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Aliases for LUC7L2 Gene

Aliases for LUC7L2 Gene

  • LUC7-Like 2 (S. Cerevisiae) 2 3
  • Putative RNA-Binding Protein Luc7-Like 2 3
  • CGI-74 Protein 2
  • CGI-59 3
  • CGI-74 3
  • LUC7B2 3

External Ids for LUC7L2 Gene

Previous GeneCards Identifiers for LUC7L2 Gene

  • GC07P138445
  • GC07P138459
  • GC07P138501
  • GC07P138695
  • GC07P139026
  • GC07P133354

Summaries for LUC7L2 Gene

Entrez Gene Summary for LUC7L2 Gene

  • This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for LUC7L2 Gene

LUC7L2 (LUC7-Like 2 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is LUC7L3.

UniProtKB/Swiss-Prot for LUC7L2 Gene

  • May bind to RNA via its Arg/Ser-rich domain

Gene Wiki entry for LUC7L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L2 Gene

Genomics for LUC7L2 Gene

Regulatory Elements for LUC7L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LUC7L2 Gene

139,340,359 bp from pter
139,423,457 bp from pter
83,099 bases
Plus strand

Genomic View for LUC7L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L2 Gene

Proteins for LUC7L2 Gene

  • Protein details for LUC7L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    Secondary Accessions:
    • B7Z500
    • Q8IUP9
    • Q9NVL3
    • Q9NVN7
    • Q9UQN1

    Protein attributes for LUC7L2 Gene

    392 amino acids
    Molecular mass:
    46514 Da
    Quaternary structure:
    • Interacts with SCNM1.
    • Sequence=AAD34069.1; Type=Frameshift; Positions=388; Evidence={ECO:0000305};

    Alternative splice isoforms for LUC7L2 Gene


neXtProt entry for LUC7L2 Gene

Proteomics data for LUC7L2 Gene at MOPED

Post-translational modifications for LUC7L2 Gene

  • Ubiquitination at Lys186
  • Modification sites at PhosphoSitePlus

Other Protein References for LUC7L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LUC7L2 Gene

Domains for LUC7L2 Gene

Protein Domains for LUC7L2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9Y383
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L2: view

No data available for Gene Families for LUC7L2 Gene

Function for LUC7L2 Gene

Molecular function for LUC7L2 Gene

UniProtKB/Swiss-Prot Function: May bind to RNA via its Arg/Ser-rich domain

Gene Ontology (GO) - Molecular Function for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 16169070
GO:0019899 enzyme binding IPI 19574390
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with LUC7L2: view

Animal Model Products

CRISPR Products

miRNA for LUC7L2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LUC7L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LUC7L2 Gene

Localization for LUC7L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUC7L2 Gene

Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for LUC7L2 Gene COMPARTMENTS Subcellular localization image for LUC7L2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005685 U1 snRNP IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with LUC7L2: view

Pathways for LUC7L2 Gene

SuperPathways for LUC7L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IEA --
genes like me logo Genes that share ontologies with LUC7L2: view

No data available for Pathways by source for LUC7L2 Gene

Transcripts for LUC7L2 Gene

mRNA/cDNA for LUC7L2 Gene

Unigene Clusters for LUC7L2 Gene

LUC7-like 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LUC7L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L2 Gene

No ASD Table

Relevant External Links for LUC7L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LUC7L2 Gene

mRNA expression in normal human tissues for LUC7L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for LUC7L2 Gene

SOURCE GeneReport for Unigene cluster for LUC7L2 Gene Hs.731488

genes like me logo Genes that share expressions with LUC7L2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LUC7L2 Gene

Orthologs for LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LUC7L2 35
  • 99.91 (n)
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
LUC7L2 35
  • 95.41 (n)
  • 98.98 (a)
(Canis familiaris)
Mammalia LUC7L2 35
  • 95.41 (n)
  • 98.98 (a)
LUC7L2 36
  • 98 (a)
(Mus musculus)
Mammalia Luc7l2 35
  • 93.71 (n)
  • 99.49 (a)
Luc7l2 16
Luc7l2 36
  • 95 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Luc7l2 35
  • 93.79 (n)
  • 99.49 (a)
(Gallus gallus)
Aves LUC7L2 35
  • 84.51 (n)
  • 97.03 (a)
LUC7L2 36
  • 85 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia cg7564-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l2 35
  • 80.91 (n)
  • 93.78 (a)
Str.1795 35
(Danio rerio)
Actinopterygii C1H7orf55 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7564 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea B0495.8 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for LUC7L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L2 Gene

Gene Tree for LUC7L2 (if available)
Gene Tree for LUC7L2 (if available)

Paralogs for LUC7L2 Gene

Paralogs for LUC7L2 Gene

Selected SIMAP similar genes for LUC7L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LUC7L2: view

Variants for LUC7L2 Gene

Sequence variations from dbSNP and Humsavar for LUC7L2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1133066 -- 139,368,274(+) AAAAA(C/T)CTAAT intron-variant
rs1133067 -- 139,368,323(+) AATAA(G/T)TTCTG intron-variant
rs1133068 -- 139,368,397(+) CATCT(A/G)TATGA intron-variant
rs1986447 -- 139,397,334(-) GGGGG(C/G)CTACT intron-variant
rs2355783 -- 139,391,133(+) TCTTA(C/T)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LUC7L2 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv889243 CNV Loss 21882294
esv2371727 CNV Deletion 18987734

Relevant External Links for LUC7L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L2 Gene

Disorders for LUC7L2 Gene

No disorders were found for LUC7L2 Gene.

No data available for UniProtKB/Swiss-Prot for LUC7L2 Gene

Publications for LUC7L2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby C.J. … Boettger A. (Science 2009) 3 4

Products for LUC7L2 Gene

Sources for LUC7L2 Gene

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