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Aliases for LTF Gene

Aliases for LTF Gene

  • Lactotransferrin 2 3
  • Growth-Inhibiting Protein 12 3 4
  • Talalactoferrin 3 4
  • GIG12 3 4
  • LF 3 4
  • Epididymis Luminal Protein 110 3
  • Neutrophil Lactoferrin 3
  • Lactoferricin 3
  • Lactoferroxin 3
  • Lactoferrin 4
  • EC 3.4.21.- 4
  • Kaliocin-1 3
  • EC 3.4.21 63
  • HEL110 3
  • HLF2 3

External Ids for LTF Gene

Previous GeneCards Identifiers for LTF Gene

  • GC03M045718
  • GC03M046296
  • GC03M046438
  • GC03M046452
  • GC03M046477

Summaries for LTF Gene

Entrez Gene Summary for LTF Gene

  • This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for LTF Gene

LTF (Lactotransferrin) is a Protein Coding gene. Diseases associated with LTF include clostridium difficile colitis and dry eye syndrome. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include serine-type endopeptidase activity and heparin binding. An important paralog of this gene is MFI2.

Gene Wiki entry for LTF Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTF Gene

Genomics for LTF Gene

Regulatory Elements for LTF Gene

Genomic Location for LTF Gene

Chromosome:
3
Start:
46,435,645 bp from pter
End:
46,485,234 bp from pter
Size:
49,590 bases
Orientation:
Minus strand

Genomic View for LTF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTF Gene

Proteins for LTF Gene

  • Protein details for LTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02788-TRFL_HUMAN
    Recommended name:
    Lactotransferrin
    Protein Accession:
    P02788
    Secondary Accessions:
    • A8K9U8
    • B2MV13
    • B7Z4X2
    • E7EQH5
    • O00756
    • Q16780
    • Q16785
    • Q16786
    • Q16789
    • Q5DSM0
    • Q8IU92
    • Q8IZH6
    • Q8TCD2
    • Q96KZ4
    • Q96KZ5
    • Q9H1Z3
    • Q9UCY5

    Protein attributes for LTF Gene

    Size:
    710 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    No Data Available

neXtProt entry for LTF Gene

Proteomics data for LTF Gene at MOPED

Post-translational modifications for LTF Gene

  • Glycosylation at Asn 156, Asn 497, and Asn 642
  • Modification sites at PhosphoSitePlus

Other Protein References for LTF Gene

Antibody Products

Domains & Families for LTF Gene

Gene Families for LTF Gene

HGNC:

Protein Domains for LTF Gene

Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LTF: view

No data available for UniProtKB/Swiss-Prot for LTF Gene

Function for LTF Gene

Molecular function for LTF Gene

GENATLAS Biochemistry:
lactotransferrin,80kDa,iron binding protein present in milk and a variety of secretions derived from glandular epithelium cells,also expressed in secondary granules of neutrophils,involved in iron transport,storage and chelation,and host defense mechanisms

Enzyme Numbers (IUBMB) for LTF Gene

Gene Ontology (GO) - Molecular Function for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005506 iron ion binding IDA 12037568
GO:0005515 protein binding IPI 1544444
GO:0008201 heparin binding IDA 11907569
genes like me logo Genes that share ontologies with LTF: view
genes like me logo Genes that share phenotypes with LTF: view

Animal Models for LTF Gene

MGI Knock Outs for LTF:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LTF

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for LTF Gene

Localization for LTF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTF Gene COMPARTMENTS Subcellular localization image for LTF gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
lysosome 2
plasma membrane 2
vacuole 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IMP 25193851
GO:0009986 cell surface IDA 17567961
genes like me logo Genes that share ontologies with LTF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LTF Gene

Pathways & Interactions for LTF Gene

genes like me logo Genes that share pathways with LTF: view

Pathways by source for LTF Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001817 regulation of cytokine production IDA 20345905
GO:0001895 retina homeostasis IEP 23580065
GO:0002227 innate immune response in mucosa IDA 12037568
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with LTF: view

No data available for SIGNOR curated interactions for LTF Gene

Drugs & Compounds for LTF Gene

(79) Drugs for LTF Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amoxicillin Approved Pharma 362
Ampicillin Approved Pharma 50
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Azathioprine Approved Pharma 145

(81) Additional Compounds for LTF Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Dodecanoic acid
  • 1-Undecanecarboxylate
  • 1-Undecanecarboxylic acid
  • ABL
  • Aliphat No. 4
  • Dodecanoate
143-07-7
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
5-Aza-2deoxycytidine
genes like me logo Genes that share compounds with LTF: view

Transcripts for LTF Gene

Unigene Clusters for LTF Gene

Lactotransferrin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LTF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTF Gene

No ASD Table

Relevant External Links for LTF Gene

GeneLoc Exon Structure for
LTF
ECgene alternative splicing isoforms for
LTF

Expression for LTF Gene

mRNA expression in normal human tissues for LTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LTF Gene

This gene is overexpressed in Minor Salivary Gland (x18.9), Whole Blood (x13.3), Kidney - Cortex (x6.1), and Breast - Mammary Tissue (x4.5).

Protein differential expression in normal tissues from HIPED for LTF Gene

This gene is overexpressed in Milk (36.8) and Neutrophil (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LTF Gene



SOURCE GeneReport for Unigene cluster for LTF Gene Hs.529517

genes like me logo Genes that share expression patterns with LTF: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LTF Gene

Orthologs for LTF Gene

This gene was present in the common ancestor of animals.

Orthologs for LTF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LTF 35
  • 77.44 (n)
  • 69.86 (a)
LTF 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LTF 35
  • 80.46 (n)
  • 73.87 (a)
LTF 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ltf 35
  • 76.53 (n)
  • 71.57 (a)
Ltf 16
Ltf 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LTF 35
  • 98.83 (n)
  • 98.03 (a)
LTF 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ltf 35
  • 71.79 (n)
  • 62.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves TF 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64306 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
tfa 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsf2 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4617 36
  • 29 (a)
ManyToMany
Species with no ortholog for LTF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTF Gene

ENSEMBL:
Gene Tree for LTF (if available)
TreeFam:
Gene Tree for LTF (if available)

Paralogs for LTF Gene

Paralogs for LTF Gene

(2) SIMAP similar genes for LTF Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LTF: view

Variants for LTF Gene

Sequence variations from dbSNP and Humsavar for LTF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9110 -- 46,439,310(-) AGGTG(A/C/G/T)TGCTC synonymous-codon, reference
rs17135 -- 46,454,226(+) GGAAT(C/T)TAATT intron-variant
rs140582949 -- 46,458,865(+) CACCG(C/T)GCCCA intron-variant
rs140978328 -- 46,455,663(+) GGATG(-/T)TTACA intron-variant
rs141041958 -- 46,463,101(+) CTGGA(A/G)CTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LTF Gene

Variant ID Type Subtype PubMed ID
esv2725234 CNV Deletion 23290073

Variation tolerance for LTF Gene

Residual Variation Intolerance Score: 96.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LTF Gene

HapMap Linkage Disequilibrium report
LTF
Human Gene Mutation Database (HGMD)
LTF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTF Gene

Disorders for LTF Gene

MalaCards: The human disease database

(68) MalaCards diseases for LTF Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
clostridium difficile colitis
  • pseudomembranous colitis
dry eye syndrome
  • tear film insufficiency
mastitis
  • inflammatory breast disease
blepharitis
  • infective eyelid dermatitis of types resulting in deformity
salivary gland disease
  • non-neoplastic salivary gland disease
- elite association
Search LTF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LTF

Genetic Association Database (GAD)
LTF
Human Genome Epidemiology (HuGE) Navigator
LTF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTF
genes like me logo Genes that share disorders with LTF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTF Gene

Publications for LTF Gene

  1. Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma. (PMID: 17476971) Yi H.M. … Ren C.P. (Oncol. Res. 2006) 2 23 67
  2. Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin. (PMID: 19820086) Sandrini S.M. … Freestone P.P. (J. Bacteriol. 2010) 23 67
  3. Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A. (PMID: 20195541) Singh R. … Lillard J.W. (PLoS ONE 2010) 23 67
  4. Lactoferrin: the path from protein to gene. (PMID: 20221787) Teng C.T. (Biometals 2010) 23 67
  5. [Effects of lactoferrin on vascular endothelial growth factor and basic fibroblast growth factor expression in human Tca8113 cell line]. (PMID: 20368037) Wang L. … Sun H.C. (Zhonghua Kou Qiang Yi Xue Za Zhi 2010) 23 67

Products for LTF Gene

Sources for LTF Gene

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