Aliases for LTA Gene
External Ids for LTA Gene
Previous HGNC Symbols for LTA Gene
Previous GeneCards Identifiers for LTA Gene
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for LTA Gene
LTA (Lymphotoxin Alpha) is a Protein Coding gene. Diseases associated with LTA include Psoriatic Arthritis and Leprosy 4. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF15.
UniProtKB/Swiss-Prot for LTA Gene
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.