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LTK Gene

protein-coding   GIFtS: 64
GCID: GC15M041795

Leukocyte Receptor Tyrosine Kinase

(Previous name: leukocyte tyrosine kinase)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte Receptor Tyrosine Kinase1 2
TYK12 3 5
Protein Tyrosine Kinase 12 3
EC 2.7.10.13 8
Leukocyte Tyrosine Kinase1
Leukocyte Tyrosine Kinase Receptor2

External Ids:    HGNC: 67211   Entrez Gene: 40582   Ensembl: ENSG000000625247   OMIM: 1515205   UniProtKB: P293763   

Export aliases for LTK gene to outside databases

Previous GC identifers: GC15M037163 GC15M034691 GC15M039374 GC15M039511 GC15M039583 GC15M018644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LTK Gene:
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases.
Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth
and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Oct 2008)

GeneCards Summary for LTK Gene:
LTK (leukocyte receptor tyrosine kinase) is a protein-coding gene. Diseases associated with LTK include reticulosarcoma, and hodgkin's lymphoma. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity and protein kinase activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: LTK_HUMAN, P29376
Function: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not
known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth
factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite
outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the
secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport

Gene Wiki entry for LTK (Leukocyte receptor tyrosine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LTK gene promoter:
         E2F-4   E2F-3a   NF-1   E2F-5   Pax-5   Brachyury   E2F-2   Evi-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLTK promoter sequence
   Search Chromatin IP Primers for LTK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LTK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1-q21.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1-q21.1

LTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LTK gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M041795:  view genomic region     (about GC identifiers)

Start:
41,795,836 bp from pter      End:
41,806,085 bp from pter
Size:
10,250 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LTK_HUMAN, P29376 (See protein sequence)
Recommended Name: Leukocyte tyrosine kinase receptor precursor  
Size: 864 amino acids; 91681 Da
Subunit: Homodimer when bound to ligand (Probable). Part of a complex including LTK, TNK2 and GRB2, in which GRB2
promotes LTK recruitment by TNK2
Miscellaneous: Transgenic mice expressing human LTK show specific activation (tyrosine phosphorylation, kinase
activity, membrane localization and homooligomerization) in heart combined with cardiac hypertrophy,
cardiomyocyte degeneration
Secondary accessions: A6NNJ8 B4DL89 E9PFX4
Alternative splicing: 5 isoforms:  P29376-1   P29376-2   P29376-3   P29376-4   P29376-5   

Explore the universe of human proteins at neXtProt for LTK: NX_P29376

Explore proteomics data for LTK at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn257, Asn380, Asn412
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LTK (P29376) (see all 5)
     WEIFSLG  YILVGQQG  KIGDFGMARDIY  CPGPVYRIMTQCWQH 


    See LTK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129157.1  NP_002335.2  NP_996844.1  

    ENSEMBL proteins: 
     ENSP00000347293   ENSP00000263800   ENSP00000458111   ENSP00000392196  

    LTK Human Recombinant Protein Products:

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    Novus Biologicals LTK Protein
    Novus Biologicals LTK Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LTK

    LTK Antibody Products:

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    Cloud-Clone Corp. Antibodies for LTK
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    LTK Assay Products:

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    Cloud-Clone Corp. CLIAs for LTK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: leukocyte receptor tyrosine kinase
    Alk family
    Leukocyte tyrosine kinase (LTK) receptor family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR026984 LTK
     IPR002011 Tyr_kinase_rcpt_2_CS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P29376

    ProtoNet protein and cluster: P29376

    2 Blocks protein domains:
    IPB002011 Receptor tyrosine kinase
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: LTK_HUMAN, P29376
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 1 protein kinase domain


    LTK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LTK_HUMAN, P29376
    Function: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not
    known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth
    factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite
    outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the
    secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for LTK:
    tyrosine kinase,receptor type,leukocyte

         Enzyme Number (IUBMB): EC 2.7.10.11 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA10445845
    GO:0004713protein tyrosine kinase activity TAS7685902
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    LTK for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for LTK:
     Decreased focal adhesion (FA)   Decreased viability in HMC1.1   Increased mitotic index  Stronger migration 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LTK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LTK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LTK

    miRNA
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    miRTarBase miRNAs that target LTK:
    hsa-mir-335-5p (MIRT018950)

    Block miRNA regulation of human, mouse, rat LTK using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate LTK:
    hsa-miR-509-5p hsa-miR-509-3-5p hsa-miR-1205 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidLTK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LTK

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LTK_HUMAN, P29376: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS7685902
    GO:0005887integral component of plasma membrane TAS7685902
    GO:0016020membrane IDA10445845
    GO:0016021integral component of membrane ----

    LTK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LTK
    Interactions:

        GeneGlobe Interaction Network for LTK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for LTK (P293762, 3 ENSP000002638004) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8029559 I2D: score=2 STRING: ENSP00000274335
    PTPN1P180312, 3, ENSP000003606834MINT-6793973 I2D: score=5 STRING: ENSP00000360683
    SHC1P293533, ENSP000004013034I2D: score=2 STRING: ENSP00000401303
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    CBLP226813, ENSP000002640334I2D: score=2 STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9223670
    GO:0007165signal transduction TAS7685902
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0008283cell proliferation IDA10445845
    GO:0010666positive regulation of cardiac muscle cell apoptotic process IDA10445845

    LTK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LTK

    1 Novoseek inferred chemical compound relationship for LTK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 62.4 42 12184370 (3), 9223670 (2), 7685902 (2), 8910363 (2) (see all 20)



    LTK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LTK gene (3 alternative transcripts): 
    NM_001135685.1  NM_002344.5  NM_206961.3  

    Unigene Cluster for LTK:

    Leukocyte receptor tyrosine kinase
    Hs.434481  [show with all ESTs]
    Unigene Representative Sequence: NM_002344
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355166(uc001zob.3 uc010ucx.1) ENST00000263800 ENST00000563518(uc001zoa.3 uc010bcg.2)
    ENST00000561619 ENST00000453182 ENST00000569283
    miRNA
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    Block miRNA regulation of human, mouse, rat LTK using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate LTK:
    hsa-miR-509-5p hsa-miR-509-3-5p hsa-miR-1205 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidLTK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LTK
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    GenScript: all cDNA clones in your preferred vector (see all 3): LTK (NM_001135685)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LTK
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LTK
      QuantiTect SYBR Green Assays in human, mouse, rat LTK
      QuantiFast Probe-based Assays in human, mouse, rat LTK

    Additional mRNA sequence: 

    AK296892.1 AK314006.1 BC143903.1 D16105.1 X52213.1 X60702.1 

    3 DOTS entries:

    DT.406078  DT.92417941  DT.100652500 

    24 AceView cDNA sequences:

    CA394397 BQ918753 BQ069815 D16105 BX280153 NM_002344 NM_206961 CR611113 
    AW451303 BC045607 AL547896 BI765396 BX353410 X52213 BI462072 X60702 
    BX389612 BX329448 AI439603 BG024154 AL572671 BX344889 BX344888 AI365420 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LTK    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                      -                       -                                                                                 
    SP2:                                      -                 -     -                                                                                 
    SP3:                                                  -     -     -     -                                                                           
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for LTK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LTK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAGCACTG
    LTK Expression
    About this image

    LTK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LTK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434481

    UniProtKB/Swiss-Prot: LTK_HUMAN, P29376
    Tissue specificity: Expressed in non-hematopoietic cell lines and T- and B-cell lines

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LTK gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ltk1 , 5 leukocyte tyrosine kinase1, 5 82.25(n)1
    79.53(a)1
      2 (59.97 cM)5
    170051  NM_203345.21  NP_976220.21 
     1197513205 
    chicken
    (Gallus gallus)
    Aves LTK6
    leukocyte receptor tyrosine kinase
    34(a)
    1 ↔ 1
    5(24001724-24083155)
    lizard
    (Anolis carolinensis)
    Reptilia LTK6
    leukocyte receptor tyrosine kinase
    41(a)
    1 ↔ 1
    1(41513958-41585098)
    zebrafish
    (Danio rerio)
    Actinopterygii ltk6
    leukocyte tyrosine kinase
    32(a)
    1 ↔ 1
    17(31459694-31542579) ENSDARG00000042861
    fruit fly
    (Drosophila melanogaster)
    Insecta Alk6
    Alk
    18(a)
    1 → many
    2R(12512798-12527516)
    worm
    (Caenorhabditis elegans)
    Secernentea scd-23 protein kinase 36(a)   V(6635869-6642021)   --


    ENSEMBL Gene Tree for LTK (if available)
    TreeFam Gene Tree for LTK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LTK gene
    ROR12  INSR2  ROS12  NTRK22  IGF1R2  DDR12  NTRK32  INSRR2  
    ROR22  DDR22  MUSK2  ALK2  NTRK12  
    Selected SIMAP similar genes for LTK using alignment to 3 protein entries:     LTK_HUMAN (see all proteins) (see all similar genes):
    EML4-ALK variant 7    A20    KIF5B-ALK    PPFIBP1-ALK    SQSTM1-ALK    EML4-ALK
    EML4-ALK variant 6    EML4/ALK fusion    TFG/ALK fusion    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1    FLT4
    ALK    MET    tec    TXK    DKFZp434L0319    PTK7

    LTK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LTK (see all 449)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999572301,2
    --41796300(+) CCCAGC/TTTTTC 6 N S mis10--------
    rs2018556401,2
    --41796329(+) TCCTGC/GGGCTG 6 P syn10--------
    rs1482817141,2
    C,F--41796352(+) GCACTC/ACAAAG 6 /E /* stg12Minor allele frequency- A:0.00NA EU 5345
    rs1413246341,2
    C,F--41796437(+) ACATCC/TGGGTC 6 P syn11Minor allele frequency- T:0.00NA 3808
    rs1902391741,2
    C--41796456(+) GAAGAA/GTCAGG 3 -- int10--------
    rs2022105111,2
    --41796475(+) GGGCAC/TAGAGT 3 -- int10--------
    rs3166181,2
    C,F,A,H--41796498(+) CCTCCT/AGACCC 3 -- int1 trp313Minor allele frequency- A:0.14EA NA NS CSA WA EU 1426
    rs762821691,2,,4
    C--41796599(+) AGGCTC/TGTGCT 6 K E mis12Minor allele frequency- T:0.04EA EU 1305
    rs559008371,2,,4
    C--41796726(+) CCTAGA/GAGGGT 6 P S mis10--------
    rs1425159481,2
    C--41796737(+) CCATCC/TGGCCT 6 Q R mis11Minor allele frequency- T:0.00NA 4484

    HapMap Linkage Disequilibrium report for LTK (41795836 - 41806085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LTK:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2362n71CNV Loss21882294
    nsv524476CNV Loss19592680
    nsv471241CNV Loss18288195
    esv33378CNV Gain17666407

    Human Gene Mutation Database (HGMD): LTK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LTK
    DNA2.0 Custom Variant and Variant Library Synthesis for LTK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151520    OMIM disorders: --

    UniProtKB/Swiss-Prot: LTK_HUMAN, P29376
  • Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to
    susceptibility to abnormal proliferation of self-reactive B-cells and, therefore, to systemic lupus erythematosus
    (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to
    represent a failure of the regulatory mechanisms of the autoimmune system

  • 10 diseases for LTK:    About MalaCards
    reticulosarcoma    hodgkin's lymphoma    non-hodgkin lymphoma    choroiditis
    systemic lupus erythematosus    lupus erythematosus    lung cancer    multiple myeloma
    myeloma    neuronitis


    LTK for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for LTK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 28.1 1 19815557 (1)
    breast carcinoma 23.5 2 11584314 (1), 12184370 (1)
    metastasis 0 1 15753374 (1)
    tumors 0 2 12184370 (1), 15753374 (1)

    Genetic Association Database (GAD): LTK
    Human Genome Epidemiology (HuGE) Navigator: LTK (1 document)
    Tumor Gene Database (TGDB): LTK

    Export disorders for LTK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LTK gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with LTK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ltk: gene structure and preferential expression in human leukemic cells. (PubMed id 2320375)1, 2, 3 Maru Y.... Takaku F. (Oncogene Res. 1990)
    2. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. (PubMed id 14695357)1, 2, 9 Li N.... Hirose S. (Hum. Mol. Genet. 2004)
    3. The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. (PubMed id 9223670)1, 2, 9 Ueno H.... Hirai H. (Oncogene 1997)
    4. Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. (PubMed id 7685902)1, 2, 9 Toyoshima H.... Hirai H. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    5. Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. (PubMed id 19815557)1, 2, 9 Pao-Chun L.... Manser E. (J. Biol. Chem. 2009)
    6. Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. (PubMed id 8084603)1, 2, 9 Kozutsumi H.... Hirai H. (Oncogene 1994)
    7. Identification and chromosomal mapping of new human tyrosine kinase genes. (PubMed id 2156206)1, 2, 9 Krolewski J.J.... Dalla-Favera R. (Oncogene 1990)
    8. Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice. (PubMed id 10445845)1, 2 Honda H.... Hirai H. (Oncogene 1999)
    9. The ltk gene encodes a novel receptor-type protein tyrosine kinase. (PubMed id 1655406)1, 2 Krolewski J.J. and Dalla-Favera R. (EMBO J. 1991)
    10. Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. (PubMed id 8910363)1, 9 Ueno H....Hirai H. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4058 HGNC: 6721 AceView: LTK Ensembl:ENSG00000062524 euGenes: HUgn4058
    ECgene: LTK H-InvDB: LTK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LTK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LTK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LTK gene:
    Search GeneIP for patents involving LTK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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