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LTA Gene

protein-coding   GIFtS: 65

GC06P031648
lymphotoxin alpha (TNF superfamily, member 1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TNFB)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
LT 1, 2
LT-alpha 3
OTTHUMP00000029184 2
OTTHUMP00000037612 2
OTTHUMP00000037613 2
OTTHUMP00000165897 2
TNF-beta 3
TNFB 2, 3, 5
TNFSF1 1, 2, 3
Descriptions
Tumor necrosis factor ligand superfamily member 1 3
lymphotoxin alpha 2
lymphotoxin alpha (TNF superfamily, member 1) 2
tumor necrosis factor beta 2
External Ids
HGNC: 67091
Entrez Gene: 40492
UniProtKB: P013743
Search outside databases for aliases for LTA gene

Previous GC identifers: GC06P031603 GC06P031593 GC06P031310 GC06P031644

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LTA:
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by
lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with
lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a
large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the
formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic
variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic
arthritis.

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374
Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and
TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced
by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo

Gene Wiki entry for LTA (Lymphotoxin_alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LTA gene  

Entrez Gene cytogenetic band: 6p21.3   HGNC cytogenetic band: 6p21.3

LTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031648:     (about GC identifiers)

Start:
31,648,072 bp from pter
End:
31,650,077 bp from pter
Size:
2,006 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  NT_113891.1  NT_113894.1  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374 (See protein sequence)
Recommended Name: Lymphotoxin-alpha precursor  
Size: 205 amino acids; 22297 Da
Subunit: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent)
two LTA and one LTB subunits
Subcellular location: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is
membrane-associated
PDB structures from and Proteopedia :
1TNR (3D)    
Secondary accessions: Q8N4C3 Q9UKS8

REFSEQ proteins (2 alternative transcripts): 
NP_000586.2  NP_001153212.1  

Human Recombinant Proteins 
Invitrogen human recombinant proteins for LTA
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for LTA  
R&D Systems Recombinant & Natural Proteins for LTA (TNF-beta/TNFSF1B)
Enzo Life Sciences proteins for LTA
Recombinant Proteins from Abcam (TNF beta)
Human Recombinant Proteins from Abnova (LTA)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for LTA: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of LTA
Sigma-Aldrich Antibodies for LTA
R&D Systems Antibodies for LTA (TNF-beta/TNFSF1B)
Antibodies from Abcam (TNF beta), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (LTA)
Novus Biologicals Antibodies for LTA

Assays for LTA: 
Invitrogen Assays for LTA
Millipore Kits and Assays for the Analysis of LTA
R&D Systems ELISAs for LTA (TNF-beta/TNFSF1B)         (see all)
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro domains/families:
 IPR006052 TNF_family
 IPR002960 TNF_beta
 IPR006053 TNF_abc
 IPR008983 Tumour_necrosis_fac-like


   GeneDecks  LTA for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P01374

ProtoNet protein and cluster: P01374

3 Blocks protein families:
IPB002960 Tumour necrosis factor beta (lymphotoxin-alpha) signature
IPB006052 Tumor Necrosis Factor
IPB006053 Tumour necrosis factor family signature


UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374
Similarity: Belongs to the tumor necrosis factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LTA)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000595

              Applied Biosystems Silencer® siRNAs for LTA

              Sigma-Aldrich siRNA and siRNA Panels for LTA  
                     Sigma-Aldrich shRNA Panels and shRNA for LTA  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for LTA
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000595
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000595
                                 untagged cDNA clone in CMV expression vector: NM_000595 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000595

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374
Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and
TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced
by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo

Genatlas biochemistry entry for LTA:
lymphotoxin alpha,expressed in T cells,tumors necrosis factor (ligand) superfamily,member 1

8 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Lta):

digestive/alimentaryendocrine/exocrine glandhematopoietic systemhomeostasis/metabolismimmune system
life span-post-weaning/agingliver/biliary systemrespiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005125 cytokine activity IEA--
GO:0005164 tumor necrosis factor receptor binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Invitrogen iPath™ Online BioAtlas - Pathway for LTA (Maps provided by GeneGo):
 NF-kB signaling pathway

   GeneDecks  LTA for the pathways selected above  
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2 Millipore Pathways for LTA
 Transcription NF-kB signaling pathway
 Apoptosis and survival Lymphotoxin-beta receptor signaling

   GeneDecks  LTA for the pathways selected above  
About GeneDecksing

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for  LTA  (Your Favorite Gene powered by Ingenuity) (see all 6
 CD40 Signaling
 Activation of IRF by Cytosolic Pattern Recognition Receptors
 Type I Diabetes Mellitus Signaling
 Lymphotoxin &beta
 NF-&kappa

   GeneDecks  LTA for the pathways selected above  
About GeneDecksing

3 Kegg Pathways  (Kegg details for LTA):
 hsa04060 Cytokine-cytokine receptor interaction
 hsa04612 Antigen processing and presentation
 hsa04940 Type I diabetes mellitus

   GeneDecks  LTA for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  LTA 


3 Interacting proteins for LTA (P013741, 2) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
TNFRSF14Q929561EBI-524105, EBI-1056653
LGALS2P051622MINT-49838 MINT-49837 MINT-49839 MINT-49836
TUBA1AQ71U362MINT-49840 MINT-49841
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5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0001775 cell activation IEA--
GO:0002037 negative regulation of L-glutamate transport IEA--
GO:0006915 apoptosis IEA--
GO:0006917 induction of apoptosis TAS6334807
GO:0006959 humoral immune response IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LTA
10/33 Novoseek chemical compound relationships for LTA gene (see all 33 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
il 10 49.77 8 16389181 (1), 8621762 (1), 7521890 (1), 9924213 (1) (see all 7)
rantes 48.33 14 10366103 (2), 12620497 (2), 9764576 (1), 14693736 (1) (see all 12)
toxin-1 46.59 2 7911750 (1), 8515117 (1)
ionomycin 35.33 4 8625537 (1), 12176893 (1), 7631148 (1), 8647171 (1)
lipoteichoic acid 31.21 2 16175622 (1), 12439617 (1)
neopterin 25.92 4 8304116 (1), 1825941 (1), 8148443 (1)
endotoxin 14.53 3 8983279 (1), 8001869 (1)
tgf beta1 12.76 3 10641032 (1), 10366103 (1), 16872485 (1)
bisindolylmaleimide 11.68 1 7589108 (1)
p005 7.74 1 12566517 (1)
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2 PharmGKB drug compound relationships for LTA gene
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
etanerceptCO  15457442
infliximabPD  11313304
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LTA)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000595

              Sigma-Aldrich siRNA and siRNA Panels for LTA  
                     Sigma-Aldrich shRNA Panels and shRNA for LTA  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000595  

REFSEQ mRNAs for LTA gene (2 alternative transcripts): 

NM_000595.2   NM_001159740.1   

NM_000595  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000595
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000595
                                 untagged cDNA clone in CMV expression vector: NM_000595 

Additional cDNA sequence: 

BC034729.1 CR542253.1 CR542273.1 CR603193.1 D00102.1 D12614.1 DQ123821.1 DQ123822.1 
DQ123823.1 DQ123824.1 DQ123825.2 DQ123826.1 DQ123827.1 X01393.1 

3 DOTS entries:

DT.411032  DT.100746901  DT.91679243 

24/28 AceView cDNA sequences (see all 28 ):

W74395 D12614 BC034729 BP338937 NM_000595 BI832977 BF796746 CR542253 
BG685356 CD697300 W72329 AI075301 CR542273 BF976097 CR603193 X01393 
BQ643169 AA910185 CD698103 BX370788 BI832903 D00102 AI702790 BX108399 

highest scoring ESTs for LTA:

D12614 AA910185 AI075301 AI239743 AI702790 BC034729 BF796746 BI832977 BU594898 BX108399 

Unigene Cluster for LTA:

Lymphotoxin alpha (TNF superfamily, member 1)
Hs.36  [show with all ESTs]
Unigene Representative Sequence: NM_000595


GeneLoc Exon Structure

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LTA expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LTA

1 / 2 / 3

4 probe-sets matching LTA gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

36296_at2, 3 U95-A 3 1.00 0.33 0.86 0.67 D12614 1.00 1.00 1.00 1

258_at2, 3 U95-A 3 1.00 0.33 0.67 1.37 M16441 0.20 0.50 0.38 1

206975_at2, 3 U133-A 3 1.00 0.33 -- -- NM_000595 0.60 1.00 0.82 1

206975_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.36

Expression variation in blood from EXPOLDB for LTA

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for LTA gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LTA1   -- lymphotoxin alpha (TNF superfamily, member 1) 85.13(n)
77.45(a)
607183  XM_843793.1  XP_848886.1 
chimpanzee
(Pan troglodytes)
LTA1   -- lymphotoxin alpha (TNF superfamily, member 1) 99.51(n)
99.51(a)
744443  XM_001153240.1  XP_001153240.1 
cow
(Bos taurus)
LTA1   -- lymphotoxin alpha (TNF superfamily, member 1) 83.5(n)
74.02(a)
280845  NM_001013401.1  NP_001013419.1 
rat
(Rattus norvegicus)
Lta1   -- lymphotoxin alpha (TNF superfamily, member 1) 80.2(n)
73.76(a)
25008  NM_080769.1  NP_542947.1 
mouse
(Mus musculus)
Lta1, 5 17 (19.06 cM)5
lymphotoxin A1, 5 80.03(n)1
73.27(a)1
169921  NM_010735.11  NP_034865.11 
 AF1097195  AK0803085  (see all 18)
About this table        Species with no ortholog for LTA
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/56 NCBI SNPs in LTA are shown (see all 56 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 85)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs20715901,2
A,C,F,H31647747(-) GGAGGC/TGGTTG 1 -- ng5112Minor allele frequency- T:0.32EA NS NA EU WA 2268
rs20096581,2
A,C,F,H31646223(+) CACATC/GAGTAG 1 -- ng5116Minor allele frequency- G:0.15MN EU EA WA NS NA 1493
rs22397041,2
A,C,F,H31648120(-) ACTGCG/TGGGCG 1 -- ut5122Minor allele frequency- T:0.40EA NS MN CSAM EU WA NA 3424
rs10419811,2
A,C,F,H31648763(+) CAGCAC/ACCTCA 1 N/T mis135Minor allele frequency- A:0.38EA MN NS EU WA NA 4706
--
rs9156541,2
A,C,F,H31646476(-) tttttA/Taaaaa 1 -- ng5112Minor allele frequency- T:0.49NS EU EA WA 1212
rs30935391,2
C,F,H31646256(+) AAGTTG/AGTATT 1 -- ng516Minor allele frequency- A:0.01NS EU EA WA 506
--
rs28444821,2
C,F,H31647746(-) GAGGTG/AGTTGA 1 -- ng5120Minor allele frequency- A:0.13NS NA EU EA WA 2024
--
rs25163121,2
C,F,H31647414(-) CCCCTT/CACTCA 1 -- ng519Minor allele frequency- C:0.02NS EU EA WA NA 772
rs18006831,2
A,C,F31648050(+) GCTCCG/ACACAG 1 -- ng514Minor allele frequency- A:0.38EA NS 1524
rs22290921,2
C,F,H31648736(+) TCAGCA/CCCCCA 1 H/P mis115Minor allele frequency- C:0.04MN NS NA EU EA WA 1310
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HapMap Linkage Disequilibrium images for LTA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 153440

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374

  • Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4)
    [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic
    infectious disease of peripheral sensory nerves caused by Mycobacterium leprae
  • Genetic variations in LTA are associated with susceptibility to psoriatic arthritis
    [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the
    population. It is characterized by red, scaly skin lesions that are usually found on the scalp,
    elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been
    defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative
    arthritis) associated with psoriasis
  • 10/95 Novoseek disease relationships for LTA gene (see all 95 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 88.11 698 9798700 (5), 15224026 (3), 12620497 (3), 8509747 (2) (see all 99)
    tumors 74.15 604 9798700 (5), 15224026 (3), 12620497 (3), 19022528 (2) (see all 99)
    tonsillar hypertrophy 51.72 1 8860357 (1)
    toxic shock syndrome 47.39 4 8515117 (3), 7911750 (1)
    leukemia t-cell 47.31 3 2039827 (1), 1976820 (1), 7696918 (1)
    autoimmune diseases 41.90 8 10600011 (1), 9098447 (1), 12568117 (1), 14617046 (1) (see all 8)
    iga deficiency selective 40.48 1 10909468 (1)
    inflammation 40.37 18 16770523 (3), 2133280 (1), 7590816 (1), 10923599 (1) (see all 15)
    genetic susceptibility 40.21 4 11037831 (1), 17767060 (1), 16939911 (1)
    multiple sclerosis 39.85 18 8624683 (5), 12568117 (2), 17295710 (2), 9098447 (1) (see all 7)
    About this table

    3 PharmGKB disease relationships for LTA gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Arthritis, RheumatoidCO  15457442
    Crohn DiseasePD  11313304
    SepsisCO  GN  10450735
    About this table

    Human Gene Mutation Database: LTA
    Genetic Association Database: LTA
    Human Genome Epidemiology Navigator: LTA (343 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/957 PubMed articles for LTA gene (see all 957 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4049 HGNC: 6709 AceView: LTA euGenes: HUgn4049 ECgene: LTA
    H-InvDB: LTA
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for LTA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Lymphotoxin
    NIEHS-SNPshttp://egp.gs.washington.edu/data/lta/
    SeattleSNPshttp://pga.gs.washington.edu/data/lta/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LTA
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LTA:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LTA-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LTA Antibodies for LTA
     Explore super-pooled esiRNAs Proteins for LTA
     Lentivirus-delivered shRNAs for LTA Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (TNF beta)
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     Search OriGene for LTA
     Search Tocris compounds for LTA




     Proteins for LTA
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LTA

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