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Aliases for LSMEM1 Gene

Aliases for LSMEM1 Gene

  • Leucine Rich Single-Pass Membrane Protein 1 2 3 5
  • Leucine-Rich Single-Pass Membrane Protein 1 2 3
  • C7orf53 3 4
  • Chromosome 7 Open Reading Frame 53 2

External Ids for LSMEM1 Gene

Previous HGNC Symbols for LSMEM1 Gene

  • C7orf53

Previous GeneCards Identifiers for LSMEM1 Gene

  • GC07P112121

Summaries for LSMEM1 Gene

GeneCards Summary for LSMEM1 Gene

LSMEM1 (Leucine Rich Single-Pass Membrane Protein 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSMEM1 Gene

Genomics for LSMEM1 Gene

Regulatory Elements for LSMEM1 Gene

Enhancers for LSMEM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F112361 0.4 ENCODE 19.2 -117.2 -117162 2.2 SMARCA4 PRDM10 LSMEM1 IFRD1 MTND5P8 GC07P112307
GH07F112448 0.2 ENCODE 17.6 -29.0 -28986 6.0 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 IMMP2L TMEM168 IFRD1 LSMEM1 MTCYBP24 MTND5P8 MTND6P24 LOC101928012 ENSG00000270997 ZNF277
GH07F112462 1.1 ENCODE 16.9 -17.7 -17694 1.0 SOX13 MAX CEBPG RAD21 ZNF2 ZNF101 RFX5 SMC3 RCOR1 CHD2 IFRD1 LSMEM1 GC07P112458
GH07F112390 0.9 Ensembl ENCODE 15.7 -88.4 -88448 2.0 SAP130 ARID4B MAX SIN3A DMAP1 ZBTB40 TEAD3 ZNF664 CTBP1 POLR2A LSMEM1 IFRD1 MTCYBP24 LOC105375456
GH07F112434 0.5 ENCODE 11 -45.1 -45084 0.9 JUND RFX1 JUN SIN3A FOS RAD21 ATF2 LSMEM1 LOC105375457 GC07P112424
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LSMEM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LSMEM1 Gene

Chromosome:
7
Start:
112,480,238 bp from pter
End:
112,491,062 bp from pter
Size:
10,825 bases
Orientation:
Plus strand

Genomic View for LSMEM1 Gene

Genes around LSMEM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSMEM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSMEM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSMEM1 Gene

Proteins for LSMEM1 Gene

  • Protein details for LSMEM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8F7-LSME1_HUMAN
    Recommended name:
    Leucine-rich single-pass membrane protein 1
    Protein Accession:
    Q8N8F7
    Secondary Accessions:
    • Q49AR6

    Protein attributes for LSMEM1 Gene

    Size:
    131 amino acids
    Molecular mass:
    14462 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LSMEM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSMEM1 Gene

Post-translational modifications for LSMEM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LSMEM1 Gene

No data available for DME Specific Peptides for LSMEM1 Gene

Domains & Families for LSMEM1 Gene

Protein Domains for LSMEM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LSMEM1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LSMEM1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LSMEM1 Gene

Function for LSMEM1 Gene

Gene Ontology (GO) - Molecular Function for LSMEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LSMEM1: view

Phenotypes for LSMEM1 Gene

genes like me logo Genes that share phenotypes with LSMEM1: view

Animal Model Products

miRNA for LSMEM1 Gene

miRTarBase miRNAs that target LSMEM1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LSMEM1 Gene

Localization for LSMEM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSMEM1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for LSMEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LSMEM1: view

No data available for Subcellular locations from COMPARTMENTS for LSMEM1 Gene

Pathways & Interactions for LSMEM1 Gene

SuperPathways for LSMEM1 Gene

No Data Available

Interacting Proteins for LSMEM1 Gene

Gene Ontology (GO) - Biological Process for LSMEM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LSMEM1 Gene

Transcripts for LSMEM1 Gene

Unigene Clusters for LSMEM1 Gene

Leucine-rich single-pass membrane protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSMEM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for LSMEM1 Gene

GeneLoc Exon Structure for
LSMEM1
ECgene alternative splicing isoforms for
LSMEM1

Expression for LSMEM1 Gene

mRNA expression in normal human tissues for LSMEM1 Gene

mRNA differential expression in normal tissues according to GTEx for LSMEM1 Gene

This gene is overexpressed in Whole Blood (x7.0) and Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for LSMEM1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LSMEM1 Gene



Protein tissue co-expression partners for LSMEM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LSMEM1 Gene:

LSMEM1

SOURCE GeneReport for Unigene cluster for LSMEM1 Gene:

Hs.396189
genes like me logo Genes that share expression patterns with LSMEM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LSMEM1 Gene

Orthologs for LSMEM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LSMEM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSMEM1 34 35
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia LSMEM1 34 35
  • 85.68 (n)
rat
(Rattus norvegicus)
Mammalia Lsmem1 34
  • 82.81 (n)
mouse
(Mus musculus)
Mammalia Lsmem1 34 16 35
  • 82.55 (n)
dog
(Canis familiaris)
Mammalia LSMEM1 34
  • 77.69 (n)
C7ORF53 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LSMEM1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7ORF53 34
  • 61.72 (n)
LSMEM1 35
  • 39 (a)
OneToOne
Species where no ortholog for LSMEM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LSMEM1 Gene

ENSEMBL:
Gene Tree for LSMEM1 (if available)
TreeFam:
Gene Tree for LSMEM1 (if available)

Paralogs for LSMEM1 Gene

No data available for Paralogs for LSMEM1 Gene

Variants for LSMEM1 Gene

Sequence variations from dbSNP and Humsavar for LSMEM1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10225870 -- 112,490,073(+) ACCCA(A/C)CCCTG utr-variant-3-prime
rs10225991 -- 112,490,206(+) GTGGG(C/T)GGCTA utr-variant-3-prime
rs10230646 -- 112,478,506(+) TATTT(A/T)TTTTT upstream-variant-2KB
rs10236486 -- 112,488,502(+) TATAT(C/T)GAGTC intron-variant
rs10246851 -- 112,486,125(+) TTTGT(G/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSMEM1 Gene

Variant ID Type Subtype PubMed ID
dgv1950e212 CNV loss 25503493
esv2422365 CNV duplication 17116639
esv3891194 CNV gain 25118596
nsv1030033 CNV loss 25217958
nsv464689 CNV gain 19166990
nsv608200 CNV gain 21841781
nsv608226 CNV gain 21841781

Variation tolerance for LSMEM1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSMEM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSMEM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSMEM1 Gene

Disorders for LSMEM1 Gene

Relevant External Links for LSMEM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSMEM1

No disorders were found for LSMEM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSMEM1 Gene

Publications for LSMEM1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for LSMEM1 Gene

Sources for LSMEM1 Gene

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