Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LTB4R Gene

Aliases for LTB4R Gene

  • Leukotriene B4 Receptor 2 3
  • Chemoattractant Receptor-Like 1 3 4
  • G-Protein Coupled Receptor 16 3 4
  • P2Y Purinoceptor 7 3 4
  • LTB4-R 1 3 4
  • LTB4-R1 3 4
  • CMKRL1 3 4
  • GPR16 3 4
  • P2RY7 3 4
  • BLTR 3 4
  • BLT1 3 4
  • P2Y7 3 4
  • Purinergic Receptor P2Y, G-Protein Coupled, 7 3
  • G Protein-Coupled Receptor 16 3
  • Chemokine Receptor-Like 1) 6
  • Chemokine Receptor-Like 1 3
  • Leukotriene B4 Receptor 1 3
  • LTB4R1 3
  • LTBR1 3
  • BLT 4

External Ids for LTB4R Gene

Previous HGNC Symbols for LTB4R Gene

  • P2RY7
  • GPR16
  • CMKRL1

Previous GeneCards Identifiers for LTB4R Gene

  • GC14P022154
  • GC14P018569
  • GC14P022770
  • GC14P022772
  • GC14P023852
  • GC14P023842
  • GC14P024780
  • GC14P004895

Summaries for LTB4R Gene

GeneCards Summary for LTB4R Gene

LTB4R (Leukotriene B4 Receptor) is a Protein Coding gene. Diseases associated with LTB4R include pancreatic cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include nucleotide binding and leukotriene B4 receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for LTB4R Gene

  • Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response

Tocris Summary for LTB4R Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high affinity stereoselective receptors that have a wide biological distribution. BLT1 and BLT2 receptors are synthesized by polymorphonuclear leukocytes and are found at their highest concentrations on myeloid cells, mast cells and macrophages.

Gene Wiki entry for LTB4R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTB4R Gene

Genomics for LTB4R Gene

Regulatory Elements for LTB4R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LTB4R Gene

Start:
24,311,450 bp from pter
End:
24,318,036 bp from pter
Size:
6,587 bases
Orientation:
Plus strand

Genomic View for LTB4R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LTB4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTB4R Gene

Proteins for LTB4R Gene

  • Protein details for LTB4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15722-LT4R1_HUMAN
    Recommended name:
    Leukotriene B4 receptor 1
    Protein Accession:
    Q15722
    Secondary Accessions:
    • Q13305
    • Q53XV5
    • Q92641
    • Q9BSU5

    Protein attributes for LTB4R Gene

    Size:
    352 amino acids
    Molecular mass:
    37557 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB16747.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LTB4R Gene

Proteomics data for LTB4R Gene at MOPED

Post-translational modifications for LTB4R Gene

  • Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
  • Glycosylation at Asn2 and Asn164
  • Modification sites at PhosphoSitePlus

Other Protein References for LTB4R Gene

Antibody Products

  • R&D Systems Antibodies for LTB4R (Leukotriene B4 R1)

No data available for DME Specific Peptides for LTB4R Gene

Domains for LTB4R Gene

Gene Families for LTB4R Gene

HGNC:
  • LTNR :GPCR / Class A : Leukotriene receptors
IUPHAR :

Suggested Antigen Peptide Sequences for LTB4R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15722

UniProtKB/Swiss-Prot:

LT4R1_HUMAN :
  • Q15722
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LTB4R: view

Function for LTB4R Gene

Molecular function for LTB4R Gene

GENATLAS Biochemistry: leukotriene B4 (LTB4) receptor,43kDa,G protein coupled receptor superfamily,expressed in leukocytes and several tissues of the immune system,involved in the regulation of the inflammatory system
UniProtKB/Swiss-Prot Function: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response

Gene Ontology (GO) - Molecular Function for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 8702478
GO:0001632 leukotriene B4 receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
GO:0004974 leukotriene receptor activity TAS 9177352
genes like me logo Genes that share ontologies with LTB4R: view
genes like me logo Genes that share phenotypes with LTB4R: view

Animal Models for LTB4R Gene

MGI Knock Outs for LTB4R:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LTB4R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LTB4R Gene

Localization for LTB4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTB4R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTB4R Gene COMPARTMENTS Subcellular localization image for LTB4R gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9177352
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with LTB4R: view

Pathways for LTB4R Gene

genes like me logo Genes that share pathways with LTB4R: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LTB4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9177352
GO:0006936 muscle contraction TAS 8702478
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 9177352
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with LTB4R: view

Compounds for LTB4R Gene

(5) Tocris Compounds for LTB4R Gene

Compound Action Cas Number
17-ODYA LTB-omega-Hydroxylase inhibitor [34450-18-5]
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor [71160-24-2]
LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor [115104-28-4]
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist [146662-42-2]

(2) HMDB Compounds for LTB4R Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Leukotriene B4
  • (6z,8e,10e,14z)-(5s,12r)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
71160-24-2

(14) IUPHAR Ligand for LTB4R Gene

Ligand Type Action Affinity Pubmed IDs
[3H]LTB4 None None 9.7
etalocib Antagonist Antagonist 9.3
BILL 260 Antagonist Antagonist 8.8
20-hydroxy-LTB4 Agonist Full agonist 8.1
RO5101576 Antagonist Antagonist 8.1
CP105696 Antagonist Antagonist 8.1
[3H]CGS23131 Antagonist Antagonist 7.9
SC-41930 Antagonist Antagonist 7.77
12R-HETE Agonist Full agonist 7.5
LY255283 Antagonist Antagonist 7.1
U75302 Antagonist Antagonist 6.4
ONO-4057 Antagonist Antagonist 6.15
CP-195543 Antagonist Antagonist 6
LTB4 Activator None

(24) Novoseek inferred chemical compound relationships for LTB4R Gene

Compound -log(P) Hits PubMed IDs
leukotriene b4 96 174
ly293111 93.8 6
ly 255283 93.4 4
5-oxoete 78.1 1
lxa4 73.1 2
genes like me logo Genes that share compounds with LTB4R: view

Transcripts for LTB4R Gene

Unigene Clusters for LTB4R Gene

Leukotriene B4 receptor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LTB4R

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTB4R Gene

No ASD Table

Relevant External Links for LTB4R Gene

GeneLoc Exon Structure for
LTB4R
ECgene alternative splicing isoforms for
LTB4R

Expression for LTB4R Gene

mRNA expression in normal human tissues for LTB4R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LTB4R Gene

This gene is overexpressed in Whole Blood (10.8), Skin - Not Sun Exposed (Suprapubic) (6.5), Esophagus - Mucosa (5.5), and Skin - Sun Exposed (Lower leg) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LTB4R Gene

SOURCE GeneReport for Unigene cluster for LTB4R Gene Hs.567248

mRNA Expression by UniProt/SwissProt for LTB4R Gene

Q15722-LT4R1_HUMAN
Tissue specificity: Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues
genes like me logo Genes that share expressions with LTB4R: view

In Situ Assay Products

Orthologs for LTB4R Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTB4R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTB4R 35
  • 99.24 (n)
  • 99.72 (a)
LTB4R 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LTB4R 35
  • 84.15 (n)
  • 79.83 (a)
LTB4R 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LTB4R 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ltb4r1 35
  • 81.23 (n)
  • 79.47 (a)
Ltb4r1 16
Ltb4r1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LTB4R 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LTB4R 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ltb4r 35
  • 82.65 (n)
  • 80.7 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia LTB4R 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ltb4r 35
  • 52.82 (n)
  • 50.48 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329657 35
  • 55.37 (n)
  • 46.05 (a)
si:ch211-272h9.1 36
  • 36 (a)
ManyToMany
si:ch211-272h9.2 36
  • 36 (a)
ManyToMany
Species with no ortholog for LTB4R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTB4R Gene

ENSEMBL:
Gene Tree for LTB4R (if available)
TreeFam:
Gene Tree for LTB4R (if available)

Paralogs for LTB4R Gene

Selected SIMAP similar genes for LTB4R Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LTB4R: view

Variants for LTB4R Gene

Sequence variations from dbSNP and Humsavar for LTB4R Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1046584 -- 24,316,578(+) ACGGG(C/T)TCCGA reference, synonymous-codon
rs1046587 -- 24,316,854(+) GAGAG(A/G)TGGAG utr-variant-3-prime
rs2224122 -- 24,314,208(-) CTTTC(C/G)CCAAG intron-variant, utr-variant-5-prime
rs2224123 -- 24,313,752(-) AAAAG(A/T)TAGCT intron-variant, utr-variant-5-prime
rs3181384 -- 24,317,770(+) CAATA(C/T)CTCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LTB4R Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV Deletion 23128226
dgv1855n71 CNV Loss 21882294

Relevant External Links for LTB4R Gene

HapMap Linkage Disequilibrium report
LTB4R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTB4R Gene

Disorders for LTB4R Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LTB4R Gene including...

Search for LTB4R Gene in MalaCards »

(1) University of Copenhagen DISEASES for LTB4R Gene

(12) Novoseek inferred disease relationships for LTB4R Gene

Disease -log(P) Hits PubMed IDs
inflammation 50.7 10
asthma 36 4
pancreatic cancer 22 3
atherosclerosis 18.8 7
inflammatory bowel diseases 18.4 1

Relevant External Links for LTB4R

Genetic Association Database (GAD)
LTB4R
Human Genome Epidemiology (HuGE) Navigator
LTB4R
genes like me logo Genes that share disorders with LTB4R: view

No data available for UniProtKB/Swiss-Prot for LTB4R Gene

Publications for LTB4R Gene

  1. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. (PMID: 8702478) Akbar G.K.M. … Kunapuli S.P. (J. Biol. Chem. 1996) 2 3 4 23
  2. Cloning of cDNA encoding a putative chemoattractant receptor. (PMID: 8921391) Owman C.S.O. … Lolait S.J. (Genomics 1996) 2 3 4 23
  3. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. (PMID: 10934229) Kato K. … Shimizu T. (J. Exp. Med. 2000) 3 4 23
  4. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. (PMID: 9177352) Yokomizo T. … Shimizu T. (Nature 1997) 3 4 23
  5. Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. (PMID: 12077128) Gaudreau R. … Rola-Pleszczynski M. (J. Biol. Chem. 2002) 3 4 23

Products for LTB4R Gene

Sources for LTB4R Gene

Back to Top

Content