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Aliases for LTF Gene

Aliases for LTF Gene

  • Lactotransferrin 2 3 3 5
  • Growth-Inhibiting Protein 12 3 4
  • Talalactoferrin 3 4
  • GIG12 3 4
  • LF 3 4
  • Epididymis Luminal Protein 110 3
  • Neutrophil Lactoferrin 3
  • Lactoferricin 3
  • Lactoferroxin 3
  • Lactoferrin 4
  • EC 3.4.21.- 4
  • Kaliocin-1 3
  • EC 3.4.21 61
  • HEL110 3
  • HLF2 3

External Ids for LTF Gene

Previous GeneCards Identifiers for LTF Gene

  • GC03M045718
  • GC03M046296
  • GC03M046438
  • GC03M046452
  • GC03M046477

Summaries for LTF Gene

Entrez Gene Summary for LTF Gene

  • This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for LTF Gene

LTF (Lactotransferrin) is a Protein Coding gene. Diseases associated with LTF include Mastitis and Clostridium Difficile Colitis. Among its related pathways are Immune System and HIV Life Cycle. GO annotations related to this gene include serine-type endopeptidase activity and heparin binding. An important paralog of this gene is TF.

UniProtKB/Swiss-Prot for LTF Gene

  • Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

  • Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.

  • Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.

  • Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.

  • Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.

  • The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.

  • Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.

Gene Wiki entry for LTF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTF Gene

Genomics for LTF Gene

Regulatory Elements for LTF Gene

Enhancers for LTF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F046505 0.3 FANTOM5 19.3 -20.7 -20734 0.3 CREB3 LTF TDGF1 MYL3 PTH1R TMIE LOC105377070 RTP3
GH03F046556 0.2 ENCODE 12.1 -72.8 -72770 3.8 PKNOX1 ATF1 CREB3L1 ARID4B DMAP1 YY1 GATA2 ZNF143 FOS REST LRRC2 LRRC2-AS1 RTP3 LTF CCR2 TDGF1
GH03F046549 1.3 FANTOM5 Ensembl ENCODE 11.7 -64.5 -64461 1.3 ATF1 ARNT ETS1 CBX5 GATA2 NCOA1 REST KAT8 CREB3 MBD2 TDGF1 RTP3 LTF LRRC2-AS1 CCR2 LOC105377070
GH03F046628 1.2 FANTOM5 Ensembl ENCODE 11.7 -144.3 -144286 2.6 HDGF ATF1 CBX3 CREB3L1 NFXL1 ZBTB40 RAD21 CBX5 ZNF143 CREM LTF ALS2CL TDGF1 RTP3 PRSS45 CCDC12 GC03P046626 GC03P046650
GH03F046515 1.2 Ensembl ENCODE 11.5 -31.8 -31788 2.4 ATF1 PKNOX1 ARNT CREB3L1 ARID4B DMAP1 ZNF48 YY1 GTF3C2 GATA2 CCDC12 SACM1L RN7SL145P BOLA2P2 LTF TDGF1 XCR1 LOC105377070 LRRC2-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LTF on UCSC Golden Path with GeneCards custom track

Genomic Location for LTF Gene

Chromosome:
3
Start:
46,435,645 bp from pter
End:
46,485,234 bp from pter
Size:
49,590 bases
Orientation:
Minus strand

Genomic View for LTF Gene

Genes around LTF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTF Gene

Proteins for LTF Gene

  • Protein details for LTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02788-TRFL_HUMAN
    Recommended name:
    Lactotransferrin
    Protein Accession:
    P02788
    Secondary Accessions:
    • A8K9U8
    • B2MV13
    • B7Z4X2
    • E7EQH5
    • O00756
    • Q16780
    • Q16785
    • Q16786
    • Q16789
    • Q5DSM0
    • Q8IU92
    • Q8IZH6
    • Q8TCD2
    • Q96KZ4
    • Q96KZ5
    • Q9H1Z3
    • Q9UCY5

    Protein attributes for LTF Gene

    Size:
    710 amino acids
    Molecular mass:
    78182 Da
    Quaternary structure:
    • Monomer. Found in a complex with LTF, CLU, EPPIN and SEMG1.

    Three dimensional structures from OCA and Proteopedia for LTF Gene

    Alternative splice isoforms for LTF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LTF Gene

Selected DME Specific Peptides for LTF Gene

P02788:
  • RKPVTEA
  • LLCPDNT
  • GDVAFVK
  • VVWCAVG
  • YSGAFKCL
  • APNHAVVS
  • SSQEPYF
  • VLKGEADA
  • YYGYTGAFRCLAE
  • VPSHAVVARSV
  • GKKSCHT

Post-translational modifications for LTF Gene

  • Isoform DeltaLf: Ubiquitinated at Lys-379 and Lys-391.
  • Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation.
  • Glycosylation at Asn 156, Asn 497, and Asn 642
  • Modification sites at PhosphoSitePlus

Domains & Families for LTF Gene

Gene Families for LTF Gene

Protein Domains for LTF Gene

Graphical View of Domain Structure for InterPro Entry

P02788

UniProtKB/Swiss-Prot:

TRFL_HUMAN :
  • Contains 2 transferrin-like domains.
  • Belongs to the transferrin family.
Domain:
  • Contains 2 transferrin-like domains.
Family:
  • Belongs to the transferrin family.
genes like me logo Genes that share domains with LTF: view

Function for LTF Gene

Molecular function for LTF Gene

GENATLAS Biochemistry:
lactotransferrin,80kDa,iron binding protein present in milk and a variety of secretions derived from glandular epithelium cells,also expressed in secondary granules of neutrophils,involved in iron transport,storage and chelation,and host defense mechanisms
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential at -Arg-Ser-Arg-Arg- - and -Arg-Arg-Ser-Arg- -, and of Z-Phe-Arg- -aminomethylcoumarin.
UniProtKB/Swiss-Prot Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
UniProtKB/Swiss-Prot Function:
Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.
UniProtKB/Swiss-Prot Function:
Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.
UniProtKB/Swiss-Prot Function:
Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.
UniProtKB/Swiss-Prot Function:
Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.
UniProtKB/Swiss-Prot Function:
The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.
UniProtKB/Swiss-Prot Function:
Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.

Enzyme Numbers (IUBMB) for LTF Gene

Gene Ontology (GO) - Molecular Function for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005506 iron ion binding IEA,IDA 12037568
GO:0005515 protein binding IPI 1544444
GO:0008201 heparin binding IEA,IDA 11907569
genes like me logo Genes that share ontologies with LTF: view
genes like me logo Genes that share phenotypes with LTF: view

Animal Models for LTF Gene

MGI Knock Outs for LTF:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LTF

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTF Gene

Localization for LTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTF Gene

Isoform 1: Secreted. Cytoplasmic granule. Note=Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.
Isoform DeltaLf: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTF Gene COMPARTMENTS Subcellular localization image for LTF gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 3
plasma membrane 3
cytoskeleton 2
cytosol 2
vacuole 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 16502470
GO:0005634 nucleus IEA,IDA 21630459
GO:0005737 cytoplasm IEA,IMP 25193851
GO:0009986 cell surface IDA 17567961
genes like me logo Genes that share ontologies with LTF: view

Pathways & Interactions for LTF Gene

genes like me logo Genes that share pathways with LTF: view

Pathways by source for LTF Gene

Gene Ontology (GO) - Biological Process for LTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001817 regulation of cytokine production IEA,IDA 20345905
GO:0001895 retina homeostasis IEP 23580065
GO:0002227 innate immune response in mucosa IDA 12037568
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LTF: view

No data available for SIGNOR curated interactions for LTF Gene

Drugs & Compounds for LTF Gene

(85) Drugs for LTF Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nimesulide Approved, Withdrawn Pharma Target Non-steroidal anti-inflammatory drug 8
Parecoxib Approved Pharma Inhibition, Inhibitor, Target 39
lauric acid Experimental Pharma Agonist, Target 0
2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE Experimental Pharma Target 0
3h-Indole-5,6-Diol Experimental Pharma Target 0

(75) Additional Compounds for LTF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
genes like me logo Genes that share compounds with LTF: view

Transcripts for LTF Gene

Unigene Clusters for LTF Gene

Lactotransferrin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LTF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTF Gene

No ASD Table

Relevant External Links for LTF Gene

GeneLoc Exon Structure for
LTF
ECgene alternative splicing isoforms for
LTF

Expression for LTF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LTF Gene

This gene is overexpressed in Minor Salivary Gland (x18.9), Whole Blood (x13.3), Kidney - Cortex (x6.1), and Breast - Mammary Tissue (x4.5).

Protein differential expression in normal tissues from HIPED for LTF Gene

This gene is overexpressed in Milk (36.8) and Neutrophil (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LTF Gene



NURSA nuclear receptor signaling pathways regulating expression of LTF Gene:

LTF

SOURCE GeneReport for Unigene cluster for LTF Gene:

Hs.529517

mRNA Expression by UniProt/SwissProt for LTF Gene:

P02788-TRFL_HUMAN
Tissue specificity: High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.
genes like me logo Genes that share expression patterns with LTF: view

Primer Products

No data available for Protein tissue co-expression partners for LTF Gene

Orthologs for LTF Gene

This gene was present in the common ancestor of animals.

Orthologs for LTF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTF 34 35
  • 98.83 (n)
dog
(Canis familiaris)
Mammalia LTF 34 35
  • 80.46 (n)
cow
(Bos Taurus)
Mammalia LTF 34 35
  • 77.44 (n)
mouse
(Mus musculus)
Mammalia Ltf 34 16 35
  • 76.53 (n)
rat
(Rattus norvegicus)
Mammalia Ltf 34
  • 71.79 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves TF 35
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64306 34
zebrafish
(Danio rerio)
Actinopterygii tfa 35
  • 41 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Tsf2 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4617 35
  • 29 (a)
ManyToMany
Species where no ortholog for LTF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTF Gene

ENSEMBL:
Gene Tree for LTF (if available)
TreeFam:
Gene Tree for LTF (if available)

Paralogs for LTF Gene

Paralogs for LTF Gene

(2) SIMAP similar genes for LTF Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with LTF: view

Variants for LTF Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LTF Gene

TRFL_HUMAN-P02788
The sequence shown corresponds to the reference genome sequence and is likely to represent the minor allele, whereas most publications refer to the longer sequence containing variant Arg-22 ins. Insertion of the additional arginine in variant Arg-22 ins creates an N-terminal basic cluster of four arginines, all of which appear to be important for the full functionality of the protein, including bactericidal and antifungal activities as well as binding to glycosaminoglycans, pspA, LPS, lysozyme and DNA.

Sequence variations from dbSNP and Humsavar for LTF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1034383 -- 46,437,717(+) GTGCC(A/G)TCACT intron-variant
rs1034384 -- 46,438,681(+) TGCAC(A/G)TTAAG intron-variant
rs1034385 -- 46,438,896(+) CCTGG(C/T)CTAGA intron-variant
rs1042055 -- 46,447,347(-) CTGCA(G/T)GCAAA reference, missense
rs1042073 -- 46,443,473(-) AGCAA(C/T)GAGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LTF Gene

Variant ID Type Subtype PubMed ID
esv2725234 CNV deletion 23290073
esv3367734 CNV duplication 20981092
nsv1013306 CNV gain 25217958
nsv1014624 CNV loss 25217958

Variation tolerance for LTF Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LTF Gene

Human Gene Mutation Database (HGMD)
LTF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTF

Disorders for LTF Gene

MalaCards: The human disease database

(34) MalaCards diseases for LTF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mastitis
  • breast inflammation
clostridium difficile colitis
  • pseudomembranous colitis
dry eye syndrome
  • xerophthalmia
dental caries
  • dental caries extending into pulp
rheumatoid vasculitis
- elite association - COSMIC cancer census association via MalaCards
Search LTF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LTF

Genetic Association Database (GAD)
LTF
Human Genome Epidemiology (HuGE) Navigator
LTF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTF
genes like me logo Genes that share disorders with LTF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTF Gene

Publications for LTF Gene

  1. Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status. (PMID: 18156281) Moreno-Navarrete J.M. … FernA!ndez-Real J.M. (Clin. Chem. 2008) 3 22 46 64
  2. Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma. (PMID: 17476971) Yi H.M. … Ren C.P. (Oncol. Res. 2006) 2 3 22 64
  3. Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide. (PMID: 15687491) Japelj B. … Jerala R. (J. Biol. Chem. 2005) 3 4 22 64
  4. Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. (PMID: 15166119) Cornish J. … Reid I.R. (Endocrinology 2004) 3 4 22 64
  5. Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites. (PMID: 12535064) Hendrixson D.R. … St Geme J.W. III (Mol. Microbiol. 2003) 3 4 22 64

Products for LTF Gene

Sources for LTF Gene

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