LTA Gene
protein-coding GIFtS: 64
GCID: GC06P031541
|
|
lymphotoxin alpha (TNF superfamily, member 1) (Previous symbol: TNFB)
| |
Aliases for LTA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Lymphotoxin Alpha (TNF Superfamily, Member 1)1 2 | | LT-Alpha1 | | TNFB1 2 3 5 | | TNF-Beta1 | | TNFSF11 2 3 | | Lymphotoxin-Alpha1 | | LT1 2 | | Tumor Necrosis Factor Beta2 | | Tumor Necrosis Factor Ligand Superfamily Member 12 3 | | |
Export aliases for LTA gene to outside databasesPrevious GC identifers: GC06P031603 GC06P031593 GC06P031310 GC06P031644 GC06P031648 GC06P031540 GC06P031326 |
Summaries for LTA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for LTA: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The proteinis highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to thecell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses,is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Geneticvariations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin'slymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.(provided by RefSeq, Jul 2012) UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In itsheterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a widerange of tumor cells in vitro and in vivo Gene Wiki entry for LTA (Lymphotoxin alpha)
|
Genomic Views for LTA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1
- NT_167249.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the LTA gene promoter: c-Fos p53 AP-1 ATF-2 c-Jun Other transcription factors
Search SABiosciences Chromatin IP Primers for LTA
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LTA |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3LTA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P031541: view genomic region
(about GC identifiers)
Start:
|
31,539,831 bp from pter |
End:
|
31,542,101 bp from pter |
Size:
|
2,271 bases |
Orientation:
|
plus strand |
6 alternative locations:
| Chr6+,ALT_REF_LOCI_5 31,531,003-31,533,227 | Chr6+,ALT_REF_LOCI_4 31,502,419-31,504,641 | Chr6+,ALT_REF_LOCI_6 31,530,070-31,567,920 | | Chr6+,ALT_REF_LOCI_3 31,521,973-31,535,280 | Chr6+,ALT_REF_LOCI_2 31,527,243-31,568,698 | Chr6+,ALT_REF_LOCI_7 31,460,142-31,462,364 | |
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Proteins for LTA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374 (See
protein sequence)Recommended Name: Lymphotoxin-alpha precursor Size: 205 amino acids; 22297 Da
Subunit: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTBsubunits
Subcellular location: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated
1 PDB 3D structure from and Proteopedia for LTA:1TNR (3D)
 
Secondary accessions: Q8N4C3 Q9UKS8Explore the universe of human proteins at neXtProt for LTA: NX_P01374
LTA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000586.2 NP_001153212.1 ENSEMBL proteins: ENSP00000403495 ENSP00000413450 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
LTA for ontologies About GeneDecksing
LTA Antibody Products: Assay Products for LTA: |
Protein
Domains / Families for LTA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LTA for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01374ProtoNet protein and cluster: P01374 3 Blocks protein families: IPB002960 Tumour necrosis factor beta (lymphotoxin-alpha) signature IPB006052 Tumor Necrosis Factor IPB006053 Tumour necrosis factor family signature
UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374Similarity: Belongs to the tumor necrosis factor family |
Function for LTA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In itsheterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a widerange of tumor cells in vitro and in vivo Genatlas biochemistry entry for LTA:lymphotoxin alpha,expressed in T cells,tumors necrosis factor (ligand) superfamily,member 1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LTA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LTA (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): LTA (NM_001833) | |  | Sino Biological Human cDNA Clone for LTA | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LTA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LTA  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTA |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
LTA for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for LTA: Animal Models: Mouse knock-outs for LTA: Lta/TnfLta/tm1Fda Ltatm1.1Sned Lta/TnfLta/tm1Eug Lta/TnfLta/tm1Jods Ltatm1Jods Ltatm1Tab Ltb/Tnf/LtaLtb/Tnf/tm1Dvk Ltatm1Dch 15 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Lta):
LTA for phenotypes About GeneDecksing
|
Pathways & Interactions for LTA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PEDF Induced Signaling | | | 2 | Rho Family GTPases | | | 3 | TRAF Pathway | | | 4 | Apoptosis and survival_Lymphotoxin-beta receptor signaling | | | 5 | Transcription NF-kB signaling pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2 EMD Millipore Pathways for LTA 2 R&D Systems Pathways for LTA 5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LTA (see all 33) 2 GeneGo (Thomson Reuters) Pathways for LTA 3 BioSystems Pathways for LTA 
2
Kegg Pathways (Kegg details for LTA):
LTA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LTA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
 5/11 Interacting proteins for LTA (P013742, 3 ENSP000004034954) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001666 | response to hypoxia |
IEA | -- | | GO:0002876 | positive regulation of chronic inflammatory response to antigenic stimulus |
IEA | -- | | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin |
IEA | -- | | GO:0006917 | induction of apoptosis |
TAS | 6334807 | | GO:0006959 | humoral immune response |
IEA | -- |
LTA for ontologies About GeneDecksing
|
Drugs & Compounds for LTA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LTA for compounds About GeneDecksing
Browse Tocris compounds for LTA
1 DrugBank Compound for LTA About this table
10/61 Novoseek chemical compound relationships for LTA gene (see all 61) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| il 10 |
53.8 |
8 |
16389181 (1), 8621762 (1), 7521890 (1), 9924213 (1) (see all 7) |
| rantes |
47.3 |
14 |
10366103 (2), 12620497 (2), 9764576 (1), 14693736 (1) (see all 12) |
| toxin-1 |
45.7 |
2 |
7911750 (1), 8515117 (1) |
| lipoteichoic acid |
36.2 |
2 |
16175622 (1), 12439617 (1) |
| ionomycin |
34.7 |
4 |
8625537 (1), 12176893 (1), 7631148 (1), 8647171 (1) |
| actinomycin d |
26.5 |
4 |
1707879 (1), 7535097 (1), 10721723 (1), 16280692 (1) |
| etanercept |
25.3 |
4 |
15005015 (1), 18473978 (1), 12749755 (1), 11458980 (1) |
| neopterin |
25 |
4 |
8304116 (1), 1825941 (1), 8148443 (1) |
| okt3 |
18.9 |
1 |
7993789 (1) |
| pge2 |
14.3 |
11 |
8442433 (3), 8777276 (2), 1707006 (1), 1815239 (1) (see all 5) |
1 PharmGKB related drug/compound annotation for LTA geneAbout this table
Search CenterWatch for drugs/clinical trials and news about LTA / TNFB 
|
Transcripts for LTA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for LTA gene (2 alternative transcripts): NM_000595.3 NM_001159740.2 Unigene Cluster for LTA: Lymphotoxin alpha (TNF superfamily, member 1) Hs.36 [show with all ESTs]Unigene Representative Sequence: NM_0011597404 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000454783(uc011dnu.1) ENST00000489638(uc003nuf.3 uc003nuh.3 uc003nug.3 uc010jsr.3) ENST00000418386(uc003nue.1) ENST00000471842
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LTA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LTA (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): LTA (NM_001833) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LTA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LTA  |
Additional cDNA sequence: BC034729.1 CR542253.1 CR542273.1 D00102.1 D12614.1 DQ123821.1 DQ123822.1 DQ123823.1 DQ123824.1 DQ123825.2 DQ123826.1 DQ123827.1 X01393.1 3 DOTS entries: DT.411032 DT.100746901 DT.91679243 24/28 AceView cDNA sequences (see all 28): W74395 BC034729 BP338937 D12614 NM_000595 CD697300 AI075301 CR603193 X01393 BI832977 CR542273 W72329 BG685356 BF976097 BQ643169 BF796746 CR542253 D00102 CD698103 BI832903 BX370788 BX108399 AI702790 AA910185 GeneLoc Exon Structure
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Expression for LTA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LTA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See LTA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for LTA
SOURCE GeneReport for Unigene cluster: Hs.36 SABiosciences Expression via Pathway-Focused PCR Arrays including LTA (see all 16):
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LTA Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LTA | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LTA | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTA | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTA |
Orthologs for LTA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LTA gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
zebrafish (Danio rerio) |
Actinopterygii |
tnfa6tnfb6 |
tumor necrosis factor a (TNF superfamily, member 2...tumor necrosis factor b (TNF superfamily, member 2... |
24(a)24(a) |
many ↔ manymany ↔ many |
19(27505097-27509684) 15(33995840-33998916) |
ENSEMBL Gene Tree for LTA (if available) TreeFam Gene Tree for LTA (if available)  |
Paralogs for LTA gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for LTA gene
- FASLG2 TNFSF152 TNFSF142 TNF2
2 SIMAP similar genes for LTA using alignment to 19 protein entries: TNFB_HUMAN (see all proteins):LTB TNF
LTA for paralogs About GeneDecksing
|
Genomic Variants for LTA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374Polymorphism: A polymorphism in LTA accounts, in part, for susceptibility to leprosy linked to chromosome 6p21.3(LPRS4) [MIM:610988]
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for LTA (31539831 - 31542101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for LTA 1 CNV: 2625 Human Gene Mutation Database (HGMD): LTA
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LTA |
|
Disorders
/ Diseases for LTA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LTA for disorders About GeneDecksing
OMIM gene information: 153440 OMIM disorders: 607507 610988 UniProtKB/Swiss-Prot: TNFB_HUMAN, P01374
Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS isan inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild,non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have beendefined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes;asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by arheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare butdeforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis) 20/230 diseases for LTA (see all 230): About MalaCardsnon-hodgkin lymphoma myocardial infarction psoriatic arthritis hodgkin's lymphoma leprosy post-transplant lymphoproliferative disease graft versus host disease monoclonal gammopathy of uncertain significance arthritis spinal cord injury dengue hemorrhagic fever diffuse large b-cell lymphoma human t-cell leukemia virus type 1 hypersensitivity reaction type ii disease acute graft versus host disease sympathetic ophthalmia chronic venous leg ulcers myocardial infarction susceptibility cor pulmonale optic neuritis
1 disease from the University of Copenhagen DISEASES database for LTA:Cancer 10/95 Novoseek disease relationships for LTA gene (see all 95) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
87.9 |
723 |
9798700 (5), 15224026 (3), 12620497 (3), 8509747 (2) (see all 99) |
| tumors |
73.9 |
627 |
9798700 (5), 15224026 (3), 12620497 (3), 19022528 (2) (see all 99) |
| tonsillar hypertrophy |
50 |
1 |
8860357 (1) |
| leukemia t-cell |
46.5 |
3 |
2039827 (1), 1976820 (1), 7696918 (1) |
| toxic shock syndrome |
46.3 |
4 |
8515117 (3), 7911750 (1) |
| genetic susceptibility |
46.1 |
4 |
11037831 (1), 17767060 (1), 16939911 (1) |
| autoimmune diseases |
41.1 |
8 |
10600011 (1), 9098447 (1), 12568117 (1), 14617046 (1) (see all 8) |
| miscarriage recurrent |
40.9 |
5 |
11737072 (3), 18299433 (1), 18394614 (1) |
| inflammation |
40.7 |
18 |
16770523 (3), 2133280 (1), 7590816 (1), 10923599 (1) (see all 15) |
| multiple sclerosis |
40.1 |
19 |
8624683 (5), 12568117 (2), 17295710 (2), 9098447 (1) (see all 8) |
Genetic Association Database (GAD): LTA Human Genome Epidemiology (HuGE) Navigator: LTA (450 documents) Export disorders for LTA gene to outside databases
|
Publications for LTA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LTA gene, integrated from 9 sources (see all 1096): (articles sorted by number of sources associating them with LTA) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. (PubMed id 1670638)1, 2, 9 Messer G.... Weiss E.H. (1991)
- Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. (PubMed id 15969671)1, 4, 9 Migita O....Arinami T. (2005)
- [Association between tumor necrosis factor-beta polymorphisms and coronary heart disease in a Chinese population.] (PubMed id 15583987)1, 4, 9 Li Y....Huang C.X. (2004)
- The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech population. (PubMed id 11591192)1, 4, 9 Izakovicova Holla L....Znojil V. (2001)
- Interactions of lymphotoxin alpha (TNF-beta), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis. (PubMed id 11210078)1, 4, 9 Holla L.I....Vacha J. (2001)
- Polymorphisms in the +252(A/G) lymphotoxin-alpha and the -308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population. (PubMed id 12828656)1, 4, 9 Fassmann A....Vanek J. (2003)
- An association study in essential hypertension using functional polymorphisms in lymphotoxin-alpha gene. (PubMed id 15533732)1, 4, 9 Nakayama T....Kokubun S. (2004)
- Association of a TNFbeta gene polymorphism with complications after major abdominal operations. (PubMed id 12558135)1, 4, 9 Riese J....Haupt W. (2003)
- [Polymorphism of angiotensin converting enzyme (ACE) and TNF-beta genes in men with disorders of spermatogenesis--pilot study] (PubMed id 11732226)1, 4, 9 Kucera M....Znojil V. (2001)
- MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus. (PubMed id 16107511)1, 4, 9 McHugh N.J....Welsh K. (2006)
|
External Searches for LTA gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LTA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LTA gene
(According to HUGE)
About This Section
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Specialized Databases showing LTA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Name | Description |
| PharmGKB entry for LTA | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for LTA | Genetics and Cytogenetics in Oncology and Haematology | | Wikipedia | http://en.wikipedia.org/wiki/Lymphotoxin | | NIEHS-SNPs | http://egp.gs.washington.edu/data/lta/ | | SeattleSNPs | http://pga.gs.washington.edu/data/lta/ | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LTA |
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About This Section
| Patent Information for LTA gene: Search GeneIP for patents involving LTA
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for LTA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | OriGene Antibodies for LTA | | OriGene shRNA RFP for LTA | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LTA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LTA | | OriGene Protein Over-expression Lysate for LTA | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for LTA | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LTA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LTA | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for LTA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for LTA | | OriGene Custom Protein Services for LTA | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LTA | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LTA | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LTA | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LTA | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LTA | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LTA |
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| | | Search Tocris compounds for LTA |
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 | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LTA |
|  |  |  | | | Search ThermoFisher Antibodies for LTA |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LTA |
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