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Aliases for LTB4R2 Gene

Aliases for LTB4R2 Gene

  • Leukotriene B4 Receptor 2 2 3 5
  • Seven Transmembrane Receptor BLTR2 3 4
  • Leukotriene B4 Receptor BLT2 3 4
  • LTB4 Receptor JULF2 3 4
  • LTB4-R 2 3 4
  • LTB4-R2 3 4
  • BLTR2 3 4
  • KPG_004 3
  • JULF2 3
  • BLT2R 4
  • BLT2 3
  • NOP9 3

External Ids for LTB4R2 Gene

Previous GeneCards Identifiers for LTB4R2 Gene

  • GC14P022150
  • GC14P018565
  • GC14P022768
  • GC14P023838
  • GC14P023848
  • GC14P024778
  • GC14P004894

Summaries for LTB4R2 Gene

GeneCards Summary for LTB4R2 Gene

LTB4R2 (Leukotriene B4 Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and leukotriene B4 receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot for LTB4R2 Gene

  • Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Tocris Summary for LTB4R2 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for LTB4R2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTB4R2 Gene

Genomics for LTB4R2 Gene

Regulatory Elements for LTB4R2 Gene

Enhancers for LTB4R2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LTB4R2 on UCSC Golden Path with GeneCards custom track

Promoters for LTB4R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LTB4R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LTB4R2 Gene

Chromosome:
14
Start:
24,305,734 bp from pter
End:
24,312,053 bp from pter
Size:
6,320 bases
Orientation:
Plus strand

Genomic View for LTB4R2 Gene

Genes around LTB4R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTB4R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTB4R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTB4R2 Gene

Proteins for LTB4R2 Gene

  • Protein details for LTB4R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPC1-LT4R2_HUMAN
    Recommended name:
    Leukotriene B4 receptor 2
    Protein Accession:
    Q9NPC1
    Secondary Accessions:
    • Q5KU28
    • Q9NPE5

    Protein attributes for LTB4R2 Gene

    Size:
    389 amino acids
    Molecular mass:
    41525 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB00610.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LTB4R2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LTB4R2 Gene

Proteomics data for LTB4R2 Gene at MOPED

Post-translational modifications for LTB4R2 Gene

  • Glycosylation at Asn 41
  • Modification sites at PhosphoSitePlus

Other Protein References for LTB4R2 Gene

No data available for DME Specific Peptides for LTB4R2 Gene

Domains & Families for LTB4R2 Gene

Gene Families for LTB4R2 Gene

Suggested Antigen Peptide Sequences for LTB4R2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPC1

UniProtKB/Swiss-Prot:

LT4R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LTB4R2: view

Function for LTB4R2 Gene

Molecular function for LTB4R2 Gene

UniProtKB/Swiss-Prot Function:
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Gene Ontology (GO) - Molecular Function for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with LTB4R2: view
genes like me logo Genes that share phenotypes with LTB4R2: view

Animal Models for LTB4R2 Gene

MGI Knock Outs for LTB4R2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTB4R2 Gene

Localization for LTB4R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTB4R2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTB4R2 Gene COMPARTMENTS Subcellular localization image for LTB4R2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with LTB4R2: view

Pathways & Interactions for LTB4R2 Gene

genes like me logo Genes that share pathways with LTB4R2: view

SIGNOR curated interactions for LTB4R2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0051546 keratinocyte migration IEA --
GO:0061737 leukotriene signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with LTB4R2: view

Drugs & Compounds for LTB4R2 Gene

(14) Drugs for LTB4R2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zafirlukast Approved, Investigational Pharma Antagonist 2
Cinalukast Approved Pharma Potent, selective CysLT1 (LTD4) antagonist; orally active 0
12-epi LTB<sub>4</sub> Pharma Partial agonist, Agonist 0
12-hydroxyheptadecatrienoic acid Pharma Full agonist, Agonist 0
12S-HETE Pharma Partial agonist, Agonist 0

(6) Additional Compounds for LTB4R2 Gene - From: Novoseek, Tocris, IUPHAR, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
LY 255283
117690-79-6
[<sup>3</sup>H]LTB4
Full agonist, Agonist
Fpl 55712
40785-97-5
SR 2640 hydrochloride
146662-42-2

(5) Tocris Compounds for LTB4R2 Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(1) ApexBio Compounds for LTB4R2 Gene

Compound Action Cas Number
Zafirlukast 107753-78-6
genes like me logo Genes that share compounds with LTB4R2: view

Transcripts for LTB4R2 Gene

Unigene Clusters for LTB4R2 Gene

Leukotriene B4 receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LTB4R2 Gene

No ASD Table

Relevant External Links for LTB4R2 Gene

GeneLoc Exon Structure for
LTB4R2
ECgene alternative splicing isoforms for
LTB4R2

Expression for LTB4R2 Gene

mRNA expression in normal human tissues for LTB4R2 Gene

Protein differential expression in normal tissues from HIPED for LTB4R2 Gene

This gene is overexpressed in Lung (57.0) and Peripheral blood mononuclear cells (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LTB4R2 Gene



SOURCE GeneReport for Unigene cluster for LTB4R2 Gene Hs.642693

mRNA Expression by UniProt/SwissProt for LTB4R2 Gene

Q9NPC1-LT4R2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with LTB4R2: view

Protein tissue co-expression partners for LTB4R2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LTB4R2 Gene

Orthologs for LTB4R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTB4R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LTB4R2 35
  • 89.92 (n)
  • 91.04 (a)
-- 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LTB4R2 35
  • 89.82 (n)
  • 90.76 (a)
mouse
(Mus musculus)
Mammalia Ltb4r2 35
  • 85.96 (n)
  • 92.7 (a)
Ltb4r2 16
Ltb4r2 36
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LTB4R2 35
  • 98.32 (n)
  • 96.93 (a)
-- 36
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ltb4r2 35
  • 86.05 (n)
  • 93.26 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ltb4r2 35
  • 51.49 (n)
  • 44 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883256 35
  • 49.47 (n)
  • 39.74 (a)
CR376803.1 36
  • 31 (a)
ManyToMany
si:ch211-272h9.1 36
  • 32 (a)
ManyToMany
si:ch211-272h9.2 36
  • 31 (a)
ManyToMany
Species with no ortholog for LTB4R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTB4R2 Gene

ENSEMBL:
Gene Tree for LTB4R2 (if available)
TreeFam:
Gene Tree for LTB4R2 (if available)

Paralogs for LTB4R2 Gene

Paralogs for LTB4R2 Gene

(6) SIMAP similar genes for LTB4R2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LTB4R2: view

Variants for LTB4R2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LTB4R2 Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV Deletion 23128226
dgv1855n71 CNV Loss 21882294

Variation tolerance for LTB4R2 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 63.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for LTB4R2 Gene

Disorders for LTB4R2 Gene

Relevant External Links for LTB4R2

Genetic Association Database (GAD)
LTB4R2
Human Genome Epidemiology (HuGE) Navigator
LTB4R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTB4R2

No disorders were found for LTB4R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LTB4R2 Gene

Publications for LTB4R2 Gene

  1. A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization. (PMID: 11006272) Wang S. … Laz T. (J. Biol. Chem. 2000) 2 3 4 67
  2. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. (PMID: 10934229) Kato K. … Shimizu T. (J. Exp. Med. 2000) 2 3 23
  3. Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. (PMID: 19748928) Choi J.A. … Kim J.H. (Carcinogenesis 2010) 3 23
  4. Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis. (PMID: 20194723) Kim G.Y. … Kim J.H. (J. Immunol. 2010) 3 23
  5. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. (PMID: 18852255) SA!nchez-GalA!n E. … TuA+A^n J. (Cardiovasc. Res. 2009) 3 23

Products for LTB4R2 Gene

Sources for LTB4R2 Gene

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