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Aliases for LTA4H Gene

Aliases for LTA4H Gene

  • Leukotriene A4 Hydrolase 2 3 5
  • Leukotriene A(4) Hydrolase 4
  • LTA-4 Hydrolase 4
  • EC 3.3.2.6 4
  • LTA4 4

External Ids for LTA4H Gene

Previous GeneCards Identifiers for LTA4H Gene

  • GC12M095829
  • GC12M096758
  • GC12M096327
  • GC12M094897
  • GC12M093456
  • GC12M096394

Summaries for LTA4H Gene

Entrez Gene Summary for LTA4H Gene

  • The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for LTA4H Gene

LTA4H (Leukotriene A4 Hydrolase) is a Protein Coding gene. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include poly(A) RNA binding and peptidase activity. An important paralog of this gene is RNPEP.

UniProtKB/Swiss-Prot for LTA4H Gene

  • Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

Tocris Summary for LTA4H Gene

  • Leukotriene A4 hydrolase, (LTA4 hydrolase, LTA4H) is a zinc-dependent epoxide hydrolase which hydrolyzes LTA4 to form LTB4 during leukotriene biosynthesis. The enzyme is the only member of the leukotriene biosynthetic pathway which is mainly cytoplasmic.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTA4H Gene

Genomics for LTA4H Gene

Regulatory Elements for LTA4H Gene

Enhancers for LTA4H Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F096043 1.5 FANTOM5 Ensembl ENCODE 20.3 -3.3 -3281 6.0 TBL1XR1 FEZF1 ZSCAN9 ZBTB40 RARA FOS HMG20B CEBPB JUNB ELF1 LTA4H HAL ELK3 SNRPF AMDHD1 GC12P096047
GH12F096176 1.4 FANTOM5 Ensembl ENCODE 16.7 -133.7 -133674 1.6 HDGF JUN ASH2L ZBTB40 EED CREM MTA2 CBFB ZBED1 TRIM22 LTA4H ELK3 CFAP54 LOC105369924
GH12F096206 1.7 FANTOM5 Ensembl ENCODE 11.3 -170.9 -170946 16.9 PKNOX1 WRNIP1 ARID4B SIN3A BRCA1 ZNF143 ZNF207 FOS DEK REST LTA4H CDK17 CFAP54 LOC102723340 PIR48131 ELK3
GH12F096232 1.4 FANTOM5 Ensembl ENCODE 11.1 -194.8 -194752 10.6 PKNOX1 JUN ZMYM3 RAD21 YY1 ZNF316 POLR2A FOS NFE2 CREM CDK17 ELK3 RNU4-24P LTA4H CFAP54 ENSG00000258177 GC12M096304
GH12F096253 1.5 FANTOM5 Ensembl ENCODE 10.1 -213.6 -213562 6.3 PKNOX1 ATF1 RARA SCRT2 CEBPB REST NR2F2 GLIS1 RCOR2 CEBPA CDK17 RNU4-24P CFAP54 LTA4H LOC102723340 ELK3 ENSG00000258177 GC12M096304
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LTA4H on UCSC Golden Path with GeneCards custom track

Genomic Location for LTA4H Gene

Chromosome:
12
Start:
96,000,753 bp from pter
End:
96,043,520 bp from pter
Size:
42,768 bases
Orientation:
Minus strand

Genomic View for LTA4H Gene

Genes around LTA4H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTA4H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTA4H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTA4H Gene

Proteins for LTA4H Gene

  • Protein details for LTA4H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09960-LKHA4_HUMAN
    Recommended name:
    Leukotriene A-4 hydrolase
    Protein Accession:
    P09960
    Secondary Accessions:
    • B4DNQ9
    • F8VV40
    • Q6IAT6
    • Q9UCT7

    Protein attributes for LTA4H Gene

    Size:
    611 amino acids
    Molecular mass:
    69285 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LTA4H Gene

    Alternative splice isoforms for LTA4H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LTA4H Gene

Post-translational modifications for LTA4H Gene

  • Phosphorylation at Ser-416 inhibits enzymatic activity.
  • Ubiquitination at Lys 20, Lys 58, Lys 64, Lys 73, Lys 83, Lys 127, Lys 225, Lys 355, Lys 414, Lys 418, Lys 480, Lys 493, Lys 557, Lys 573, Lys 580, and Lys 593
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LTA4H Gene

Domains & Families for LTA4H Gene

Graphical View of Domain Structure for InterPro Entry

P09960

UniProtKB/Swiss-Prot:

LKHA4_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with LTA4H: view

Function for LTA4H Gene

Molecular function for LTA4H Gene

GENATLAS Biochemistry:
leukotriene A4 hydrolase,highly expressed in spleen,lung,small intestine
UniProtKB/Swiss-Prot CatalyticActivity:
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by bestatin. Subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379.
UniProtKB/Swiss-Prot Function:
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

Enzyme Numbers (IUBMB) for LTA4H Gene

Gene Ontology (GO) - Molecular Function for LTA4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IDA 15078870
GO:0004301 epoxide hydrolase activity TAS 11154734
GO:0004463 leukotriene-A4 hydrolase activity IEA,TAS --
GO:0005515 protein binding IPI 21044950
GO:0008233 peptidase activity IEA,TAS 1881903
genes like me logo Genes that share ontologies with LTA4H: view
genes like me logo Genes that share phenotypes with LTA4H: view

Animal Models for LTA4H Gene

MGI Knock Outs for LTA4H:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTA4H Gene

Localization for LTA4H Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTA4H Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LTA4H gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LTA4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with LTA4H: view

Pathways & Interactions for LTA4H Gene

genes like me logo Genes that share pathways with LTA4H: view

Pathways by source for LTA4H Gene

UniProtKB/Swiss-Prot P09960-LKHA4_HUMAN

  • Pathway: Lipid metabolism; leukotriene B4 biosynthesis.

Gene Ontology (GO) - Biological Process for LTA4H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006691 leukotriene metabolic process TAS --
GO:0019370 leukotriene biosynthetic process IEA,IDA 15078870
GO:0043171 peptide catabolic process IDA 15078870
genes like me logo Genes that share ontologies with LTA4H: view

No data available for SIGNOR curated interactions for LTA4H Gene

Drugs & Compounds for LTA4H Gene

(37) Drugs for LTA4H Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Captopril Approved Pharma Inhibition, Inhibitor, Target ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 32
Montelukast Approved Pharma Antagonist 266
Water Approved Pharma 0
(2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid Experimental Pharma Target 0
(4-fluorophenyl)(pyridin-4-yl)methanone Experimental Pharma Target 0

(14) Additional Compounds for LTA4H Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-Keto-tetrahydro-leukotriene B4
  • 12-Keto-10,11,14,15-tetrahydro-LTB4
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoate
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoic acid
Leukotriene A4
  • (5S,6S,7E,9E,11Z,14Z)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
  • (5S,6S,7E,9E,11Z,14Z)-5,6-Epoxyicosa-7,9,11,14-tetraenoic acid
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoic acid
  • (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate
72059-45-1

(1) Tocris Compounds for LTA4H Gene

Compound Action Cas Number
Captopril ACE inhibitor; also inhibits LTA4 hydrolase 62571-86-2

(2) ApexBio Compounds for LTA4H Gene

Compound Action Cas Number
Bestatin Aminopeptidase inhibitor 58970-76-6
SC 57461A LTA4 hydrolase inhibitor,potent and selective 423169-68-0
genes like me logo Genes that share compounds with LTA4H: view

Drug Products

Transcripts for LTA4H Gene

Unigene Clusters for LTA4H Gene

Leukotriene A4 hydrolase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LTA4H Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: - - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:

ExUns: 23b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for LTA4H Gene

GeneLoc Exon Structure for
LTA4H
ECgene alternative splicing isoforms for
LTA4H

Expression for LTA4H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LTA4H Gene

mRNA differential expression in normal tissues according to GTEx for LTA4H Gene

This gene is overexpressed in Whole Blood (x8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LTA4H Gene



Protein tissue co-expression partners for LTA4H Gene

NURSA nuclear receptor signaling pathways regulating expression of LTA4H Gene:

LTA4H

SOURCE GeneReport for Unigene cluster for LTA4H Gene:

Hs.524648

mRNA Expression by UniProt/SwissProt for LTA4H Gene:

P09960-LKHA4_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
genes like me logo Genes that share expression patterns with LTA4H: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for LTA4H Gene

Orthologs for LTA4H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LTA4H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTA4H 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia LTA4H 34 35
  • 90.78 (n)
cow
(Bos Taurus)
Mammalia LTA4H 34 35
  • 90.45 (n)
mouse
(Mus musculus)
Mammalia Lta4h 34 16 35
  • 87.23 (n)
rat
(Rattus norvegicus)
Mammalia Lta4h 34
  • 86.25 (n)
oppossum
(Monodelphis domestica)
Mammalia LTA4H 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LTA4H 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves LTA4H 34 35
  • 74.74 (n)
lizard
(Anolis carolinensis)
Reptilia LTA4H 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lta4h 34
  • 68.37 (n)
zebrafish
(Danio rerio)
Actinopterygii lta4h 34 35
  • 64.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009907 34
  • 54.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10602 36 34 35
  • 51.29 (n)
worm
(Caenorhabditis elegans)
Secernentea ZC416.6 36 34 35
  • 53.14 (n)
C42C1.11 35
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAP2 34 35 37
  • 49.48 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03883g 34
  • 48.53 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13520 34
  • 46.71 (n)
rice
(Oryza sativa)
Liliopsida Os03g0819100 34
  • 46.1 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.27066 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1322.05c 34
  • 49.1 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06732 34
  • 48.17 (n)
Species where no ortholog for LTA4H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LTA4H Gene

ENSEMBL:
Gene Tree for LTA4H (if available)
TreeFam:
Gene Tree for LTA4H (if available)

Paralogs for LTA4H Gene

Paralogs for LTA4H Gene

(2) SIMAP similar genes for LTA4H Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LTA4H: view

Variants for LTA4H Gene

Sequence variations from dbSNP and Humsavar for LTA4H Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs142926035 untested 96,000,349(+) CCCAG(G/T)CTGGA intron-variant, downstream-variant-500B
rs281860641 untested 96,036,093(+) GGGAG(A/G)CACAG intron-variant, upstream-variant-2KB
rs10492226 -- 96,010,211(-) ATTAC(A/T)CTAAT intron-variant, nc-transcript-variant
rs1050970 -- 96,000,913(-) AGCTC(A/C)CAATT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10735340 -- 96,045,212(+) TCTGC(A/G)TGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LTA4H Gene

Variant ID Type Subtype PubMed ID
esv3630445 CNV gain 21293372
esv3630446 CNV loss 21293372
nsv523292 CNV gain 19592680
nsv7234 OTHER inversion 18451855

Variation tolerance for LTA4H Gene

Residual Variation Intolerance Score: 9.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LTA4H Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LTA4H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTA4H Gene

Disorders for LTA4H Gene

Relevant External Links for LTA4H

Genetic Association Database (GAD)
LTA4H
Human Genome Epidemiology (HuGE) Navigator
LTA4H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LTA4H

No disorders were found for LTA4H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LTA4H Gene

Publications for LTA4H Gene

  1. Cloning and characterization of the human leukotriene A4 hydrolase gene. (PMID: 7628486) Mancini J.A. … Evans J.F. (Eur. J. Biochem. 1995) 2 3 4 22 64
  2. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. (PMID: 20067482) Via M. … GonzA!lez Burchard E. (Clin. Exp. Allergy 2010) 3 22 46 64
  3. 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira K.G. … Weiss S.T. (Pharmacogenet. Genomics 2009) 3 22 46 64
  4. Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis. (PMID: 19130089) Crosslin D.R. … Hauser E.R. (Hum. Genet. 2009) 3 22 46 64
  5. Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene. (PMID: 19622707) Zhao J. … Vaccarino V. (Psychosom Med 2009) 3 22 46 64

Products for LTA4H Gene

Sources for LTA4H Gene

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