Aliases for LSS Gene
External Ids for LSS Gene
Previous GeneCards Identifiers for LSS Gene
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
GeneCards Summary for LSS Gene
LSS (Lanosterol Synthase) is a Protein Coding gene. Diseases associated with LSS include Cataract 44 and Holoprosencephaly 1. Among its related pathways are cholesterol biosynthesis I and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. GO annotations related to this gene include intramolecular transferase activity and lanosterol synthase activity.
UniProtKB/Swiss-Prot for LSS Gene
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.