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Aliases for LUC7L Gene

Aliases for LUC7L Gene

  • LUC7 Like 2 3 5
  • Putative SR Protein LUC7B1 3 4
  • SR+89 3 4
  • Putative RNA-Binding Protein Luc7-Like 1 3
  • Sarcoplasmic Reticulum Protein LUC7B1 3
  • LUC7 (S. Cerevisiae)-Like 2
  • LUC7-Like (S. Cerevisiae) 2
  • LUC7-Like 2
  • HLuc7B1 3
  • LUC7B1 3
  • LUC7L1 4
  • Luc7 3

External Ids for LUC7L Gene

Previous GeneCards Identifiers for LUC7L Gene

  • GC16M000258
  • GC16M000178
  • GC16M000238

Summaries for LUC7L Gene

Entrez Gene Summary for LUC7L Gene

  • The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LUC7L Gene

LUC7L (LUC7 Like) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and RS domain binding. An important paralog of this gene is LUC7L2.

UniProtKB/Swiss-Prot for LUC7L Gene

  • May bind to RNA via its Arg/Ser-rich domain.

Gene Wiki entry for LUC7L Gene

Additional gene information for LUC7L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUC7L Gene

Genomics for LUC7L Gene

Regulatory Elements for LUC7L Gene

Enhancers for LUC7L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H000323 2 FANTOM5 Ensembl ENCODE dbSUPER 68.7 -97.0 -96970 5 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF416 ZNF207 FOS WDR90 LUC7L JMJD8 UBE2I ENSG00000228779 ENSG00000261505 RHOT2 WDR24 ENSG00000262528 MPG
GH16H000233 1.2 ENCODE 57.7 -5.5 -5487 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 WDR90 LUC7L RHOT2 ENSG00000268836 JMJD8 WASH4P ENSG00000228779 WDR24 LMF1 HBZP1
GH16H000640 1.4 ENCODE dbSUPER 44.5 -416.1 -416093 10 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LUC7L IFT140 UBE2I CRAMP1 WDR90 WDR24 WFIKKN1 TELO2 ENSG00000262528 UNKL
GH16H000718 1.3 ENCODE dbSUPER 44.9 -491.3 -491301 3 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B ZNF143 ZNF207 DEK SP3 MXD4 CRAMP1 IFT140 LUC7L UBE2I WDR90 TELO2 UNKL WDR24 ENSG00000268836 ENSG00000269482
GH16H000396 1.4 ENCODE dbSUPER 30.8 -170.4 -170421 7 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 WDR90 ENSG00000261505 WASH4P RHOT2 UBE2I NME4 WDR24 JMJD8 LUC7L CAPN15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LUC7L on UCSC Golden Path with GeneCards custom track

Promoters for LUC7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082145 363 1401 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF766 CBX5

Genomic Location for LUC7L Gene

Chromosome:
16
Start:
188,969 bp from pter
End:
229,463 bp from pter
Size:
40,495 bases
Orientation:
Minus strand

Genomic View for LUC7L Gene

Genes around LUC7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUC7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUC7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUC7L Gene

Proteins for LUC7L Gene

  • Protein details for LUC7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ29-LUC7L_HUMAN
    Recommended name:
    Putative RNA-binding protein Luc7-like 1
    Protein Accession:
    Q9NQ29
    Secondary Accessions:
    • B8ZZ13
    • Q96S32
    • Q9NPH4

    Protein attributes for LUC7L Gene

    Size:
    371 amino acids
    Molecular mass:
    43728 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LUC7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LUC7L Gene

Post-translational modifications for LUC7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for LUC7L
  • Santa Cruz Biotechnology (SCBT) Antibodies for LUC7L

No data available for DME Specific Peptides for LUC7L Gene

Domains & Families for LUC7L Gene

Gene Families for LUC7L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LUC7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NQ29

UniProtKB/Swiss-Prot:

LUC7L_HUMAN :
  • Belongs to the Luc7 family.
Family:
  • Belongs to the Luc7 family.
genes like me logo Genes that share domains with LUC7L: view

Function for LUC7L Gene

Molecular function for LUC7L Gene

UniProtKB/Swiss-Prot Function:
May bind to RNA via its Arg/Ser-rich domain.

Phenotypes From GWAS Catalog for LUC7L Gene

Gene Ontology (GO) - Molecular Function for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 22365833
GO:0042802 identical protein binding IPI 22365833
GO:0050733 RS domain binding IEA --
genes like me logo Genes that share ontologies with LUC7L: view
genes like me logo Genes that share phenotypes with LUC7L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LUC7L

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LUC7L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LUC7L Gene

Localization for LUC7L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LUC7L gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005685 U1 snRNP IEA,IBA --
GO:0071004 U2-type prespliceosome IBA --
genes like me logo Genes that share ontologies with LUC7L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LUC7L Gene

Pathways & Interactions for LUC7L Gene

SuperPathways for LUC7L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LUC7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IBA,IEA --
GO:0045843 negative regulation of striated muscle tissue development IEA --
genes like me logo Genes that share ontologies with LUC7L: view

No data available for Pathways by source and SIGNOR curated interactions for LUC7L Gene

Drugs & Compounds for LUC7L Gene

No Compound Related Data Available

Transcripts for LUC7L Gene

Unigene Clusters for LUC7L Gene

LUC7-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LUC7L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LUC7L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2:
SP3:
SP4: - - - - - - -
SP5:
SP6: -
SP7:

Relevant External Links for LUC7L Gene

GeneLoc Exon Structure for
LUC7L
ECgene alternative splicing isoforms for
LUC7L

Expression for LUC7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LUC7L Gene

Protein differential expression in normal tissues from HIPED for LUC7L Gene

This gene is overexpressed in Lung (31.7) and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LUC7L Gene



Protein tissue co-expression partners for LUC7L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LUC7L Gene:

LUC7L

SOURCE GeneReport for Unigene cluster for LUC7L Gene:

Hs.16803

mRNA Expression by UniProt/SwissProt for LUC7L Gene:

Q9NQ29-LUC7L_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for LUC7L Gene

  • Lung(4.3)
  • Blood(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LUC7L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LUC7L Gene

Orthologs for LUC7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LUC7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LUC7L 34 33
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LUC7L 34 33
  • 93.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LUC7L 34 33
  • 93.11 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LUC7L 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Luc7l 16 34 33
  • 91.9 (n)
rat
(Rattus norvegicus)
Mammalia Luc7l 33
  • 90.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LUC7L 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-1564 34
  • 92 (a)
OneToOne
LUC7L 33
  • 85.26 (n)
lizard
(Anolis carolinensis)
Reptilia LUC7L 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia luc7l 33
  • 79.06 (n)
zebrafish
(Danio rerio)
Actinopterygii luc7l 34 33
  • 76.58 (n)
OneToOne
wufb51e07 33
fruit fly
(Drosophila melanogaster)
Insecta CG7564 34 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.8 34
  • 35 (a)
OneToMany
B0495.8a 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 33 34 36
  • 45.32 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR271W 33
  • 43.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU05645 33
  • 47.11 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes usp106 33
  • 44.77 (n)
Species where no ortholog for LUC7L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LUC7L Gene

ENSEMBL:
Gene Tree for LUC7L (if available)
TreeFam:
Gene Tree for LUC7L (if available)

Paralogs for LUC7L Gene

Paralogs for LUC7L Gene

genes like me logo Genes that share paralogs with LUC7L: view

Variants for LUC7L Gene

Sequence variations from dbSNP and Humsavar for LUC7L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000034731 -- 218,416(+) ATTGA(G/T)TGAGT intron-variant
rs1000191719 -- 200,967(+) ATCAC(A/G)AGGTC intron-variant
rs1000292110 -- 214,091(+) AAATG(-/C)GAGTC intron-variant
rs1000320242 -- 215,584(+) CGCCA(C/T)TGCAC intron-variant
rs1000344083 -- 208,030(+) GACAA(C/G)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LUC7L Gene

Variant ID Type Subtype PubMed ID
dgv2690n100 CNV gain 25217958
esv2422427 CNV duplication 17116639
esv2665628 CNV deletion 23128226
esv2670048 CNV deletion 23128226
esv2673364 CNV deletion 23128226
esv3637552 CNV loss 21293372
esv3637553 CNV loss 21293372
esv3637554 CNV loss 21293372
esv3637555 CNV loss 21293372
esv3637556 CNV loss 21293372
esv3637557 CNV loss 21293372
nsv1044142 CNV gain 25217958
nsv1698 CNV deletion 18451855
nsv474922 CNV novel sequence insertion 20440878
nsv518291 CNV loss 19592680

Variation tolerance for LUC7L Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUC7L Gene

Human Gene Mutation Database (HGMD)
LUC7L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LUC7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUC7L Gene

Disorders for LUC7L Gene

Relevant External Links for LUC7L

Genetic Association Database (GAD)
LUC7L
Human Genome Epidemiology (HuGE) Navigator
LUC7L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LUC7L

No disorders were found for LUC7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LUC7L Gene

Publications for LUC7L Gene

  1. Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. (PMID: 11170747) Tufarelli C … Higgs DR (Genomics 2001) 3 4 22 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for LUC7L Gene

Sources for LUC7L Gene

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