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Aliases for LSR Gene

Aliases for LSR Gene

  • Lipolysis Stimulated Lipoprotein Receptor 2 3 5
  • Immunoglobulin-Like Domain Containing Receptor 3 2 3
  • Lipolysis-Stimulated Remnant 2 3
  • Liver-Specific BHLH-Zip Transcription Factor 3
  • LISCH Protein 3
  • LISCH7 3
  • ILDR3 3
  • LISCH 4

External Ids for LSR Gene

Previous GeneCards Identifiers for LSR Gene

  • GC19P040432
  • GC19P035739
  • GC19P032248

Summaries for LSR Gene

GeneCards Summary for LSR Gene

LSR (Lipolysis Stimulated Lipoprotein Receptor) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism. An important paralog of this gene is ILDR1.

UniProtKB/Swiss-Prot for LSR Gene

  • Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).

Gene Wiki entry for LSR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSR Gene

Genomics for LSR Gene

Regulatory Elements for LSR Gene

Enhancers for LSR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LSR on UCSC Golden Path with GeneCards custom track

Promoters for LSR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LSR on UCSC Golden Path with GeneCards custom track

Genomic Location for LSR Gene

Chromosome:
19
Start:
35,248,330 bp from pter
End:
35,267,964 bp from pter
Size:
19,635 bases
Orientation:
Plus strand

Genomic View for LSR Gene

Genes around LSR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSR Gene

Proteins for LSR Gene

  • Protein details for LSR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X29-LSR_HUMAN
    Recommended name:
    Lipolysis-stimulated lipoprotein receptor
    Protein Accession:
    Q86X29
    Secondary Accessions:
    • A6NDW3
    • B4DKL4
    • E9PHD4
    • O00112
    • O00426
    • Q6ZT80
    • Q8NBM0
    • Q9BT33
    • Q9UQL3

    Protein attributes for LSR Gene

    Size:
    649 amino acids
    Molecular mass:
    71439 Da
    Quaternary structure:
    • Homotrimer or homotetramer.
    SequenceCaution:
    • Sequence=AAB51178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAB58317.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH04381.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LSR Gene

neXtProt entry for LSR Gene

Proteomics data for LSR Gene at MOPED

Post-translational modifications for LSR Gene

  • Ubiquitination at Lys 410
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LSR (LISCH)

No data available for DME Specific Peptides for LSR Gene

Domains & Families for LSR Gene

Gene Families for LSR Gene

Protein Domains for LSR Gene

Graphical View of Domain Structure for InterPro Entry

Q86X29

UniProtKB/Swiss-Prot:

LSR_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. LISCH7 family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. LISCH7 family.
genes like me logo Genes that share domains with LSR: view

Function for LSR Gene

Molecular function for LSR Gene

UniProtKB/Swiss-Prot Function:
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
genes like me logo Genes that share phenotypes with LSR: view

Animal Models for LSR Gene

MGI Knock Outs for LSR:

Animal Model Products

  • Taconic Biosciences Mouse Models for LSR

miRNA for LSR Gene

miRTarBase miRNAs that target LSR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSR Gene

Localization for LSR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSR Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LSR Gene COMPARTMENTS Subcellular localization image for LSR gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LSR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,ISS --
GO:0034362 low-density lipoprotein particle IEA --
GO:0042627 chylomicron IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with LSR: view

Pathways & Interactions for LSR Gene

SuperPathways for LSR Gene

Superpath Contained pathways
1 Glucose / Energy Metabolism
genes like me logo Genes that share pathways with LSR: view

Pathways by source for LSR Gene

1 Cell Signaling Technology pathway for LSR Gene

Gene Ontology (GO) - Biological Process for LSR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development ISS --
GO:0060856 establishment of blood-brain barrier IEA --
genes like me logo Genes that share ontologies with LSR: view

No data available for SIGNOR curated interactions for LSR Gene

Drugs & Compounds for LSR Gene

(1) Drugs for LSR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for LSR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LSR: view

Transcripts for LSR Gene

Unigene Clusters for LSR Gene

Lipolysis stimulated lipoprotein receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LSR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8:
SP9: - - - -

Relevant External Links for LSR Gene

GeneLoc Exon Structure for
LSR
ECgene alternative splicing isoforms for
LSR

Expression for LSR Gene

mRNA expression in normal human tissues for LSR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LSR Gene

This gene is overexpressed in Liver (x6.1), Colon - Transverse (x4.9), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for LSR Gene

This gene is overexpressed in Pancreas (16.1), Islet of Langerhans (14.1), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for LSR Gene



SOURCE GeneReport for Unigene cluster for LSR Gene Hs.466507

genes like me logo Genes that share expression patterns with LSR: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LSR Gene

Orthologs for LSR Gene

This gene was present in the common ancestor of chordates.

Orthologs for LSR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LSR 35
  • 84.66 (n)
  • 85.29 (a)
LSR 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LSR 35
  • 85.59 (n)
  • 85.93 (a)
LSR 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lsr 35
  • 80.94 (n)
  • 82.32 (a)
Lsr 16
Lsr 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LSR 35
  • 99.18 (n)
  • 98.61 (a)
LSR 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lsr 35
  • 80.8 (n)
  • 83.42 (a)
oppossum
(Monodelphis domestica)
Mammalia LSR 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LSR 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LSR 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lsr 35
  • 60.04 (n)
  • 60.04 (a)
Str.15753 35
zebrafish
(Danio rerio)
Actinopterygii lsr 35
  • 55.64 (n)
  • 53.58 (a)
lsr 36
  • 42 (a)
OneToOne
Species with no ortholog for LSR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LSR Gene

ENSEMBL:
Gene Tree for LSR (if available)
TreeFam:
Gene Tree for LSR (if available)

Paralogs for LSR Gene

Paralogs for LSR Gene

(1) SIMAP similar genes for LSR Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LSR: view

Variants for LSR Gene

Sequence variations from dbSNP and Humsavar for LSR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34259399 - 35,266,524(-) AGCTA(C/T)TCCTG reference, missense
rs7259405 -- 35,256,220(+) cagag(C/T)gagac intron-variant
rs12977477 -- 35,256,729(+) atgaa(A/T)gaaag intron-variant
rs8100411 -- 35,252,360(+) gagaa(C/T)ttcaa intron-variant
rs12981527 -- 35,263,238(+) atcac(A/G)ccact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSR Gene

Variant ID Type Subtype PubMed ID
nsv510765 CNV Loss 20534489
dgv1080e1 CNV Complex 17122850
nsv911618 CNV Loss 21882294
esv2665499 CNV Deletion 23128226
dgv3850n71 CNV Loss 21882294
esv27788 CNV Loss 19812545

Variation tolerance for LSR Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSR Gene

HapMap Linkage Disequilibrium report
LSR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSR Gene

Disorders for LSR Gene

Relevant External Links for LSR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSR

No disorders were found for LSR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSR Gene

Publications for LSR Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver. (PMID: 10224102) Yen F.T. … Bihain B.E. (J. Biol. Chem. 1999) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR). (PMID: 25882847) Hemmasi S. … Papatheodorou P. (J. Biol. Chem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for LSR Gene

Sources for LSR Gene

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