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Aliases for LSP1 Gene

Aliases for LSP1 Gene

  • Lymphocyte-Specific Protein 1 2 3 5
  • Lymphocyte-Specific Antigen WP34 3 4
  • 47 KDa Actin-Binding Protein 3 4
  • 52 KDa Phosphoprotein 3 4
  • WP34 3 4
  • Pp52 3 4
  • F-Actin Binding And Cytoskeleton Associated Protein 3
  • Leufactin (Leukocyte F-Actin Binding Protein) 3
  • 47 KDa Actin Binding Protein 3
  • Leukocyte-Specific Protein 1 3

External Ids for LSP1 Gene

Previous GeneCards Identifiers for LSP1 Gene

  • GC11M000728
  • GC11M001913
  • GC11P001833
  • GC11P001838
  • GC11P001801
  • GC11P001830
  • GC11P001874
  • GC11P001665

Summaries for LSP1 Gene

Entrez Gene Summary for LSP1 Gene

  • This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for LSP1 Gene

LSP1 (Lymphocyte-Specific Protein 1) is a Protein Coding gene. Among its related pathways are Tuberculosis and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include actin binding and signal transducer activity.

UniProtKB/Swiss-Prot for LSP1 Gene

  • May play a role in mediating neutrophil activation and chemotaxis.

Gene Wiki entry for LSP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSP1 Gene

Genomics for LSP1 Gene

Regulatory Elements for LSP1 Gene

Promoters for LSP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LSP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LSP1 Gene

Chromosome:
11
Start:
1,852,970 bp from pter
End:
1,892,267 bp from pter
Size:
39,298 bases
Orientation:
Plus strand

Genomic View for LSP1 Gene

Genes around LSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSP1 Gene

Proteins for LSP1 Gene

  • Protein details for LSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33241-LSP1_HUMAN
    Recommended name:
    Lymphocyte-specific protein 1
    Protein Accession:
    P33241
    Secondary Accessions:
    • B3KPP1
    • B3KRR6
    • E9PBV6
    • E9PFP3
    • Q16096
    • Q53H48
    • Q6FHM3
    • Q9BUY8

    Protein attributes for LSP1 Gene

    Size:
    339 amino acids
    Molecular mass:
    37192 Da
    Quaternary structure:
    • Binds actin.

    Three dimensional structures from OCA and Proteopedia for LSP1 Gene

    Alternative splice isoforms for LSP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSP1 Gene

Proteomics data for LSP1 Gene at MOPED

Post-translational modifications for LSP1 Gene

  • Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LSP1 (LSP1)

No data available for DME Specific Peptides for LSP1 Gene

Domains & Families for LSP1 Gene

Protein Domains for LSP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LSP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LSP1 Gene

Function for LSP1 Gene

Molecular function for LSP1 Gene

GENATLAS Biochemistry:
lymphocyte specific protein 1 (pp52),52kDa
UniProtKB/Swiss-Prot Function:
May play a role in mediating neutrophil activation and chemotaxis.
genes like me logo Genes that share phenotypes with LSP1: view

Animal Models for LSP1 Gene

MGI Knock Outs for LSP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for LSP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSP1 Gene

Localization for LSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSP1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LSP1 Gene COMPARTMENTS Subcellular localization image for LSP1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
nucleus 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for LSP1 Gene

Pathways & Interactions for LSP1 Gene

genes like me logo Genes that share pathways with LSP1: view

Pathways by source for LSP1 Gene

1 BioSystems pathway for LSP1 Gene
1 KEGG pathway for LSP1 Gene

Interacting Proteins for LSP1 Gene

Gene Ontology (GO) - Biological Process for LSP1 Gene

None

No data available for SIGNOR curated interactions for LSP1 Gene

Drugs & Compounds for LSP1 Gene

(1) Drugs for LSP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LSP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LSP1: view

Transcripts for LSP1 Gene

Unigene Clusters for LSP1 Gene

Lymphocyte-specific protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LSP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^
SP1: - - -
SP2: - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9:
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - - -
SP16:
SP17: - - - -

ExUns: 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for LSP1 Gene

GeneLoc Exon Structure for
LSP1
ECgene alternative splicing isoforms for
LSP1

Expression for LSP1 Gene

mRNA expression in normal human tissues for LSP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LSP1 Gene

This gene is overexpressed in Whole Blood (x25.6).

Protein differential expression in normal tissues from HIPED for LSP1 Gene

This gene is overexpressed in Lavage (22.6), NK cells (6.4), and Blymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LSP1 Gene



SOURCE GeneReport for Unigene cluster for LSP1 Gene Hs.56729

mRNA Expression by UniProt/SwissProt for LSP1 Gene

P33241-LSP1_HUMAN
Tissue specificity: Activated T-lymphocytes.
genes like me logo Genes that share expression patterns with LSP1: view

Protein tissue co-expression partners for LSP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LSP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LSP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LSP1 35
  • 78.6 (n)
  • 72.19 (a)
LSP1 36
  • 60 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LSP1 35
  • 83.54 (n)
  • 77.61 (a)
-- 36
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lsp1 35
  • 75.19 (n)
  • 71.52 (a)
Lsp1 16
Lsp1 36
  • 66 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LSP1 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Lsp1 35
  • 73.81 (n)
  • 69.88 (a)
chicken
(Gallus gallus)
Aves LSP1 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lsp1 35
  • 56.06 (n)
  • 48.38 (a)
Str.4872 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18245 35
LSP1 36
  • 19 (a)
OneToMany
Species with no ortholog for LSP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LSP1 Gene

ENSEMBL:
Gene Tree for LSP1 (if available)
TreeFam:
Gene Tree for LSP1 (if available)

Paralogs for LSP1 Gene

genes like me logo Genes that share paralogs with LSP1: view

No data available for Paralogs for LSP1 Gene

Variants for LSP1 Gene

Sequence variations from dbSNP and Humsavar for LSP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs621679 - 1,881,538(+) AGGGC(A/G)CCTTG reference, missense
rs1803928 - 1,884,549(+) TTGAT(A/C)AGTGG reference, missense
rs11545725 - 1,881,563(+) CCCCC(A/T)GTGCA reference, missense
rs485055 -- 1,873,002(+) AGGTT(C/T)GGATT intron-variant
rs477476 -- 1,852,252(+) ATCCC(G/T)CCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LSP1 Gene

Variant ID Type Subtype PubMed ID
nsv896727 CNV Gain 21882294
nsv896728 CNV Gain 21882294
nsv896731 CNV Loss 21882294
nsv467645 CNV Gain 19166990
nsv469926 CNV Loss 18288195
nsv896737 CNV Loss 21882294
dgv983n71 CNV Loss 21882294
esv29980 CNV Loss 17803354
nsv896746 CNV Loss 21882294
nsv522320 CNV Loss 19592680
nsv467647 CNV Loss 19166990
nsv467648 CNV Loss 19166990
nsv7643 CNV Loss 18451855
esv2667353 CNV Deletion 23128226
esv2743968 CNV Deletion 23290073
esv2743969 CNV Deletion 23290073
esv2743970 CNV Deletion 23290073
esv2743971 CNV Deletion 23290073
esv2743972 CNV Deletion 23290073
esv1740077 CNV Insertion 17803354
esv2743973 CNV Deletion 23290073
nsv61 CNV Loss 15895083
nsv7213 OTHER Inversion 18451855
esv2743974 CNV Deletion 23290073
nsv39720 CNV Insertion 16902084
esv1011285 CNV Loss 20482838
nsv825699 CNV Gain 20364138
nsv825700 CNV Gain+Loss 20364138
esv26638 CNV Gain 19812545
esv1011096 OTHER Inversion 20482838

Variation tolerance for LSP1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSP1 Gene

HapMap Linkage Disequilibrium report
LSP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSP1 Gene

Disorders for LSP1 Gene

Relevant External Links for LSP1

Genetic Association Database (GAD)
LSP1
Human Genome Epidemiology (HuGE) Navigator
LSP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSP1

No disorders were found for LSP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSP1 Gene

Publications for LSP1 Gene

  1. Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen. (PMID: 2174784) Kadiyala R.K. … Krensky A.M. (Eur. J. Immunol. 1990) 2 3 4 23 67
  2. Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations. (PMID: 18973230) Gates M.A. … Cramer D.W. (Int. J. Cancer 2009) 3 23
  3. Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort. (PMID: 19232126) Woolcott C.G. … Kolonel L.N. (Breast Cancer Res. 2009) 3 23
  4. HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1. (PMID: 19700666) Anand A.R. … Ganju R.K. (Blood 2009) 3 23
  5. Association of breast cancer susceptibility variants with risk of pancreatic cancer. (PMID: 19843670) Couch F.J. … Petersen G.M. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23

Products for LSP1 Gene

Sources for LSP1 Gene

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