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LTA Gene

protein-coding GIFtS: 65

GC06P031648

lymphotoxin alpha (TNF superfamily, member 1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TNFB)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
LT ^¹, ²
LT-alpha ^³
OTTHUMP00000029184 ^²
OTTHUMP00000037612 ^²
OTTHUMP00000037613 ^²
OTTHUMP00000165897 ^²
TNF-beta ^³
TNFB ^², ³, ⁵
TNFSF1 ^¹, ², ³

Descriptions
Tumor necrosis factor ligand superfamily member 1 ^³
lymphotoxin alpha ^²
lymphotoxin alpha (TNF superfamily, member 1) ^²
tumor necrosis factor beta ^²

External Ids
HGNC: 6709¹
Entrez Gene: 4049²
UniProtKB: P01374³

Search outside databases for aliases for LTA gene

Previous GC identifers: GC06P031603 GC06P031593 GC06P031310 GC06P031644

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LTA:

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by

lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with

lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a

large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the

formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic

variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic

arthritis.

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374

Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and

TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced

by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo

Gene Wiki entry for LTA (Lymphotoxin_alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LTA gene

Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3

LTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P031648: (about GC identifiers)

Start:	31,648,072 bp from pter
End:	31,650,077 bp from pter
Size:	2,006 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113894.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374 (See protein sequence)

Recommended Name: Lymphotoxin-alpha precursor

Size: 205 amino acids; 22297 Da

Subunit: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent)

two LTA and one LTB subunits

Subcellular location: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is

membrane-associated

PDB structures from and Proteopedia :

1TNR (3D)

Secondary accessions: Q8N4C3 Q9UKS8

REFSEQ proteins (2 alternative transcripts):

NP_000586.2 NP_001153212.1

Human Recombinant Proteins

	Invitrogen human recombinant proteins for LTA
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for LTA
	R&D Systems Recombinant & Natural Proteins for LTA (TNF-beta/TNFSF1B)
	Enzo Life Sciences proteins for LTA
	Recombinant Proteins from Abcam (TNF beta)
	Human Recombinant Proteins from Abnova (LTA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for LTA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LTA
	Sigma-Aldrich Antibodies for LTA
	R&D Systems Antibodies for LTA (TNF-beta/TNFSF1B)
	Antibodies from Abcam (TNF beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LTA)
	Novus Biologicals Antibodies for LTA

Assays for LTA:

	Invitrogen Assays for LTA
	Millipore Kits and Assays for the Analysis of LTA
	R&D Systems ELISAs for LTA (TNF-beta/TNFSF1B) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01374

ProtoNet protein and cluster: P01374

3 Blocks protein families:

IPB002960 Tumour necrosis factor beta (lymphotoxin-alpha) signature

IPB006052 Tumor Necrosis Factor

IPB006053 Tumour necrosis factor family signature

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374

Similarity: Belongs to the tumor necrosis factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LTA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000595

Applied Biosystems Silencer® siRNAs for LTA

Sigma-Aldrich siRNA and siRNA Panels for LTA

Sigma-Aldrich shRNA Panels and shRNA for LTA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LTA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000595
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000595
untagged cDNA clone in CMV expression vector: NM_000595

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000595

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374

Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and

TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced

by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo

Genatlas biochemistry entry for LTA:

lymphotoxin alpha,expressed in T cells,tumors necrosis factor (ligand) superfamily,member 1

8 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Lta):

digestive/alimentary	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
life span-post-weaning/aging	liver/biliary system	respiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005164	tumor necrosis factor receptor binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for LTA (Your Favorite Gene powered by Ingenuity) (see all 6 )

CD40 Signaling
Activation of IRF by Cytosolic Pattern Recognition Receptors
Type I Diabetes Mellitus Signaling
Lymphotoxin &beta
NF-&kappa

GeneDecks LTA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for LTA

3 Interacting proteins for LTA (P01374^{1, 2}) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
TNFRSF14 Q92956¹ EBI-524105, EBI-1056653
LGALS2 P05162² MINT-49838 MINT-49837 MINT-49839 MINT-49836
TUBA1A Q71U36² MINT-49840 MINT-49841
About this table
5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0001775 cell activation IEA --
GO:0002037 negative regulation of L-glutamate transport IEA --
GO:0006915 apoptosis IEA --
GO:0006917 induction of apoptosis TAS 6334807
GO:0006959 humoral immune response IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LTA
10/33 Novoseek chemical compound relationships for LTA gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
il 10	49.77	8	16389181 (1), 8621762 (1), 7521890 (1), 9924213 (1) (see all 7)
rantes	48.33	14	10366103 (2), 12620497 (2), 9764576 (1), 14693736 (1) (see all 12)
toxin-1	46.59	2	7911750 (1), 8515117 (1)
ionomycin	35.33	4	8625537 (1), 12176893 (1), 7631148 (1), 8647171 (1)
lipoteichoic acid	31.21	2	16175622 (1), 12439617 (1)
neopterin	25.92	4	8304116 (1), 1825941 (1), 8148443 (1)
endotoxin	14.53	3	8983279 (1), 8001869 (1)
tgf beta1	12.76	3	10641032 (1), 10366103 (1), 16872485 (1)
bisindolylmaleimide	11.68	1	7589108 (1)
p005	7.74	1	12566517 (1)

About this table

2 PharmGKB drug compound relationships for LTA gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
etanercept	CO	15457442
infliximab	PD	11313304

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LTA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000595

Sigma-Aldrich siRNA and siRNA Panels for LTA

Sigma-Aldrich shRNA Panels and shRNA for LTA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000595

REFSEQ mRNAs for LTA gene (2 alternative transcripts):

NM_000595.2 NM_001159740.1

NM_000595

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000595
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000595
                                 untagged cDNA clone in CMV expression vector: NM_000595

Additional cDNA sequence:

BC034729.1 CR542253.1 CR542273.1 CR603193.1 D00102.1 D12614.1 DQ123821.1 DQ123822.1

DQ123823.1 DQ123824.1 DQ123825.2 DQ123826.1 DQ123827.1 X01393.1

3 DOTS entries:

DT.411032 DT.100746901 DT.91679243

24/28 AceView cDNA sequences (see all 28 ):

W74395 D12614 BC034729 BP338937 NM_000595 BI832977 BF796746 CR542253

BG685356 CD697300 W72329 AI075301 CR542273 BF976097 CR603193 X01393

BQ643169 AA910185 CD698103 BX370788 BI832903 D00102 AI702790 BX108399

highest scoring ESTs for LTA:

D12614 AA910185 AI075301 AI239743 AI702790 BC034729 BF796746 BI832977 BU594898 BX108399

Unigene Cluster for LTA:

Lymphotoxin alpha (TNF superfamily, member 1)

Hs.36 [show with all ESTs]

Unigene Representative Sequence: NM_000595

GeneLoc Exon Structure

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LTA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LTA

¹ / ² / ³

4 probe-sets matching LTA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36296_at²^{, 3}	U95-A	3	1.00	0.33	0.86	0.67	D12614	1.00	1.00	1.00	1
258_at²^{, 3}	U95-A	3	1.00	0.33	0.67	1.37	M16441	0.20	0.50	0.38	1
206975_at²^{, 3}	U133-A	3	1.00	0.33	--	--	NM_000595	0.60	1.00	0.82	1
206975_at²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.36
Expression variation in blood from EXPOLDB for LTA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LTA gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LTA¹	--	lymphotoxin alpha (TNF superfamily, member 1)	85.13(n) 77.45(a)	607183 XM_843793.1 XP_848886.1
chimpanzee (Pan troglodytes)	LTA¹	--	lymphotoxin alpha (TNF superfamily, member 1)	99.51(n) 99.51(a)	744443 XM_001153240.1 XP_001153240.1
cow (Bos taurus)	LTA¹	--	lymphotoxin alpha (TNF superfamily, member 1)	83.5(n) 74.02(a)	280845 NM_001013401.1 NP_001013419.1
rat (Rattus norvegicus)	Lta¹	--	lymphotoxin alpha (TNF superfamily, member 1)	80.2(n) 73.76(a)	25008 NM_080769.1 NP_542947.1
mouse (Mus musculus)	Lta^{1, 5}	17 (19.06 cM)⁵	lymphotoxin A^{1, 5}	80.03(n)¹ 73.27(a)¹	16992¹ NM_010735.1¹ NP_034865.1¹ AF109719⁵ AK080308⁵ (see all 18)

About this table Species with no ortholog for LTA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/56 NCBI SNPs in LTA are shown (see all 56 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 85)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2071590^1,2	A,C,F,H	31647747(-)	`GGAGGC/TGGTTG`	1	--	ng5¹		12	EA NS NA EU WA	2268
	rs2009658^1,2	A,C,F,H	31646223(+)	`CACATC/GAGTAG`	1	--	ng5¹		16	MN EU EA WA NS NA	1493
	rs2239704^1,2	A,C,F,H	31648120(-)	`ACTGCG/TGGGCG`	1	--	ut5¹		22	EA NS MN CSAM EU WA NA	3424
	rs1041981^1,2	A,C,F,H	31648763(+)	`CAGCAC/ACCTCA`	1	N/T	mis¹		35	EA MN NS EU WA NA	4706
--	rs915654^1,2	A,C,F,H	31646476(-)	`tttttA/Taaaaa`	1	--	ng5¹		12	NS EU EA WA	1212
	rs3093539^1,2	C,F,H	31646256(+)	`AAGTTG/AGTATT`	1	--	ng5¹		6	NS EU EA WA	506
--	rs2844482^1,2	C,F,H	31647746(-)	`GAGGTG/AGTTGA`	1	--	ng5¹		20	NS NA EU EA WA	2024
--	rs2516312^1,2	C,F,H	31647414(-)	`CCCCTT/CACTCA`	1	--	ng5¹		9	NS EU EA WA NA	772
	rs1800683^1,2	A,C,F	31648050(+)	`GCTCCG/ACACAG`	1	--	ng5¹		4	EA NS	1524
	rs2229092^1,2	C,F,H	31648736(+)	`TCAGCA/CCCCCA`	1	H/P	mis¹		15	MN NS NA EU EA WA	1310

About this table

HapMap Linkage Disequilibrium images for LTA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 153440

UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374

Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4)

[MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic

infectious disease of peripheral sensory nerves caused by Mycobacterium leprae

Genetic variations in LTA are associated with susceptibility to psoriatic arthritis

[MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the

population. It is characterized by red, scaly skin lesions that are usually found on the scalp,

elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been

defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative

arthritis) associated with psoriasis

10/95 Novoseek disease relationships for LTA gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	88.11	698	9798700 (5), 15224026 (3), 12620497 (3), 8509747 (2) (see all 99)
tumors	74.15	604	9798700 (5), 15224026 (3), 12620497 (3), 19022528 (2) (see all 99)
tonsillar hypertrophy	51.72	1	8860357 (1)
toxic shock syndrome	47.39	4	8515117 (3), 7911750 (1)
leukemia t-cell	47.31	3	2039827 (1), 1976820 (1), 7696918 (1)
autoimmune diseases	41.90	8	10600011 (1), 9098447 (1), 12568117 (1), 14617046 (1) (see all 8)
iga deficiency selective	40.48	1	10909468 (1)
inflammation	40.37	18	16770523 (3), 2133280 (1), 7590816 (1), 10923599 (1) (see all 15)
genetic susceptibility	40.21	4	11037831 (1), 17767060 (1), 16939911 (1)
multiple sclerosis	39.85	18	8624683 (5), 12568117 (2), 17295710 (2), 9098447 (1) (see all 7)

About this table

3 PharmGKB disease relationships for LTA gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Arthritis, Rheumatoid	CO	15457442
Crohn Disease	PD	11313304
Sepsis	CO GN	10450735

About this table

Human Gene Mutation Database: LTA
Genetic Association Database: LTA
Human Genome Epidemiology Navigator: LTA (343 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/957 PubMed articles for LTA gene (see all 957 ):

The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. (PubMed id 15457442)^{1, 3, 6, 7} Criswell L.A....Bridges S.L. (2004)
Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. (PubMed id 1670638)^{1, 3, 4} Messer G.... Weiss E.H. (1991)
Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. (PubMed id 15969671)^{1, 3, 6} Migita O....Arinami T. (2005)
[Association between tumor necrosis factor-beta polymorphisms and coronary heart disease in a Chinese population.] (PubMed id 15583987)^{1, 3, 6} Li Y....Huang C.X. (2004)
Interactions of lymphotoxin alpha (TNF-beta), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis. (PubMed id 11210078)^{1, 3, 6} Holla L.I....Vacha J. (2001)
The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech population. (PubMed id 11591192)^{1, 3, 6} Izakovicova Holla L....Znojil V. (2001)
Polymorphisms in the +252(A/G) lymphotoxin-alpha and the -308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population. (PubMed id 12828656)^{1, 3, 6} Fassmann A....Vanek J. (2003)
An association study in essential hypertension using functional polymorphisms in lymphotoxin-alpha gene. (PubMed id 15533732)^{1, 3, 6} Nakayama T....Kokubun S. (2004)
Association of a TNFbeta gene polymorphism with complications after major abdominal operations. (PubMed id 12558135)^{1, 3, 6} Riese J....Haupt W. (2003)
[Polymorphism of angiotensin converting enzyme (ACE) and TNF-beta genes in men with disorders of spermatogenesis--pilot study] (PubMed id 11732226)^{1, 3, 6} Kucera M....Znojil V. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4049	HGNC: 6709	AceView: LTA	euGenes: HUgn4049	ECgene: LTA
H-InvDB: LTA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LTA	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Lymphotoxin
NIEHS-SNPs	http://egp.gs.washington.edu/data/lta/
SeattleSNPs	http://pga.gs.washington.edu/data/lta/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LTA

Licensable Technologies for LTA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LTA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LTA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LTA		Antibodies for LTA
	Explore super-pooled esiRNAs		Proteins for LTA
	Lentivirus-delivered shRNAs for LTA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Recombinant Proteins (LTA)
	Antibodies (LTA)
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Antibodies for LTA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LTA Gene at Home site.
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LTA Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for LTA

Summaries
for LTA

Genomic Location
for LTA

Proteins
for LTA

Protein Domains/
Families
for LTA

Gene Function
for LTA

Pathways & Interactions
for LTA

Drugs & Compounds
for LTA

Transcripts
for LTA

Expression
for LTA

Orthologs
for LTA

Paralogs
for LTA

SNPs/Variants
for LTA

Disorders & Mutations
for LTA

Medical News
for LTA

Publications
for LTA

Search for LTA

Genome Databases showing LTA

Other Databases showing LTA

Specialized Databases showing LTA

Licensable Technologies
for LTA

Services
for LTA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LTA Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor LTA

Summariesfor LTA

Genomic Locationfor LTA

Proteinsfor LTA

Protein Domains/Familiesfor LTA

Gene Functionfor LTA

Pathways & Interactionsfor LTA

Drugs & Compoundsfor LTA

Transcriptsfor LTA

Expression for LTA

Orthologsfor LTA

Paralogsfor LTA

SNPs/Variantsfor LTA

Disorders & Mutationsfor LTA

Medical Newsfor LTA

Publicationsfor LTA

Search for LTA

Genome Databases showing LTA

Other Databases showing LTA

Specialized Databases showing LTA

Licensable Technologiesfor LTA

Servicesfor LTA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LTA

Summaries
for LTA

Genomic Location
for LTA

Proteins
for LTA

Protein Domains/
Families
for LTA

Gene Function
for LTA

Pathways & Interactions
for LTA

Drugs & Compounds
for LTA

Transcripts
for LTA

Expression
for LTA

Orthologs
for LTA

Paralogs
for LTA

SNPs/Variants
for LTA

Disorders & Mutations
for LTA

Medical News
for LTA

Publications
for LTA

Licensable Technologies
for LTA

Services
for LTA