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Aliases for LTB4R2 Gene

Aliases for LTB4R2 Gene

  • Leukotriene B4 Receptor 2 2 3 5
  • Seven Transmembrane Receptor BLTR2 3 4
  • Leukotriene B4 Receptor BLT2 3 4
  • LTB4 Receptor JULF2 3 4
  • LTB4-R 2 3 4
  • LTB4-R2 3 4
  • BLTR2 3 4
  • KPG_004 3
  • JULF2 3
  • BLT2R 4
  • BLT2 3
  • NOP9 3

External Ids for LTB4R2 Gene

Previous GeneCards Identifiers for LTB4R2 Gene

  • GC14P022150
  • GC14P018565
  • GC14P022768
  • GC14P023838
  • GC14P023848
  • GC14P024778
  • GC14P004894

Summaries for LTB4R2 Gene

GeneCards Summary for LTB4R2 Gene

LTB4R2 (Leukotriene B4 Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and leukotriene B4 receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot for LTB4R2 Gene

  • Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Tocris Summary for LTB4R2 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for LTB4R2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTB4R2 Gene

Genomics for LTB4R2 Gene

Regulatory Elements for LTB4R2 Gene

Enhancers for LTB4R2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F023550 0.5 ENCODE 11.9 -754.5 -754464 2.2 MLX ZNF133 ZFP64 SIN3A ARID4B GLI4 ZNF48 ETS1 YY1 GTF3C2 AP1G2 MMP14 KHNYN NFATC4 RNA5SP383 LOC102724814 NOP9 BCL2L2-PABPN1 LTB4R2 CIDEB
GH14F024277 1 FANTOM5 ENCODE 11.4 -27.0 -27022 3.1 CTCF PKNOX1 USF1 MAX EBF1 RAD21 RFX5 RELA NFYB EED DHRS1 TINF2 NOP9 NEDD8 NEDD8-MDP1 LTB4R2 CIDEB LTB4R MDP1 CHMP4A
GH14F024435 0.2 ENCODE 11 +131.4 131378 3.1 ELF3 ARID4B THRB RAD21 ZNF143 ZNF548 MIXL1 PAF1 ZNF654 REST SDR39U1 NYNRIN NOP9 KHNYN RNA5SP383 ADCY4 LTB4R CIDEB DHRS1 LTB4R2
GH14F024303 0.9 ENCODE 0.8 -1.9 -1855 0.2 LTB4R2 PIR42208
GH14F024306 1 ENCODE 0.8 +1.9 1852 2.5 HDGF MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF143 PAF1 DHRS1 LTB4R TGM1 CIDEB LTB4R2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LTB4R2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LTB4R2 Gene

Chromosome:
14
Start:
24,305,734 bp from pter
End:
24,312,053 bp from pter
Size:
6,320 bases
Orientation:
Plus strand

Genomic View for LTB4R2 Gene

Genes around LTB4R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTB4R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTB4R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTB4R2 Gene

Proteins for LTB4R2 Gene

  • Protein details for LTB4R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPC1-LT4R2_HUMAN
    Recommended name:
    Leukotriene B4 receptor 2
    Protein Accession:
    Q9NPC1
    Secondary Accessions:
    • Q5KU28
    • Q9NPE5

    Protein attributes for LTB4R2 Gene

    Size:
    389 amino acids
    Molecular mass:
    41525 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB00610.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LTB4R2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LTB4R2 Gene

Post-translational modifications for LTB4R2 Gene

  • Glycosylation at Asn 41
  • Modification sites at PhosphoSitePlus

Other Protein References for LTB4R2 Gene

No data available for DME Specific Peptides for LTB4R2 Gene

Domains & Families for LTB4R2 Gene

Gene Families for LTB4R2 Gene

Suggested Antigen Peptide Sequences for LTB4R2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPC1

UniProtKB/Swiss-Prot:

LT4R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LTB4R2: view

Function for LTB4R2 Gene

Molecular function for LTB4R2 Gene

UniProtKB/Swiss-Prot Function:
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Gene Ontology (GO) - Molecular Function for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001632 leukotriene B4 receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004974 leukotriene receptor activity TAS 10889186
GO:0008528 G-protein coupled peptide receptor activity IBA --
genes like me logo Genes that share ontologies with LTB4R2: view
genes like me logo Genes that share phenotypes with LTB4R2: view

Animal Models for LTB4R2 Gene

MGI Knock Outs for LTB4R2:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LTB4R2 (Leukotriene B4 R2)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTB4R2 Gene

Localization for LTB4R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTB4R2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTB4R2 Gene COMPARTMENTS Subcellular localization image for LTB4R2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10913346
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LTB4R2: view

Pathways & Interactions for LTB4R2 Gene

genes like me logo Genes that share pathways with LTB4R2: view

SIGNOR curated interactions for LTB4R2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for LTB4R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10889186
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007194 negative regulation of adenylate cyclase activity TAS 10889186
genes like me logo Genes that share ontologies with LTB4R2: view

Drugs & Compounds for LTB4R2 Gene

(20) Drugs for LTB4R2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cinalukast Approved Pharma 0
Zafirlukast Approved, Investigational Pharma Antagonist 3
Leukotriene B4 Pharma BLT1/BLT2 receptor agonist and potent chemotactic factor 0
SR 2640 hydrochloride Pharma Potent, selective LTD4 /LTE4 receptor antagonist 0
12-epi LTB<sub>4</sub> Pharma Partial agonist, Agonist 0

(3) Additional Compounds for LTB4R2 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]LTB4
Full agonist, Agonist
Arachidonic acid (in Tocrisolve100)
506-32-1

(5) Tocris Compounds for LTB4R2 Gene

Compound Action Cas Number
Arachidonic acid (in Tocrisolve100) Endogenous free fatty acid (in water-soluble emulsion) 506-32-1
BAY-u 9773 Dual CysLT1 and CysLT2 antagonist 154978-38-8
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor 115104-28-4
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(6) ApexBio Compounds for LTB4R2 Gene

Compound Action Cas Number
Cinalukast 128312-51-6
FPL 55712 40785-97-5
Leukotriene B4 71160-24-2
LY 255283 117690-79-6
SR 2640 hydrochloride 146662-42-2
Zafirlukast 107753-78-6
genes like me logo Genes that share compounds with LTB4R2: view

Transcripts for LTB4R2 Gene

Unigene Clusters for LTB4R2 Gene

Leukotriene B4 receptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LTB4R2 (Leukotriene B4 R2)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTB4R2 Gene

No ASD Table

Relevant External Links for LTB4R2 Gene

GeneLoc Exon Structure for
LTB4R2
ECgene alternative splicing isoforms for
LTB4R2

Expression for LTB4R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LTB4R2 Gene

Protein differential expression in normal tissues from HIPED for LTB4R2 Gene

This gene is overexpressed in Lung (57.0) and Peripheral blood mononuclear cells (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LTB4R2 Gene



Protein tissue co-expression partners for LTB4R2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LTB4R2 Gene:

LTB4R2

SOURCE GeneReport for Unigene cluster for LTB4R2 Gene:

Hs.642693

mRNA Expression by UniProt/SwissProt for LTB4R2 Gene:

Q9NPC1-LT4R2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with LTB4R2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LTB4R2 Gene

Orthologs for LTB4R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTB4R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTB4R2 34
  • 98.32 (n)
-- 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 91 (a)
OneToMany
LTB4R2 34
  • 89.92 (n)
dog
(Canis familiaris)
Mammalia LTB4R2 34
  • 89.82 (n)
rat
(Rattus norvegicus)
Mammalia Ltb4r2 34
  • 86.05 (n)
mouse
(Mus musculus)
Mammalia Ltb4r2 34 16 35
  • 85.96 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ltb4r2 34
  • 51.49 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883256 34
  • 49.47 (n)
si:ch211-272h9.1 35
  • 32 (a)
ManyToMany
CR376803.1 35
  • 31 (a)
ManyToMany
si:ch211-272h9.2 35
  • 31 (a)
ManyToMany
Species where no ortholog for LTB4R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTB4R2 Gene

ENSEMBL:
Gene Tree for LTB4R2 (if available)
TreeFam:
Gene Tree for LTB4R2 (if available)

Paralogs for LTB4R2 Gene

Paralogs for LTB4R2 Gene

(6) SIMAP similar genes for LTB4R2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LTB4R2: view

Variants for LTB4R2 Gene

Sequence variations from dbSNP and Humsavar for LTB4R2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs112486638 -- 24,311,287(+) ACGGC(A/T)GCGGG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs113326269 -- 24,311,261(+) CTCGG(C/T)TGCTA upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs115374801 -- 24,311,881(+) CACTT(A/G)GGGCA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs11553526 -- 24,311,972(+) ATGTA(A/C)CCATG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs115630307 -- 24,310,727(+) CGGGC(A/C/T)ACAGG upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for LTB4R2 Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV deletion 23128226
esv3633804 CNV loss 21293372
nsv564058 CNV loss 21841781
nsv564059 CNV loss 21841781
nsv564060 CNV loss 21841781

Variation tolerance for LTB4R2 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 63.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LTB4R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTB4R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTB4R2 Gene

Disorders for LTB4R2 Gene

Relevant External Links for LTB4R2

Genetic Association Database (GAD)
LTB4R2
Human Genome Epidemiology (HuGE) Navigator
LTB4R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTB4R2

No disorders were found for LTB4R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LTB4R2 Gene

Publications for LTB4R2 Gene

  1. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. (PMID: 10934229) Kato K. … Shimizu T. (J. Exp. Med. 2000) 2 3 22 64
  2. A novel hepatointestinal leukotriene B4 receptor: cloning and functional characterization. (PMID: 11006272) Wang S. … Laz T. (J. Biol. Chem. 2000) 2 3 4 64
  3. Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. (PMID: 19748928) Choi J.A. … Kim J.H. (Carcinogenesis 2010) 3 22 64
  4. Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis. (PMID: 20194723) Kim G.Y. … Kim J.H. (J. Immunol. 2010) 3 22 64
  5. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. (PMID: 18852255) SA!nchez-GalA!n E. … TuA+A^n J. (Cardiovasc. Res. 2009) 3 22 64

Products for LTB4R2 Gene

Sources for LTB4R2 Gene

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