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Aliases for LTV1 Gene

Aliases for LTV1 Gene

  • LTV1 Ribosome Biogenesis Factor 2 3 5
  • C6orf93 3 4
  • Chromosome 6 Open Reading Frame 93 2
  • LTV1 Homolog (S. Cerevisiae) 2
  • Protein LTV1 Homolog 3
  • LTV1 Homolog 3
  • DJ468K18.4 3

External Ids for LTV1 Gene

Previous HGNC Symbols for LTV1 Gene

  • C6orf93

Previous GeneCards Identifiers for LTV1 Gene

  • GC06P144207
  • GC06P144208
  • GC06P144164
  • GC06P141728

Summaries for LTV1 Gene

GeneCards Summary for LTV1 Gene

LTV1 (LTV1 Ribosome Biogenesis Factor) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. An important paralog of this gene is ENSG00000280148.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTV1 Gene

Genomics for LTV1 Gene

Regulatory Elements for LTV1 Gene

Enhancers for LTV1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G143449 1.5 FANTOM5 ENCODE 58.6 -392.6 -392638 3.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 LTV1 ENSG00000270890 VDAC1P8 TUBB8P2 PEX3 ADAT2 RNA5SP221
GH06G143691 1.5 Ensembl ENCODE dbSUPER 43.2 -150.6 -150572 2.9 HNRNPUL1 PKNOX1 FOXA2 ARNT MLX ARID4B ZNF2 SLC30A9 GATA2 ZNF548 LTV1 VDAC1P8 ENSG00000270890 ZC2HC1B GC06M143473 GC06P143680
GH06G143741 1.7 Ensembl ENCODE dbSUPER 23.8 -97.6 -97595 9.5 MLX CREB3L1 AGO1 FEZF1 DMAP1 SP3 NFYC TBX21 SSRP1 ZNF610 VDAC1P8 LTV1 ENSG00000270890 PHACTR2 PHACTR2-AS1 TUBB8P2 ZC2HC1B GC06P143748 GC06P143711
GH06G143895 1.4 ENCODE dbSUPER 26.3 +52.8 52772 1.3 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 SLC30A9 LTV1 TUBB8P2 ZC2HC1B PHACTR2 GC06P143999
GH06G143894 1.3 ENCODE dbSUPER 26 +51.5 51535 0.2 HDGF CREB3L1 ARNT SIN3A GLI4 DMAP1 ZNF48 ZNF2 YY1 GLIS2 LTV1 ZC2HC1B TUBB8P2 PHACTR2 GC06P143999
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LTV1 on UCSC Golden Path with GeneCards custom track

Promoters for LTV1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000204378 56 1601 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1

Genomic Location for LTV1 Gene

Chromosome:
6
Start:
143,843,344 bp from pter
End:
143,863,812 bp from pter
Size:
20,469 bases
Orientation:
Plus strand

Genomic View for LTV1 Gene

Genes around LTV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTV1 Gene

Proteins for LTV1 Gene

  • Protein details for LTV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GA3-LTV1_HUMAN
    Recommended name:
    Protein LTV1 homolog
    Protein Accession:
    Q96GA3
    Secondary Accessions:
    • Q96JX8

    Protein attributes for LTV1 Gene

    Size:
    475 amino acids
    Molecular mass:
    54855 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55388.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LTV1 Gene

Post-translational modifications for LTV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LTV1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LTV1 Gene

Domains & Families for LTV1 Gene

Protein Domains for LTV1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LTV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GA3

UniProtKB/Swiss-Prot:

LTV1_HUMAN :
  • Belongs to the LTV1 family.
Family:
  • Belongs to the LTV1 family.
genes like me logo Genes that share domains with LTV1: view

No data available for Gene Families for LTV1 Gene

Function for LTV1 Gene

Gene Ontology (GO) - Molecular Function for LTV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LTV1: view

Phenotypes for LTV1 Gene

genes like me logo Genes that share phenotypes with LTV1: view

Animal Model Products

CRISPR Products

miRNA for LTV1 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LTV1 Gene

Localization for LTV1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTV1 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 3

Gene Ontology (GO) - Cellular Components for LTV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030688 preribosome, small subunit precursor IBA --
GO:0031902 late endosome membrane IBA --
genes like me logo Genes that share ontologies with LTV1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LTV1 Gene

Pathways & Interactions for LTV1 Gene

genes like me logo Genes that share pathways with LTV1: view

Gene Ontology (GO) - Biological Process for LTV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000056 ribosomal small subunit export from nucleus IBA --
GO:0006364 rRNA processing TAS --
GO:0042274 ribosomal small subunit biogenesis IBA --
genes like me logo Genes that share ontologies with LTV1: view

No data available for SIGNOR curated interactions for LTV1 Gene

Drugs & Compounds for LTV1 Gene

No Compound Related Data Available

Transcripts for LTV1 Gene

mRNA/cDNA for LTV1 Gene

Unigene Clusters for LTV1 Gene

LTV1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTV1 Gene

No ASD Table

Relevant External Links for LTV1 Gene

GeneLoc Exon Structure for
LTV1
ECgene alternative splicing isoforms for
LTV1

Expression for LTV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LTV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LTV1 Gene

This gene is overexpressed in Lung (46.9) and Breast (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LTV1 Gene



Protein tissue co-expression partners for LTV1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LTV1 Gene:

LTV1

SOURCE GeneReport for Unigene cluster for LTV1 Gene:

Hs.185675

Evidence on tissue expression from TISSUES for LTV1 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with LTV1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LTV1 Gene

Orthologs for LTV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LTV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTV1 35 34
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LTV1 35 34
  • 90.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LTV1 35 34
  • 89.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ltv1 16 35 34
  • 83.9 (n)
rat
(Rattus norvegicus)
Mammalia Ltv1 34
  • 81.56 (n)
oppossum
(Monodelphis domestica)
Mammalia LTV1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LTV1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LTV1 34 35
  • 72.22 (n)
lizard
(Anolis carolinensis)
Reptilia LTV1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ltv1 34
  • 70.06 (n)
Str.12211 34
zebrafish
(Danio rerio)
Actinopterygii ltv1 35 34
  • 62.6 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.939 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010572 34
  • 54.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7686 34 35
  • 50.61 (n)
worm
(Caenorhabditis elegans)
Secernentea T23D8.3 34 35
  • 48.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13508 34
Species where no ortholog for LTV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LTV1 Gene

ENSEMBL:
Gene Tree for LTV1 (if available)
TreeFam:
Gene Tree for LTV1 (if available)

Paralogs for LTV1 Gene

Paralogs for LTV1 Gene

Pseudogenes.org Pseudogenes for LTV1 Gene

genes like me logo Genes that share paralogs with LTV1: view

Variants for LTV1 Gene

Sequence variations from dbSNP and Humsavar for LTV1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000147197 -- 143,843,943(+) CCAGT(G/T)TAGAG intron-variant
rs1000175575 -- 143,847,849(+) TATAC(-/T)TTTTT intron-variant
rs1000298555 -- 143,847,607(+) CTGCC(G/T)GCCTC intron-variant
rs1000365730 -- 143,849,507(+) CATGG(C/T)GATAC intron-variant
rs1000450271 -- 143,842,021(+) CTGCC(C/G)CCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LTV1 Gene

Variant ID Type Subtype PubMed ID
nsv1034894 CNV gain 25217958
nsv5514 CNV insertion 18451855
nsv830830 CNV gain 17160897

Variation tolerance for LTV1 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LTV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTV1 Gene

Disorders for LTV1 Gene

Relevant External Links for LTV1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTV1

No disorders were found for LTV1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LTV1 Gene

Publications for LTV1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Hrr25/CK1I'-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth. (PMID: 25778921) Ghalei H. … Karbstein K. (J. Cell Biol. 2015) 3 64
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for LTV1 Gene

Sources for LTV1 Gene

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