3) ENST00000548071 ENST00000546642

    miRNA
    Products:             		 OriGene 3'-UTR Clone: LUM
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LUM
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate LUM:
    hsa-miR-33a* hsa-miR-4307 hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmid: LUM 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LUM (see all 7)
    OriGene shRNA RFP: LUM
    OriGene siRNA: LUM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LUM
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LUM (see all 3)
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    GenScript: all cDNA clones in your preferred vector: LUM (NM_002345)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LUM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LUM 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LUM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LUM

    Additional cDNA sequence: 

    AK223177.1 AK312682.1 BC007038.1 BC035997.1 BT006707.1 U18728.1 U21128.1 

    24/32 DOTS entries (see all 32):

    DT.92466681  DT.100889137  DT.100889151  DT.95165813  DT.100889127  DT.97795167  DT.95165763  DT.100889116 
    DT.100889145  DT.121108384  DT.102843961  DT.95165745  DT.100889112  DT.101970518  DT.100889104  DT.100889155 
    DT.121108482  DT.121108426  DT.95165711  DT.100889119  DT.95165705  DT.100889144  DT.100889150  DT.121108402 

    24/1083 AceView cDNA sequences (see all 1083):

    BP373215 AI627741 CR610309 AI360686 AU138679 BX417687 AA010935 AU117865 
    U21128 AW167068 AI961919 AI687790 AI249973 AL514022 AU138544 AW518949 
    BM807256 AI567800 BP372826 AU120612 AI598274 CA412933 CR614927 BX118443 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LUM    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c
    SP1:                                                      
    SP2:                    -     -                           
    SP3:                    -                                 


    ECgene alternative splicing isoforms for LUM

    Expression
    for LUM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LUM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATGTTTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LUM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Tendons & LigamentsAxial Tendon PrimordiaEarly Tenocyte CellsTendons & Ligaments
    Tendons & LigamentsAxial Tendons and LigamnetsTenocytesTendons & Ligaments
    Tendons & LigamentsLimb Tendon PrimordiaEarly Tenocyte CellsTendons & Ligaments
    Tendons & LigamentsLimb Tendons and LigamnetsTenocytesTendons & Ligaments
    CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13) 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Trophoblast-like cells (Generation of tropho...)
    Embryoid bodies (Two-step protocol fo...)
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)
    DKK1-induced cells (Derivation of cardio...)

    See LUM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LUM

    SOURCE GeneReport for Unigene cluster: Hs.406475

    UniProtKB/Swiss-Prot: LUM_HUMAN, P51884
    Tissue specificity: Cornea and other tissues

        SABiosciences Custom PCR Arrays for LUM
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    In Situ
    Assay Products:     
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    Orthologs
    for LUM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LUM gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LUM1 lumican 69.94(n)
    70.24(a)    		   417891  XM_416135.3  XP_416135.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LUM6
    		 --
    		 64(a)
    		 1 ↔ 1
    		 5(32347747-32352407)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC645272 hypothetical protein MGC64527 73.93(n)    BC054282.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lum1 lumican 57.35(n)
    51.75(a)    		   415149  NM_001002059.1  NP_001002059.1 


    ENSEMBL Gene Tree for LUM (if available)
    TreeFam Gene Tree for LUM (if available) 

    Paralogs
    for LUM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LUM gene
    OGN2  OPTC2  PODN2  PODNL12  FMOD2  PRELP2  KERA2  ASPN2  
    OMD2  BGN2  DCN2  EPYC2  ECM22  
    8 SIMAP similar genes for LUM using alignment to 1 protein entry:     LUM_HUMAN:
    FMOD    KERA    MST161    PRELP    OMD    ASPN
    DCN    BGN

    LUM for paralogs           About GeneDecksing



    Genomic Variants
    for LUM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 NCBI SNPs in LUM are shown (see all 246)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs778621481,2
    		C,F,--91496761(+) CTCCAC/TACATA 1 -- ds50011Minor allele frequency- T:0.16WA 118
    rs787732721,2
    		F,--91496764(+) CACACA/GTAGGT 1 -- ds50011Minor allele frequency- G:0.16WA 118
    rs117561,2
    		C,F,O,--91496824(+) GAGTAT/GTTATC 1 -- ds50016Minor allele frequency- G:0.11MN NA 634
    rs1421985391,2
    		--91497004(+) TTTCTC/TGACAA 1 -- ds50010--------
    rs742378721,2
    		C,--91497020(+) GAGTGA/GGTGCT 1 -- ds50013Minor allele frequency- G:0.16CSA WA EA 240
    rs797526081,2
    		C,F,--91497040(+) TAGCAG/TCTTCT 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs170187151,2
    		C,--91497053(+) TCTAAT/CAGAAT 1 -- ds50013Minor allele frequency- C:0.01NA 142
    rs1459264151,2
    		--91497175(+) GTGAAC/TGCTAG 1 -- ds50010--------
    rs1837924871,2
    		--91497240(+) AGGCCA/GGAGAT 1 -- ut310--------
    rs37418361,2
    		C,F,H,--91497272(-) TACATA/CAAACA 1 -- ut31 ese314Minor allele frequency- C:0.09NS EA CSA 2098

    HapMap Linkage Disequilibrium report for LUM (91496406 - 91505608 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for LUM
         1 CNV: 53592
    Human Gene Mutation Database (HGMD): LUM

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    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LUM
    DNA2.0 Custom Variant and Variant Library Synthesis for LUM

    Disorders / Diseases
    for LUM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LUM for disorders           About GeneDecksing

    OMIM gene information: 600616    OMIM disorders: --

    20/23 diseases for LUM (see all 23):    About MalaCards
    macular corneal dystrophy    corneal dystrophy    amyotrophic lateral sclerosis    lateral sclerosis
    fatty liver disease    breast cancer susceptibility    liver disease    squamous cell carcinoma
    breast cancer    myopia    leprosy    hepatitis b
    lung adenocarcinoma    cervical cancer    cervicitis    pancreatic cancer
    colorectal cancer    osteosarcoma    adenocarcinoma    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for LUM:
    Myopia
    Human Genome Epidemiology (HuGE) Navigator: LUM (46 documents)

    Export disorders for LUM gene to outside databases

    Publications
    for LUM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LUM gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with LUM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. (PubMed id 7558030)1, 2, 3, 9 Chakravarti S....Hassell J.R. (1995)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human lumican gene. Organization, chromosomal location, and expression in articular cartilage. (PubMed id 7665616)1, 2 Grover J.... Roughley P.J. (1995)
    6. Association of the lumican gene functional 3'-UTR pol ymorphism with high myopia. (PubMed id 19643966)1, 9 Lin H.J....Tsai F.J. (2010)
    7. Overexpression of lumican affects the migration of hum an colon cancer cells through up-regulation of gelsolin and filamentous actin re organization. (PubMed id 22814255)1 Radwanska A....Malicka-Blaszkiewicz M. (2012)
    8. Ten SNPs of PAX6, Lumican, and MYOC genes are not asso ciated with high myopia in Han Chinese. (PubMed id 22809227)1 Dai L....Fu S.B. (2012)
    9. Assessment of gene expression profiles in peripheral o cclusive arterial disease. (PubMed id 22721676)1 Bubenek S....Dima S. (2012)
    10. Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in a Taiwan Chinese Han population. (PubMed id 21885486)1 Chang P.C....Tsai F.J. (2011)

    External Searches for LUM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LUM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4060 HGNC: 6724 AceView: LUM Ensembl:ENSG00000139329 euGenes: HUgn4060
    ECgene: LUM H-InvDB: LUM

    Other Databases showing LUM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LUM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LUM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LUM Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for LUM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LUM gene:
    Search GeneIP for patents involving LUM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     LUM Proteins, Antibodies, CLIAs, and ELISAs
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