Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LUC7L2 Gene

Aliases for LUC7L2 Gene

  • LUC7 Like 2, Pre-MRNA Splicing Factor 2 3 5
  • Putative RNA-Binding Protein Luc7-Like 2 3
  • LUC7-Like 2 (S. Cerevisiae) 2
  • CGI-74 Protein 2
  • LUC7-Like 2 3
  • CGI-59 3
  • CGI-74 3
  • LUC7B2 3

External Ids for LUC7L2 Gene

Previous GeneCards Identifiers for LUC7L2 Gene

  • GC07P138445
  • GC07P138459
  • GC07P138501
  • GC07P138695
  • GC07P139026
  • GC07P133354
  • GC07P139341

Summaries for LUC7L2 Gene

Entrez Gene Summary for LUC7L2 Gene

  • This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for LUC7L2 Gene

LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA binding. An important paralog of this gene is C7orf55-LUC7L2.

UniProtKB/Swiss-Prot for LUC7L2 Gene

  • May bind to RNA via its Arg/Ser-rich domain.

Gene Wiki entry for LUC7L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L2 Gene

Genomics for LUC7L2 Gene

Regulatory Elements for LUC7L2 Gene

Enhancers for LUC7L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F139403 0.7 ENCODE 11.1 +63.2 63217 0.8 ATF1 CBX3 HCFC1 NR2F1 ATF2 CHAMP1 ZNF316 ATF3 ZNF143 NR2F6 ENSG00000273391 FMC1 LUC7L2 LOC100129148 GC07P139363
GH07F139394 0.4 ENCODE 10.7 +54.3 54321 0.1 GATA3 HMBOX1 ENSG00000273391 LUC7L2 FMC1 GC07P139363 LOC100129148
GH07F139724 1.7 FANTOM5 Ensembl ENCODE 1.8 +391.8 391785 15.0 HDGF PKNOX1 ZNF133 ZFP64 ARID4B SIN3A FEZF1 ZNF48 ZNF2 YY1 TBXAS1 ZC3HAV1L HIPK2 FCF1P11 TTC26 PARP12 KDM7A TMEM213 KIAA1549 LUC7L2
GH07F139820 0.8 FANTOM5 ENCODE 2.7 +479.9 479945 0.3 ZNF316 PBX2 TBXAS1 HIPK2 LUC7L2 GC07P139864
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LUC7L2 on UCSC Golden Path with GeneCards custom track

Promoters for LUC7L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000683482 742 3400 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D

Genomic Location for LUC7L2 Gene

139,340,359 bp from pter
139,423,457 bp from pter
83,099 bases
Plus strand

Genomic View for LUC7L2 Gene

Genes around LUC7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L2 Gene

Proteins for LUC7L2 Gene

  • Protein details for LUC7L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    Secondary Accessions:
    • B7Z500
    • Q8IUP9
    • Q9NVL3
    • Q9NVN7
    • Q9UQN1

    Protein attributes for LUC7L2 Gene

    392 amino acids
    Molecular mass:
    46514 Da
    Quaternary structure:
    • Interacts with SCNM1.
    • Sequence=AAD34069.1; Type=Frameshift; Positions=388; Evidence={ECO:0000305};

    Alternative splice isoforms for LUC7L2 Gene


neXtProt entry for LUC7L2 Gene

Post-translational modifications for LUC7L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LUC7L2 Gene

No data available for DME Specific Peptides for LUC7L2 Gene

Domains & Families for LUC7L2 Gene

Protein Domains for LUC7L2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Luc7 family.
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L2: view

No data available for Gene Families for LUC7L2 Gene

Function for LUC7L2 Gene

Molecular function for LUC7L2 Gene

UniProtKB/Swiss-Prot Function:
May bind to RNA via its Arg/Ser-rich domain.

Gene Ontology (GO) - Molecular Function for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 16169070
GO:0019899 enzyme binding IPI 19574390
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with LUC7L2: view
genes like me logo Genes that share phenotypes with LUC7L2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L2 Gene

Localization for LUC7L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUC7L2 Gene

Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUC7L2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005685 U1 snRNP IBA --
GO:0016607 nuclear speck IEA --
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L2: view

Pathways & Interactions for LUC7L2 Gene

SuperPathways for LUC7L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IBA --
genes like me logo Genes that share ontologies with LUC7L2: view

No data available for Pathways by source and SIGNOR curated interactions for LUC7L2 Gene

Transcripts for LUC7L2 Gene

Unigene Clusters for LUC7L2 Gene

LUC7-like 2 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L2 Gene

No ASD Table

Relevant External Links for LUC7L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LUC7L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LUC7L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LUC7L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LUC7L2 Gene

Protein tissue co-expression partners for LUC7L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LUC7L2 Gene:


SOURCE GeneReport for Unigene cluster for LUC7L2 Gene:

genes like me logo Genes that share expression patterns with LUC7L2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LUC7L2 Gene

Orthologs for LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LUC7L2 34 35
  • 99.91 (n)
(Bos Taurus)
Mammalia LUC7L2 34
  • 95.41 (n)
-- 35
  • 81 (a)
(Canis familiaris)
Mammalia LUC7L2 34 35
  • 95.41 (n)
(Rattus norvegicus)
Mammalia Luc7l2 34
  • 93.79 (n)
(Mus musculus)
Mammalia Luc7l2 34 16 35
  • 93.71 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
(Gallus gallus)
Aves LUC7L2 34 35
  • 84.51 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l2 34
  • 80.91 (n)
Str.1795 34
African clawed frog
(Xenopus laevis)
Amphibia cg7564-prov 34
(Danio rerio)
Actinopterygii C1H7orf55 35
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7564 35
  • 47 (a)
(Caenorhabditis elegans)
Secernentea B0495.8 35
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
Species where no ortholog for LUC7L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L2 Gene

Gene Tree for LUC7L2 (if available)
Gene Tree for LUC7L2 (if available)

Paralogs for LUC7L2 Gene

Paralogs for LUC7L2 Gene

(3) SIMAP similar genes for LUC7L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LUC7L2: view

Variants for LUC7L2 Gene

Sequence variations from dbSNP and Humsavar for LUC7L2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10085527 -- 139,379,614(+) GGCCC(A/G)GGTGG intron-variant
rs10085555 -- 139,410,068(+) TGGGC(G/T)AGGTG intron-variant
rs10085770 -- 139,415,603(+) ACAGG(A/G)TCTCA intron-variant
rs10085796 -- 139,412,160(+) GTGGT(A/T)GGATC intron-variant
rs10085814 -- 139,379,343(+) AGGAA(A/G)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LUC7L2 Gene

Variant ID Type Subtype PubMed ID
nsv478581 CNV novel sequence insertion 20440878
nsv1137296 CNV deletion 24896259
nsv1117762 CNV deletion 24896259
nsv1110976 OTHER inversion 24896259
esv3572166 CNV loss 25503493
esv3572165 CNV loss 25503493
esv2735231 CNV deletion 23290073
esv2735212 CNV deletion 23290073
esv2371727 CNV deletion 18987734
esv2292861 CNV deletion 18987734

Variation tolerance for LUC7L2 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUC7L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L2 Gene

Disorders for LUC7L2 Gene

Relevant External Links for LUC7L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LUC7L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L2 Gene

Publications for LUC7L2 Gene

  1. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby C.J. … Boettger A. (Science 2009) 3 4 64
  2. Evidence for a direct role of the disease modifier SCNM1 in splicing. (PMID: 17656373) Howell V.M. … Meisler M.H. (Hum. Mol. Genet. 2007) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for LUC7L2 Gene

Sources for LUC7L2 Gene

Loading form....