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Aliases for LSMEM2 Gene

Aliases for LSMEM2 Gene

  • Leucine-Rich Single-Pass Membrane Protein 2 2 3
  • C3orf45 3 4
  • Chromosome 3 Open Reading Frame 45 2

External Ids for LSMEM2 Gene

Previous HGNC Symbols for LSMEM2 Gene

  • C3orf45

Summaries for LSMEM2 Gene

GeneCards Summary for LSMEM2 Gene

LSMEM2 (Leucine-Rich Single-Pass Membrane Protein 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSMEM2 Gene

Genomics for LSMEM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LSMEM2 Gene

50,277,915 bp from pter
50,288,114 bp from pter
10,200 bases
Plus strand

Genomic View for LSMEM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LSMEM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSMEM2 Gene

No data available for Regulatory Elements for LSMEM2 Gene

Proteins for LSMEM2 Gene

  • Protein details for LSMEM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich single-pass membrane protein 2
    Protein Accession:

    Protein attributes for LSMEM2 Gene

    164 amino acids
    Molecular mass:
    17868 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LSMEM2 Gene

Proteomics data for LSMEM2 Gene at MOPED

Post-translational modifications for LSMEM2 Gene

No Post-translational modifications

Other Protein References for LSMEM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LSMEM2 Gene

Domains & Families for LSMEM2 Gene

Protein Domains for LSMEM2 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LSMEM2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LSMEM2 Gene

Function for LSMEM2 Gene

Gene Ontology (GO) - Molecular Function for LSMEM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LSMEM2: view

Phenotypes for LSMEM2 Gene

GenomeRNAi human phenotypes for LSMEM2:
genes like me logo Genes that share phenotypes with LSMEM2: view

Animal Model Products

CRISPR Products

miRNA for LSMEM2 Gene

miRTarBase miRNAs that target LSMEM2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSMEM2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LSMEM2 Gene

Localization for LSMEM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSMEM2 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for LSMEM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LSMEM2: view

No data available for Subcellular locations from COMPARTMENTS for LSMEM2 Gene

Pathways & Interactions for LSMEM2 Gene

SuperPathways for LSMEM2 Gene

No Data Available

Interacting Proteins for LSMEM2 Gene

Selected Interacting proteins: Q8N112-LSME2_HUMAN for LSMEM2 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for LSMEM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LSMEM2 Gene

Drugs & Compounds for LSMEM2 Gene

No Compound Related Data Available

Transcripts for LSMEM2 Gene

mRNA/cDNA for LSMEM2 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LSMEM2 Gene

Leucine-rich single-pass membrane protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSMEM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSMEM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b

Relevant External Links for LSMEM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LSMEM2 Gene

mRNA expression in normal human tissues for LSMEM2 Gene

mRNA differential expression in normal tissues according to GTEx for LSMEM2 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.2), Testis (x5.5), Heart - Atrial Appendage (x5.0), and Muscle - Skeletal (x4.9).

SOURCE GeneReport for Unigene cluster for LSMEM2 Gene Hs.315177

genes like me logo Genes that share expression patterns with LSMEM2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LSMEM2 Gene

Orthologs for LSMEM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LSMEM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LSMEM2 35
  • 80.27 (n)
  • 80.27 (a)
  • 80 (a)
(Canis familiaris)
Mammalia LSMEM2 35
  • 83.22 (n)
  • 82.55 (a)
  • 79 (a)
(Mus musculus)
Mammalia Lsmem2 35
  • 79.11 (n)
  • 82.67 (a)
BY080835 16
(Pan troglodytes)
Mammalia LSMEM2 35
  • 99.19 (n)
  • 99.39 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Lsmem2 35
  • 78.22 (n)
  • 81.33 (a)
(Monodelphis domestica)
Mammalia LSMEM2 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia LSMEM2 36
  • 63 (a)
Species with no ortholog for LSMEM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LSMEM2 Gene

Gene Tree for LSMEM2 (if available)
Gene Tree for LSMEM2 (if available)

Paralogs for LSMEM2 Gene

No data available for Paralogs for LSMEM2 Gene

Variants for LSMEM2 Gene

Sequence variations from dbSNP and Humsavar for LSMEM2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4688681 -- 50,281,059(-) AAAAA(A/T)TTTCC intron-variant
rs4688736 -- 50,284,590(-) ATGCC(C/G)AGTTA intron-variant
rs4688738 -- 50,280,039(-) AAATT(A/G)GCTAG intron-variant
rs6776145 -- 50,278,688(+) GGTCA(C/T)GCAGT upstream-variant-2KB, utr-variant-5-prime, intron-variant
rs6788132 -- 50,279,643(+) TGGGG(G/T)TCCCT intron-variant

Variation tolerance for LSMEM2 Gene

Residual Variation Intolerance Score: 75.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSMEM2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LSMEM2 Gene

Disorders for LSMEM2 Gene

Relevant External Links for LSMEM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LSMEM2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSMEM2 Gene

Publications for LSMEM2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for LSMEM2 Gene

Sources for LSMEM2 Gene

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