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Aliases for LUC7L2 Gene

Aliases for LUC7L2 Gene

  • LUC7-Like 2 Pre-MRNA Splicing Factor 2 3 5
  • LUC7-Like 2 (S. Cerevisiae) 2
  • CGI-74 Protein 2
  • CGI-59 3
  • CGI-74 3
  • LUC7B2 3

External Ids for LUC7L2 Gene

Previous GeneCards Identifiers for LUC7L2 Gene

  • GC07P138445
  • GC07P138459
  • GC07P138501
  • GC07P138695
  • GC07P139026
  • GC07P133354
  • GC07P139341

Summaries for LUC7L2 Gene

Entrez Gene Summary for LUC7L2 Gene

  • This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for LUC7L2 Gene

LUC7L2 (LUC7-Like 2 Pre-MRNA Splicing Factor) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA binding. An important paralog of this gene is C7orf55-LUC7L2.

UniProtKB/Swiss-Prot for LUC7L2 Gene

  • May bind to RNA via its Arg/Ser-rich domain.

Gene Wiki entry for LUC7L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L2 Gene

Genomics for LUC7L2 Gene

Regulatory Elements for LUC7L2 Gene

Enhancers for LUC7L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LUC7L2 on UCSC Golden Path with GeneCards custom track

Promoters for LUC7L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LUC7L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LUC7L2 Gene

Chromosome:
7
Start:
139,340,359 bp from pter
End:
139,423,457 bp from pter
Size:
83,099 bases
Orientation:
Plus strand

Genomic View for LUC7L2 Gene

Genes around LUC7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L2 Gene

Proteins for LUC7L2 Gene

  • Protein details for LUC7L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y383-LC7L2_HUMAN
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    Q9Y383
    Secondary Accessions:
    • B7Z500
    • Q8IUP9
    • Q9NVL3
    • Q9NVN7
    • Q9UQN1

    Protein attributes for LUC7L2 Gene

    Size:
    392 amino acids
    Molecular mass:
    46514 Da
    Quaternary structure:
    • Interacts with SCNM1.
    SequenceCaution:
    • Sequence=AAD34069.1; Type=Frameshift; Positions=388; Evidence={ECO:0000305};

    Alternative splice isoforms for LUC7L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUC7L2 Gene

Proteomics data for LUC7L2 Gene at MOPED

Post-translational modifications for LUC7L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LUC7L2 Gene

Antibody Products

No data available for DME Specific Peptides for LUC7L2 Gene

Domains & Families for LUC7L2 Gene

Protein Domains for LUC7L2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y383

UniProtKB/Swiss-Prot:

LC7L2_HUMAN :
  • Belongs to the Luc7 family.
Family:
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L2: view

No data available for Gene Families for LUC7L2 Gene

Function for LUC7L2 Gene

Molecular function for LUC7L2 Gene

UniProtKB/Swiss-Prot Function:
May bind to RNA via its Arg/Ser-rich domain.

Gene Ontology (GO) - Molecular Function for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with LUC7L2: view
genes like me logo Genes that share phenotypes with LUC7L2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L2 Gene

Localization for LUC7L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUC7L2 Gene

Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LUC7L2 Gene COMPARTMENTS Subcellular localization image for LUC7L2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L2: view

Pathways & Interactions for LUC7L2 Gene

SuperPathways for LUC7L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LUC7L2 Gene

Drugs & Compounds for LUC7L2 Gene

No Compound Related Data Available

Transcripts for LUC7L2 Gene

Unigene Clusters for LUC7L2 Gene

LUC7-like 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L2 Gene

No ASD Table

Relevant External Links for LUC7L2 Gene

GeneLoc Exon Structure for
LUC7L2
ECgene alternative splicing isoforms for
LUC7L2

Expression for LUC7L2 Gene

mRNA expression in normal human tissues for LUC7L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LUC7L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LUC7L2 Gene



SOURCE GeneReport for Unigene cluster for LUC7L2 Gene Hs.731488

genes like me logo Genes that share expression patterns with LUC7L2: view

Protein tissue co-expression partners for LUC7L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LUC7L2 Gene

Orthologs for LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LUC7L2 35
  • 95.41 (n)
  • 98.98 (a)
-- 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LUC7L2 35
  • 95.41 (n)
  • 98.98 (a)
LUC7L2 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Luc7l2 35
  • 93.71 (n)
  • 99.49 (a)
Luc7l2 16
Luc7l2 36
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LUC7L2 35
  • 99.91 (n)
  • 100 (a)
LUC7L2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Luc7l2 35
  • 93.79 (n)
  • 99.49 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves LUC7L2 35
  • 84.51 (n)
  • 97.03 (a)
LUC7L2 36
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l2 35
  • 80.91 (n)
  • 93.78 (a)
Str.1795 35
African clawed frog
(Xenopus laevis)
Amphibia cg7564-prov 35
zebrafish
(Danio rerio)
Actinopterygii C1H7orf55 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7564 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.8 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for LUC7L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L2 Gene

ENSEMBL:
Gene Tree for LUC7L2 (if available)
TreeFam:
Gene Tree for LUC7L2 (if available)

Paralogs for LUC7L2 Gene

Paralogs for LUC7L2 Gene

(3) SIMAP similar genes for LUC7L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LUC7L2: view

Variants for LUC7L2 Gene

Sequence variations from dbSNP and Humsavar for LUC7L2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_034067 -
rs60016688 -- 139,338,387(+) TCCGC(-/A/G)CCCCC upstream-variant-2KB
rs368931700 -- 139,338,386(+) ATCCG(-/G)CCCCC upstream-variant-2KB
rs547695975 -- 139,338,388(+) TCCGC(C/G)CCCCC upstream-variant-2KB
rs533542159 -- 139,338,392(+) CCCCC(A/C)CTTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LUC7L2 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv889243 CNV Loss 21882294
esv2371727 CNV Deletion 18987734

Variation tolerance for LUC7L2 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUC7L2 Gene

HapMap Linkage Disequilibrium report
LUC7L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L2 Gene

Disorders for LUC7L2 Gene

Relevant External Links for LUC7L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LUC7L2

No disorders were found for LUC7L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L2 Gene

Publications for LUC7L2 Gene

  1. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PMID: 19574390) Webby C.J. … Boettger A. (Science 2009) 3 4 67
  2. Evidence for a direct role of the disease modifier SCNM1 in splicing. (PMID: 17656373) Howell V.M. … Meisler M.H. (Hum. Mol. Genet. 2007) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for LUC7L2 Gene

Sources for LUC7L2 Gene

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