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Aliases for LTV1 Gene

Aliases for LTV1 Gene

  • LTV1 Ribosome Biogenesis Factor 2 3 5
  • C6orf93 3 4
  • Chromosome 6 Open Reading Frame 93 2
  • LTV1 Homolog (S. Cerevisiae) 2
  • LTV1 Homolog 3
  • DJ468K18.4 3

External Ids for LTV1 Gene

Previous HGNC Symbols for LTV1 Gene

  • C6orf93

Previous GeneCards Identifiers for LTV1 Gene

  • GC06P144207
  • GC06P144208
  • GC06P144164
  • GC06P141728

Summaries for LTV1 Gene

GeneCards Summary for LTV1 Gene

LTV1 (LTV1 Ribosome Biogenesis Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. An important paralog of this gene is ENSG00000280148.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTV1 Gene

Genomics for LTV1 Gene

Regulatory Elements for LTV1 Gene

Promoters for LTV1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LTV1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LTV1 Gene

Chromosome:
6
Start:
143,843,344 bp from pter
End:
143,863,812 bp from pter
Size:
20,469 bases
Orientation:
Plus strand

Genomic View for LTV1 Gene

Genes around LTV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTV1 Gene

Proteins for LTV1 Gene

  • Protein details for LTV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GA3-LTV1_HUMAN
    Recommended name:
    Protein LTV1 homolog
    Protein Accession:
    Q96GA3
    Secondary Accessions:
    • Q96JX8

    Protein attributes for LTV1 Gene

    Size:
    475 amino acids
    Molecular mass:
    54855 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55388.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LTV1 Gene

Proteomics data for LTV1 Gene at MOPED

Post-translational modifications for LTV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LTV1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LTV1 Gene

Domains & Families for LTV1 Gene

Protein Domains for LTV1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LTV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GA3

UniProtKB/Swiss-Prot:

LTV1_HUMAN :
  • Belongs to the LTV1 family.
Family:
  • Belongs to the LTV1 family.
genes like me logo Genes that share domains with LTV1: view

No data available for Gene Families for LTV1 Gene

Function for LTV1 Gene

Phenotypes for LTV1 Gene

genes like me logo Genes that share phenotypes with LTV1: view

Animal Model Products

miRNA for LTV1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LTV1 Gene

Localization for LTV1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTV1 Gene COMPARTMENTS Subcellular localization image for LTV1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for LTV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with LTV1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LTV1 Gene

Pathways & Interactions for LTV1 Gene

genes like me logo Genes that share pathways with LTV1: view

Pathways by source for LTV1 Gene

Gene Ontology (GO) - Biological Process for LTV1 Gene

None

No data available for SIGNOR curated interactions for LTV1 Gene

Drugs & Compounds for LTV1 Gene

No Compound Related Data Available

Transcripts for LTV1 Gene

mRNA/cDNA for LTV1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(313) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LTV1 Gene

LTV1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LTV1 Gene

No ASD Table

Relevant External Links for LTV1 Gene

GeneLoc Exon Structure for
LTV1
ECgene alternative splicing isoforms for
LTV1

Expression for LTV1 Gene

mRNA expression in normal human tissues for LTV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LTV1 Gene

This gene is overexpressed in Lung (46.9) and Breast (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LTV1 Gene



SOURCE GeneReport for Unigene cluster for LTV1 Gene Hs.185675

genes like me logo Genes that share expression patterns with LTV1: view

Protein tissue co-expression partners for LTV1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LTV1 Gene

Orthologs for LTV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LTV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LTV1 35
  • 90.13 (n)
  • 89.22 (a)
LTV1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LTV1 35
  • 89.41 (n)
  • 89.83 (a)
LTV1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ltv1 35
  • 83.9 (n)
  • 86.6 (a)
Ltv1 16
Ltv1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LTV1 35
  • 99.44 (n)
  • 99.16 (a)
LTV1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ltv1 35
  • 81.56 (n)
  • 84.89 (a)
oppossum
(Monodelphis domestica)
Mammalia LTV1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LTV1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LTV1 35
  • 72.22 (n)
  • 75 (a)
LTV1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LTV1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ltv1 35
  • 70.06 (n)
  • 69.48 (a)
Str.12211 35
zebrafish
(Danio rerio)
Actinopterygii ltv1 35
  • 62.6 (n)
  • 64.27 (a)
ltv1 36
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.939 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010572 35
  • 54.38 (n)
  • 51.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7686 35
  • 50.61 (n)
  • 46.35 (a)
CG7686 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T23D8.3 35
  • 48.17 (n)
  • 38.03 (a)
T23D8.3 36
  • 33 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13508 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for LTV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LTV1 Gene

ENSEMBL:
Gene Tree for LTV1 (if available)
TreeFam:
Gene Tree for LTV1 (if available)

Paralogs for LTV1 Gene

Paralogs for LTV1 Gene

Pseudogenes.org Pseudogenes for LTV1 Gene

genes like me logo Genes that share paralogs with LTV1: view

Variants for LTV1 Gene

Sequence variations from dbSNP and Humsavar for LTV1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1047117 -- 143,860,132(+) TCTGA(C/T)GTAAT intron-variant
rs1047118 -- 143,860,141(+) ATCTG(A/T)GCTGC intron-variant
rs1047119 -- 143,860,144(+) TGTGC(G/T)GCCTA intron-variant
rs1884089 -- 143,860,815(+) TAGAA(C/T)GTAAT intron-variant
rs1810524 -- 143,861,046(+) TGCAC(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LTV1 Gene

Variant ID Type Subtype PubMed ID
nsv5514 CNV Insertion 18451855
nsv830830 CNV Gain 17160897

Variation tolerance for LTV1 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LTV1 Gene

HapMap Linkage Disequilibrium report
LTV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTV1 Gene

Disorders for LTV1 Gene

Relevant External Links for LTV1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTV1

No disorders were found for LTV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LTV1 Gene

Publications for LTV1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for LTV1 Gene

Sources for LTV1 Gene

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