Aliases for LTBP3 Gene
External Ids for LTBP3 Gene
Previous HGNC Symbols for LTBP3 Gene
Previous GeneCards Identifiers for LTBP3 Gene
The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for LTBP3 Gene
LTBP3 (Latent Transforming Growth Factor Beta Binding Protein 3) is a Protein Coding gene. Diseases associated with LTBP3 include Dental Anomalies And Short Stature and Verloes Bourguignon Syndrome. Among its related pathways are Elastic fibre formation and p70S6K Signaling. GO annotations related to this gene include calcium ion binding and transforming growth factor beta binding. An important paralog of this gene is LTBP1.
UniProtKB/Swiss-Prot for LTBP3 Gene
May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM).