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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LTBR Gene

protein-coding GIFtS: 60
GCID: GC12P006467

lymphotoxin beta receptor (TNFR superfamily, member 3)

(Previous symbol: D12S370)

Explore 29 diseases affiliated with
LTBR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3)¹ ²		Tumor Necrosis Factor Receptor Type III² ³
TNFCR¹ ² ³ ⁵		TNFR3² ³
D12S370¹ ² ³		CD18²
TNFRSF3¹ ² ³		LT-BETA-R²
TNF-R-III¹ ²		Lymphotoxin B Receptor²
TNFR-RP¹ ²		Tumor Necrosis Factor Receptor Superfamily Member 3²
TNFR2-RP¹ ²		TNF-RIII³
Tumor Necrosis Factor C Receptor² ³		TNFR-III³
Tumor Necrosis Factor Receptor 2-Related Protein² ³		Lymphotoxin-Beta Receptor³

External Ids:	HGNC: 6718¹	Entrez Gene: 4055²	Ensembl: ENSG00000111321⁷	OMIM: 600979⁵	UniProtKB: P36941³

Export aliases for LTBR gene to outside databases

Previous GC identifers: GC12P006348 GC12P006363 GC12P006347

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LTBR:

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor

include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a

role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and

programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced

transcript variants encoding multiple isoforms have been observed. (provided by RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: TNR3_HUMAN, P36941

Function: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis

via TRAF3 and TRAF5. May play a role in the development of lymphoid organs

Gene Wiki entry for LTBR (Lymphotoxin beta receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009759.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LTBR gene promoter:
AhR GR AP-1 ATF-2 GR-beta STAT3 Chx10 GR-alpha c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LTBR promoter sequence

Search SABiosciences Chromatin IP Primers for LTBR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LTBR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

LTBR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LTBR gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P006467: view genomic region (about GC identifiers)

Start:	6,484,211 bp from pter	End:	6,500,734 bp from pter
Size:	16,524 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR3_HUMAN, P36941 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 3 precursor

Size: 435 amino acids; 46709 Da

Subunit: Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein

Subcellular location: Membrane; Single-pass type I membrane protein

1 PDB 3D structure from and Proteopedia for LTBR:

1RF3 (3D)

Secondary accessions: D3DUR2

Explore the universe of human proteins at neXtProt for LTBR: NX_P36941

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P36941

LTBR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001257916.1 NP_002333.1

ENSEMBL proteins:

ENSP00000440875 ENSP00000228918 ENSP00000437647 ENSP00000438955 ENSP00000437954

ENSP00000438605

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for LTBR (Lymphotoxin beta R/TNFRSF3)
	Enzo Life Sciences proteins for LTBR
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: LTBR OriGene Custom Protein Services for LTBR
	GenScript Custom Purified and Recombinant Proteins Services for LTBR
	Novus Biologicals LTBR Protein Novus Biologicals LTBR Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

LTBR for ontologies About GeneDecksing

LTBR Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for LTBR (Lymphotoxin beta R/TNFRSF3)
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	GenScript Custom Superior Antibodies Services for LTBR
	Novus Biologicals LTBR Antibodies
	Search for Antibodies for LTBR at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for LTBR

Assay Products for LTBR:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LTBR
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LTBR for domains About GeneDecksing

2 InterPro domains/families:

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR017349 TNFR_3_LTBR

Graphical View of Domain Structure for InterPro Entry P36941

ProtoNet protein and cluster: P36941

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR3_HUMAN, P36941

Similarity: Contains 4 TNFR-Cys repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TNR3_HUMAN, P36941

Function: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis

via TRAF3 and TRAF5. May play a role in the development of lymphoid organs

Genatlas biochemistry entry for LTBR:

lymphotoxin B receptor,(tumor necrosis factor receptor TNFR superfamily,member 3),expressed at the surface of most cell

types,including cells of epithelial and myeloid lineages but not on T and B cells,involved in lymphoid organ

development and apoptosis through interaction with TRAF3

miRNA Products:		OriGene 3'-UTR Clone: LTBR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LTBR
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate LTBR:
		hsa-miR-409-5p hsa-miR-146b-3p hsa-miR-29a hsa-miR-29c hsa-miR-455-3p hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: LTBR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LTBR (see all 7) OriGene shRNA RFP: LTBR OriGene siRNA: LTBR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LTBR

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LTBR

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LTBR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LTBR OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LTBR (NM_002342)
		Sino Biological Human cDNA Clone for LTBR
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LTBR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LTBR

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LTBR
		Search LifeMap BioReagents cell lines for LTBR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTBR

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	IPI	--
GO:0031625	ubiquitin protein ligase binding	IPI	11279055
GO:0042802	identical protein binding	IPI	--

LTBR for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ltbr^tm1Kpf for LTBR
     7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ltbr):

digestive/alimentary	growth/size	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	normal

LTBR for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and survival_Lymphotoxin-beta receptor signaling

	Apoptosis and survival Lymphotoxin-beta receptor signaling	1.00			LT-BetaR Pathway	0.46
	Apoptosis and survival_Lymphotoxin-beta receptor signaling	1.00

Transcription NF-kB signaling pathway

Transcription NF-kB signaling pathway

1.00

Transcription_NF-kB signaling pathway

0.85

Apoptosis and survival_Apoptotic TNF-family pathways

Apoptosis and survival_Apoptotic TNF-family pathways

1.00

Apoptosis and survival Apoptotic TNF-family pathways

1.00

TRAF Pathway

TNF Superfamily Pathway

0.42

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

0.08

Busulfan Pathway, Pharmacodynamics

Busulfan Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for LTBR

	Transcription NF-kB signaling pathway
	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Lymphotoxin-beta receptor signaling

1 R&D Systems Pathway for LTBR

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LTBR

	LT-BetaR Pathway
	TNF Superfamily Pathway
	NF-KappaB Family Pathway

3 GeneGo (Thomson Reuters) Pathways for LTBR

	Apoptosis and survival Apoptotic TNF-family pathways
	Transcription NF-kB signaling pathway
	Apoptosis and survival Lymphotoxin-beta receptor signaling

1 PharmGKB Pathway for LTBR

Busulfan Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for LTBR):

	Cytokine-cytokine receptor interaction
	Intestinal immune network for IgA production

LTBR for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LTBR

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/21 Interacting proteins for LTBR (P36941^{1, 3} ENSP00000228918⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF5	O00463³, ENSP00000261464⁴	I2D: score=5 STRING: ENSP00000261464
DIABLO	Q9NR28³, ENSP00000267169⁴	I2D: score=4 STRING: ENSP00000267169
LTB	Q06643³, ENSP00000410481⁴	I2D: score=3 STRING: ENSP00000410481
TNFSF14	O43557³, ENSP00000245912⁴	I2D: score=3 STRING: ENSP00000245912
TRAF4	Q9BUZ4³, ENSP00000262395⁴	I2D: score=3 STRING: ENSP00000262395

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007165	signal transduction	TAS	8171323
GO:0019048	virus-host interaction	IEA	--
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP	12761501
GO:0044419	interspecies interaction between organisms	--	--

LTBR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LTBR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LTBR
5 Novoseek chemical compound relationships for LTBR gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucuronoxylomannan	55.1	2	15593014 (1), 12145626 (1)
rantes	24	1	9029113 (1)
retinoic acid	17.4	21	12485937 (8), 16581781 (6), 18789152 (1)
zinc	0	2	9388227 (1)
serine	0	3	9202035 (2), 18550257 (1)

Search CenterWatch for drugs/clinical trials and news about LTBR / TNR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LTBR gene (2 alternative transcripts):

NM_001270987.1 NM_002342.2

Unigene Cluster for LTBR:

Lymphotoxin beta receptor (TNFR superfamily, member 3)

Hs.1116 [show with all ESTs]

Unigene Representative Sequence: AK128019

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000546296 ENST00000542830 ENST00000539925 ENST00000228918(uc010sfc.1 uc001qny.1 uc001qnz.1)

ENST00000536876 ENST00000535739 ENST00000543190 ENST00000545445 ENST00000544454

ENST00000541102 ENST00000440421 ENST00000444814 ENST00000541005 ENST00000543542

ENST00000441074

miRNA Products:		OriGene 3'-UTR Clone: LTBR Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LTBR
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate LTBR:
		hsa-miR-409-5p hsa-miR-146b-3p hsa-miR-29a hsa-miR-29c hsa-miR-455-3p hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: LTBR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LTBR (see all 7) OriGene shRNA RFP: LTBR OriGene siRNA: LTBR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LTBR

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LTBR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LTBR OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LTBR (NM_002342)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LTBR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LTBR

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LTBR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LTBR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LTBR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTBR

Additional cDNA sequence:

AK027080.1 AK095418.1 AK128019.1 AK293187.1 BC026262.1 BX648074.1 L04270.1

23 DOTS entries:

DT.100044531 DT.100845908 DT.453091 DT.100782830 DT.100845903 DT.100040462 DT.100730296 DT.95289420

DT.100845892 DT.100845906 DT.100773870 DT.95151755 DT.100845901 DT.306234 DT.95151741 DT.100845898

DT.121189406 DT.121189410 DT.92433541 DT.450261 DT.75100038 DT.92044705 DT.97819447

10 AceView cDNA sequences:

CR626362 BC026262 CR620746 AK027080 AK128019 L04270 NM_002342 AK095418

BX648074 L04489

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LTBR (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11
SP1:													-						-												-
SP2:													-		-				-												-
SP3:													-						-
SP4:													-						-				-		-		-				-
SP5:													-

ECgene alternative splicing isoforms for LTBR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LTBR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

LTBR expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Thoracic Rib

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

See LTBR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LTBR

SOURCE GeneReport for Unigene cluster: Hs.1116

SABiosciences Expression via Pathway-Focused PCR Arrays including LTBR:

HIV Host Response in human mouse rat

TNF Ligands & Receptors in human mouse rat

NFKB Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LTBR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LTBR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LTBR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTBR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTBR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LTBR gene from 1/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	CABZ01053483.2⁶	--	18(a)	1 ↔ 1	16(34198766-34214589)

ENSEMBL Gene Tree for LTBR (if available)
TreeFam Gene Tree for LTBR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LTBR gene

TNFRSF21² TNFRSF6B² CD40² TNFRSF1B² TNFRSF4² TNFRSF11A² NGFR² TNFRSF14²

TNFRSF11B² TNFRSF9²

LTBR for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12371926^1,2	H	--	6355037(+)	`AATCAG/TATCTC`	1	--	us2k¹		4		NS EA	420
rs41412444^1,2	C,	--	6355053(+)	`TGTTCC/TGCAGG`	1	--	us2k¹		2		WA	120
rs72645122^1,2	C,F,	--	6482770(+)	`TCCACG/ACTTAC`	4	--	int¹ us2k¹		1		NS	1114
rs2286600^1,2	C,F,A,H,	--	6482786(-)	`GAAACC/TGGAGC`	4	--	int¹ us2k¹		16		EA NS NA WA	3704
rs145325222^1,2		--	6482837(+)	`GTTCAC/GGACAC`	4	--	int¹ us2k¹		0	--	--	--	--
rs184115464^1,2		--	6482858(+)	`GTAAAC/GGTCAG`	4	--	int¹ us2k¹		0	--	--	--	--
rs72645124^1,2	C,F,	--	6482872(+)	`CCTGGG/ACAGGT`	4	--	int¹ us2k¹		1		NS	1114
rs72645125^1,2	C	--	6482907(+)	`GTCTTT/CTGGGG`	4	--	us2k¹ int¹		1		NS	1114
rs142315932^1,2		--	6482918(+)	`GAAGAA/GCTTCA`	4	--	us2k¹ int¹		0	--	--	--	--
rs188464755^1,2		--	6483011(+)	`AACCTC/TCACGA`	4	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LTBR (6484211 - 6500734 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for LTBR
3 CNVs: 3872 2967 8705

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LTBR

DNA2.0 Custom Variant and Variant Library Synthesis for LTBR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LTBR for disorders           About GeneDecksing

OMIM gene information: 600979    OMIM disorders: --

20/29 diseases for LTBR (see all 29):    About MalaCards

graft versus host disease non-hodgkin lymphoma chronic granulomatous disease acute promyelocytic leukemia

hodgkin's lymphoma rheumatoid arthritis hepatitis c multiple myeloma

peritonitis hepatitis b encephalomyelitis arthritis

meningitis myeloma rhabdomyosarcoma hepatitis

hepatocellular carcinoma meningioma melanoma nephropathy

10/18 Novoseek disease relationships for LTBR gene (see all 18) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
latent virus infection	71.4	1	11278268 (1)
herpes	68.2	26	12566458 (2), 15814693 (1), 10358762 (1), 15917993 (1) (see all 14)
necrosis	67.7	62	14517219 (2), 10753918 (2), 8995654 (1), 9388227 (1) (see all 42)
tumors	52.8	81	9739048 (3), 8642291 (3), 14517219 (2), 19701890 (2) (see all 47)
inflammation	30	8	15067315 (2), 9029113 (1), 18292573 (1), 19111021 (1) (see all 5)
autoimmunity	27	2	14517552 (1), 12953095 (1)
rheumatoid arthritis	26.1	1	18412315 (1)
herpes simplex	23.2	5	12466117 (1), 12566458 (1), 15814693 (1), 15546385 (1)
colitis	21.2	5	15521015 (4), 12704158 (1)
inflammatory bowel diseases	12.3	1	15521015 (1)

Human Genome Epidemiology (HuGE) Navigator: LTBR (7 documents)

Export disorders for LTBR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LTBR gene, integrated from 9 sources (see all 185):
(articles sorted by number of sources associating them with LTBR)

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A lymphotoxin-beta-specific receptor. (PubMed id 8171323)^{1, 2, 3, 9} Crowe P.D.... Smith C.A. (1994)
Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. (PubMed id 8486360)^{1, 2, 3} Baens M....Marynen P. (1993)
TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. (PubMed id 8663299)^{1, 2, 9} Nakano H.... Okumura K. (1996)
The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells. (PubMed id 10207006)^{1, 2, 9} Wu M.-Y.... Hsieh S.-L. (1999)
The lymphotoxin-beta receptor is necessary and sufficient for LIGHT- mediated apoptosis of tumor cells. (PubMed id 10799510)^{1, 2, 9} Rooney I.A.... Ware C.F. (2000)
TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. (PubMed id 9626059)^{1, 2, 9} Krajewska M.... Reed J.C. (1998)
Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. (PubMed id 8995654)^{1, 2, 9} Matsumoto M....Lai M.M.C. (1997)
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)^{1, 2, 9} Mizushima S.... Inoue J. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
GA-binding protein (GABP) and Sp1 are required, along with retinoid receptors, to mediate retinoic acid responsiveness of CD18 (beta 2 leukocyte integrin): a novel mechanism of transcriptional regulation in myeloid cells. (PubMed id 12485937)^{1, 9} Bush T.S....Rosmarin A.G. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4055	HGNC: 6718	AceView: LTBR	Ensembl:ENSG00000111321	euGenes: HUgn4055
ECgene: LTBR	Kegg: 4055	H-InvDB: LTBR

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LTBR	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LTBR	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LTBR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LTBR gene:
Search GeneIP for patents involving LTBR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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lymphotoxin beta receptor (TNFR superfamily, member 3)

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lymphotoxin beta receptor (TNFR superfamily, member 3)

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