V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

LTB Gene

protein-coding GIFtS: 60

GC06M031656

lymphotoxin beta (TNF superfamily, member 3)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TNFC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LT-beta ^³
OTTHUMP00000029185 ^²
OTTHUMP00000038214 ^²
TNF-C ^³
TNFC ^², ³, ⁵
TNFSF3 ^¹, ², ³
lymphotoxin-beta ^²
p33 ^¹, ²

Descriptions
Tumor necrosis factor C ^², ³
Tumor necrosis factor ligand superfamily member 3 ^³
lymphotoxin beta (TNF superfamily, member 3) ^²

External Ids
HGNC: 6711¹
Entrez Gene: 4050²
UniProtKB: Q06643³
Ensembl: ENSG00000204487⁷

Search outside databases for aliases for LTB gene

Previous GC identifers: GC06M031611 GC06M031602 GC06M031319 GC06M031652

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LTB:

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to

the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is

the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex

is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha

2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development

of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha

suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative

splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643

Function: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response

regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the

cell surface. Isoform 2 is probably non-functional

Gene Wiki entry for LTB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LTB gene

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3

LTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M031656: (about GC identifiers)

Start:	31,656,314 bp from pter
End:	31,658,181 bp from pter
Size:	1,868 bases
Orientation:	minus strand

2 alternative locations:

Chr6-,c6_QBL 31,681,431-31,683,298

Chr6-,c6_COX 31,683,001-31,684,868

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113894.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643 (See protein sequence)

Recommended Name: Lymphotoxin-beta

Size: 244 amino acids; 25390 Da

Subunit: Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two

LTA subunits

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Secondary accessions: P78370 Q99761

Alternative splicing: 2 isoforms: Q06643-1 Q06643-2

REFSEQ proteins (2 alternative transcripts):

NP_002332.1 NP_033666.1

ENSEMBL proteins:

ENSP00000365283 ENSP00000365285

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for LTB
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Lymphotoxin Beta)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	9299492
GO:0005615	extracellular space	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for LTB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for LTB (Lymphotoxin beta/TNFSF3)
	Antibodies from Abcam (Lymphotoxin Beta), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LTB

Assays for LTB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q06643

ProtoNet protein and cluster: Q06643

3 Blocks protein families:

IPB002961 Tumour necrosis factor c (lymphotoxin-beta) signature

IPB006052 Tumor Necrosis Factor

IPB006053 Tumour necrosis factor family signature

UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643

Similarity: Belongs to the tumor necrosis factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LTB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_009588

Applied Biosystems Silencer® siRNAs for LTB

Sigma-Aldrich siRNA and siRNA Panels for LTB

Sigma-Aldrich shRNA Panels and shRNA for LTB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LTB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002341
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002341
untagged cDNA clones in CMV expression vector (see all 3): NM_002341

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002341

UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643

Function: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response

regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the

cell surface. Isoform 2 is probably non-functional

Genatlas biochemistry entry for LTB:

lymphotoxin beta,expressed in macrophages,,tumors necrosis factor (ligand) superfamily,member 3

6 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Ltb):

hematopoietic system	immune system	life span-post-weaning/aging	liver/biliary system	no phenotypic analysis
respiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005164	tumor necrosis factor receptor binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for LTB (Your Favorite Gene powered by Ingenuity)

Lymphotoxin &beta
Dendritic Cell Maturation

GeneDecks LTB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for LTB

5 Interacting proteins for LTB (ENSP00000365285³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LTBR	ENSP00000228918³	STRING (score=.985)
NCR3	ENSP00000342156³	STRING (score=.847)
TNFRSF1A	ENSP00000162749³	STRING (score=.845)
TNFRSF1B	ENSP00000365435³	STRING (score=.794)
IFNG	ENSP00000229135³	STRING (score=.773)

About this table

5/20 Gene Ontology (GO) biological process terms (links to tree view) (see all 20 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001775	cell activation	IEA	--
GO:0002037	negative regulation of L-glutamate transport	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0006917	induction of apoptosis	IEA	--
GO:0006955	immune response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LTB
1 Novoseek chemical compound relationship for LTB gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	40.32	3	11818457 (1), 12828562 (1), 10544185 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LTB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_009588

Sigma-Aldrich siRNA and siRNA Panels for LTB

Sigma-Aldrich shRNA Panels and shRNA for LTB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002341 NM_009588

REFSEQ mRNAs for LTB gene (2 alternative transcripts):

NM_002341.1 NM_009588.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002341 NM_009588

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002341
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002341
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002341

Additional cDNA sequence:

AK095821.1 AK312210.1 BC055090.1 BC069330.1 BC093783.1 L11015.1 U79029.1 U89922.1

7 DOTS entries:

DT.210387 DT.92422644 DT.99936177 DT.100743069 DT.95215874 DT.446271 DT.95281755

13 AceView cDNA sequences:

BC069330 BX095063 NM_002341 NM_009588 U79029 L11015 U89922 AK095821

BC055090 AW978651 BC018898 AA847198 AA836521

highest scoring ESTs for LTB:

BC069330 L11015 U79029 U89922 AA836521 AA847198 AW978651 BC055090 BC093783 BF238152

Unigene Cluster for LTB:

Lymphotoxin beta (TNF superfamily, member 3)

Hs.376208 [show with all ESTs]

Unigene Representative Sequence: AK095821

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000376115 ENST00000376117

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LTB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LTB

¹ / ² / ³

3 probe-sets matching LTB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40729_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Y14768	0.20	0.50	0.38	1
207339_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002341	0.60	1.00	0.82	1
207339_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LTB for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAGTGGGAA

SOURCE GeneReport for Unigene cluster: Hs.376208
Expression variation in blood from EXPOLDB for LTB
UniProtKB/Swiss-Prot: TNFC_HUMAN, Q06643
Tissue specificity: Spleen and thymus

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LTB gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LTB¹	--	lymphotoxin beta (TNF superfamily, member 3)	84.56(n) 81.15(a)	481712 XM_538833.2 XP_538833.2
chimpanzee (Pan troglodytes)	LTB¹	--	lymphotoxin beta (TNF superfamily, member 3)	99.73(n) 99.59(a)	744486 XM_001153356.1 XP_001153356.1
cow (Bos taurus)	LTB¹	--	lymphotoxin beta (TNF superfamily, member 3)	84.29(n) 80.33(a)	529757 XM_608214.3 XP_608214.2
rat (Rattus norvegicus)	Ltb¹	--	lymphotoxin beta (TNF superfamily, member 3)	80.69(n) 75.83(a)	361795 NM_212507.2 NP_997672.1
mouse (Mus musculus)	Ltb^{1, 5}	17 (19.06 cM)⁵	lymphotoxin B^{1, 5}	79.97(n)¹ 74.7(a)¹	16994¹ NM_008518.1¹ NP_032544.1¹ AF109719⁵ AI662801⁵ (see all 12)

About this table Species with no ortholog for LTB

ENSEMBL Gene Tree for LTB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/49 NCBI SNPs in LTB are shown (see all 49 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3093554^1,2	C,F,H	31657386(-)	`TCCAGG/AGTTTC`	2	E/G S/G	mis¹ ese³		13	NS EU EA WA NA	1064
	rs769175^1,2	C,F,H	31656347(-)	`TGAAAA/GTAAAG`	2	--	ut3¹		7	NA NS MN EU EA WA	870
	rs3093562^1,2	C,F,H	31659516(-)	`gtctgG/Cgtgac`	2	--	ng3¹		14	NS EU EA WA NA	1236
--	rs769174^1,2	A,C,F	31659045(-)	`ccaaaG/Ctgttg`	2	--	ng3¹		4	NA NS	432
	rs3093556^1,2	C,F,H	31656430(-)	`GAATAT/CTGGGG`	2	--	ut3¹ ese³		8	NS EU EA WA	822
	rs7766988^1,2	F,H	31659326(+)	`GTCAAG/CGGAAG`	2	--	ng3¹ trp³		4	EU EA WA	410
	rs2022045^1,2	C,H	31658539(-)	`TTGAGG/AGTATA`	2	--	ng3¹		6	MN EU EA WA NA	659
--	rs4248165^1,2	C,F	31656507(+)	`CTCGCG/AAAGTC`	2	F/F	syn¹ ut3¹		2	NS	324
--	rs3093550^1,2	C,F	31658518(-)	`AACCAC/TATTGG`	2	--	ng3¹ tfbs³		6	NS NA	408
	rs4645846^1,2	F,H	31656245(+)	`GAAGAG/CTACTG`	2	--	ng5¹		5	NS EU EA WA	556

About this table

HapMap Linkage Disequilibrium images for LTB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600978

10 Novoseek disease relationships for LTB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	60.11	15	9307242 (1), 12912866 (1), 15969671 (1), 10358762 (1) (see all 13)
synovitis	42.17	1	15248211 (1)
tumors	40.60	16	9299492 (2), 7995952 (1), 9307242 (1), 10358762 (1) (see all 13)
herpes	27.61	1	10358762 (1)
hepatitis c	18.53	1	12912866 (1)
inflammation	17.10	4	18379788 (1), 18292573 (1), 11747624 (1)
hepatitis c chronic	16.08	2	12912866 (1)
lymphoma non-hodgkins	4.98	1	9299492 (1)
leukemia	1.99	2	12801841 (1)
liver diseases	0.00	2	12912866 (1)

About this table

Genetic Association Database: LTB
Human Genome Epidemiology Navigator: LTB (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/87 PubMed articles for LTB gene (see all 87 ):

Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. (PubMed id 7916655)^{2, 3, 4} Browning J.L.... Ware C.F. (1993)
Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas. (PubMed id 9299492)^{1, 3, 4} Warzocha K....Salles G. (1997)
Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. (PubMed id 15969671)^{1, 3, 6} Migita O....Arinami T. (2005)
Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma. (PubMed id 1714477)^{1, 2, 3} Browning J.L....Ware C.F. (1991)
Association of the major histocompatibility complex with response to infliximab therapy in rheumatoid arthritis patients. (PubMed id 15077289)^{3, 6} Martinez A....Fernandez-Gutierrez B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)^{3, 4} Xie T.... Hood L. (2003)
A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. (PubMed id 10202016)^{3, 4} Neville M.J. and Campbell R.D. (1999)
High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations. (PubMed id 18379788)^{1, 3} O'Rourke K.P....O'Gara F. (2008)
Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis. (PubMed id 15248211)^{1, 3} Braun A....Weyand C.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4050	HGNC: 6711	AceView: LTB	Ensembl:ENSG00000204487	euGenes: HUgn4050
ECgene: LTB	H-InvDB: LTB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LTB	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ltb/
SeattleSNPs	http://pga.gs.washington.edu/data/ltb/

Licensable Technologies for LTB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LTB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LTB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LTB		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for LTB
	Lentivirus-delivered shRNAs for LTB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Lymphotoxin Beta)
	Antibodies (Lymphotoxin Beta)

Search OriGene for LTB

Search Tocris compounds for LTB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for LTB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
LTB Gene at Home site.
Version 2.41.1
server5.xennexinc.com

LTB Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for LTB

Summaries
for LTB

Genomic Location
for LTB

Proteins
for LTB

Protein Domains/
Families
for LTB

Gene Function
for LTB

Pathways & Interactions
for LTB

Drugs & Compounds
for LTB

Transcripts
for LTB

Expression
for LTB

Orthologs
for LTB

Paralogs
for LTB

SNPs/Variants
for LTB

Disorders & Mutations
for LTB

Medical News
for LTB

Publications
for LTB

Search for LTB

Genome Databases showing LTB

Other Databases showing LTB

Specialized Databases showing LTB

Licensable Technologies
for LTB

Services
for LTB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LTB Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor LTB

Summariesfor LTB

Genomic Locationfor LTB

Proteinsfor LTB

Protein Domains/Familiesfor LTB

Gene Functionfor LTB

Pathways & Interactionsfor LTB

Drugs & Compoundsfor LTB

Transcriptsfor LTB

Expression for LTB

Orthologsfor LTB

Paralogsfor LTB

SNPs/Variantsfor LTB

Disorders & Mutationsfor LTB

Medical Newsfor LTB

Publicationsfor LTB

Search for LTB

Genome Databases showing LTB

Other Databases showing LTB

Specialized Databases showing LTB

Licensable Technologiesfor LTB

Servicesfor LTB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LTB

Summaries
for LTB

Genomic Location
for LTB

Proteins
for LTB

Protein Domains/
Families
for LTB

Gene Function
for LTB

Pathways & Interactions
for LTB

Drugs & Compounds
for LTB

Transcripts
for LTB

Expression
for LTB

Orthologs
for LTB

Paralogs
for LTB

SNPs/Variants
for LTB

Disorders & Mutations
for LTB

Medical News
for LTB

Publications
for LTB

Licensable Technologies
for LTB

Services
for LTB