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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LTC4S Gene

protein-coding GIFtS: 62
GCID: GC05P179220

leukotriene C4 synthase

Explore 30 diseases affiliated with
LTC4S via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leukotriene C4 Synthase¹ ²
LTC4 Synthase² ³
MGC33147¹
EC 4.4.1.20³
Leukotriene-C(4) Synthase³

External Ids:	HGNC: 6719¹	Entrez Gene: 4056²	Ensembl: ENSG00000213316⁷	OMIM: 246530⁵	UniProtKB: Q16873³

Export aliases for LTC4S gene to outside databases

Previous GC identifers: GC05P179333 GC05P180165 GC05P179285 GC05P179330 GC05P179153 GC05P173947

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LTC4S:

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human

proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the

first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid.

Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial

asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873

Function: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4

Gene Wiki entry for LTC4S (Leukotriene C4 synthase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LTC4S gene promoter:
Sp1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LTC4S promoter sequence

Search SABiosciences Chromatin IP Primers for LTC4S

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LTC4S

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35

LTC4S Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LTC4S gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P179220: view genomic region (about GC identifiers)

Start:	179,220,981 bp from pter	End:	179,223,648 bp from pter
Size:	2,668 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873 (See protein sequence)

Recommended Name: Leukotriene C4 synthase

Size: 150 amino acids; 16567 Da

Subunit: Homotrimer. Interacts with ALOX5AP and ALOX5

Subcellular location: Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass

membrane protein

6/7 PDB 3D structures from and Proteopedia for LTC4S (see all 7):

2PNO (3D)

2UUH (3D)

2UUI (3D)

3B29 (3D)

3HKK (3D)

3LEO (3D)

Secondary accessions: Q8N6P0 Q9UC73 Q9UD18

Explore the universe of human proteins at neXtProt for LTC4S: NX_Q16873

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16873

LTC4S Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_665874.1

ENSEMBL proteins:

ENSP00000427299 ENSP00000292596 ENSP00000385627

Reactome Protein details: Q16873
Human Recombinant Protein Products:

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	Uscn Proteins for LTC4S

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005635	nuclear envelope	TAS	--
GO:0005640	nuclear outer membrane	IEA	--
GO:0005783	endoplasmic reticulum	IDA	19233132
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	--	--

LTC4S for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for LTC4S

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LTC4S for domains About GeneDecksing

4 InterPro domains/families:

IPR001446 5_LipOase_AP

IPR018295 FLAP/GST2/LTC4S_CS

IPR023352 MAPEG-like_dom

IPR001129 Membr-assoc_MAPEG

Graphical View of Domain Structure for InterPro Entry Q16873

ProtoNet protein and cluster: Q16873

1 Blocks protein family: IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873

Similarity: Belongs to the MAPEG family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873

Function: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4

Catalytic activity: Leukotriene C(4) = leukotriene A(4) + glutathione

Genatlas biochemistry entry for LTC4S:

leukotriene C4 synthase,microsomal,GST superfamily

Enzyme Number (IUBMB): EC 4.4.1.20¹

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for LTC4S

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	glutathione transferase activity	IBA	--
GO:0004464	leukotriene-C4 synthase activity	TAS	--
GO:0004602	glutathione peroxidase activity	IBA	--
GO:0005515	protein binding	IPI	19233132
GO:0008047	enzyme activator activity	IEA	--

LTC4S for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ltc4s^tm1Blam for LTC4S
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ltc4s):

cardiovascular system

immune system

integument

respiratory system

LTC4S for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

leukotriene biosynthesis

	leukotriene biosynthesis	1.00			Leukotriene modifiers pathway, Pharmacodynamics	0.33
	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.47

Arachidonic acid metabolism

	Arachidonic acid metabolism	1.00			Eicosanoid Synthesis	0.31
	Arachidonic acid metabolism	0.42

Synthesis of 15-eicosatetraenoic acid derivatives

Synthesis of 5-eicosatetraenoic acids

0.33

Synthesis of Lipoxins (LX)

0.00

PEDF Induced Signaling

all-trans-Retinoic Acid Signaling in Brain

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LTC4S

all-trans-Retinoic Acid Signaling in Brain

2 BioSystems Pathways for LTC4S

	Eicosanoid Synthesis
	leukotriene biosynthesis

5/6 Reactome Pathways for LTC4S (see all 6)

	Synthesis of Lipoxins (LX)
	Metabolism
	Synthesis of Leukotrienes (LT) and Eoxins (EX)
	Arachidonic acid metabolism
	Synthesis of 5-eicosatetraenoic acids

1 PharmGKB Pathway for LTC4S

Leukotriene modifiers pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for LTC4S):

	Arachidonic acid metabolism
	Metabolic pathways

LTC4S for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LTC4S

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for LTC4S (Q16873³ ENSP00000292596⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALOX5	P09917³, ENSP00000363512⁴	I2D: score=1 STRING: ENSP00000363512
ALOX5AP	P20292³, ENSP00000369858⁴	I2D: score=1 STRING: ENSP00000369858
MGST1	P10620³, ENSP00000010404⁴	I2D: score=1 STRING: ENSP00000010404
ABCC1	ENSP00000382342⁴	STRING: ENSP00000382342
LTA4H	ENSP00000228740⁴	STRING: ENSP00000228740

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006691	leukotriene metabolic process	IDA	8706658
GO:0006692	prostanoid metabolic process	--	--
GO:0006750	glutathione biosynthetic process	IBA	--
GO:0010035	response to inorganic substance	--	--
GO:0019370	leukotriene biosynthetic process	IEA	--

LTC4S for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LTC4S for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for LTC4S

Browse Tocris compounds for LTC4S

3 HMDB Compounds for LTC4S About this table

Compound	Synonyms	CAS #	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Leukotriene A4	LTA4 (see all 10)	72059-45-1	--
Leukotriene C4	(R-(R,S-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine (see all 12)	72025-60-6	--

1 DrugBank Compound for LTC4S About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 5)	70-18-8	target	--	17632548 17632546

10/25 Novoseek chemical compound relationships for LTC4S gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ltc4	95.5	289	1517222 (9), 8703034 (7), 8052639 (6), 9492288 (6) (see all 73)
leukotriene b4	75.6	12	8630722 (2), 10337029 (1), 10102384 (1), 17623009 (1) (see all 10)
lte4	74.6	1	8425605 (1)
ltd4	73.5	2	8425605 (1), 8386188 (1)
montelukast	69.6	11	17883728 (3), 17460547 (1), 19214143 (1)
arachidonic acid	68.9	18	12569976 (3), 9004830 (1), 10436863 (1), 17632548 (1) (see all 9)
zileuton	63.9	2	9113110 (1), 19214143 (1)
aspirin	58.2	39	12569976 (5), 16433794 (4), 16583357 (4), 10887308 (2) (see all 12)
epoxide	47.7	1	9153254 (1)
uridine diphosphate	45.7	2	11877481 (1)

2 PharmGKB related drug/compound annotations for LTC4S gene

Drug/compound	PharmGKB Annotation
aspirin	CA
montelukast	CA

About this table

Search CenterWatch for drugs/clinical trials and news about LTC4S

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LTC4S gene:

NM_145867.1

Unigene Cluster for LTC4S:

Leukotriene C4 synthase

Hs.706741 [show with all ESTs]

Unigene Representative Sequence: BM921522

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000465572(uc003mko.3) ENST00000505170 ENST00000292596 ENST00000401985

ENST00000466071 ENST00000486713 ENST00000510544 ENST00000509898

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTC4S

Additional cDNA sequence:

AK312033.1 BC029498.1 U09353.1 U11552.1

3 DOTS entries:

DT.440928 DT.95270740 DT.100020399

24/34 AceView cDNA sequences (see all 34):

BI820422 U09353 NM_145867 BC029498 BI668417 BU616225 BI458484 AI658628

NM_000897 BI597970 AL040755 BX358710 AW089665 AL040754 AI768316 AI242991

AW663477 AW594576 BI819419 AW295885 AI480325 AI299075 BI457632 BX279770

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LTC4S expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGGGCGGC

About this image

LTC4S expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LTC4S Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LTC4S

SOURCE GeneReport for Unigene cluster: Hs.706741

UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873

Tissue specificity: Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S

activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells,

vascular smooth muscle cells and platelets

SABiosciences Custom PCR Arrays for LTC4S

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTC4S

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for LTC4S

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LTC4S gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ltc4s^{1 , 5}	leukotriene C4 synthase^{1, 5}	87.11(n)¹ 88(a)¹		11 (30.40 cM)⁵ 17001¹ NM_008521.1¹ NP_032547.1¹ 50236469⁵
chicken (Gallus gallus)	Aves	LOC770619¹	leukotriene C4 synthase-like	72.52(n) 70.99(a)		770619 XM_001233957.2 XP_001233958.2
zebrafish (Danio rerio)	Actinopterygii	ltc4s⁶	leukotriene C4 synthase	54(a)	1 ↔ 1	14(14053762-14062342)

ENSEMBL Gene Tree for LTC4S (if available)
TreeFam Gene Tree for LTC4S (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LTC4S gene

ALOX5AP² MGST2²

2 SIMAP similar genes for LTC4S using alignment to 3 protein entries: LTC4S_HUMAN (see all proteins):

MGST2 ALOX5AP

LTC4S for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79329237^1,2		--	173945169(+)	`GGGGTC/GGGGGC`	1	--	us2k¹		0	--	--	--	--
rs7706693^1,2	C,H	--	173945532(+)	`GTATGC/TGTGGT`	1	--	us2k¹		5		NS EA NA	420
rs80086381^1,2	F,	--	173946165(+)	`CGGCCG/AGGGGC`	1	--	us2k¹		1		WA	118
rs3776944^1,2	C,F,H,	--	173946185(-)	`TCCCTC/TGCCCC`	1	--	us2k¹		7		EA NS NA	408
rs73349925^1,2	C,	--	173946277(+)	`GGCCCG/ACCGTA`	1	--	us2k¹		2		WA	120
rs77590779^1,2	C,F,	--	173946279(+)	`CCCGCC/TGTAGT`	1	--	us2k¹		1		WA	118
rs76018357^1,2	F,	--	173946582(+)	`CTCCCG/ACCACC`	1	--	us2k¹		1		WA	118
rs28365147^1,2	C,F,	--	173947152(+)	`AGCACC/TGAGGC`	1	--	us2k¹		1		--	62
rs28365148^1,2	C,F,	--	173947206(+)	`TAAGCG/ATTCCC`	1	--	ut5¹		3		CSA WA	187
rs28365146^1,2	C,	--	173947471(+)	`TGGCTG/ATGAGA`	1	--	int¹		2		NA	60

HapMap Linkage Disequilibrium report for LTC4S (179220981 - 179223648 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LTC4S
1 CNV: 0068
Human Gene Mutation Database (HGMD): LTC4S

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LTC4S for disorders About GeneDecksing

OMIM gene information: 246530 OMIM disorders: --

UniProtKB/Swiss-Prot: LTC4S_HUMAN, Q16873

Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530].

LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia,

psychomotor retardation, failure to thrive, and microcephaly

20/30 diseases for LTC4S (see all 30): About MalaCards

bronchial asthma henoch-schoenlein purpura asthma common cold

urticaria monocytic leukemia angioedema allergic rhinitis

chronic myeloid leukemia atopy myeloid leukemia purpura

rhinitis sinusitis cerebrovascular disease nephrotic syndrome

hodgkin's lymphoma leukemia eosinophilia microcephaly

1 disease from the University of Copenhagen DISEASES database for LTC4S:

Asthma

10/17 Novoseek disease relationships for LTC4S gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	71.2	51	10887308 (3), 10624490 (3), 12728163 (2), 19280718 (2) (see all 30)
leukemia basophilic	60.7	3	8203889 (1), 11034337 (1), 8630722 (1)
monocytic leukemia	51.8	1	8425605 (1)
idiopathic urticaria	44.6	1	16433794 (1)
urticaria	36.8	6	16433794 (3), 16825866 (1), 19862937 (1)
inflammation	36.3	9	10591082 (2), 10224472 (1), 8626689 (1), 17110605 (1) (see all 6)
angioedema	35.3	5	16825866 (1), 17641958 (1)
mastocytoma	33.1	1	11034337 (1)
bronchial hyperreactivity	30.1	2	10436863 (1), 10591082 (1)
sinusitis	21.5	2	16675331 (1), 17063752 (1)

Genetic Association Database (GAD): LTC4S
Human Genome Epidemiology (HuGE) Navigator: LTC4S (52 documents)

Export disorders for LTC4S gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LTC4S gene, integrated from 9 sources (see all 206):
(articles sorted by number of sources associating them with LTC4S)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. (PubMed id 17632548)^{1, 2, 7, 9} Ago H....Miyano M. (2007)
Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. (PubMed id 8052639)^{1, 2, 3, 9} Lam B.K.... Austen K.F. (1994)
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. (PubMed id 17632546)^{1, 2, 7, 9} Martinez Molina D....Nordlund P. (2007)
Molecular cloning and expression of human leukotriene-C4 synthase. (PubMed id 7937884)^{1, 2, 9} Welsch D.J....Isakson P.C. (1994)
Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody. (PubMed id 7599836)^{1, 2, 9} Penrose J.F....Austen K.F. (1995)
Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. (PubMed id 8626689)^{1, 2, 9} Penrose J.F.... Lam B.K. (1996)
Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits. (PubMed id 8446623)^{1, 2, 9} Nicholson D.W.... Ford-Hutchinson A.W. (1993)
Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (PubMed id 14749922)^{1, 4, 9} Choi J.H....Shin H.D. (2004)
Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma. (PubMed id 12968987)^{1, 4, 9} Currie G.P....Lipworth B.J. (2003)
Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma. (PubMed id 12728163)^{1, 4, 9} Sayers I....Holgate S.T. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4056	HGNC: 6719	AceView: LTC4S	Ensembl:ENSG00000213316	euGenes: HUgn4056
ECgene: LTC4S	Kegg: 4056	H-InvDB: LTC4S

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LTC4S	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LTC4S gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LTC4S gene:
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GeneCards and IP:
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