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Aliases for LSP1 Gene

Aliases for LSP1 Gene

  • Lymphocyte-Specific Protein 1 2 3 5
  • Lymphocyte-Specific Antigen WP34 3 4
  • 52 KDa Phosphoprotein 3 4
  • WP34 3 4
  • Pp52 3 4
  • F-Actin Binding And Cytoskeleton Associated Protein 3
  • Leufactin (Leukocyte F-Actin Binding Protein) 3
  • 47 KDa Actin Binding Protein 3
  • Leukocyte-Specific Protein 1 3
  • 47 KDa Actin-Binding Protein 4

External Ids for LSP1 Gene

Previous GeneCards Identifiers for LSP1 Gene

  • GC11M000728
  • GC11M001913
  • GC11P001833
  • GC11P001838
  • GC11P001801
  • GC11P001830
  • GC11P001874
  • GC11P001665

Summaries for LSP1 Gene

Entrez Gene Summary for LSP1 Gene

  • This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for LSP1 Gene

LSP1 (Lymphocyte-Specific Protein 1) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways and Tuberculosis. GO annotations related to this gene include actin binding and signal transducer activity.

UniProtKB/Swiss-Prot for LSP1 Gene

  • May play a role in mediating neutrophil activation and chemotaxis.

Gene Wiki entry for LSP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSP1 Gene

Genomics for LSP1 Gene

Regulatory Elements for LSP1 Gene

Enhancers for LSP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G001849 1.6 FANTOM5 ENCODE dbSUPER 16.1 -0.2 -166 6.3 HDGF SIN3A GLI4 GLIS2 ELK1 ZNF143 ZNF207 ZNF263 ZNF202 JUNB LSP1 TNNI2 TNNT3 H19 C11orf21 TSPAN32 IGF2
GH11G001780 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -70.7 -70676 3.4 HDAC1 PKNOX1 RAD21 TCF12 FOS EGR2 USF2 CEBPB MEF2D RAD51 LSP1 TNNI2 ENSG00000250397 SYT8 TOLLIP LOC105376517 RPL36AP39
GH11G001837 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -11.1 -11122 9.5 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 YBX1 YY1 ZNF207 ZNF143 TNNI2 IFITM10 LSP1 LINC01219 C11orf21
GH11G002139 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +293.2 293170 13.0 PKNOX1 ZNF48 GLIS2 ZNF143 FOS MXD4 JUNB REST SREBF1 ZNF579 ENSG00000199550 CD81 LSP1 KRTAP5-6 FAM99B LOC100505570 KRTAP5-5 IGF2 TH TNNT3
GH11G001770 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -81.0 -81022 3.8 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A ZBTB7B GATA2 FOS KLF13 IFITM10 TNNI2 ENSG00000255142 SYT8 KRTAP5-6 LOC100505570 FAM99B LSP1 ENSG00000235027 TOLLIP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LSP1 on UCSC Golden Path with GeneCards custom track

Promoters for LSP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035847 630 1201 TBP TBL1XR1 SIN3A BMI1 RFX5 GLIS2 EGR1 ZNF143 ZNF207 RCOR1

Genomic Location for LSP1 Gene

Chromosome:
11
Start:
1,852,970 bp from pter
End:
1,892,267 bp from pter
Size:
39,298 bases
Orientation:
Plus strand

Genomic View for LSP1 Gene

Genes around LSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSP1 Gene

Proteins for LSP1 Gene

  • Protein details for LSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33241-LSP1_HUMAN
    Recommended name:
    Lymphocyte-specific protein 1
    Protein Accession:
    P33241
    Secondary Accessions:
    • B3KPP1
    • B3KRR6
    • E9PBV6
    • E9PFP3
    • Q16096
    • Q53H48
    • Q6FHM3
    • Q9BUY8

    Protein attributes for LSP1 Gene

    Size:
    339 amino acids
    Molecular mass:
    37192 Da
    Quaternary structure:
    • Binds actin.

    Three dimensional structures from OCA and Proteopedia for LSP1 Gene

    Alternative splice isoforms for LSP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSP1 Gene

Post-translational modifications for LSP1 Gene

  • Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LSP1 Gene

Domains & Families for LSP1 Gene

Protein Domains for LSP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LSP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LSP1 Gene

Function for LSP1 Gene

Molecular function for LSP1 Gene

GENATLAS Biochemistry:
lymphocyte specific protein 1 (pp52),52kDa
UniProtKB/Swiss-Prot Function:
May play a role in mediating neutrophil activation and chemotaxis.

Gene Ontology (GO) - Molecular Function for LSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 8274738
GO:0004871 signal transducer activity IEA --
genes like me logo Genes that share ontologies with LSP1: view
genes like me logo Genes that share phenotypes with LSP1: view

Animal Models for LSP1 Gene

MGI Knock Outs for LSP1:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSP1 Gene

Localization for LSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSP1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LSP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for LSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton TAS 8274738
GO:0016020 membrane IEA,IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with LSP1: view

Pathways & Interactions for LSP1 Gene

genes like me logo Genes that share pathways with LSP1: view

Pathways by source for LSP1 Gene

1 Cell Signaling Technology pathway for LSP1 Gene
1 BioSystems pathway for LSP1 Gene
1 KEGG pathway for LSP1 Gene

Gene Ontology (GO) - Biological Process for LSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 8274738
GO:0006935 chemotaxis IEA --
GO:0006952 defense response IEA --
GO:0006968 cellular defense response TAS 2174784
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with LSP1: view

No data available for SIGNOR curated interactions for LSP1 Gene

Drugs & Compounds for LSP1 Gene

(1) Drugs for LSP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LSP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LSP1: view

Transcripts for LSP1 Gene

Unigene Clusters for LSP1 Gene

Lymphocyte-specific protein 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^
SP1: - - -
SP2: - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9:
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - -
SP16:
SP17: - - - -

ExUns: 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for LSP1 Gene

GeneLoc Exon Structure for
LSP1
ECgene alternative splicing isoforms for
LSP1

Expression for LSP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LSP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LSP1 Gene

This gene is overexpressed in Whole Blood (x25.6).

Protein differential expression in normal tissues from HIPED for LSP1 Gene

This gene is overexpressed in Lavage (22.6), NK cells (6.4), and Blymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LSP1 Gene



Protein tissue co-expression partners for LSP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LSP1 Gene:

LSP1

SOURCE GeneReport for Unigene cluster for LSP1 Gene:

Hs.56729

mRNA Expression by UniProt/SwissProt for LSP1 Gene:

P33241-LSP1_HUMAN
Tissue specificity: Activated T-lymphocytes.

Evidence on tissue expression from TISSUES for LSP1 Gene

  • Blood(4.7)
  • Liver(4.3)
  • Spleen(3.1)
  • Lung(2.7)
  • Lymph node(2.6)
  • Bone marrow(2.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with LSP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LSP1 Gene

Orthologs for LSP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSP1 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia LSP1 34
  • 83.54 (n)
-- 35
  • 66 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LSP1 34 35
  • 78.6 (n)
mouse
(Mus musculus)
Mammalia Lsp1 34 16 35
  • 75.19 (n)
rat
(Rattus norvegicus)
Mammalia Lsp1 34
  • 73.81 (n)
chicken
(Gallus gallus)
Aves LSP1 35
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lsp1 34
  • 56.06 (n)
Str.4872 34
zebrafish
(Danio rerio)
Actinopterygii LSP1 35
  • 19 (a)
OneToMany
Dr.18245 34
Species where no ortholog for LSP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LSP1 Gene

ENSEMBL:
Gene Tree for LSP1 (if available)
TreeFam:
Gene Tree for LSP1 (if available)

Paralogs for LSP1 Gene

No data available for Paralogs for LSP1 Gene

Variants for LSP1 Gene

Sequence variations from dbSNP and Humsavar for LSP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000004253 -- 1,851,723(+) GCAGG(A/G)CTCTG upstream-variant-2KB
rs1000020674 -- 1,890,617(+) TGGTC(A/G)GGCCA intron-variant
rs1000076990 -- 1,862,288(+) ATGCT(C/T)TAGTT intron-variant
rs1000117247 -- 1,885,779(+) CCTCC(A/C)TCCAA intron-variant
rs1000256358 -- 1,866,331(+) GGCCA(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSP1 Gene

Variant ID Type Subtype PubMed ID
dgv1565n54 CNV loss 21841781
esv1011096 OTHER inversion 20482838
esv1011285 CNV loss 20482838
esv1740077 CNV insertion 17803354
esv26638 CNV gain 19812545
esv2667353 CNV deletion 23128226
esv2743968 CNV deletion 23290073
esv2743969 CNV deletion 23290073
esv2743970 CNV deletion 23290073
esv2743971 CNV deletion 23290073
esv2743972 CNV deletion 23290073
esv2743973 CNV deletion 23290073
esv2743974 CNV deletion 23290073
esv29980 CNV loss 17803354
esv3625118 CNV loss 21293372
nsv1039289 CNV gain 25217958
nsv1047474 CNV gain 25217958
nsv1110192 CNV duplication 24896259
nsv1118489 CNV duplication 24896259
nsv1139450 CNV deletion 24896259
nsv1159792 CNV deletion 26073780
nsv39720 CNV insertion 16902084
nsv467645 CNV gain 19166990
nsv467647 CNV loss 19166990
nsv467648 CNV loss 19166990
nsv469926 CNV loss 18288195
nsv522320 CNV loss 19592680
nsv553047 CNV gain 21841781
nsv553050 CNV loss 21841781
nsv553053 CNV loss 21841781
nsv553054 CNV loss 21841781
nsv553058 CNV loss 21841781
nsv553059 CNV loss 21841781
nsv553060 CNV loss 21841781
nsv61 CNV deletion 15895083
nsv7213 OTHER inversion 18451855
nsv7643 CNV deletion 18451855
nsv825699 CNV gain 20364138
nsv825700 CNV gain+loss 20364138
nsv951281 CNV deletion 24416366
nsv951282 CNV deletion 24416366
nsv975138 CNV duplication 23825009

Variation tolerance for LSP1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSP1 Gene

Disorders for LSP1 Gene

Relevant External Links for LSP1

Genetic Association Database (GAD)
LSP1
Human Genome Epidemiology (HuGE) Navigator
LSP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSP1

No disorders were found for LSP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSP1 Gene

Publications for LSP1 Gene

  1. Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen. (PMID: 2174784) Kadiyala R.K. … Krensky A.M. (Eur. J. Immunol. 1990) 2 3 4 22 64
  2. Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations. (PMID: 18973230) Gates M.A. … Cramer D.W. (Int. J. Cancer 2009) 3 22 46 64
  3. Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort. (PMID: 19232126) Woolcott C.G. … Kolonel L.N. (Breast Cancer Res. 2009) 3 22 46 64
  4. Association of breast cancer susceptibility variants with risk of pancreatic cancer. (PMID: 19843670) Couch F.J. … Petersen G.M. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 22 46 64
  5. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. (PMID: 18437204) Garcia-Closas M. … Pharoah P.D. (PLoS Genet. 2008) 3 22 46 64

Products for LSP1 Gene

Sources for LSP1 Gene

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