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Aliases for LST1 Gene

Aliases for LST1 Gene

  • Leukocyte Specific Transcript 1 2 3 5
  • B144 3 4
  • Lymphocyte Antigen 117 3
  • Protein B144 4
  • D6S49E 3
  • LST-1 3

External Ids for LST1 Gene

Previous GeneCards Identifiers for LST1 Gene

  • GC06P031617
  • GC06P031324
  • GC06P031658
  • GC06P031661
  • GC06P031556
  • GC06P031557
  • GC06P031340
  • GC06P031558
  • GC06P031568
  • GC06P031718
  • GC06P031760
  • GC06P031615
  • GC06P031625

Summaries for LST1 Gene

Entrez Gene Summary for LST1 Gene

  • The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for LST1 Gene

LST1 (Leukocyte Specific Transcript 1) is a Protein Coding gene. Diseases associated with LST1 include Hyperbilirubinemia, Rotor Type, Digenic and Chronic Venous Leg Ulcers.

UniProtKB/Swiss-Prot for LST1 Gene

  • Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.

Gene Wiki entry for LST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LST1 Gene

Genomics for LST1 Gene

Regulatory Elements for LST1 Gene

Enhancers for LST1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LST1 on UCSC Golden Path with GeneCards custom track

Promoters for LST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LST1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LST1 Gene

Chromosome:
6
Start:
31,586,124 bp from pter
End:
31,588,909 bp from pter
Size:
2,786 bases
Orientation:
Plus strand

Genomic View for LST1 Gene

Genes around LST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for LST1 Gene

  • Protein details for LST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00453-LST1_HUMAN
    Recommended name:
    Leukocyte-specific transcript 1 protein
    Protein Accession:
    O00453
    Secondary Accessions:
    • B0S8E0
    • B0S8E1
    • B0S8E5
    • O00452
    • O00454
    • Q13669
    • Q2HNT3
    • Q5HYS9
    • Q5SP24
    • Q5STA5
    • Q5STA6
    • Q5STA7
    • Q5STA8
    • Q5STW6
    • Q9UJR5
    • Q9UJR6
    • Q9UJR7
    • Q9UJR8
    • Q9UJS1

    Protein attributes for LST1 Gene

    Size:
    97 amino acids
    Molecular mass:
    10792 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX45332.1; Type=Erroneous termination; Positions=47; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for LST1 Gene

neXtProt entry for LST1 Gene

Proteomics data for LST1 Gene at MOPED

Post-translational modifications for LST1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for LST1

No data available for DME Specific Peptides for LST1 Gene

Domains & Families for LST1 Gene

Protein Domains for LST1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LST1 Gene

Graphical View of Domain Structure for InterPro Entry

O00453

UniProtKB/Swiss-Prot:

LST1_HUMAN :
  • Belongs to the LST1 family.
Family:
  • Belongs to the LST1 family.
genes like me logo Genes that share domains with LST1: view

No data available for Gene Families for LST1 Gene

Function for LST1 Gene

Molecular function for LST1 Gene

GENATLAS Biochemistry:
leukocyte specific transcript 1,with several alternatively spliced isoforms,homolog of the mouse B144 transcript,predominantly expressed in monocytes
UniProtKB/Swiss-Prot Function:
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma. Up-regulated upon autoimmune and bacterially-induced inflammation.

Phenotypes for LST1 Gene

genes like me logo Genes that share phenotypes with LST1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LST1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LST1 Gene

Localization for LST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LST1 Gene

Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LST1 Gene COMPARTMENTS Subcellular localization image for LST1 gene
Compartment Confidence
extracellular 3
nucleus 2

Gene Ontology (GO) - Cellular Components for LST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
genes like me logo Genes that share ontologies with LST1: view

Pathways & Interactions for LST1 Gene

SuperPathways for LST1 Gene

No Data Available

Interacting Proteins for LST1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365261%0d%0a9606.ENSP00000206595%0d%0a9606.ENSP00000305355%0d%0a
Selected Interacting proteins: ENSP00000365261 O00453-LST1_HUMAN for LST1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for LST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0008360 regulation of cell shape IEA --
genes like me logo Genes that share ontologies with LST1: view

No data available for Pathways by source and SIGNOR curated interactions for LST1 Gene

Drugs & Compounds for LST1 Gene

(4) Drugs for LST1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abacavir Approved, Investigational Pharma 205
Carbamazepine Approved, Investigational Pharma 128
Cyclosporine Approved, Investigational Pharma Immunosuppressant drug 0
Mycophenolate mofetil Approved, Investigational Pharma IMPDH inhibitor 906
genes like me logo Genes that share compounds with LST1: view

Transcripts for LST1 Gene

Unigene Clusters for LST1 Gene

Leukocyte specific transcript 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LST1 Gene

No ASD Table

Relevant External Links for LST1 Gene

GeneLoc Exon Structure for
LST1
ECgene alternative splicing isoforms for
LST1

Expression for LST1 Gene

mRNA expression in normal human tissues for LST1 Gene

mRNA differential expression in normal tissues according to GTEx for LST1 Gene

This gene is overexpressed in Whole Blood (x33.4) and Spleen (x6.0).

Protein differential expression in normal tissues from HIPED for LST1 Gene

This gene is overexpressed in Urine (36.9), Monocytes (17.5), and Peripheral blood mononuclear cells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LST1 Gene



SOURCE GeneReport for Unigene cluster for LST1 Gene Hs.436066

mRNA Expression by UniProt/SwissProt for LST1 Gene

O00453-LST1_HUMAN
Tissue specificity: Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain.
genes like me logo Genes that share expression patterns with LST1: view

Protein tissue co-expression partners for LST1 Gene

- Elite partner

Primer Products

Orthologs for LST1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LST1 35
  • 99.31 (n)
  • 98.97 (a)
dog
(Canis familiaris)
Mammalia LST1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lst1 36
  • 53 (a)
OneToOne
Species with no ortholog for LST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LST1 Gene

ENSEMBL:
Gene Tree for LST1 (if available)
TreeFam:
Gene Tree for LST1 (if available)

Paralogs for LST1 Gene

No data available for Paralogs for LST1 Gene

Variants for LST1 Gene

Sequence variations from dbSNP and Humsavar for LST1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs7738261 -- 31,585,087(+) gcaac(A/G)tagta upstream-variant-2KB
rs2256965 -- 31,587,353(-) AGGAC(A/C/T)CTCTC intron-variant
rs2256974 -- 31,587,615(-) GGTTA(A/G/T)GAAGC intron-variant
rs7758790 -- 31,585,073(+) CAAAA(C/T)CAGCC upstream-variant-2KB
rs2471961 -- 31,585,397(-) TCAGG(G/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LST1 Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294

Variation tolerance for LST1 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LST1 Gene

Human Gene Mutation Database (HGMD)
LST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LST1 Gene

Disorders for LST1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LST1 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
hyperbilirubinemia, rotor type, digenic
  • rotor syndrome
chronic venous leg ulcers
- elite association - COSMIC cancer census association via MalaCards
Search LST1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LST1

Genetic Association Database (GAD)
LST1
Human Genome Epidemiology (HuGE) Navigator
LST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LST1
genes like me logo Genes that share disorders with LST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LST1 Gene

Publications for LST1 Gene

  1. Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing. (PMID: 9367684) de Baey A. … Weiss E.H. (Genomics 1997) 2 3 4 67
  2. LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. (PMID: 16362817) Mulcahy H. … O'gara F. (Immunogenetics 2006) 3 23
  3. LST1: a gene with extensive alternative splicing and immunomodulatory function. (PMID: 10706707) Rollinger-Holzinger I. … Zwierzina H. (J. Immunol. 2000) 3 23
  4. Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts. (PMID: 10944527) Yu X. … Weissman S.M. (J. Biol. Chem. 2000) 3 23
  5. Genes in a 220-kb region spanning the TNF cluster in human MHC. (PMID: 8824804) Nalabolu S.R. … Weissman S.M. (Genomics 1996) 2 3

Products for LST1 Gene

Sources for LST1 Gene

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