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Aliases for LUC7L Gene

Aliases for LUC7L Gene

  • LUC7 Like 2 3 5
  • Putative SR Protein LUC7B1 3 4
  • SR+89 3 4
  • Putative RNA-Binding Protein Luc7-Like 1 3
  • Sarcoplasmic Reticulum Protein LUC7B1 3
  • LUC7 (S. Cerevisiae)-Like 2
  • LUC7-Like (S. Cerevisiae) 2
  • LUC7-Like 2
  • HLuc7B1 3
  • LUC7B1 3
  • LUC7L1 4
  • Luc7 3

External Ids for LUC7L Gene

Previous GeneCards Identifiers for LUC7L Gene

  • GC16M000258
  • GC16M000178
  • GC16M000238

Summaries for LUC7L Gene

Entrez Gene Summary for LUC7L Gene

  • The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LUC7L Gene

LUC7L (LUC7 Like) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and RS domain binding. An important paralog of this gene is LUC7L2.

UniProtKB/Swiss-Prot for LUC7L Gene

  • May bind to RNA via its Arg/Ser-rich domain.

Gene Wiki entry for LUC7L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L Gene

Genomics for LUC7L Gene

Regulatory Elements for LUC7L Gene

Enhancers for LUC7L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000323 1.8 FANTOM5 Ensembl ENCODE 15.1 -96.9 -96891 5.5 PKNOX1 SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF416 ZNF207 FOS SP3 TMEM8A LUC7L FAM234A LOC100129478 JMJD8 ENSG00000268836 PDIA2 AXIN1 NHLRC4 NME4
GH16F000252 1.1 Ensembl ENCODE 12.4 -23.3 -23342 1.6 HDGF HDAC1 CBX3 ARNT EGR1 ZBTB2 ZEB2 TBX21 NR2F2 CREB3 LOC100129478 LUC7L FAM234A HBM HBZ ARHGDIG ENSG00000269881 PIR53440
GH16F000342 1 ENCODE 11.1 -113.3 -113332 1.3 ATF1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF121 HBM HBZ FAM234A LOC100129478 LUC7L MRPL28 TMEM8A ARHGDIG PDIA2 PIR38678
GH16F000144 0.9 FANTOM5 11.7 +86.3 86308 0.3 HDAC1 TBL1XR1 GATA2 CREM ZBTB11 ZEB2 MBD2 KLF16 SMARCA4 MYNN HBM LOC100129478 LUC7L FAM234A HBQ1 NHLRC4 HBZ GC16M000144
GH16F000200 0.7 ENCODE 12.9 +29.0 28955 0.9 ZNF362 BHLHE40 INSM2 ZIC2 HIC1 ZNF335 ZFHX2 PRDM10 ZNF600 ZBTB33 FAM234A LUC7L LOC100129478 HBM HBZ NPRL3 ENSG00000228779 GC16P000374 GC16M000176
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LUC7L on UCSC Golden Path with GeneCards custom track

Promoters for LUC7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147078 363 1800 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for LUC7L Gene

Chromosome:
16
Start:
188,969 bp from pter
End:
229,463 bp from pter
Size:
40,495 bases
Orientation:
Minus strand

Genomic View for LUC7L Gene

Genes around LUC7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L Gene

Proteins for LUC7L Gene

  • Protein details for LUC7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ29-LUC7L_HUMAN
    Recommended name:
    Putative RNA-binding protein Luc7-like 1
    Protein Accession:
    Q9NQ29
    Secondary Accessions:
    • B8ZZ13
    • Q96S32
    • Q9NPH4

    Protein attributes for LUC7L Gene

    Size:
    371 amino acids
    Molecular mass:
    43728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LUC7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUC7L Gene

Post-translational modifications for LUC7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LUC7L Gene

Domains & Families for LUC7L Gene

Protein Domains for LUC7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NQ29

UniProtKB/Swiss-Prot:

LUC7L_HUMAN :
  • Belongs to the Luc7 family.
Family:
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L: view

No data available for Gene Families for LUC7L Gene

Function for LUC7L Gene

Molecular function for LUC7L Gene

UniProtKB/Swiss-Prot Function:
May bind to RNA via its Arg/Ser-rich domain.

Gene Ontology (GO) - Molecular Function for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 22365833
GO:0042802 identical protein binding IPI 22365833
GO:0050733 RS domain binding IEA --
genes like me logo Genes that share ontologies with LUC7L: view
genes like me logo Genes that share phenotypes with LUC7L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LUC7L

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L Gene

Localization for LUC7L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUC7L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005685 U1 snRNP IEA,IBA --
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LUC7L Gene

Pathways & Interactions for LUC7L Gene

SuperPathways for LUC7L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IEA,IBA --
GO:0045843 negative regulation of striated muscle tissue development IEA --
genes like me logo Genes that share ontologies with LUC7L: view

No data available for Pathways by source and SIGNOR curated interactions for LUC7L Gene

Transcripts for LUC7L Gene

Unigene Clusters for LUC7L Gene

LUC7-like (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2:
SP3:
SP4: - - - - - - -
SP5:
SP6: -
SP7:

Relevant External Links for LUC7L Gene

GeneLoc Exon Structure for
LUC7L
ECgene alternative splicing isoforms for
LUC7L

Expression for LUC7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LUC7L Gene

Protein differential expression in normal tissues from HIPED for LUC7L Gene

This gene is overexpressed in Lung (31.7) and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LUC7L Gene



Protein tissue co-expression partners for LUC7L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LUC7L Gene:

LUC7L

SOURCE GeneReport for Unigene cluster for LUC7L Gene:

Hs.16803

mRNA Expression by UniProt/SwissProt for LUC7L Gene:

Q9NQ29-LUC7L_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with LUC7L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LUC7L Gene

Orthologs for LUC7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LUC7L 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia LUC7L 34 35
  • 93.26 (n)
cow
(Bos Taurus)
Mammalia LUC7L 34 35
  • 93.11 (n)
oppossum
(Monodelphis domestica)
Mammalia LUC7L 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Luc7l 34 16 35
  • 91.9 (n)
rat
(Rattus norvegicus)
Mammalia Luc7l 34
  • 90.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LUC7L 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-1564 35
  • 92 (a)
OneToOne
LUC7L 34
  • 85.26 (n)
lizard
(Anolis carolinensis)
Reptilia LUC7L 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l 34
  • 79.06 (n)
zebrafish
(Danio rerio)
Actinopterygii luc7l 34 35
  • 76.58 (n)
wufb51e07 34
fruit fly
(Drosophila melanogaster)
Insecta CG7564 36 35
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea B0495.8 35
  • 35 (a)
OneToMany
B0495.8a 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 34 35 37
  • 45.32 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR271W 34
  • 43.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU05645 34
  • 47.11 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes usp106 34
  • 44.77 (n)
Species where no ortholog for LUC7L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L Gene

ENSEMBL:
Gene Tree for LUC7L (if available)
TreeFam:
Gene Tree for LUC7L (if available)

Paralogs for LUC7L Gene

Paralogs for LUC7L Gene

genes like me logo Genes that share paralogs with LUC7L: view

Variants for LUC7L Gene

Sequence variations from dbSNP and Humsavar for LUC7L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10153052 -- 190,341(+) TACTC(C/G)TGTCA intron-variant
rs10153124 -- 190,339(+) GATAC(C/T)CCTGT intron-variant
rs10454709 -- 211,037(+) gacag(C/G)gcaac intron-variant
rs10591607 -- 230,360(+) TTTTA(-/TTTG)TTTAT upstream-variant-2KB
rs1062900 -- 189,221(-) CAGAA(A/G)AGAAG reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LUC7L Gene

Variant ID Type Subtype PubMed ID
nsv518291 CNV loss 19592680
nsv474922 CNV novel sequence insertion 20440878
nsv1698 CNV deletion 18451855
nsv1044142 CNV gain 25217958
esv3637557 CNV loss 21293372
esv3637556 CNV loss 21293372
esv3637555 CNV loss 21293372
esv3637554 CNV loss 21293372
esv3637553 CNV loss 21293372
esv3637552 CNV loss 21293372
esv2673364 CNV deletion 23128226
esv2670048 CNV deletion 23128226
esv2665628 CNV deletion 23128226
esv2422427 CNV duplication 17116639
dgv2690n100 CNV gain 25217958

Variation tolerance for LUC7L Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUC7L Gene

Human Gene Mutation Database (HGMD)
LUC7L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LUC7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L Gene

Disorders for LUC7L Gene

Relevant External Links for LUC7L

Genetic Association Database (GAD)
LUC7L
Human Genome Epidemiology (HuGE) Navigator
LUC7L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LUC7L

No disorders were found for LUC7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L Gene

Publications for LUC7L Gene

  1. Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. (PMID: 11170747) Tufarelli C. … Higgs D.R. (Genomics 2001) 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for LUC7L Gene

Sources for LUC7L Gene

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