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LSS Gene

protein-coding   GIFtS: 60

GC21M047608
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for LSS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
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Aliases & Descriptions
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)1 2     FLJ350152
OSC1 2 3     2,3-epoxysqualene-lanosterol cyclase2
Oxidosqualene--lanosterol cyclase2 3     FLJ394502
2,3-epoxysqualene--lanosterol cyclase2 3     FLJ254862
hOSC2 3     EC 5.4.99.73
lanosterol synthase2     human lanosterol synthase, EC 5.4.99.79
FLJ463932     

External Ids:    HGNC: 67081   Entrez Gene: 40472   Ensembl: ENSG000001602857   UniProtKB: P484493   

Search outside databases for aliases for LSS gene

Previous GC identifers: GC21M044116 GC21M046464 GC21M046465 GC21M046432

Summaries
for LSS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  User Feedback		 Entrez Gene summary for LSS:
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein
is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol,
steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different
isoforms.

UniProtKB/Swiss-Prot: ERG7_HUMAN, P48449
Function: Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus

Genomic Views
for LSS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the LSS gene upstream (promoter) region "":
p53   Arnt   Max   c-Myc   MRF-2   POU3F1   Meis-1   GR-alpha   Max1   POU3F2   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for LSS:  ""
MePH26536-3A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
LSS Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M047608:   GeneLoc Nature:405,311-319
Start:
 47,608,360 bp from pter       33,114,827 bp from centromere
End:
 47,648,738 bp from pter 33,155,144 bp from centromere
Size:
 40,379 bases 40,318 bases
Orientation:
 minus strand minus strand
RefSeq DNA sequence:
NC_000021.8  NT_011515.12  

Whole chromosome sequencing:
cDNA sequence: D63807
genomic clones: 21B35B20 R178H12

Proteins
for LSS gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: ERG7_HUMAN, P48449 (See protein sequence)
Recommended Name: Lanosterol synthase  
Size: 732 amino acids; 83309 Da
Subunit: Monomer
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein
PDB structure from "" and Proteopedia "" :
1W6J (3D) ""    1W6K (3D) ""    
Secondary accessions: Q8IYL6 Q9UEZ1

REFSEQ proteins (4 alternative transcripts): 
NP_001001438.1  NP_001138908.1  NP_001138909.1  NP_002331.3  


ENSEMBL proteins: 
ENSP00000409191 ENSP00000410678 ENSP00000391368 ENSP00000380837 ENSP00000348762 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Browse Human Recombinant Proteins at Sigma-Aldrich
"" Browse R&D Systems for human recombinant proteins
""Browse recombinant and purified proteins available from Enzo Life Sciences
""HuPro® and/or Recombinant Proteins from Abnova for LSS ""
""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
""Novus Biologicals Protein for LSS  ""
""Browse Sino Biological Recombinant Proteins  ""

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0005792 microsome IEA--
GO:0016020 membrane IEA--
About this table

"" LSS for ontologies           About GeneDecksing



Antibodies for LSS: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Sigma-Aldrich Antibodies for LSS
"" Browse R&D Systems for Antibodies
""Monoclonal and Polyclonal Antibodies from Abnova (LSS)
""Browse Origene Antibodies ""
""Novus Biologicals Antibody for LSS
""Browse antibodies at Epitomics

Assays for LSS: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Browse Enzo Life Sciences for kits & assays

Protein Domains/
Families
for LSS gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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"" LSS for domains           About GeneDecksing

4 InterPro domains/families:
 IPR018333 Squalene_cyclase
 IPR002365 Terpene_synthase_CS
 IPR008930 Terpenoid_cyclase/PrenylTrfase
 IPR001330 Prenyltrans

Graphical View of Domain Structure for InterPro Entry P48449

ProtoNet protein and cluster: P48449

2 Blocks protein families:
IPB001330 Prenyltransferase/squalene oxidase
IPB002365 Terpene synthase


UniProtKB/Swiss-Prot: ERG7_HUMAN, P48449
Similarity: Belongs to the terpene cyclase/mutase family
Similarity: Contains 4 PFTB repeats

Gene Function
for LSS gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): LSS
Origene shRNA RFP (see all 4): LSS
Origene basic RS shRNA (see all 4): LSS

""Applied Biosystems Silencer® siRNAs for LSS
""Sigma-Aldrich siRNA for LSS
Sigma-Aldrich shRNA for LSS
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector (see all 4): LSS
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): LSS
Origene untagged cDNA clones in CMV expression vector (see all 6): LSS
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: ERG7_HUMAN, P48449
Function: Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus
Catalytic activity: (S)-2,3-epoxysqualene = lanosterol
Enzyme Number (IUBMB): EC 5.4.99.7 

Genatlas biochemistry entry for LSS:
lanosterol synthase catalyzing cyclization of squalene-2,3-epoxide to lanosterol (cholesterol biosynthesis),not
involved in holoprosencephaly (HPE1)

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000250 lanosterol synthase activity IEA--
GO:0003824 catalytic activity ----
GO:0016866 intramolecular transferase activity IEA--
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"" LSS for ontologies           About GeneDecksing

Animal Models: 2 MGI phenotypic alleles "" for Lss (no phenotypes)


"" LSS for phenotypes           About GeneDecksing

Pathways & Interactions
for LSS gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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"" LSS for pathways           About GeneDecksing

1 "" Sigma-Aldrich "Your Favorite Gene" Pathway for  LSS  (Your Favorite Gene powered by Ingenuity)
  ""  Biosynthesis of Steroids

2 "" Kegg Pathways  (Kegg details for LSS):
  ""  hsa00100 Steroid biosynthesis
hsa01100 Metabolic pathways

UniProtKB/Swiss-Prot: ERG7_HUMAN, P48449
Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3

"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LSS

3 Interacting proteins for LSS (ENSP000003487623) via UniProtKB, MINT, and/or STRING ""

InteractantInteraction Details
GeneCardExternal ID(s)
SQLEENSP000002658963STRING: ENSP00000265896
DHCR24ENSP000003603163STRING: ENSP00000360316
CYP51A1ENSP000000031003STRING: ENSP00000003100
About this table

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006694 steroid biosynthetic process IEA--
GO:0006695 cholesterol biosynthetic process IMP17186944
GO:0008202 steroid metabolic process TAS7639730
GO:0016125 sterol metabolic process IEA--
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"" LSS for ontologies           About GeneDecksing


Drugs & Compounds
for LSS gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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"" LSS for compounds           About GeneDecksing

"" Enzo Life Sciences drugs & compounds for LSS
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for LSS
10/74 ""Novoseek chemical compound relationships for LSS gene (see all 74 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
lanosterol 100.00 123 17925399 (8), 8604986 (7), 7639730 (5), 17928701 (5) (see all 70)
squalene 58.75 27 17928701 (3), 857899 (2), 7791532 (2), 9162756 (1) (see all 23)
cycloartenol 46.78 15 16445886 (2), 16218577 (2), 15256745 (2), 7791532 (1) (see all 12)
2,3-oxidosqualene 41.92 13 2185141 (2), 19119143 (2), 9101437 (1), 8691425 (1) (see all 11)
beta-amyrin 25.58 9 15256745 (2), 9746369 (1), 7791532 (1), 19796960 (1) (see all 8)
sterol 23.50 17 16165233 (2), 8593458 (1), 7896706 (1), 7791529 (1) (see all 16)
cholesterol 22.00 42 17460354 (4), 15951028 (4), 9162756 (3), 17925399 (3) (see all 22)
24(s),25-epoxycholesterol 19.88 6 17186944 (2), 15951028 (2), 15763540 (1), 14512442 (1)
soyasaponin 5.86 2 15256745 (1), 12721381 (1)
mevalonate pyrophosphate 5.58 2 17514523 (1), 11485325 (1)
About this table


Transcripts
for LSS gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
""Applied Biosystems Silencer® siRNAs:  NM_001001438  NM_001145436  NM_001145437  NM_002340  
"" Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): LSS
Origene shRNA RFP (see all 4): LSS
Origene basic RS shRNA (see all 4): LSS

""Sigma-Aldrich siRNA for LSS
Sigma-Aldrich shRNA for LSS
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate LSS: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_001001438  NM_001145436  NM_001145437  NM_002340  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 4): LSS
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): LSS
Origene untagged cDNA clones in CMV expression vector (see all 6): LSS
Primers:"" Origene genome-wide validated SYBR primer pairs: LSS
""SABiosciences RT2 qPCR Primer Assay for LSS: PPH06366A ""

REFSEQ mRNAs for LSS gene (4 alternative transcripts): 

NM_001001438.2  NM_001145436.1  NM_001145437.1  NM_002340.5  

Additional cDNA sequence: 

AK226141.1 AK296313.1 AK312489.1 AY927524.1 BC035638.1 D63807.1 S81221.1 X87809.1 

24 DOTS entries:

DT.97867743  DT.92440609  DT.87016843  DT.95224941  DT.100886300  DT.100029897  DT.91960419  DT.100886302 
DT.121134433  DT.100886311  DT.101962318  DT.442515  DT.95256312  DT.121134338  DT.430891  DT.95370193 
DT.121134469  DT.121134471  DT.100016669  DT.121134345  DT.121134434  DT.92440599  DT.97777135  DT.121643862 

24/311 AceView cDNA sequences (see all 311 ):

BM794385 BE313246 AA437389 AA495836 AU133253 BM564937 BQ944522 AI805983 
CN484000 AI801379 D63807 BP343348 CB125855 BM928564 AU130260 CD674488 
AA495780 AI831305 Z98506 BQ959185 BX494572 AA814300 X87809 CB152175 

"" highest scoring ESTs for LSS:

S81221 U22526 AU127551 BG897623 BU553127 BU554041 BU855034 BX443698 BX472528 BC035638 

Unigene Cluster for LSS:

Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Hs.596543  [show with all ESTs]
Unigene Representative Sequence: NM_001145437


GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for LSS (see all 11 )

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1:                                -           -                                         -                                                                     
SP2:                                                                                                                                                  -         
SP3:              -     -                       -                                                                                                               
SP4:                                -           -           -                                                                                                   
SP5:                                                                                                                                                            

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP1:                                          
SP2:                                          
SP3:                                          
SP4:                                          
SP5:                                          

About this scheme

ECgene alternative splicing isoforms for LSS

10 Ensembl transcripts including schematic representations:
ENST00000457828  ENST00000484808  ENST00000419093  ENST00000464357  ENST00000472272  ENST00000450351  
ENST00000491729  ENST00000474319  ENST00000397728  ENST00000356396  

Expression
for LSS gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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LSS expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for LSS

1""  / 2""  / 3""

8 probe-sets matching LSS gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
39108_at2, 3 U95-A 1 1.00 1.00 0.92 1.37 U22526 1.00 0.90 0.95 1
39107_at2, 3 U95-A 1 0.69 1.00 0.95 0.64 S81221 1.00 0.90 0.95 1
211018_at2, 3 U133-A 1 1.00 1.00 -- -- D63807 0.80 0.88 0.84 1
211019_s_at2, 3 U133-A 1 1.00 1.00 -- -- D63807 0.80 0.88 0.84 1
202245_at2, 3 U133-A 1 1.00 1.00 -- -- AW084510 0.40 1.00 0.76 1
211018_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
211019_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
202245_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTCAGACTGT

SOURCE GeneReport for Unigene cluster: Hs.596543

Expression variation in blood from EXPOLDB for LSS

Primers:"" Origene genome-wide validated SYBR primer pairs: LSS ""
""SABiosciences RT2 qPCR Primer Assay for LSS: PPH06366A ""

Orthologs
for LSS gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for LSS gene from 5/18 species (see all 18 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 LSS1   -- lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 99.32(n)
99.32(a)		 474058  XM_001159379.1  XP_001159379.1 
cow
(Bos taurus)		 LSS1   -- lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 85.15(n)
85.52(a)		 615906  NM_001046564.1  NP_001040029.1 
rat
(Rattus norvegicus)		 Lss1   -- lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 82.49(n)
84.54(a)		 81681  NM_031049.1  NP_112311.1 
mouse
(Mus musculus)		 Lss1, 5 10 (41.10 cM)5
 lanosterol synthase1, 5 83.04(n)1
85.77(a)1		 169871  NM_146006.11  NP_666118.11 
 AC0079375  AI4489155  (see all 27)
chicken
(Gallus gallus)		 LSS1   -- lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 74.4(n)
78.84(a)		 424037  NM_001006514.1  NP_001006514.1 
About this table        Species with no ortholog for LSS

ENSEMBL Gene Tree for LSS

Paralogs
for LSS gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Genomic Variants
for LSS gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/386 NCBI SNPs in LSS are shown (see all 386 )
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 95)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 21 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
""
rs22545241,2
C,F,O,A,H47614469(+) CTGCAC/AATAAC 8 /V /L mis1 ref1""28Minor allele frequency- A:0.22EA NA NS 3502""
""
rs29681,2
C,F,O,A,H32990433(+) TCTTCA/GTGGAA 3 -- ng31 ese3""21Minor allele frequency- G:0.47EA MN NS NA WA 5718""
""
rs28391581,2
C,F,O,A,H47641794(+) GGGCTC/TGTACC 8 Q R mis1 ref1 ese3""15Minor allele frequency- A:0.01NA NS EA 1234""
""
rs9158041,2
C,F,A33032033(+) GGTCCG/CTAAGT 4 -- ng51""19Minor allele frequency- C:0.46EA NA NS WA 1152""
""
rs22986931,2
C,F33032423(+) GCAAGA/CGGGCA 4 -- ng51""6Minor allele frequency- C:0.01EA NS 1996""
""
rs172937051,2
C,F47611799(+) CCTGCG/AGCCAG 8 /P /L ref1 mis1 ese3""7Minor allele frequency- A:0.01NA NS EA 558""
--
rs733865431,2
C,F33031533(+) CTCTCG/CCGCTG 4 -- ng51""1Minor allele frequency- C:0.10WA 50""
""
rs341152871,2
C,F47635176(-) TGCCCA/GCCTGC 8 H R ref1 mis1""5Minor allele frequency- G:0.03NA NS EA 494""
--
rs731447641,2
C,F33032148(+) CTCCTC/TAATTC 4 -- ng51""2Minor allele frequency- T:0.15NA EA 160""
""
rs357854461,2
C,F47614553(-) TCTCCC/TGGGCC 8 R W ref1 mis1""2Minor allele frequency- T:0.03NA WA 126""
About this table

HapMap Linkage Disequilibrium images for LSS (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
Database of Genomic Variants (DGV): 4 variations for LSS
     3 CNVs: 103123 67819 44060
     1 Indel: 46194

Disorders & Mutations
for LSS gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600909

10/11 ""Novoseek disease relationships for LSS gene (see all 11 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
holoprosencephalies 6.61 4 10598817 (4)
cholesterol deposition 2.48 1 15951028 (1)
cataract 2.37 5 16440058 (2), 15102886 (2), 17460354 (1)
insertion mutation 1.51 1 17460354 (1)
enzyme inhibition 1.01 1 9003518 (1)
cholelithiasis 0.71 1 14684588 (1)
chagas disease 0.70 1 16477810 (1)
dyslipidemia 0.60 1 16210564 (1)
hypercholesterolemia 0.45 1 15951028 (1)
down syndrome 0.24 1 8655142 (1)
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1 PharmGKB disease relationship for LSS gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
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Human Genome Epidemiology Navigator: LSS (5 documents)

Medical News
for LSS gene

(Possibly Related Articles in Doctor's Guide)
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Publications
for LSS gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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  User Feedback		10/69 PubMed articles for LSS gene (see all 69 ):

Search for LSS gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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Genome Databases showing LSS gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4047 HGNC: 6708 AceView: LSS Ensembl:ENSG00000160285 euGenes: HUgn4047
ECgene: LSS Kegg: 4047 H-InvDB: LSS

Other Databases showing LSS gene

(According to HUGE)
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Specialized Databases showing LSS gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property
for LSS gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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  User Feedback		Patent Information for LSS gene: ""
Search GeneIP for patents involving LSS

GeneCards and IP: ""
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


Services
for LSS gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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