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LTC4S Gene

protein-coding   GIFtS: 59
GCID: GC05P179220

Leukotriene C4 Synthase

  See LTC4S-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukotriene C4 Synthase1 2
LTC4 Synthase2 3
EC 4.4.1.203
Leukotriene-C(4) Synthase3

External Ids:    HGNC: 67191   Entrez Gene: 40562   Ensembl: ENSG000002133167   OMIM: 2465305   UniProtKB: Q168733   

Export aliases for LTC4S gene to outside databases

Previous GC identifers: GC05P179333 GC05P180165 GC05P179285 GC05P179330 GC05P179153 GC05P173947


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LTC4S Gene:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of
human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that
catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from
arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such
as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.
(provided by RefSeq, Jul 2008)

GeneCards Summary for LTC4S Gene:
LTC4S (leukotriene C4 synthase) is a protein-coding gene. Diseases associated with LTC4S include henoch-schoenlein purpura, and leukotriene c4 synthase deficiency. GO annotations related to this gene include lipid binding and glutathione transferase activity. An important paralog of this gene is ALOX5AP.

UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873
Function: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4

Gene Wiki entry for LTC4S (Leukotriene C4 synthase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LTC4S gene promoter:
         Sp1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLTC4S promoter sequence
   Search Chromatin IP Primers for LTC4S

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LTC4S


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

LTC4S Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LTC4S gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P179220:  view genomic region     (about GC identifiers)

Start:
179,220,981 bp from pter      End:
179,223,648 bp from pter
Size:
2,668 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873 (See protein sequence)
Recommended Name: Leukotriene C4 synthase  
Size: 150 amino acids; 16567 Da
Subunit: Homotrimer. Interacts with ALOX5AP and ALOX5
Selected PDB 3D structures from and Proteopedia for LTC4S (see all 12):
2PNO (3D)        2UUH (3D)        2UUI (3D)        3B29 (3D)        3HKK (3D)        3LEO (3D)    
Secondary accessions: Q8N6P0 Q9UC73 Q9UD18

Explore the universe of human proteins at neXtProt for LTC4S: NX_Q16873

Explore proteomics data for LTC4S at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LTC4S Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_665874.1  
    ENSEMBL proteins: 
     ENSP00000427299   ENSP00000292596   ENSP00000385627  
    Reactome Protein details: Q16873

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Leukotriene C4 synthase
    Leukotriene and lipoxin metabolism

    4 InterPro protein domains:
     IPR001446 5_LipOase_AP
     IPR018295 FLAP/GST2/LTC4S_CS
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry Q16873

    ProtoNet protein and cluster: Q16873

    1 Blocks protein domain: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

    UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873
    Similarity: Belongs to the MAPEG family


    Find genes that share domains with LTC4S           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LTC4S_HUMAN, Q16873
    Function: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4
    Catalytic activity: Leukotriene C(4) = leukotriene A(4) + glutathione

         Genatlas biochemistry entry for LTC4S:
    leukotriene C4 synthase,microsomal,GST superfamily

         Enzyme Number (IUBMB): EC 4.4.1.201

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364glutathione transferase activity IBA--
    GO:0004464leukotriene-C4 synthase activity IDA8706658
    GO:0004602glutathione peroxidase activity IBA--
    GO:0005515protein binding IPI19233132
    GO:0008047enzyme activator activity IEA--
         
    Find genes that share ontologies with LTC4S           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ltc4s):
     cardiovascular system  immune system  integument  respiratory system 

    Find genes that share phenotypes with LTC4S           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ltc4stm1Blam for LTC4S

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    miRTarBase miRNAs that target LTC4S:
    hsa-mir-335-5p (MIRT016938)

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    SwitchGear 3'UTR luciferase reporter plasmidLTC4S 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LTC4S_HUMAN, Q16873: Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane;
    Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    extracellular2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS--
    GO:0005640nuclear outer membrane IEA--
    GO:0005783endoplasmic reticulum IDA19233132
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LTC4S           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LTC4S About    
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    leukotriene biosynthesis0.00
    Arachidonic acid metabolism0.40
    Synthesis of 5-eicosatetraenoic acids0.00
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    Synthesis of Lipoxins (LX)0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3PEDF Induced Signaling
    all-trans-Retinoic Acid Signaling in Brain0.71
    4Leukotriene modifiers pathway, Pharmacodynamics
    Leukotriene modifiers pathway, Pharmacodynamics
    5Eicosanoid Synthesis
    Eicosanoid Synthesis


    Find genes that share SuperPaths with LTC4S           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for LTC4S
        all-trans-Retinoic Acid Signaling in Brain

    2 BioSystems Pathways for LTC4S
        Eicosanoid Synthesis
    leukotriene biosynthesis


    3 Reactome Pathways for LTC4S
        Synthesis of Lipoxins (LX)
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Synthesis of 5-eicosatetraenoic acids

    1 PharmGKB Pathway for LTC4S
        Leukotriene modifiers pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for LTC4S):
        Arachidonic acid metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LTC4S
    Interactions:

        GeneGlobe Interaction Network for LTC4S

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for LTC4S (Q168733 ENSP000002925964) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX5P099173, ENSP000003635124I2D: score=1 STRING: ENSP00000363512
    ALOX5APP202923, ENSP000003698584I2D: score=1 STRING: ENSP00000369858
    MGST1P106203, ENSP000000104044I2D: score=1 STRING: ENSP00000010404
    ABCC1ENSP000003823424STRING: ENSP00000382342
    LTA4HENSP000002287404STRING: ENSP00000228740
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006691leukotriene metabolic process TAS--
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019370leukotriene biosynthetic process IBA--
    GO:0019372lipoxygenase pathway TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with LTC4S           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for LTC4S
      Browse compounds at ApexBio 

    Browse Tocris compounds for LTC4S

    3 HMDB Compounds for LTC4S    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Leukotriene A4LTA4 (see all 10)72059-45-1--
    Leukotriene C4(R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine (see all 12)72025-60-6--

    1 DrugBank Compound for LTC4S    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--17632548 17632546

    Selected Novoseek inferred chemical compound relationships for LTC4S gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ltc4 95.5 289 1517222 (9), 8703034 (7), 8052639 (6), 9492288 (6) (see all 73)
    leukotriene b4 75.6 12 8630722 (2), 10337029 (1), 10102384 (1), 17623009 (1) (see all 10)
    lte4 74.6 1 8425605 (1)
    ltd4 73.5 2 8425605 (1), 8386188 (1)
    montelukast 69.6 11 17883728 (3), 17460547 (1), 19214143 (1)
    arachidonic acid 68.9 18 12569976 (3), 9004830 (1), 10436863 (1), 17632548 (1) (see all 9)
    zileuton 63.9 2 9113110 (1), 19214143 (1)
    aspirin 58.2 39 12569976 (5), 16433794 (4), 16583357 (4), 10887308 (2) (see all 12)
    epoxide 47.7 1 9153254 (1)
    uridine diphosphate 45.7 2 11877481 (1)

    2 PharmGKB related drug/compound annotations for LTC4S gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  
    montelukastCA  



    Find genes that share compounds with LTC4S           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LTC4S gene: 
    NM_145867.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465572(uc003mko.3) ENST00000505170 ENST00000292596 ENST00000401985
    ENST00000466071 ENST00000486713 ENST00000510544 ENST00000509898
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    Selected AceView cDNA sequences (see all 34):

    U09353 NM_145867 BI820422 BC029498 BX358710 BI668417 BI458484 AW663477 
    AL040755 AL040754 AI242991 BI597970 AW089665 AI658628 NM_000897 BU616225 
    AI768316 BI819419 AI299075 AW295885 BI457632 AW594576 AI480325 U11552 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LTC4S expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGGCGGC
    LTC4S Expression
    About this image


    LTC4S expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
    LTC4S Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LTC4S Protein Expression

    UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873
    Tissue specificity: Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level).
    LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells,
    endothelial cells, vascular smooth muscle cells and platelets

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTC4S

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LTC4S gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ltc4s1 , 5 leukotriene C4 synthase1, 5 89.19(n)1
    93.69(a)1
      11 (30.40 cM)5
    170011  NM_008521.11  NP_032547.11 
     502364695 
    chicken
    (Gallus gallus)
    Aves LOC7706191 leukotriene C4 synthase-like 72.37(n)
    70.27(a)
      770619  XM_001233957.3  XP_001233958.3 
    lizard
    (Anolis carolinensis)
    Reptilia LTC4S6
    leukotriene C4 synthase
    60(a)
    1 ↔ 1
    2(140280142-140287099)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mgst21 microsomal glutathione S-transferase 2 66.36(n)
    69.72(a)
      100127769  NM_001113094.1  NP_001106565.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ltc4s6
    leukotriene C4 synthase
    54(a)
    1 ↔ 1
    14(14053762-14062342) ENSDARG00000062598


    ENSEMBL Gene Tree for LTC4S (if available)
    TreeFam Gene Tree for LTC4S (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LTC4S gene
    ALOX5AP2  MGST22  
    2 SIMAP similar genes for LTC4S using alignment to 3 protein entries:     LTC4S_HUMAN (see all proteins):
    MGST2    ALOX5AP

    Find genes that share paralogs with LTC4S           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LTC4S (see all 109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793292371,2
    --179439418(+) GGGGTC/GGGGGC 1 -- us2k10--------
    rs1416237221,2
    --179439433(+) CTGGCC/TCTCCT 1 -- us2k10--------
    rs1472213201,2
    --179439480(+) GACAGA/CCTGGG 1 -- us2k10--------
    rs1405606481,2
    --179439659(+) TTCAGA/GCCTTG 1 -- us2k10--------
    rs77066931,2
    C,H--179439781(+) GTATGC/TGTGGT 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 420
    rs1839752981,2
    --179439888(+) TTCAGA/GGAGGA 1 -- us2k10--------
    rs1444354411,2
    --179439903(+) GGCTGA/CGTGGG 1 -- us2k10--------
    rs1473957981,2
    --179439924(+) GGACGC/TGGCCA 1 -- us2k10--------
    rs1889210671,2
    --179440030(+) GGGGCC/TGGGCC 1 -- us2k10--------
    rs1391400961,2
    --179440034(+) CCGGGC/TCTGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LTC4S (179220981 - 179223648 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LTC4S (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv823361CNV Loss20364138
    nsv883270CNV Loss21882294
    nsv469579CNV Loss16826518
    nsv883278CNV Loss21882294
    nsv483062CNV Loss15286789
    dgv6403n71CNV Loss21882294
    nsv518964CNV Loss19592680
    dgv6401n71CNV Loss21882294
    dgv6402n71CNV Loss21882294
    nsv883275CNV Loss21882294

    Human Gene Mutation Database (HGMD): LTC4S
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LTC4S
    DNA2.0 Custom Variant and Variant Library Synthesis for LTC4S

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 246530   
    OMIM disorders: 614037  
    UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873
  • Note=LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by
    muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly

  • 8 diseases for LTC4S:    
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    henoch-schoenlein purpura    leukotriene c4 synthase deficiency    urticaria    venous thromboembolism
    sinusitis    abdominal aortic aneurysm    atopy    asthma

    1 disease from the University of Copenhagen DISEASES database for LTC4S:
    Asthma

    Find genes that share disorders with LTC4S           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LTC4S gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 71.2 51 10887308 (3), 10624490 (3), 12728163 (2), 19280718 (2) (see all 30)
    leukemia basophilic 60.7 3 8203889 (1), 11034337 (1), 8630722 (1)
    monocytic leukemia 51.8 1 8425605 (1)
    idiopathic urticaria 44.6 1 16433794 (1)
    urticaria 36.8 6 16433794 (3), 16825866 (1), 19862937 (1)
    inflammation 36.3 9 10591082 (2), 10224472 (1), 8626689 (1), 17110605 (1) (see all 6)
    angioedema 35.3 5 16825866 (1), 17641958 (1)
    mastocytoma 33.1 1 11034337 (1)
    bronchial hyperreactivity 30.1 2 10436863 (1), 10591082 (1)
    sinusitis 21.5 2 16675331 (1), 17063752 (1)

    Genetic Association Database (GAD): LTC4S
    Human Genome Epidemiology (HuGE) Navigator: LTC4S (52 documents)

    Export disorders for LTC4S gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LTC4S gene, integrated from 10 sources (see all 212):
    (articles sorted by number of sources associating them with LTC4S)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. (PubMed id 17632548)1, 2, 7, 9 Ago H....Miyano M. (Nature 2007)
    2. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. (PubMed id 8052639)1, 2, 3, 9 Lam B.K.... Austen K.F. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. (PubMed id 17632546)1, 2, 7, 9 Martinez Molina D....Nordlund P. (Nature 2007)
    4. Molecular cloning and expression of human leukotriene-C4 synthase. (PubMed id 7937884)1, 2, 9 Welsch D.J....Isakson P.C. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    5. Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. (PubMed id 17063752)1, 4, 9 de AlarcA^n A....Borish L. (Am J Rhinol 2006)
    6. Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody. (PubMed id 7599836)1, 2, 9 Penrose J.F....Austen K.F. (Am. J. Respir. Crit. Care Med. 1995)
    7. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. (PubMed id 8626689)1, 2, 9 Penrose J.F.... Lam B.K. (J. Biol. Chem. 1996)
    8. Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA). (PubMed id 17883728)1, 4, 9 Lee S.Y....Hong S.J. (Clin. Exp. Allergy 2007)
    9. Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits. (PubMed id 8446623)1, 2, 9 Nicholson D.W.... Ford-Hutchinson A.W. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    10. Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. (PubMed id 19280718)1, 4, 9 Freiberg J.J....Nordestgaard B.G. (J. Mol. Cell. Cardiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4056 HGNC: 6719 AceView: LTC4S Ensembl:ENSG00000213316 euGenes: HUgn4056
    ECgene: LTC4S Kegg: 4056 H-InvDB: LTC4S

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LTC4S Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LTC4S gene:
    Search GeneIP for patents involving LTC4S

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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