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Aliases for LSMEM1 Gene

Aliases for LSMEM1 Gene

  • Leucine-Rich Single-Pass Membrane Protein 1 2 3
  • C7orf53 3 4
  • Chromosome 7 Open Reading Frame 53 2

External Ids for LSMEM1 Gene

Previous HGNC Symbols for LSMEM1 Gene

  • C7orf53

Previous GeneCards Identifiers for LSMEM1 Gene

  • GC07P112121

Summaries for LSMEM1 Gene

GeneCards Summary for LSMEM1 Gene

LSMEM1 (Leucine-Rich Single-Pass Membrane Protein 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSMEM1 Gene

Genomics for LSMEM1 Gene

Genomic Location for LSMEM1 Gene

112,480,327 bp from pter
112,491,062 bp from pter
10,736 bases
Plus strand

Genomic View for LSMEM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LSMEM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSMEM1 Gene

No data available for Regulatory Elements for LSMEM1 Gene

Proteins for LSMEM1 Gene

  • Protein details for LSMEM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich single-pass membrane protein 1
    Protein Accession:
    Secondary Accessions:
    • Q49AR6

    Protein attributes for LSMEM1 Gene

    131 amino acids
    Molecular mass:
    14462 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LSMEM1 Gene


neXtProt entry for LSMEM1 Gene

Proteomics data for LSMEM1 Gene at MOPED

Post-translational modifications for LSMEM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LSMEM1 Gene

No data available for DME Specific Peptides for LSMEM1 Gene

Domains for LSMEM1 Gene

Protein Domains for LSMEM1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LSMEM1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LSMEM1 Gene

Function for LSMEM1 Gene

Gene Ontology (GO) - Molecular Function for LSMEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LSMEM1: view

Phenotypes for LSMEM1 Gene

GenomeRNAi human phenotypes for LSMEM1:
genes like me logo Genes that share phenotypes with LSMEM1: view

Animal Model Products

miRNA for LSMEM1 Gene

miRTarBase miRNAs that target LSMEM1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSMEM1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LSMEM1 Gene

Localization for LSMEM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSMEM1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for LSMEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LSMEM1: view

No data available for Subcellular locations from COMPARTMENTS for LSMEM1 Gene

Pathways for LSMEM1 Gene

SuperPathways for LSMEM1 Gene

No Data Available

Interacting Proteins for LSMEM1 Gene

Selected Interacting proteins: Q8N8F7-LSME1_HUMAN for LSMEM1 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for LSMEM1 Gene


No data available for Pathways by source for LSMEM1 Gene

Transcripts for LSMEM1 Gene

Unigene Clusters for LSMEM1 Gene

Leucine-rich single-pass membrane protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSMEM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSMEM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for LSMEM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LSMEM1 Gene

mRNA expression in normal human tissues for LSMEM1 Gene

mRNA differential expression in normal tissues according to GTEx for LSMEM1 Gene

This gene is overexpressed in Whole Blood (7.0) and Muscle - Skeletal (5.2).

Protein differential expression in normal tissues for LSMEM1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LSMEM1 Gene

SOURCE GeneReport for Unigene cluster for LSMEM1 Gene Hs.396189

genes like me logo Genes that share expressions with LSMEM1: view

Expression partners for LSMEM1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LSMEM1 Gene

Orthologs for LSMEM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LSMEM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LSMEM1 35
  • 85.68 (n)
  • 79.69 (a)
  • 78 (a)
(Canis familiaris)
Mammalia LSMEM1 35
  • 77.69 (n)
  • 73.23 (a)
C7ORF53 36
  • 72 (a)
(Mus musculus)
Mammalia Lsmem1 35
  • 82.55 (n)
  • 83.59 (a)
Gm889 16
Lsmem1 36
  • 84 (a)
(Pan troglodytes)
Mammalia LSMEM1 35
  • 99.75 (n)
  • 99.24 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Lsmem1 35
  • 82.81 (n)
  • 79.69 (a)
(Monodelphis domestica)
Mammalia LSMEM1 36
  • 63 (a)
(Gallus gallus)
Aves C7ORF53 35
  • 61.72 (n)
  • 48.44 (a)
  • 39 (a)
Species with no ortholog for LSMEM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LSMEM1 Gene

Gene Tree for LSMEM1 (if available)
Gene Tree for LSMEM1 (if available)

Paralogs for LSMEM1 Gene

No data available for Paralogs for LSMEM1 Gene

Variants for LSMEM1 Gene

Sequence variations from dbSNP and Humsavar for LSMEM1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs547419190 -- 112,487,967(+) ATTTC(A/G)TTCAG intron-variant
rs547317913 -- 112,480,747(+) ATCGC(G/T)TTTTG upstream-variant-2KB, utr-variant-5-prime
rs546996735 -- 112,481,609(+) CAATA(C/T)TGGTG intron-variant, upstream-variant-2KB
rs546983125 -- 112,482,961(+) TTTTT(A/G)GTCCA intron-variant, upstream-variant-2KB
rs546960757 -- 112,490,530(+) AGTTA(C/T)GTGGG utr-variant-3-prime

Relevant External Links for LSMEM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LSMEM1 Gene

Disorders for LSMEM1 Gene

No disorders were found for LSMEM1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for LSMEM1 Gene

Publications for LSMEM1 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for LSMEM1 Gene

Sources for LSMEM1 Gene

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