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Aliases for LTBR Gene

Aliases for LTBR Gene

  • Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3) 2 3
  • TNFCR 3 4 6
  • Tumor Necrosis Factor Receptor 2-Related Protein 3 4
  • Tumor Necrosis Factor Receptor Type III 3 4
  • Tumor Necrosis Factor C Receptor 3 4
  • D12S370 3 4
  • TNFRSF3 3 4
  • TNFR3 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 3 3
  • Lymphotoxin-Beta Receptor 4
  • Lymphotoxin B Receptor 3
  • LT-BETA-R 3
  • TNF-R-III 3
  • TNFR2-RP 3
  • TNF-RIII 4
  • TNFR-III 4
  • TNFR-RP 3
  • CD18 3

External Ids for LTBR Gene

Previous HGNC Symbols for LTBR Gene

  • D12S370

Previous GeneCards Identifiers for LTBR Gene

  • GC12P006348
  • GC12P006467
  • GC12P006363
  • GC12P006484

Summaries for LTBR Gene

Entrez Gene Summary for LTBR Gene

  • This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

GeneCards Summary for LTBR Gene

LTBR (Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3)) is a Protein Coding gene. Diseases associated with LTBR include chronic granulomatous disease. Among its related pathways are NF-KappaB Family Pathway and HIF-1 signaling pathway. GO annotations related to this gene include identical protein binding and ubiquitin protein ligase binding. An important paralog of this gene is TNFRSF14.

UniProtKB/Swiss-Prot for LTBR Gene

  • Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Gene Wiki entry for LTBR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTBR Gene

Genomics for LTBR Gene

Regulatory Elements for LTBR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LTBR Gene

6,375,045 bp from pter
6,391,571 bp from pter
16,527 bases
Plus strand

Genomic View for LTBR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LTBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTBR Gene

Proteins for LTBR Gene

  • Protein details for LTBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 3
    Protein Accession:
    Secondary Accessions:
    • B7Z1D2
    • D3DUR2
    • F5GXE7

    Protein attributes for LTBR Gene

    435 amino acids
    Molecular mass:
    46709 Da
    Quaternary structure:
    • Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.

    Three dimensional structures from OCA and Proteopedia for LTBR Gene

    Alternative splice isoforms for LTBR Gene


neXtProt entry for LTBR Gene

Proteomics data for LTBR Gene at MOPED

Post-translational modifications for LTBR Gene

  • Glycosylation at Asn40 and Asn177
  • Modification sites at PhosphoSitePlus

Other Protein References for LTBR Gene

Antibody Products

  • R&D Systems Antibodies for LTBR (Lymphotoxin beta R/TNFRSF3)

No data available for DME Specific Peptides for LTBR Gene

Domains for LTBR Gene

Gene Families for LTBR Gene

  • TNFRSF :Tumor necrosis factor receptor superfamily

Protein Domains for LTBR Gene

Graphical View of Domain Structure for InterPro Entry



  • P36941
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with LTBR: view

Function for LTBR Gene

Molecular function for LTBR Gene

GENATLAS Biochemistry: lymphotoxin B receptor,(tumor necrosis factor receptor TNFR superfamily,member 3),expressed at the surface of most cell types,including cells of epithelial and myeloid lineages but not on T and B cells,involved in lymphoid organ development and apoptosis through interaction with TRAF3
UniProtKB/Swiss-Prot Function: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Gene Ontology (GO) - Molecular Function for LTBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12393901
GO:0031625 ubiquitin protein ligase binding IPI 11279055
GO:0042802 identical protein binding IPI 20732415
genes like me logo Genes that share ontologies with LTBR: view
genes like me logo Genes that share phenotypes with LTBR: view

Animal Models for LTBR Gene

MGI Knock Outs for LTBR:

Animal Model Products

CRISPR Products

miRNA for LTBR Gene

miRTarBase miRNAs that target LTBR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LTBR Gene

Localization for LTBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTBR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LTBR Gene COMPARTMENTS Subcellular localization image for LTBR gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LTBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LTBR: view

Pathways for LTBR Gene

genes like me logo Genes that share pathways with LTBR: view

PCR Array Products

Gene Ontology (GO) - Biological Process for LTBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 8171323
GO:0016032 viral process IEA --
GO:0043011 myeloid dendritic cell differentiation IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP 12761501
genes like me logo Genes that share ontologies with LTBR: view

Compounds for LTBR Gene

(1) IUPHAR Ligand for LTBR Gene

Ligand Type Action Affinity Pubmed IDs
LIGHT None None

(5) Novoseek inferred chemical compound relationships for LTBR Gene

Compound -log(P) Hits PubMed IDs
glucuronoxylomannan 55.1 2
rantes 24 1
retinoic acid 17.4 15
zinc 0 1
serine 0 3
genes like me logo Genes that share compounds with LTBR: view

Transcripts for LTBR Gene

mRNA/cDNA for LTBR Gene

Unigene Clusters for LTBR Gene

Lymphotoxin beta receptor (TNFR superfamily, member 3):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LTBR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTBR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - - -
SP5: -
SP6: -
SP8: - -

Relevant External Links for LTBR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LTBR Gene

mRNA expression in normal human tissues for LTBR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LTBR Gene

SOURCE GeneReport for Unigene cluster for LTBR Gene Hs.1116

genes like me logo Genes that share expressions with LTBR: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LTBR Gene

Orthologs for LTBR Gene

This gene was present in the common ancestor of mammals.

Orthologs for LTBR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LTBR 35
  • 98.85 (n)
  • 98.16 (a)
  • 98 (a)
(Bos Taurus)
Mammalia LTBR 35
  • 78.18 (n)
  • 71.46 (a)
  • 70 (a)
(Canis familiaris)
Mammalia LTBR 35
  • 80.69 (n)
  • 73.8 (a)
  • 72 (a)
(Mus musculus)
Mammalia Ltbr 35
  • 76.28 (n)
  • 70.17 (a)
Ltbr 16
Ltbr 36
  • 69 (a)
(Monodelphis domestica)
Mammalia LTBR 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Ltbr 35
  • 76.1 (n)
  • 69.27 (a)
Species with no ortholog for LTBR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LTBR Gene

Gene Tree for LTBR (if available)
Gene Tree for LTBR (if available)

Paralogs for LTBR Gene

genes like me logo Genes that share paralogs with LTBR: view

Variants for LTBR Gene

Sequence variations from dbSNP and Humsavar for LTBR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12354 -- 6,390,939(+) CTGAC(G/T)GAGTC utr-variant-3-prime
rs1042318 -- 6,385,104(+) CACTG(G/T)AACTA reference, missense
rs1804534 -- 6,390,305(+) GCCGC(A/G)GTTGG reference, missense
rs2286599 -- 6,390,367(-) TCCTT(C/T)CTCTC intron-variant
rs2302255 -- 6,384,745(-) GCGAG(A/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LTBR Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850

Relevant External Links for LTBR Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTBR Gene

Disorders for LTBR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LTBR Gene including...

Search for LTBR Gene in MalaCards »

(18) Novoseek inferred disease relationships for LTBR Gene

Disease -log(P) Hits PubMed IDs
latent virus infection 71.4 1
herpes 68.2 15
necrosis 67.7 44
tumors 52.8 55
inflammation 30 6

Relevant External Links for LTBR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LTBR: view

No data available for UniProtKB/Swiss-Prot for LTBR Gene

Publications for LTBR Gene

  1. A lymphotoxin-beta-specific receptor. (PMID: 8171323) Crowe P.D. … Smith C.A. (Science 1994) 2 3 4 23
  2. TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. (PMID: 8663299) Nakano H. … Okumura K. (J. Biol. Chem. 1996) 3 4 23
  3. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. (PMID: 8995654) Matsumoto M. … Lai M.M.C. (J. Virol. 1997) 3 4 23
  4. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PMID: 9511754) Mizushima S. … Inoue J. (Gene 1998) 3 4 23
  5. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. (PMID: 9626059) Krajewska M. … Reed J.C. (Am. J. Pathol. 1998) 3 4 23

Products for LTBR Gene

Sources for LTBR Gene

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