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Aliases for LUC7L Gene

Aliases for LUC7L Gene

  • LUC7 Like 2 3
  • LUC7-Like 2 3 5
  • Putative SR Protein LUC7B1 3 4
  • SR+89 3 4
  • Sarcoplasmic Reticulum Protein LUC7B1 3
  • LUC7 (S. Cerevisiae)-Like 2
  • LUC7-Like (S. Cerevisiae) 2
  • HLuc7B1 3
  • LUC7B1 3
  • LUC7L1 4
  • Luc7 3

External Ids for LUC7L Gene

Previous GeneCards Identifiers for LUC7L Gene

  • GC16M000258
  • GC16M000178
  • GC16M000238

Summaries for LUC7L Gene

Entrez Gene Summary for LUC7L Gene

  • The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LUC7L Gene

LUC7L (LUC7 Like) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and RS domain binding. An important paralog of this gene is C7orf55-LUC7L2.

UniProtKB/Swiss-Prot for LUC7L Gene

  • May bind to RNA via its Arg/Ser-rich domain.

Gene Wiki entry for LUC7L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L Gene

Genomics for LUC7L Gene

Regulatory Elements for LUC7L Gene

Enhancers for LUC7L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LUC7L on UCSC Golden Path with GeneCards custom track

Promoters for LUC7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LUC7L on UCSC Golden Path with GeneCards custom track

Genomic Location for LUC7L Gene

Chromosome:
16
Start:
188,969 bp from pter
End:
229,463 bp from pter
Size:
40,495 bases
Orientation:
Minus strand

Genomic View for LUC7L Gene

Genes around LUC7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L Gene

Proteins for LUC7L Gene

  • Protein details for LUC7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ29-LUC7L_HUMAN
    Recommended name:
    Putative RNA-binding protein Luc7-like 1
    Protein Accession:
    Q9NQ29
    Secondary Accessions:
    • B8ZZ13
    • Q96S32
    • Q9NPH4

    Protein attributes for LUC7L Gene

    Size:
    371 amino acids
    Molecular mass:
    43728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LUC7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUC7L Gene

Proteomics data for LUC7L Gene at MOPED

Post-translational modifications for LUC7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LUC7L Gene

Domains & Families for LUC7L Gene

Protein Domains for LUC7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NQ29

UniProtKB/Swiss-Prot:

LUC7L_HUMAN :
  • Belongs to the Luc7 family.
Family:
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L: view

No data available for Gene Families for LUC7L Gene

Function for LUC7L Gene

Molecular function for LUC7L Gene

UniProtKB/Swiss-Prot Function:
May bind to RNA via its Arg/Ser-rich domain.

Gene Ontology (GO) - Molecular Function for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
genes like me logo Genes that share ontologies with LUC7L: view
genes like me logo Genes that share phenotypes with LUC7L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LUC7L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L Gene

Localization for LUC7L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LUC7L Gene COMPARTMENTS Subcellular localization image for LUC7L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LUC7L Gene

Pathways & Interactions for LUC7L Gene

SuperPathways for LUC7L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LUC7L Gene

Drugs & Compounds for LUC7L Gene

No Compound Related Data Available

Transcripts for LUC7L Gene

Unigene Clusters for LUC7L Gene

LUC7-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2:
SP3:
SP4: - - - - - - -
SP5:
SP6: -
SP7:

Relevant External Links for LUC7L Gene

GeneLoc Exon Structure for
LUC7L
ECgene alternative splicing isoforms for
LUC7L

Expression for LUC7L Gene

mRNA expression in normal human tissues for LUC7L Gene

Protein differential expression in normal tissues from HIPED for LUC7L Gene

This gene is overexpressed in Lung (31.7) and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LUC7L Gene



SOURCE GeneReport for Unigene cluster for LUC7L Gene Hs.16803

mRNA Expression by UniProt/SwissProt for LUC7L Gene

Q9NQ29-LUC7L_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with LUC7L: view

Protein tissue co-expression partners for LUC7L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LUC7L Gene

Orthologs for LUC7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LUC7L 35
  • 93.11 (n)
  • 99.59 (a)
LUC7L 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LUC7L 35
  • 93.26 (n)
  • 98.65 (a)
LUC7L 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Luc7l 35
  • 91.9 (n)
  • 98.77 (a)
Luc7l 16
Luc7l 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LUC7L 35
  • 99.73 (n)
  • 100 (a)
LUC7L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Luc7l 35
  • 90.69 (n)
  • 98.16 (a)
oppossum
(Monodelphis domestica)
Mammalia LUC7L 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LUC7L 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves LUC7L 35
  • 85.26 (n)
  • 99.59 (a)
gga-mir-1564 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LUC7L 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l 35
  • 79.06 (n)
  • 95.87 (a)
zebrafish
(Danio rerio)
Actinopterygii luc7l 35
  • 76.58 (n)
  • 90.08 (a)
wufb51e07 35
luc7l 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7564 37
  • 66 (a)
CG7564 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.8a 37
  • 34 (a)
B0495.8 36
  • 35 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR271W 35
  • 43.38 (n)
  • 29.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 35
  • 45.32 (n)
  • 35.09 (a)
LUC7 36
  • 31 (a)
OneToMany
LUC7 38
bread mold
(Neurospora crassa)
Ascomycetes NCU05645 35
  • 47.11 (n)
  • 41.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes usp106 35
  • 44.77 (n)
  • 37.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for LUC7L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L Gene

ENSEMBL:
Gene Tree for LUC7L (if available)
TreeFam:
Gene Tree for LUC7L (if available)

Paralogs for LUC7L Gene

Paralogs for LUC7L Gene

genes like me logo Genes that share paralogs with LUC7L: view

Variants for LUC7L Gene

Sequence variations from dbSNP and Humsavar for LUC7L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3859141 -- 195,080(-) ACAGG(A/G)TGAGC intron-variant
rs3918352 -- 197,889(+) GCGGT(A/G)AGGGG intron-variant
rs8062939 -- 223,701(+) gtctc(A/G)ctctg intron-variant
rs4427800 -- 194,155(+) atgga(A/G)tgcag intron-variant
rs9673892 -- 215,648(+) aatac(A/C)gaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LUC7L Gene

Variant ID Type Subtype PubMed ID
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
nsv518291 CNV Loss 19592680
dgv2458n71 CNV Loss 21882294
nsv904637 CNV Loss 21882294
nsv904652 CNV Loss 21882294
nsv1698 CNV Loss 18451855
esv2665628 CNV Deletion 23128226
esv2670048 CNV Deletion 23128226
esv2673364 CNV Deletion 23128226

Variation tolerance for LUC7L Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUC7L Gene

HapMap Linkage Disequilibrium report
LUC7L
Human Gene Mutation Database (HGMD)
LUC7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L Gene

Disorders for LUC7L Gene

Relevant External Links for LUC7L

Genetic Association Database (GAD)
LUC7L
Human Genome Epidemiology (HuGE) Navigator
LUC7L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LUC7L

No disorders were found for LUC7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L Gene

Publications for LUC7L Gene

  1. Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. (PMID: 11170747) Tufarelli C. … Higgs D.R. (Genomics 2001) 3 4 23 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for LUC7L Gene

Sources for LUC7L Gene

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