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Aliases for LTB4R Gene

Aliases for LTB4R Gene

  • Leukotriene B4 Receptor 2 3 5
  • Chemoattractant Receptor-Like 1 3 4
  • G-Protein Coupled Receptor 16 3 4
  • P2Y Purinoceptor 7 3 4
  • LTB4-R 1 3 4
  • LTB4-R1 3 4
  • CMKRL1 3 4
  • GPR16 3 4
  • P2RY7 3 4
  • BLT1 3 4
  • BLTR 3 4
  • P2Y7 3 4
  • Purinergic Receptor P2Y, G-Protein Coupled, 7 3
  • G Protein-Coupled Receptor 16 3
  • Chemokine Receptor-Like 1 3
  • LTB4R1 3
  • LTBR1 3
  • BLT 4

External Ids for LTB4R Gene

Previous HGNC Symbols for LTB4R Gene

  • P2RY7
  • GPR16
  • CMKRL1

Previous GeneCards Identifiers for LTB4R Gene

  • GC14P022154
  • GC14P018569
  • GC14P022770
  • GC14P022772
  • GC14P023852
  • GC14P023842
  • GC14P024780
  • GC14P004895

Summaries for LTB4R Gene

GeneCards Summary for LTB4R Gene

LTB4R (Leukotriene B4 Receptor) is a Protein Coding gene. Diseases associated with LTB4R include allergic encephalomyelitis. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is LTB4R2.

UniProtKB/Swiss-Prot for LTB4R Gene

  • Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Tocris Summary for LTB4R Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for LTB4R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTB4R Gene

Genomics for LTB4R Gene

Regulatory Elements for LTB4R Gene

Promoters for LTB4R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LTB4R on UCSC Golden Path with GeneCards custom track

Genomic Location for LTB4R Gene

Chromosome:
14
Start:
24,311,450 bp from pter
End:
24,318,036 bp from pter
Size:
6,587 bases
Orientation:
Plus strand

Genomic View for LTB4R Gene

Genes around LTB4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTB4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTB4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTB4R Gene

Proteins for LTB4R Gene

  • Protein details for LTB4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15722-LT4R1_HUMAN
    Recommended name:
    Leukotriene B4 receptor 1
    Protein Accession:
    Q15722
    Secondary Accessions:
    • Q13305
    • Q53XV5
    • Q92641
    • Q9BSU5

    Protein attributes for LTB4R Gene

    Size:
    352 amino acids
    Molecular mass:
    37557 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB16747.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LTB4R Gene

Proteomics data for LTB4R Gene at MOPED

Post-translational modifications for LTB4R Gene

  • Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
  • Glycosylation at Asn 2 and Asn 164
  • Modification sites at PhosphoSitePlus

Other Protein References for LTB4R Gene

Antibody Products

  • R&D Systems Antibodies for LTB4R (Leukotriene B4 R1)

No data available for DME Specific Peptides for LTB4R Gene

Domains & Families for LTB4R Gene

Gene Families for LTB4R Gene

Suggested Antigen Peptide Sequences for LTB4R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15722

UniProtKB/Swiss-Prot:

LT4R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LTB4R: view

Function for LTB4R Gene

Molecular function for LTB4R Gene

GENATLAS Biochemistry:
leukotriene B4 (LTB4) receptor,43kDa,G protein coupled receptor superfamily,expressed in leukocytes and several tissues of the immune system,involved in the regulation of the inflammatory system
UniProtKB/Swiss-Prot Function:
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Gene Ontology (GO) - Molecular Function for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with LTB4R: view
genes like me logo Genes that share phenotypes with LTB4R: view

Animal Models for LTB4R Gene

MGI Knock Outs for LTB4R:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LTB4R Gene

Localization for LTB4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTB4R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTB4R Gene COMPARTMENTS Subcellular localization image for LTB4R gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with LTB4R: view

Pathways & Interactions for LTB4R Gene

genes like me logo Genes that share pathways with LTB4R: view

Gene Ontology (GO) - Biological Process for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9177352
GO:0007165 signal transduction IEA --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with LTB4R: view

No data available for SIGNOR curated interactions for LTB4R Gene

Drugs & Compounds for LTB4R Gene

(26) Drugs for LTB4R Gene - From: Novoseek, IUPHAR, DGIdb, HMDB, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zafirlukast Approved, Investigational Pharma Antagonist 2
Cinalukast Approved Pharma Potent, selective CysLT1 (LTD4) antagonist; orally active 0
[<sup>3</sup>H]CGS23131 Pharma Antagonist 0
12R-HETE Pharma Full agonist, Agonist 0
20-hydroxy-LTB<sub>4</sub> Pharma Full agonist, Agonist 0

(17) Additional Compounds for LTB4R Gene - From: Novoseek, Tocris, IUPHAR, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
LY 255283
117690-79-6
[<sup>3</sup>H]LTB4
Full agonist, Agonist
Fpl 55712
40785-97-5
SR 2640 hydrochloride
146662-42-2
genes like me logo Genes that share compounds with LTB4R: view

Transcripts for LTB4R Gene

Unigene Clusters for LTB4R Gene

Leukotriene B4 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTB4R Gene

No ASD Table

Relevant External Links for LTB4R Gene

GeneLoc Exon Structure for
LTB4R
ECgene alternative splicing isoforms for
LTB4R

Expression for LTB4R Gene

mRNA expression in normal human tissues for LTB4R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LTB4R Gene

This gene is overexpressed in Whole Blood (x10.8), Skin - Not Sun Exposed (Suprapubic) (x6.5), Esophagus - Mucosa (x5.5), and Skin - Sun Exposed (Lower leg) (x5.3).

Protein differential expression in normal tissues from HIPED for LTB4R Gene

This gene is overexpressed in Monocytes (57.3) and Neutrophil (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LTB4R Gene



SOURCE GeneReport for Unigene cluster for LTB4R Gene Hs.567248

mRNA Expression by UniProt/SwissProt for LTB4R Gene

Q15722-LT4R1_HUMAN
Tissue specificity: Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.
genes like me logo Genes that share expression patterns with LTB4R: view

Protein tissue co-expression partners for LTB4R Gene

Primer Products

In Situ Assay Products

Orthologs for LTB4R Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTB4R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTB4R 36
  • 100 (a)
OneToOne
LTB4R 35
  • 99.24 (n)
  • 99.72 (a)
cow
(Bos Taurus)
Mammalia LTB4R 35
  • 84.15 (n)
  • 79.83 (a)
LTB4R 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LTB4R 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ltb4r1 16
Ltb4r1 36
  • 77 (a)
OneToOne
Ltb4r1 35
  • 81.23 (n)
  • 79.47 (a)
oppossum
(Monodelphis domestica)
Mammalia LTB4R 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LTB4R 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ltb4r 35
  • 82.65 (n)
  • 80.7 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia LTB4R 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ltb4r 35
  • 52.82 (n)
  • 50.48 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329657 35
  • 55.37 (n)
  • 46.05 (a)
si:ch211-272h9.1 36
  • 36 (a)
ManyToMany
si:ch211-272h9.2 36
  • 36 (a)
ManyToMany
Species with no ortholog for LTB4R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTB4R Gene

ENSEMBL:
Gene Tree for LTB4R (if available)
TreeFam:
Gene Tree for LTB4R (if available)

Paralogs for LTB4R Gene

Paralogs for LTB4R Gene

(16) SIMAP similar genes for LTB4R Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LTB4R: view

Variants for LTB4R Gene

Sequence variations from dbSNP and Humsavar for LTB4R Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17849864 - 24,316,687(+) GCCCT(C/T)TCAAG reference, missense
rs1046584 -- 24,316,578(+) ACGGG(C/T)TCCGA reference, synonymous-codon
rs1046587 -- 24,316,854(+) GAGAG(A/G)TGGAG utr-variant-3-prime
rs4981503 -- 24,317,087(+) AGACT(G/T)CCCCC utr-variant-3-prime
rs35205820 -- 24,316,941(+) ATTTG(-/T)GTCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LTB4R Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV Deletion 23128226
dgv1855n71 CNV Loss 21882294

Variation tolerance for LTB4R Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LTB4R Gene

HapMap Linkage Disequilibrium report
LTB4R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTB4R Gene

Disorders for LTB4R Gene

MalaCards: The human disease database

(1) MalaCards diseases for LTB4R Gene - From: GeneCards

Disorder Aliases PubMed IDs
allergic encephalomyelitis
  • experimental autoimmune encephalomyelitis
- elite association - COSMIC cancer census association via MalaCards
Search LTB4R in MalaCards View complete list of genes associated with diseases

Relevant External Links for LTB4R

Genetic Association Database (GAD)
LTB4R
Human Genome Epidemiology (HuGE) Navigator
LTB4R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTB4R
genes like me logo Genes that share disorders with LTB4R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LTB4R Gene

Publications for LTB4R Gene

  1. Cloning of cDNA encoding a putative chemoattractant receptor. (PMID: 8921391) Owman C.S.O. … Lolait S.J. (Genomics 1996) 2 3 4 23 67
  2. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. (PMID: 8702478) Akbar G.K.M. … Kunapuli S.P. (J. Biol. Chem. 1996) 2 3 23
  3. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. (PMID: 18852255) SA!nchez-GalA!n E. … TuA+A^n J. (Cardiovasc. Res. 2009) 3 23
  4. G protein activation by the leukotriene B4 receptor dimer. Evidence for an absence of trans-activation. (PMID: 18490452) Damian M. … BanA"res J.L. (J. Biol. Chem. 2008) 3 23
  5. Critical role for polar residues in coupling leukotriene B4 binding to signal transduction in BLT1. (PMID: 17237498) Basu S. … Haribabu B. (J. Biol. Chem. 2007) 3 23

Products for LTB4R Gene

Sources for LTB4R Gene

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