Aliases for LTB4R Gene
External Ids for LTB4R Gene
Previous HGNC Symbols for LTB4R Gene
Previous GeneCards Identifiers for LTB4R Gene
GeneCards Summary for LTB4R Gene
LTB4R (Leukotriene B4 Receptor) is a Protein Coding gene. Diseases associated with LTB4R include pancreatic cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include nucleotide binding and leukotriene B4 receptor activity. An important paralog of this gene is FPR2.
UniProtKB/Swiss-Prot for LTB4R Gene
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high affinity stereoselective receptors that have a wide biological distribution. BLT1 and BLT2 receptors are synthesized by polymorphonuclear leukocytes and are found at their highest concentrations on myeloid cells, mast cells and macrophages.