Aliases for LTB Gene
External Ids for LTB Gene
Previous HGNC Symbols for LTB Gene
Previous GeneCards Identifiers for LTB Gene
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for LTB Gene
LTB (Lymphotoxin Beta) is a Protein Coding gene. Diseases associated with LTB include Rheumatoid Arthritis. Among its related pathways are PEDF Induced Signaling and TNF Signaling (sino). GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.
UniProtKB/Swiss-Prot for LTB Gene
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.