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Aliases for LSR Gene

Aliases for LSR Gene

  • Lipolysis Stimulated Lipoprotein Receptor 2 3 5
  • Immunoglobulin-Like Domain Containing Receptor 3 2 3
  • Lipolysis-Stimulated Remnant 2 3
  • Liver-Specific BHLH-Zip Transcription Factor 3
  • Lipolysis-Stimulated Lipoprotein Receptor 3
  • LISCH Protein 3
  • LISCH7 3
  • ILDR3 3
  • LISCH 4

External Ids for LSR Gene

Previous GeneCards Identifiers for LSR Gene

  • GC19P040432
  • GC19P035739
  • GC19P032248
  • GC19P035249
  • GC19P035250

Summaries for LSR Gene

GeneCards Summary for LSR Gene

LSR (Lipolysis Stimulated Lipoprotein Receptor) is a Protein Coding gene. Among its related pathways are Metabolism and Glucose / Energy Metabolism. An important paralog of this gene is ILDR2.

UniProtKB/Swiss-Prot for LSR Gene

  • Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).

Gene Wiki entry for LSR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSR Gene

Genomics for LSR Gene

Regulatory Elements for LSR Gene

Enhancers for LSR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035253 1.1 ENCODE 20.7 +5.7 5715 1.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 LSR FAM187B ZNF146 WTIP ENSG00000233214 LOC105372372 FXYD3 MIR6887 HAUS5 FFAR2
GH19F035246 1.2 ENCODE 18.6 +0.3 295 3.4 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 RBM42 TMEM147-AS1 KIAA0355 HAUS5 ZNF792 KMT2B LSR ENSG00000268947 LINC01766 ENSG00000270544
GH19F035266 1.2 ENCODE 16.6 +20.1 20131 4.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 KMT2B RBM42 HAUS5 TMEM147-AS1 ZNF792 LRFN3 ZNF146 LINC01766 LSR ENSG00000267626
GH19F035202 1.7 FANTOM5 Ensembl ENCODE 11.7 -42.8 -42789 6.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF302 TMEM147-AS1 RBM42 ZNF792 KIAA0355 HAUS5 KMT2B ENSG00000267049 SDHAF1 LRFN3 LOC101927572
GH19F035239 1 Ensembl ENCODE 17.5 -7.8 -7762 1.3 BCOR ZNF263 KLF1 MAZ ZMYM3 DPF2 KLF4 CBX1 CTBP1 GLIS2 LSR ENSG00000268947 FAM187B2P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LSR on UCSC Golden Path with GeneCards custom track

Promoters for LSR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000345861 470 2401 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263

Genomic Location for LSR Gene

Chromosome:
19
Start:
35,248,330 bp from pter
End:
35,267,964 bp from pter
Size:
19,635 bases
Orientation:
Plus strand

Genomic View for LSR Gene

Genes around LSR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSR Gene

Proteins for LSR Gene

  • Protein details for LSR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X29-LSR_HUMAN
    Recommended name:
    Lipolysis-stimulated lipoprotein receptor
    Protein Accession:
    Q86X29
    Secondary Accessions:
    • A6NDW3
    • B4DKL4
    • E9PHD4
    • O00112
    • O00426
    • Q6ZT80
    • Q8NBM0
    • Q9BT33
    • Q9UQL3

    Protein attributes for LSR Gene

    Size:
    649 amino acids
    Molecular mass:
    71439 Da
    Quaternary structure:
    • Homotrimer or homotetramer.
    SequenceCaution:
    • Sequence=AAB51178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAB58317.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH04381.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LSR Gene

neXtProt entry for LSR Gene

Post-translational modifications for LSR Gene

  • Ubiquitination at Lys 410
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LSR Gene

Domains & Families for LSR Gene

Gene Families for LSR Gene

Protein Domains for LSR Gene

Graphical View of Domain Structure for InterPro Entry

Q86X29

UniProtKB/Swiss-Prot:

LSR_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. LISCH7 family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. LISCH7 family.
genes like me logo Genes that share domains with LSR: view

Function for LSR Gene

Molecular function for LSR Gene

UniProtKB/Swiss-Prot Function:
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
genes like me logo Genes that share phenotypes with LSR: view

Animal Models for LSR Gene

MGI Knock Outs for LSR:

Animal Model Products

  • Taconic Biosciences Mouse Models for LSR

miRNA for LSR Gene

miRTarBase miRNAs that target LSR

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSR Gene

Localization for LSR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSR Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LSR gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytosol 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LSR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0034361 very-low-density lipoprotein particle IEA --
GO:0034362 low-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with LSR: view

Pathways & Interactions for LSR Gene

genes like me logo Genes that share pathways with LSR: view

Pathways by source for LSR Gene

Gene Ontology (GO) - Biological Process for LSR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development ISS --
GO:0019216 regulation of lipid metabolic process IEA --
GO:0060856 establishment of blood-brain barrier IEA --
GO:1904274 tricellular tight junction assembly IEA --
genes like me logo Genes that share ontologies with LSR: view

No data available for SIGNOR curated interactions for LSR Gene

Drugs & Compounds for LSR Gene

(1) Drugs for LSR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for LSR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LSR: view

Transcripts for LSR Gene

Unigene Clusters for LSR Gene

Lipolysis stimulated lipoprotein receptor:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8:
SP9: - - - -

Relevant External Links for LSR Gene

GeneLoc Exon Structure for
LSR
ECgene alternative splicing isoforms for
LSR

Expression for LSR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LSR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LSR Gene

This gene is overexpressed in Liver (x6.1), Colon - Transverse (x4.9), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for LSR Gene

This gene is overexpressed in Pancreas (16.1), Islet of Langerhans (14.1), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LSR Gene



NURSA nuclear receptor signaling pathways regulating expression of LSR Gene:

LSR

SOURCE GeneReport for Unigene cluster for LSR Gene:

Hs.466507
genes like me logo Genes that share expression patterns with LSR: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LSR Gene

Orthologs for LSR Gene

This gene was present in the common ancestor of chordates.

Orthologs for LSR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSR 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia LSR 34 35
  • 85.59 (n)
cow
(Bos Taurus)
Mammalia LSR 34 35
  • 84.66 (n)
mouse
(Mus musculus)
Mammalia Lsr 34 16 35
  • 80.94 (n)
rat
(Rattus norvegicus)
Mammalia Lsr 34
  • 80.8 (n)
oppossum
(Monodelphis domestica)
Mammalia LSR 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LSR 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LSR 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lsr 34
  • 60.04 (n)
Str.15753 34
zebrafish
(Danio rerio)
Actinopterygii lsr 34 35
  • 55.64 (n)
Species where no ortholog for LSR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LSR Gene

ENSEMBL:
Gene Tree for LSR (if available)
TreeFam:
Gene Tree for LSR (if available)

Paralogs for LSR Gene

Paralogs for LSR Gene

(1) SIMAP similar genes for LSR Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LSR: view

Variants for LSR Gene

Sequence variations from dbSNP and Humsavar for LSR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10153449 -- 35,253,526(+) AGTTG(G/T)GCATG intron-variant
rs10412357 -- 35,249,166(+) GAACG(C/G)CGGAG intron-variant
rs10416084 -- 35,246,710(+) acatc(G/T)ttagt upstream-variant-2KB
rs10419861 -- 35,255,865(+) TCTAG(A/G)AGGGC intron-variant
rs10421791 -- 35,246,990(+) ccagt(A/G)ttcac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LSR Gene

Variant ID Type Subtype PubMed ID
nsv953283 CNV deletion 24416366
nsv510765 CNV deletion 20534489
nsv1066553 CNV gain 25217958
esv3644232 CNV loss 21293372
esv3644228 CNV gain 21293372
esv27788 CNV loss 19812545
esv2758758 CNV loss 17122850
esv2665499 CNV deletion 23128226

Variation tolerance for LSR Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSR Gene

Disorders for LSR Gene

Relevant External Links for LSR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSR

No disorders were found for LSR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSR Gene

Publications for LSR Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver. (PMID: 10224102) Yen F.T. … Bihain B.E. (J. Biol. Chem. 1999) 2 3 64

Products for LSR Gene

Sources for LSR Gene

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