Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LUC7L2 Gene

Aliases for LUC7L2 Gene

  • LUC7 Like 2, Pre-MRNA Splicing Factor 2 3 5
  • Putative RNA-Binding Protein Luc7-Like 2 3
  • LUC7-Like 2 (S. Cerevisiae) 2
  • CGI-74 Protein 2
  • LUC7-Like 2 3
  • CGI-59 3
  • CGI-74 3
  • LUC7B2 3

External Ids for LUC7L2 Gene

Previous GeneCards Identifiers for LUC7L2 Gene

  • GC07P138445
  • GC07P138459
  • GC07P138501
  • GC07P138695
  • GC07P139026
  • GC07P133354
  • GC07P139341

Summaries for LUC7L2 Gene

Entrez Gene Summary for LUC7L2 Gene

  • This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for LUC7L2 Gene

LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA binding. An important paralog of this gene is C7orf55-LUC7L2.

UniProtKB/Swiss-Prot for LUC7L2 Gene

  • May bind to RNA via its Arg/Ser-rich domain.

Gene Wiki entry for LUC7L2 Gene

Additional gene information for LUC7L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L2 Gene

Genomics for LUC7L2 Gene

Regulatory Elements for LUC7L2 Gene

Enhancers for LUC7L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H139101 2.1 FANTOM5 Ensembl ENCODE dbSUPER 70.2 -232.9 -232873 11 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 LUC7L2 UBN2 TTC26 ZC3HAV1 ZC3HAV1L PARP12 RPL17P28
GH07H139339 1.5 ENCODE dbSUPER 71.7 +0.9 926 3 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 LUC7L2 UBN2 ENSG00000273391 TTC26 KLRG2 LOC100499191 C7orf55-LUC7L2
GH07H138457 1.4 ENCODE dbSUPER 45.6 -880.0 -880047 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF207 FOS LUC7L2 UBN2 LOC100499191 TRIM24 RPS3AP28
GH07H139117 2 FANTOM5 Ensembl ENCODE dbSUPER 30.9 -221.4 -221409 2 HDGF PKNOX1 FOXA2 ARNT SIN3A ZNF766 CBX5 ZNF143 FOS JUNB LUC7L2 ZC3HAV1 UBN2 GC07M139117 TTC26
GH07H139090 1.6 Ensembl ENCODE dbSUPER 37.6 -246.4 -246417 6 HDGF PKNOX1 ARNT ZNF766 CBX5 ZNF143 REST SMARCB1 ZNF592 MEF2D LUC7L2 UBN2 ZC3HAV1 TTC26 RPL17P28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LUC7L2 on UCSC Golden Path with GeneCards custom track

Promoters for LUC7L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218930 642 2800 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610

Genomic Location for LUC7L2 Gene

Chromosome:
7
Start:
139,340,359 bp from pter
End:
139,423,457 bp from pter
Size:
83,099 bases
Orientation:
Plus strand

Genomic View for LUC7L2 Gene

Genes around LUC7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L2 Gene

Proteins for LUC7L2 Gene

  • Protein details for LUC7L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y383-LC7L2_HUMAN
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    Q9Y383
    Secondary Accessions:
    • B7Z500
    • Q8IUP9
    • Q9NVL3
    • Q9NVN7
    • Q9UQN1

    Protein attributes for LUC7L2 Gene

    Size:
    392 amino acids
    Molecular mass:
    46514 Da
    Quaternary structure:
    • Interacts with SCNM1.
    SequenceCaution:
    • Sequence=AAD34069.1; Type=Frameshift; Positions=388; Evidence={ECO:0000305};

    Alternative splice isoforms for LUC7L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUC7L2 Gene

Post-translational modifications for LUC7L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LUC7L2 Gene

No data available for DME Specific Peptides for LUC7L2 Gene

Domains & Families for LUC7L2 Gene

Gene Families for LUC7L2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LUC7L2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y383

UniProtKB/Swiss-Prot:

LC7L2_HUMAN :
  • Belongs to the Luc7 family.
Family:
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L2: view

Function for LUC7L2 Gene

Molecular function for LUC7L2 Gene

UniProtKB/Swiss-Prot Function:
May bind to RNA via its Arg/Ser-rich domain.

Phenotypes From GWAS Catalog for LUC7L2 Gene

Gene Ontology (GO) - Molecular Function for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 15324660
GO:0019899 enzyme binding IPI 19574390
genes like me logo Genes that share ontologies with LUC7L2: view
genes like me logo Genes that share phenotypes with LUC7L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LUC7L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L2 Gene

Localization for LUC7L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUC7L2 Gene

Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUC7L2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005685 U1 snRNP IBA --
GO:0016607 nuclear speck IEA --
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L2: view

Pathways & Interactions for LUC7L2 Gene

SuperPathways for LUC7L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IBA --
genes like me logo Genes that share ontologies with LUC7L2: view

No data available for Pathways by source and SIGNOR curated interactions for LUC7L2 Gene

Drugs & Compounds for LUC7L2 Gene

No Compound Related Data Available

Transcripts for LUC7L2 Gene

Unigene Clusters for LUC7L2 Gene

LUC7-like 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LUC7L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L2 Gene

No ASD Table

Relevant External Links for LUC7L2 Gene

GeneLoc Exon Structure for
LUC7L2
ECgene alternative splicing isoforms for
LUC7L2

Expression for LUC7L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LUC7L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LUC7L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LUC7L2 Gene



Protein tissue co-expression partners for LUC7L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LUC7L2 Gene:

LUC7L2

SOURCE GeneReport for Unigene cluster for LUC7L2 Gene:

Hs.731488

Evidence on tissue expression from TISSUES for LUC7L2 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(4.3)
  • Kidney(2.5)
  • Lung(2.4)
  • Spleen(2.1)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with LUC7L2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LUC7L2 Gene

Orthologs for LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LUC7L2 33 34
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia LUC7L2 34 33
  • 95.41 (n)
OneToMany
cow
(Bos Taurus)
Mammalia LUC7L2 33
  • 95.41 (n)
-- 34
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Luc7l2 33
  • 93.79 (n)
mouse
(Mus musculus)
Mammalia Luc7l2 16 34 33
  • 93.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves LUC7L2 33 34
  • 84.51 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l2 33
  • 80.91 (n)
Str.1795 33
African clawed frog
(Xenopus laevis)
Amphibia cg7564-prov 33
zebrafish
(Danio rerio)
Actinopterygii C1H7orf55 34
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7564 34
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.8 34
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToMany
Species where no ortholog for LUC7L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L2 Gene

ENSEMBL:
Gene Tree for LUC7L2 (if available)
TreeFam:
Gene Tree for LUC7L2 (if available)

Paralogs for LUC7L2 Gene

Paralogs for LUC7L2 Gene

(3) SIMAP similar genes for LUC7L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LUC7L2: view

Variants for LUC7L2 Gene

Sequence variations from dbSNP and Humsavar for LUC7L2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000078372 -- 139,356,027(+) AACCA(C/T)TGGGC intron-variant
rs1000087403 -- 139,339,108(+) TTACT(C/T)ATTAA upstream-variant-2KB
rs1000154260 -- 139,366,595(+) CGATT(C/T)ATATA intron-variant
rs1000162485 -- 139,359,653(+) GCCAG(A/C)CCTAC intron-variant, upstream-variant-2KB
rs1000163825 -- 139,379,124(+) TGCTG(A/G)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LUC7L2 Gene

Variant ID Type Subtype PubMed ID
esv2292861 CNV deletion 18987734
esv2371727 CNV deletion 18987734
esv2735212 CNV deletion 23290073
esv2735231 CNV deletion 23290073
esv3572165 CNV loss 25503493
esv3572166 CNV loss 25503493
nsv1110976 OTHER inversion 24896259
nsv1117762 CNV deletion 24896259
nsv1137296 CNV deletion 24896259
nsv478581 CNV novel sequence insertion 20440878

Variation tolerance for LUC7L2 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUC7L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LUC7L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L2 Gene

Disorders for LUC7L2 Gene

Relevant External Links for LUC7L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LUC7L2

No disorders were found for LUC7L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L2 Gene

Publications for LUC7L2 Gene

  1. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby CJ … Böttger A (Science (New York, N.Y.) 2009) 3 4 60
  2. Evidence for a direct role of the disease modifier SCNM1 in splicing. (PMID: 17656373) Howell VM … Meisler MH (Human molecular genetics 2007) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60

Products for LUC7L2 Gene

Sources for LUC7L2 Gene

Content
Loading form....