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LTB4R Gene

protein-coding   GIFtS: 65
GCID: GC14P024780

Leukotriene B4 Receptor


(Previous symbols: P2RY7, GPR16, CMKRL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukotriene B4 Receptor1 2     LTB4-R 12 3
CMKRL11 2 3 5     P2Y Purinoceptor 72 3
P2RY71 2 3 5     LTB4R12
GPR161 2 3     LTBR12
BLTR2 3 5     Chemokine Receptor-Like 12
Chemoattractant Receptor-Like 12 3     G Protein-Coupled Receptor 162
BLT12 3     Leukotriene B4 Receptor 12
LTB4-R12 3     Purinergic Receptor P2Y, G-Protein Coupled, 72
P2Y72 3     BLT3
G-Protein Coupled Receptor 162 3     

External Ids:    HGNC: 67131   Entrez Gene: 12412   Ensembl: ENSG000002139037   OMIM: 6015315   UniProtKB: Q157223   

Export aliases for LTB4R gene to outside databases

Previous GC identifers: GC14P022154 GC14P018569 GC14P022770 GC14P022772 GC14P023852 GC14P023842 GC14P004895


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LTB4R Gene:
LTB4R (leukotriene B4 receptor) is a protein-coding gene. Diseases associated with LTB4R include allergic encephalomyelitis, and anoxia. GO annotations related to this gene include leukotriene B4 receptor activity and nucleotide binding. An important paralog of this gene is GPR33.

UniProtKB/Swiss-Prot: LT4R1_HUMAN, Q15722
Function: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins
which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved
in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for
leukotriene B4, a potent chemoattractant involved in inflammation and immune response

summary for LTB4R Gene:
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4,
LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase
enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene
receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high
affinity stereoselective receptors that have a wide biological distribution. BLT1 and BLT2 receptors are
synthesized by polymorphonuclear leukocytes and are found at their highest concentrations on myeloid cells,
mast cells and macrophages.

Gene Wiki entry for LTB4R (Leukotriene B4 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LTB4R gene promoter:
         PPAR-alpha   GR   GR-alpha   Roaz   c-Ets-1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LTB4R promoter sequence
   Search Chromatin IP Primers for LTB4R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LTB4R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2-q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2-q12

LTB4R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LTB4R gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024780:  view genomic region     (about GC identifiers)

Start:
24,780,656 bp from pter      End:
24,787,242 bp from pter
Size:
6,587 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LT4R1_HUMAN, Q15722 (See protein sequence)
Recommended Name: Leukotriene B4 receptor 1  
Size: 352 amino acids; 37557 Da
Sequence caution: Sequence=AAB16747.1; Type=Erroneous initiation;
Secondary accessions: Q13305 Q53XV5 Q92641 Q9BSU5

Explore the universe of human proteins at neXtProt for LTB4R: NX_Q15722

Explore proteomics data for LTB4R at MOPED

Post-translational modifications: 

  • Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization1
  • Glycosylation2 at Asn2, Asn164
  • Modification sites at PhosphoSitePlus

  • See LTB4R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137391.1  NP_858043.1  

    ENSEMBL proteins: 
     ENSP00000450457   ENSP00000307445   ENSP00000380008   ENSP00000451929   ENSP00000380002  
    Reactome Protein details: Q15722

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LTNR: GPCR / Class A : Leukotriene receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: BLT1 receptor
    Leukotriene receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003983 Leukotriene_B4_typ-1_rcpt
     IPR003981 Leukotriene_B4_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q15722

    ProtoNet protein and cluster: Q15722

    2 Blocks protein domains:
    IPB003981 Leukotriene B4 receptor signature
    IPB003983 Leukotriene B4 type 1 receptor signature


    UniProtKB/Swiss-Prot: LT4R1_HUMAN, Q15722
    Similarity: Belongs to the G-protein coupled receptor 1 family


    LTB4R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LT4R1_HUMAN, Q15722
    Function: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins
    which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved
    in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for
    leukotriene B4, a potent chemoattractant involved in inflammation and immune response

         Genatlas biochemistry entry for LTB4R:
    leukotriene B4 (LTB4) receptor,43kDa,G protein coupled receptor superfamily,expressed in leukocytes and several
    tissues of the immune system,involved in the regulation of the inflammatory system

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS8702478
    GO:0001632leukotriene B4 receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004974leukotriene receptor activity TAS9177352
         
    LTB4R for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ltb4r1):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     respiratory system  skeleton 

    LTB4R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LTB4R: Ltb4r1/Ltb4r2Ltb4r1/tm2Bodd Ltb4r1tm1Adl Ltb4r1tm1Bodd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LTB4R
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LTB4R
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LTB4R

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate LTB4R:
    hsa-miR-22 hsa-miR-642a hsa-miR-205* hsa-miR-193a-5p hsa-miR-3156-5p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidLTB4R 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LTB4R

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LT4R1_HUMAN, Q15722: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9177352
    GO:0016021integral component of membrane ----

    LTB4R for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LTB4R About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Inhibitory action of Lipoxins on Superoxide production in neutrophils
    Inhibitory action of Lipoxins on Superoxide production in neutrophils0.48
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions0.48
    5Eicosanoid ligand-binding receptors
    Eicosanoid ligand-binding receptors0.31
    Leukotriene receptors0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for LTB4R
        Inhibitory action of Lipoxins on Superoxide production in neutrophils
    Inhibitory action of Lipoxins on neutrophil migration
    Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions

    3 BioSystems Pathways for LTB4R
        Spinal Cord Injury
    GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs

    2 Reactome Pathways for LTB4R
        Leukotriene receptors
    G alpha (q) signalling events

    1 PharmGKB Pathway for LTB4R
        Leukotriene modifiers pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for LTB4R):
        Neuroactive ligand-receptor interaction


    LTB4R for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LTB4R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LTB4R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LTB4R (Q157223 ENSP000003074454) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA15P306793, ENSP000002629584I2D: score=2 STRING: ENSP00000262958
    GRK6P432503, ENSP000003772044I2D: score=2 STRING: ENSP00000377204
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    AGTR1ENSP000002734304STRING: ENSP00000273430
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9177352
    GO:0006936muscle contraction TAS8702478
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS9177352
    GO:0007165signal transduction ----

    LTB4R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for LTB4R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-ODYALTB-omega-Hydroxylase inhibitor[34450-18-5]
    MK 571Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor[115104-28-4]
    Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active [128312-51-6]
    LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
    Leukotriene B4BLT1/BLT2 receptor agonist and potent chemotactic factor[71160-24-2]

    2 HMDB Compounds for LTB4R    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Leukotriene B4(6z,8e,10e,14z)-(5s,12r)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate (see all 6)71160-24-2--

    Selected IUPHAR Ligands for LTB4R (BLT1 receptor) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]LTB4
    AgonistFull agonist9.89177352
    LTB4
    AgonistFull agonist9.4--
    etalocib
    AntagonistAntagonist7.5 - 9.39862783
    BILL 260
    AntagonistAntagonist8.811259574 17170051
    CP-195543
    AntagonistAntagonist8.179618393
    20-hydroxy-LTB4
    AgonistFull agonist8.19177352
    RO5101576
    AntagonistAntagonist8.120214997
    CP105696
    AntagonistAntagonist8.17714764
    [3H]CGS23131
    AntagonistAntagonist7.91320692
    SC-41930
    AntagonistAntagonist7.777786309

    Selected Novoseek inferred chemical compound relationships for LTB4R gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukotriene b4 96 276 11907121 (7), 18852255 (6), 1378422 (5), 17237498 (4) (see all 99)
    ly293111 93.8 7 16151469 (1), 19672152 (1), 8994512 (1), 9174114 (1) (see all 6)
    ly 255283 93.4 4 1316967 (1), 1329112 (1), 11907121 (1), 17581202 (1)
    5-oxoete 78.1 1 16159627 (1)
    lxa4 73.1 2 10430612 (1), 8757340 (1)
    fmlp 49.4 2 9593037 (1), 12946443 (1)
    arachidonic acid 47.5 3 1661162 (1), 9737867 (1), 18794213 (1)
    12-hydroxyeicosatetraenoic acid 44.4 2 1650525 (1)
    lutein 40.9 1 15554873 (1)
    calcium 37 19 15363951 (2), 9367903 (2), 12902512 (2), 1717073 (1) (see all 13)



    LTB4R for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LTB4R gene (2 alternative transcripts): 
    NM_001143919.2  NM_181657.3  

    Unigene Cluster for LTB4R:

    Leukotriene B4 receptor
    Hs.567248  [show with all ESTs]
    Unigene Representative Sequence: NM_181657
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553481 ENST00000345363 ENST00000396789(uc001wos.3 uc010alp.3 uc001wou.3)
    ENST00000556141 ENST00000396782
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    SwitchGear 3'UTR luciferase reporter plasmidLTB4R 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat LTB4R
      QuantiFast Probe-based Assays in human, mouse, rat LTB4R

    Additional mRNA sequence: 

    BC004545.2 BT007267.1 D89078.1 D89079.1 U41070.1 X98356.1 

    10 DOTS entries:

    DT.99940351  DT.91679493  DT.100813754  DT.95179100  DT.97838837  DT.95084967  DT.95349292  DT.120794940 
    DT.95171377  DT.95297143 

    Selected AceView cDNA sequences (see all 247):

    BT007267 BM786156 CR618079 BG752524 AB029892 AK123717 BC038437 CR590406 
    AI223801 AA258472 AI369257 BM975595 CB241246 NM_019839 AB095941 BM769146 
    BG678198 BU146237 BQ182452 AI572517 CR619293 AF277230 BX099451 BG911571 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LTB4R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCTGTGCT
    LTB4R Expression
    About this image


    LTB4R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
    LTB4R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LTB4R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567248

    UniProtKB/Swiss-Prot: LT4R1_HUMAN, Q15722
    Tissue specificity: Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver.
    High level of expression in lymphoid tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LTB4R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LTB4R
    OriGene qSTAR qPCR primer pairs in human, mouse for LTB4R
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LTB4R gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ltb4r11 , 5 leukotriene B4 receptor 11, 5 81.23(n)1
    79.47(a)1
      14 (28.19 cM)5
    169951  NM_008519.21  NP_032545.11 
     557659625 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    30(a)
    many ↔ many
    11(51584-52510)
    lizard
    (Anolis carolinensis)
    Reptilia LTB4R6
    leukotriene B4 receptor
    45(a)
    1 ↔ 1
    GL343220.1(538077-539210)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ltb4r1 leukotriene B4 receptor 52.82(n)
    50.48(a)
      101731424  XM_004910745.1  XP_004910802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003296571 leukotriene B4 receptor 1-like 55.37(n)
    46.05(a)
      100329657  XM_002662721.3  XP_002662767.3 


    ENSEMBL Gene Tree for LTB4R (if available)
    TreeFam Gene Tree for LTB4R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LTB4R gene
    GPR332  LTB4R22  FPR32  FPR12  C5AR12  GPR322  GPR1522  FPR22  
    C5AR22  C3AR12  PTGDR22  GPR12  ENSG000002726582  CMKLR12  
    16 SIMAP similar genes for LTB4R using alignment to 3 protein entries:     LT4R1_HUMAN (see all proteins):
    LTB4R2    CCR5    C3AR1    GPR1    GPR68    GALR1
    GPR141    FPR1    MCHR1    P2RY6    SSTR5    C5AR1
    SSTR3    FPR2    PTGDR2    SSTR2

    LTB4R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LTB4R (see all 86)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116406141,2
    F--24782627(+) GGTCAT/ACTCTG 2 -- ut51 int12Minor allele frequency- A:0.03CSA WA 120
    rs1480272731,2
    --24782770(+) TGAAGA/GAAGGA 2 -- ut51 int10--------
    rs2016129711,2
    C--24782788(+) GTTTC-/TTT   
       TTTTT
    TTTTT
    2 -- ut51 int10--------
    rs58072511,2
    C--24782802(+) TTTTT-/TTT   
       TTTTT
    GAGAT
    2 -- ut51 int11Minor allele frequency- TTTTTTTT:0.00NA 2
    rs1928352211,2
    --24782910(+) CCTCAA/GCCTCC 2 -- ut51 int10--------
    rs1417378571,2
    C--24782932(+) GACTAC/TAGGCA 2 -- ut51 int10--------
    rs1505261871,2
    C--24782955(+) CCCAGA/CTATCT 2 -- ut51 int10--------
    rs22241231,2
    C,A--24782958(-) AAAAGT/ATAGCT 2 -- ut51 int18Minor allele frequency- A:0.00NA WA CSA 14
    rs1443564541,2
    --24783270(+) CAGCTC/TGGCCT 2 -- ut51 int10--------
    rs1473468761,2
    --24783292(+) GTCTAA/GAGTGG 2 -- ut51 int10--------

    HapMap Linkage Disequilibrium report for LTB4R (24780656 - 24787242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LTB4R:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669637CNV Deletion23128226
    dgv1855n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LTB4R
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601531    OMIM disorders: --

    Selected diseases for LTB4R (see all 33):    
    About MalaCards
    allergic encephalomyelitis    anoxia    acute monocytic leukemia    monocytic leukemia
    abdominal aortic aneurysm    pancreatic cancer    aortic aneurysm    encephalomyelitis
    pertussis    anaplastic large cell lymphoma    psoriasis    bronchiolitis
    atherosclerosis    inflammatory bowel disease    gastritis    cholera
    spinal cord injury    blindness    crohn's disease    endometriosis

    1 disease from the University of Copenhagen DISEASES database for LTB4R:
    Asthma

    LTB4R for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for LTB4R gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 50.7 11 15814727 (2), 10430612 (1), 16179368 (1), 8543366 (1) (see all 9)
    asthma 36 4 17237498 (1), 8994512 (1), 17481554 (1), 12949531 (1)
    pancreatic cancer 22 3 19672152 (1), 18633535 (1), 17414622 (1)
    atherosclerosis 18.8 8 14656734 (4), 18852255 (2), 17237498 (1)
    inflammatory bowel diseases 18.4 1 2173749 (1)
    pneumonia 8.25 2 15998790 (1)
    necrosis 3.27 2 16624877 (1), 18852255 (1)
    arthritis 1.44 2 17237498 (1), 12913925 (1)
    rheumatoid arthritis 0 4 12913925 (2), 17967719 (1)
    tumors 0 1 16624877 (1)

    Genetic Association Database (GAD): LTB4R
    Human Genome Epidemiology (HuGE) Navigator: LTB4R (4 documents)

    Export disorders for LTB4R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LTB4R gene, integrated from 10 sources (see all 194):
    (articles sorted by number of sources associating them with LTB4R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of cDNA encoding a putative chemoattractant receptor. (PubMed id 8921391)1, 2, 3, 9 Owman C.S.O.... Lolait S.J. (Genomics 1996)
    2. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. (PubMed id 8702478)1, 2, 3, 9 Akbar G.K.M....Kunapuli S.P. (J. Biol. Chem. 1996)
    3. Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. (PubMed id 12077128)1, 2, 9 Gaudreau R....Rola-Pleszczynski M. (J. Biol. Chem. 2002)
    4. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. (PubMed id 10934229)1, 2, 9 Kato K.... Shimizu T. (J. Exp. Med. 2000)
    5. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. (PubMed id 9177352)1, 2, 9 Yokomizo T.... Shimizu T. (Nature 1997)
    6. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    7. Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations. (PubMed id 18323512)1, 4 Bevan S....Markus H.S. ( a journal of cerebral circulation 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. New members of the chemokine receptor gene family. (PubMed id 8558062)1, 2 Raport C.J.... Gray P.W. (J. Leukoc. Biol. 1996)
    10. Pro- and anti-inflammatory substances modulate expression of the leukotriene B4 receptor, BLT1, in human monocytes. (PubMed id 15728714)1, 9 Pettersson A....Karlsson U. (J. Leukoc. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1241 HGNC: 6713 AceView: LTB4R2andC14orf21andLTB4R Ensembl:ENSG00000213903 euGenes: HUgn1241
    ECgene: LTB4R Kegg: 1241 H-InvDB: LTB4R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LTB4R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LTB4R gene:
    Search GeneIP for patents involving LTB4R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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