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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LTF Gene

protein-coding GIFtS: 68
GCID: GC03M046477

lactotransferrin

Explore 164 diseases affiliated with
LTF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lactotransferrin¹		Talalactoferrin³
HLF2¹ ²		EC 3.4.21.-³
LF² ³		Lactoferrin³
GIG12²		Talalactoferrin³
Growth-Inhibiting Protein 12²		EC 3.4.21⁸
Neutrophil Lactoferrin²

External Ids:	HGNC: 6720¹	Entrez Gene: 4057²	Ensembl: ENSG00000012223⁷	OMIM: 150210⁵	UniProtKB: P02788³

Export aliases for LTF gene to outside databases

Previous GC identifers: GC03M045718 GC03M046296 GC03M046438 GC03M046452

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LTF:

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of

neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity,

making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of

properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections,

anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer

development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for

this gene. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: TRFL_HUMAN, P02788

Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the

binding of an anion, usually bicarbonate

Function: Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration

Function: Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors,

while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors

Function: The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family

that cuts arginine rich regions. This function contributes to the antimicrobial activity

Function: Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds

to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters

Gene Wiki entry for LTF (Lactoferrin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LTF gene promoter:
CREB AP-1 deltaCREB ATF-2 STAT3 c-Jun STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LTF promoter sequence

Search SABiosciences Chromatin IP Primers for LTF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LTF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31

LTF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LTF gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M046477: view genomic region (about GC identifiers)

Start:	46,477,136 bp from pter	End:	46,526,724 bp from pter
Size:	49,589 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRFL_HUMAN, P02788 (See protein sequence)

Recommended Name: Lactotransferrin precursor

Size: 710 amino acids; 78182 Da

Subunit: Monomer. Found in a complex with LTF, CLU, EPPIN and SEMG1

Subcellular location: Isoform 1: Secreted

Subcellular location: Isoform DeltaLf: Cytoplasm. Nucleus

6/32 PDB 3D structures from and Proteopedia for LTF (see all 32):

1B0L (3D)

1BKA (3D)

1CB6 (3D)

1DSN (3D)

1EH3 (3D)

1FCK (3D)

Secondary accessions: B7Z4X2 E7EQH5 O00756 Q16780 Q16785 Q16786 Q16789 Q8IU92 Q8IZH6 Q8TCD2 Q96KZ4

Q96KZ5 Q9H1Z3 Q9UCY5

Alternative promoter usage: 2 isoforms: P02788-1 P02788-2 (Phosphorylated at Ser-10. Glycosylated at Ser-10. O-GlcNAcylation at Ser-10 inhibits DNA binding and negatively regulates DeltaLf transcriptional activity, whereas phosphorylation activates it. Phosphorylation at Ser-10 also promotes proteasomal degradation)

Explore the universe of human proteins at neXtProt for LTF: NX_P02788

Post-translational modifications:

Isoform DeltaLf: Ubiquitinated at Lys-379 and Lys-391¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02788

4/11 DME Specific Peptides for LTF (P02788) (see all 11)

RKPVTEA

SSQEPYF

GKKSCHT

LLCPDNT

LTF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186078.1 NP_002334.2

ENSEMBL proteins:

ENSP00000231751 ENSP00000405546 ENSP00000397427 ENSP00000395234 ENSP00000400254

ENSP00000405719

Reactome Protein details: P02788
Human Recombinant Protein Products for LTF:

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	ProSpec Recombinant Protein for LTF
	Uscn Proteins for LTF

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0030141	secretory granule	IDA	11907569
GO:0097013	phagocytic vesicle lumen	TAS	--

LTF for ontologies About GeneDecksing

LTF Antibody Products:

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	Novus Biologicals LTF Antibodies
	Abcam antibodies for LTF
	Uscn Antibodies for LTF
	ThermoFisher Antibodies for LTF

Assay Products for LTF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LTF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LTF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LTF for domains About GeneDecksing

3 InterPro domains/families:

IPR018195 Transferrin_Fe_BS

IPR016357 Transferrin

IPR001156 Transferrin_fam

Graphical View of Domain Structure for InterPro Entry P02788

ProtoNet protein and cluster: P02788

1 Blocks protein family: IPB001156 Transferrin

UniProtKB/Swiss-Prot: TRFL_HUMAN, P02788

Similarity: Belongs to the transferrin family

Similarity: Contains 2 transferrin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRFL_HUMAN, P02788

Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the

binding of an anion, usually bicarbonate

Function: Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration

Function: Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors,

while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors

Function: The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family

that cuts arginine rich regions. This function contributes to the antimicrobial activity

Function: Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds

to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters

Catalytic activity: Preferential at -Arg-Ser-Arg-Arg- - and -Arg-Arg-Ser-Arg- -, and of Z-Phe-Arg- -aminomethylcoumarin

Genatlas biochemistry entry for LTF:

lactotransferrin,80kDa,iron binding protein present in milk and a variety of secretions derived from glandular

epithelium cells,also expressed in secondary granules of neutrophils,involved in iron transport,storage and

chelation,and host defense mechanisms

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.-¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004252	serine-type endopeptidase activity	TAS	9770539
GO:0005515	protein binding	IPI	1544444
GO:0008199	ferric iron binding	IEA	--
GO:0008201	heparin binding	IDA	11907569

LTF for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for LTF:

Increased gamma-H2AX phosphory

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ltf):

hematopoietic system

homeostasis/metabolism

immune system

liver/biliary system

LTF for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ltf^tm1Omc for LTF

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LTF

miRNA Products:		OriGene 3'-UTR Clone: LTF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LTF
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate LTF:
		hsa-miR-214 hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: LTF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LTF (see all 7) OriGene shRNA RFP: LTF OriGene siRNA: LTF
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		Sirion Biotech Custom design and validation of potent shRNA sequences against LTF

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LTF
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LTF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LTF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): LTF (NM_001199149)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LTF
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		Sirion Biotech Customized stable knockdown cell line services for LTF Sirion Biotech Customized inducible knockdown cell line services for LTF Sirion Biotech Customized stable overexpressing cell line services for LTF Sirion Biotech Customized inducible overexpressing cell line services for LTF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTF

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Amyloid precursor proteins form ordered fibrils

	Amyloid precursor proteins form ordered fibrils	1.00			Mtb iron assimilation by chelation	0.05
	Amyloids	0.43			Response of Mtb to phagocytosis	0.05

Insulin receptor recycling

Phagosomal maturation (early endosomal stage)

0.64

Latent infection of Homo sapiens with Mycobacterium tuberculosis

0.64

Disease

Disease

1.00

Selected targets of ESR1

Selected targets of ESR1

1.00

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for LTF

	Selected targets of ESR1
	Selected targets of C/EBPalpha

5/7 Reactome Pathways for LTF (see all 7)

	Amyloids
	Mtb iron assimilation by chelation
	Amyloid precursor proteins form ordered fibrils
	Phagosomal maturation (early endosomal stage)
	Response of Mtb to phagocytosis

LTF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LTF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for LTF (P02788^{1, 2, 3} ENSP00000231751⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCL	P19338²^,³, ENSP00000318195⁴	MINT-8176174 I2D: score=1 STRING: ENSP00000318195
CALM1	P62158³, ENSP00000349467⁴	I2D: score=2 STRING: ENSP00000349467
CALM2	P62158³	I2D: score=2
CALM3	P62158³	I2D: score=2
LYZ	P61626³, ENSP00000261267⁴	I2D: score=2 STRING: ENSP00000261267

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006508	proteolysis	IEA	--
GO:0006826	iron ion transport	IEA	--
GO:0006879	cellular iron ion homeostasis	--	--

LTF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LTF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LTF

2 HMDB Compounds for LTF About this table

Compound	Synonyms	CAS #	PubMed Ids
Hydrogen carbonate	Bicarbonate (see all 19)	71-52-3	--
Iron	Armco iron (see all 19)	7439-89-6	--

7 DrugBank Compounds for LTF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3h-Indole-5,6-Diol	--	3131-52-0	target	--	17139284 17016423 10592235
Alpha-D-Fucose	--	--	target	--	17139284 17016423 10592235
Nitrilotriacetic Acid	--	--	target	--	17139284 17016423 10592235
2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE	--	--	target	--	10592235
Alpha-D-Mannose	--	3458-28-4	target	--	10592235
Nimesulide	--	51803-78-2	target	--	10592235
parecoxib	--	--	target	--	10592235

10/151 Novoseek chemical compound relationships for LTF gene (see all 151) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	79.1	1054	8662718 (8), 16469988 (8), 7874020 (7), 11397094 (6) (see all 99)
whey	70.6	66	17369245 (3), 17517705 (3), 20308020 (2), 8763041 (2) (see all 39)
l-bpa	68.5	6	7752881 (1), 9620956 (1), 20155302 (1), 15222471 (1) (see all 6)
ipabc	68.4	3	12508150 (2), 11787716 (1)
hypothiocyanite	67.1	9	8478785 (2), 9437402 (1), 1644785 (1), 8764554 (1) (see all 8)
apotransferrin	63.7	6	11683638 (1), 2230644 (1), 15563106 (1), 15897999 (1) (see all 6)
fe3+	61.5	25	16266273 (2), 19820086 (2), 7490743 (1), 17416063 (1) (see all 19)
fmlp	61.1	32	8695817 (5), 8338131 (3), 1849951 (2), 1647754 (2) (see all 17)
n-formylmethionyl-leucylphenylalanine	57.3	9	8975881 (1), 11830497 (1), 8724704 (1), 8338131 (1) (see all 8)
edda	48.3	4	7553361 (1), 8704995 (1)

Search CenterWatch for drugs/clinical trials and news about LTF / TRFL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LTF gene (2 alternative transcripts):

NM_001199149.1 NM_002343.3

Unigene Cluster for LTF:

Lactotransferrin

Hs.529517 [show with all ESTs]

Unigene Representative Sequence: AK093852

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000231751(uc003cpq.3 uc010hjh.3) ENST00000417439 ENST00000443496(uc003cpr.3)

ENST00000493056 ENST00000478874 ENST00000462667 ENST00000431944 ENST00000415180

ENST00000498301 ENST00000426532(uc003fzr.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LTF
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate LTF:
		hsa-miR-214 hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: LTF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LTF (see all 7) OriGene shRNA RFP: LTF OriGene siRNA: LTF
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		GenScript: all cDNA clones in your preferred vector (see all 2): LTF (NM_001199149)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTF

Additional cDNA sequence:

AF332168.1 AK093852.1 AK126237.1 AK290859.1 AK292813.1 AK298035.1 AK303889.1 AK303995.1

AK316330.1 AY137470.1 AY165046.1 AY178998.2 AY360320.1 AY493417.1 AY875691.1 BC015822.1

BC015823.1 BC022347.1 DQ522304.1 EU779935.1 M18642.1 M83202.1 M83205.1 M93150.1

U07643.1 U84119.1 X52941.1 X53961.1

24/40 DOTS entries (see all 40):

DT.95290797 DT.91779287 DT.120841139 DT.120841167 DT.120841202 DT.120841183 DT.120841210 DT.120841194

DT.120841178 DT.95112836 DT.95290880 DT.120841201 DT.95290798 DT.91873587 DT.95290884 DT.91729222

DT.95290875 DT.95357232 DT.120841140 DT.120841144 DT.95302187 DT.120841119 DT.120841150 DT.120841155

24/625 AceView cDNA sequences (see all 625):

BF932988 CD724188 CA946385 CK430793 CK430671 CD722485 CK429178 CK430285

CK430922 CD723547 CD721978 AW468590 CK430687 CD722287 CD723320 BI021334

CD722125 BX487369 CK429813 CD722388 CK430537 CD723769 CD723129 CD723948

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LTF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAAACAAC

About this image

LTF expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

See LTF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LTF

SOURCE GeneReport for Unigene cluster: Hs.529517

SABiosciences Expression via Pathway-Focused PCR Array including LTF:

Antibacterial Response in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LTF gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	Q5ZJA5_CHICK⁶	Uncharacterized protein	34(a)	1 → many	9(5622785-5643560)
lizard (Anolis carolinensis)	Reptilia	--	--	35(a)	1 → many	3(30950579-30982630)
African clawed frog (Xenopus laevis)	Amphibia	MGC64306²	hypothetical protein MGC64306	74.93(n)		BC043632.1
zebrafish (Danio rerio)	Actinopterygii	BC054944.1²	--	74.9(n)		321190 BC054944.1
fruit fly (Drosophila melanogaster)	Insecta	Tsf2⁶ Tsf1⁶ (see all 3)	Transferrin 1 (see all 3)	26(a) 22(a) (see all 3)	possible ortholog possible ortholog (see all 3)	3L(12523536-12526824) X(18281965-18284377)

ENSEMBL Gene Tree for LTF (if available)
TreeFam Gene Tree for LTF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LTF gene

MFI2² TF²

3 SIMAP similar genes for LTF using alignment to 7 protein entries: TRFL_HUMAN (see all proteins):

GIG12 TF MFI2

LTF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148754589^1,2		--	46477143(+)	`TTATAC/GCAAAC`	2	--	ds500¹		0	--	--	--	--
rs34278344^1,2	C,F	--	46477222(+)	`GCTTGC/TTCTTC`	2	--	ds500¹		4		NA	126
rs146288743^1,2		--	46477299(+)	`GTGAAC/TAACCA`	2	--	ds500¹		0	--	--	--	--
rs76019827^1,2	C	--	46477302(+)	`AATAAA/CCAACA`	2	--	ds500¹		0	--	--	--	--
rs183434463^1,2		--	46477394(+)	`GGAGGG/TGCTGG`	2	--	ds500¹		0	--	--	--	--
rs144469141^1,2		--	46477558(+)	`GAATTC/GTAAGC`	2	--	ut3¹		0	--	--	--	--
rs187002237^1,2		--	46477791(+)	`CAATAA/CATCAA`	2	--	int¹		0	--	--	--	--
rs56063910^1,2	C	--	46477826(+)	`CCCTTC/TTCCCA`	2	--	int¹		1		CSA	2
rs75094754^1,2	C,F	--	46477830(+)	`TCTCCC/TATCAC`	2	--	int¹		2		CSA	4
rs149837129^1,2		--	46478136(+)	`GTGCTA/CAGTGC`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LTF (46477136 - 46526724 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LTF: --
Human Gene Mutation Database (HGMD): LTF

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LTF

DNA2.0 Custom Variant and Variant Library Synthesis for LTF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LTF for disorders           About GeneDecksing

OMIM gene information: 150210    OMIM disorders: --

20/164 diseases for LTF (see all 164):    About MalaCards

specific granule deficiency churg-strauss syndrome perinatal necrotizing enterocolitis protein-energy malnutrition

polyarteritis nodosa tick-borne encephalitis keratoconjunctivitis sicca lactose intolerance

salivary gland disease dry eye syndrome clostridium difficile hypersensitivity reaction type ii disease

bacterial vaginosis dental caries iron deficiency anemia otitis media

connective tissue disease amyloidosis corneal sclerosing cholangitis common variable immunodeficiency

16 diseases from the University of Copenhagen DISEASES database for LTF:

Mastitis Inflammatory bowel disease Dry eye syndrome Diarrhea

Periodontal disease Vasculitis Keratoconjunctivitis Pancreatitis

Cancer Perinatal necrotizing enterocolitis Dental caries Hypersensitivity reaction type II disease

Arthritis Blepharitis Irritable bowel syndrome Candidiasis

10/98 Novoseek disease relationships for LTF gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
specific granule deficiency	72.2	3	15941779 (1), 9833431 (1), 18321995 (1)
inflammation	58.6	194	11014359 (6), 17507875 (4), 16800860 (4), 8574844 (4) (see all 99)
colitis ulcerative	58.1	48	17461450 (3), 9093012 (2), 12974208 (2), 18001547 (2) (see all 32)
inflammatory bowel diseases	51.4	47	9093012 (6), 19172123 (2), 17852860 (2), 9781375 (2) (see all 27)
amyloidosis, corneal	50.3	2	9873069 (1)
keratoconjunctivitis sicca	49.6	6	7842709 (3), 8908435 (1), 1603200 (1), 7825407 (1)
sjogrens syndrome secondary	48.3	5	10451125 (1), 11016688 (1), 7825407 (1)
vasculitis	47.5	9	9017617 (1), 7922264 (1), 18640073 (1), 8542262 (1) (see all 7)
mastitis	43.4	13	19584041 (3), 12161968 (2), 16954396 (2), 16462118 (1) (see all 7)
dry eye syndromes	41.6	3	9145691 (2), 7825407 (1)

Genetic Association Database (GAD): LTF
Human Genome Epidemiology (HuGE) Navigator: LTF (20 documents)

Export disorders for LTF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LTF gene, integrated from 9 sources (see all 1507):
(articles sorted by number of sources associating them with LTF)

Utopia: connect your pdf to the dynamic
world of online information

Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites. (PubMed id 12535064)^{1, 2, 9} Hendrixson D.R.... St Geme J.W. III (2003)
Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma. (PubMed id 17476971)^{1, 3, 9} Yi H.M....Ren C.P. (2006)
Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene. (PubMed id 9873069)^{1, 2, 9} Klintworth G.K.... Teng C.T. (1998)
Isolation and characterization of opioid antagonist peptides derived from human lactoferrin. (PubMed id 1369293)^{1, 2, 9} Tani F.... Yoshikawa M. (1990)
Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor. (PubMed id 22320386)^{1, 2} Mariller C....Pierce A. (2012)
O-GlcNAcylation/phosphorylation cycling at Ser10 cont rols both transcriptional activity and stability of delta-lactoferrin. (PubMed id 20404350)^{1, 2} HardivillAc S....Pierce A. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
cDNA cloning and sequence analysis of human lactoferrin. (PubMed id 11702692)^{1, 2} Cheng H.... Huan L.D. (2001)
Is tumor necrosis factor genotype (TNFA2/TNFA2)a genetic prognostic factor of an unfavorable outcome in IgA nephropathy? (PubMed id 11748357)^{1, 4} Lee E.Y....Hong S.Y. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4057	HGNC: 6720	AceView: LTF	Ensembl:ENSG00000012223	euGenes: HUgn4057
ECgene: LTF	H-InvDB: LTF

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LTF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LTF	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Lactotransferrin

Intellectual Property for LTF gene
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Patent Information for LTF gene:
Search GeneIP for patents involving LTF

GeneCards and IP:
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lactotransferrin

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Gingivitis
TRICHIASIS
Arthritis Reactive
preterm delivery
Dental Caries
Conjunctivitis Giant Papillary
sepsis
Hepatitis Chronic
Oral candidiasis
Cystic Fibrosis
Colitis Ulcerative
Helicobacter Infections
Nasal Epithelium
Iron deficiency anemia
Sjogrens Syndrome Primary
NSCLC
Gastrointestinal Diseases
BILIARY CIRRHOSIS PRIMARY
RHEUMATOID VASCULITIS
Blepharitis
Periodontal Diseases
Polyarteritis Nodosa
Pancreatitis
CHOLANGITIS PRIMARY SCLEROSING
effusion
Bronchoalveolar Lavage Fluid
Ulcer
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PANCREAS EXOCRINE
Bacterial Vaginosis
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Enterocolitis Necrotizing
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Psoriasis
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Hepatitis B
ENDOMETRIAL CARCINOMA
Rheumatoid Arthritis
Periodontitis Juvenile
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Mastitis
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Cirrhosis
Otitis Media
Melanoma
Autoimmune Diseases
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Critically Ill
Xerostomia
Amyloid deposition
Vasculitis
Infectious diarrhea
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Lactose Intolerance
Shigellosis
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Campylobacter Infections
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Intestinal infection
retinopathy
Salivary Gland Diseases
Churg-Strauss Syndrome
Enteritis
Postoperative Complications
Sjogrens Syndrome
Cytopathic Effect Viral
Prostatitis
Dental Plaque
Bronchitis Chronic
AMYLOIDOSIS, CORNEAL
Connective Tissue Diseases
chronic pancreatitis
Inflammatory Bowel Diseases
Influenza
CLOSTRIDIUM DIFFICILE COLITIS
INFECTION FUNGAL
Keratoconjunctivitis Sicca
Dry Eye Syndromes
Ascites
Sjogrens Syndrome Secondary
benign prostatic hyperplasia
Chronic periodontitis
microbial disease
solid tumor
Gastritis
Hepatitis C Chronic
Chorioamnionitis
Pouchitis
bowel disease
SPECIFIC GRANULE DEFICIENCY
Lupus Erythematosus Systemic
Arthritis
Renal Failure Chronic

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LTF Gene

lactotransferrin

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