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LTB Gene

protein-coding   GIFtS: 62
GCID: GC06M031582

Lymphotoxin Beta (TNF Superfamily, Member 3)


(Previous symbol: TNFC)
  Search for LTB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lymphotoxin Beta (TNF Superfamily, Member 3)1 2     TNF-C2 3
TNFC1 2 3 5     TNFSF32 3
Tumor Necrosis Factor C2 3     lymphotoxin-beta2
Tumor Necrosis Factor Ligand Superfamily Member 32 3     p332
LT-beta2 3     

External Ids:    HGNC: 67111   Entrez Gene: 40502   Ensembl: ENSG000002275077   OMIM: 6009785   UniProtKB: Q066433   
ORGUL members:         

Export aliases for LTB gene to outside databases

Previous GC identifers: GC06M031611 GC06M031602 GC06M031319 GC06M031652 GC06M031656 GC06M031549 GC06M031335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LTB Gene:
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface
through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2
complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta
receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system
and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with
lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Jul 2008)

GeneCards Summary for LTB Gene:
LTB (lymphotoxin beta (TNF superfamily, member 3)) is a protein-coding gene. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding.

UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643
Function: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides
the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably
non-functional

Gene Wiki entry for LTB (Lymphotoxin beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LTB gene promoter:
         COUP-TF   p53   AP-1   ATF-2   COUP   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLTB promoter sequence
   Search Chromatin IP Primers for LTB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LTB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

LTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LTB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031582:  view genomic region     (about GC identifiers)

Start:
31,548,302 bp from pter      End:
31,550,299 bp from pter
Size:
1,998 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_167247 2,928,041-2,929,908      Chr6-,NT_167244 2,863,053-2,864,920      Chr6-,NT_167245 2,833,876-2,835,743     
Chr6-,NT_167248 2,841,975-2,843,842      Chr6-,NT_167249 2,879,136-2,881,003      Chr6-,NT_167246 2,891,219-2,893,086     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643 (See protein sequence)
Recommended Name: Lymphotoxin-beta  
Size: 244 amino acids; 25390 Da
Subunit: Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits
1 PDB 3D structure from and Proteopedia for LTB:
4MXW (3D)    
Secondary accessions: P78370 Q52LU8 Q99761
Alternative splicing: 2 isoforms:  Q06643-1   Q06643-2   

Explore the universe of human proteins at neXtProt for LTB: NX_Q06643

Explore proteomics data for LTB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn222

  • See LTB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002332.1  NP_033666.1  

    ENSEMBL proteins: 
     ENSP00000410481   ENSP00000416113  

    LTB Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Abcam antibodies for LTB
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    LSBio Antibodies in human, mouse, rat for LTB

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    Search eBioscience for ELISAs for LTB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNFSF: Tumor necrosis factor (ligand) superfamily

    5 InterPro protein domains:
     IPR021184 TNF_CS
     IPR002961 TNF_C
     IPR006052 TNF_dom
     IPR006053 TNF
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry Q06643

    ProtoNet protein and cluster: Q06643

    3 Blocks protein domains:
    IPB002961 Tumour necrosis factor c (lymphotoxin-beta) signature
    IPB006052 Tumor Necrosis Factor
    IPB006053 Tumour necrosis factor family signature


    UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643
    Similarity: Belongs to the tumor necrosis factor family


    Find genes that share domains with LTB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFC_HUMAN, Q06643
    Function: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides
    the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably
    non-functional

         Genatlas biochemistry entry for LTB:
    lymphotoxin beta,expressed in macrophages,,tumors necrosis factor (ligand) superfamily,member 3

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7916655
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LTB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LTB:
     Decreased nuclei size in G2M 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Ltb):
     digestive/alimentary  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  nervous system  no phenotypic analysis  respiratory system 
     vision/eye 

    Find genes that share phenotypes with LTB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LTB: Ltbtm1Kpf Ltbtm1Krn Ltb/Tnf/LtaLtb/Tnf/tm1Dvk Ltbtm1Flv Ltb/TnfLtb/tm1.1Dvk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LTB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LTB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LTB

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    Gene Editing
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    Sino Biological Human cDNA Clone for LTB
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LTB

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNFC_HUMAN, Q06643: Membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005615extracellular space IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LTB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LTB About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1LT-BetaR Pathway
    LT-BetaR Pathway0.46
    Apoptosis and survival Lymphotoxin beta receptor signaling0.46
    2TNF Signaling
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    NF-kB (NFkB) Pathway0.46
    3NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    4PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    5TRAF Pathway
    TNF Superfamily Pathway0.42


    Find genes that share SuperPaths with LTB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for LTB
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LTB
        LT-BetaR Pathway
    OX40 Pathway
    TNF Superfamily Pathway
    NF-KappaB Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for LTB
        Apoptosis and survival Lymphotoxin-beta receptor signaling

    1 BioSystems Pathway for LTB
        Spinal Cord Injury

    1 Sino Biological Pathway for LTB
        NF-kB (NFkB) Pathway


    3 Kegg Pathways  (Kegg details for LTB):
        Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    Rheumatoid arthritis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LTB (see all 9): 
              NFKB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LTB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for LTB (Q066433 ENSP000004104814) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LTAP013743, ENSP000004034954I2D: score=4 STRING: ENSP00000403495
    ENSG00000230279P013743I2D: score=4 
    ENSG00000231408P013743I2D: score=4 
    TNFSF14O435573, ENSP000002459124I2D: score=2 STRING: ENSP00000245912
    LTBRP369413, ENSP000002289184I2D: score=3 STRING: ENSP00000228918
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS7916655
    GO:0007267cell-cell signaling TAS7916655
    GO:0010467gene expression IEA--
    GO:0043588skin development IEA--

    Find genes that share ontologies with LTB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LTB (TNFC)

    1 HMDB Compound for LTB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    2 Novoseek inferred chemical compound relationships for LTB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 38.6 3 11818457 (1), 12828562 (1), 10544185 (1)
    cyclosporin a 0 5 12176893 (2), 7518925 (1)

    1 PharmGKB related drug/compound annotation for LTB gene    About this table
    Drug/compound PharmGKB Annotation
    abacavirCA  



    Find genes that share compounds with LTB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LTB gene (2 alternative transcripts): 
    NM_002341.1  NM_009588.1  

    Unigene Cluster for LTB:

    Lymphotoxin beta (TNF superfamily, member 3)
    Hs.376208  [show with all ESTs]
    Unigene Representative Sequence: AK095821
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483972 ENST00000429299(uc003nuk.3) ENST00000446745(uc003nul.3)
    ENST00000482429
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat LTB

    Additional mRNA sequence: 

    AK095821.1 AK312210.1 BC055090.1 BC069330.1 BC093783.1 L11015.1 U79029.1 U89922.1 

    7 DOTS entries:

    DT.210387  DT.92422644  DT.99936177  DT.100743069  DT.95215874  DT.446271  DT.95281755 

    13 AceView cDNA sequences:

    L11015 NM_002341 AK095821 BC069330 U89922 BX095063 U79029 NM_009588 
    AW978651 BC055090 AA847198 BC018898 AA836521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LTB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGTGGGAA
    LTB Expression
    About this image


    LTB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Periderm Cells Embryonic Epidermis
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Epithelial Cells
             Periderm Cells Embryonic Epidermis
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
    LTB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LTB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.376208

    UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643
    Tissue specificity: Spleen and thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LTB (see all 9): 
              NFKB Signaling Targets in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat LTB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for LTB gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ltb1 , 5 lymphotoxin B1, 5 79.66(n)1
    74.41(a)1
      17 (18.59 cM)5
    169941  NM_008518.21  NP_032544.11 
     351944395 


    ENSEMBL Gene Tree for LTB (if available)
    TreeFam Gene Tree for LTB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LTB gene
    1 SIMAP similar gene for LTB using alignment to 2 protein entries:     TNFC_HUMAN (see all proteins):
    LTA

    Find genes that share paralogs with LTB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LTB (see all 123)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835175011,2
    --31547887(+) AGAGAA/GGCCTT 2 -- ds50010--------
    rs1386807401,2
    --31547999(+) TGGGCC/TCTGTA 2 -- ds50010--------
    rs1878782331,2
    --31548176(+) CAGAGA/GCAGGG 2 -- ds50010--------
    rs30935571,2
    C,F--31548196(-) GTCTGC/TCTGTC 2 -- ds50014Minor allele frequency- T:0.02NS WA 214
    rs46458461,2
    C,F,H--31548266(+) GAAGAG/CTACTG 2 -- ds50015Minor allele frequency- C:0.01NS EA 556
    rs7691751,2
    C,F,H--31548368(-) TGAAAA/GTAAAG 2 -- ut317Minor allele frequency- G:0.00NA NS MN EA 870
    rs30935561,2
    C,F,H--31548451(-) GAATAT/CTGGGG 2 -- ut3112Minor allele frequency- C:0.01NS EA WA EU 2385
    rs42481651,2
    C,F--31548528(+) CTCGCG/AAAGTC 3 /F syn1 ut313Minor allele frequency- A:0.00NS NA 4862
    rs1491398351,2
    F--31548586(+) GGAGCT/CGCACC 3 /Q /R mis1 ut311Minor allele frequency- C:0.00NA 4504
    rs22296991,2,,4
    C,F,H--31548856(-) GGACGA/C/TCGAGG 5 D A V mis1 ut319MN NS EA 1172

    HapMap Linkage Disequilibrium report for LTB (31548302 - 31550299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LTB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv884418CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LTB
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600978    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for LTB:
    Cholera

    Find genes that share disorders with LTB           About GenesLikeMe

    10 Novoseek inferred disease relationships for LTB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 58.5 15 9307242 (1), 12912866 (1), 15969671 (1), 10358762 (1) (see all 13)
    synovitis 40.3 1 15248211 (1)
    tumors 38.5 16 9299492 (2), 7995952 (1), 9307242 (1), 10358762 (1) (see all 13)
    herpes 25.6 1 10358762 (1)
    inflammation 18.1 4 18379788 (1), 18292573 (1), 11747624 (1)
    hepatitis c 16.3 1 12912866 (1)
    hepatitis c chronic 13.9 2 12912866 (1)
    lymphoma non-hodgkins 3.01 1 9299492 (1)
    leukemia 0 2 12801841 (1)
    liver diseases 0 2 12912866 (1)

    Genetic Association Database (GAD): LTB
    Human Genome Epidemiology (HuGE) Navigator: LTB (14 documents)

    Export disorders for LTB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LTB gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with LTB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. (PubMed id 7916655)1, 2, 3 Browning J.L.... Ware C.F. (Cell 1993)
    2. Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas. (PubMed id 9299492)1, 2, 9 Warzocha K....Salles G. (Biochem. Biophys. Res. Commun. 1997)
    3. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. (PubMed id 15969671)1, 4, 9 Migita O....Arinami T. (Clin. Exp. Allergy 2005)
    4. Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma. (PubMed id 1714477)1, 3, 9 Browning J.L....Ware C.F. (J. Immunol. 1991)
    5. Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke. (PubMed id 17981284)1, 4, 9 Bis J.C....Psaty B.M. (Atherosclerosis 2008)
    6. A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults. (PubMed id 21029472)1, 4 Randall L.M....Engwerda C.R. (Malar. J. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    9. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PubMed id 19115949)1, 4 Limou S....Zagury J.F. (J. Infect. Dis. 2009)
    10. Candidate gene polymorphisms for ischemic stroke. (PubMed id 19729601)1, 4 Matarin M....Meschia J.F. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4050 HGNC: 6711 AceView: LTB Ensembl:ENSG00000227507 euGenes: HUgn4050
    ECgene: LTB Kegg: 4050 H-InvDB: LTB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LTB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LTB Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ltb/
    SeattleSNPshttp://pga.gs.washington.edu/data/ltb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LTB gene:
    Search GeneIP for patents involving LTB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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