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Aliases & Descriptions for LSM8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2 | | MAK31-like protein 2 | | U6 snRNA-associated Sm-like protein LSm8 2 |
|
| | Search outside databases for aliases for LSM8 genePrevious GC identifers: GC07P116302 GC07P117364 GC07P117378 GC07P117418 |
Summaries for LSM8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LSM8: This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq] UniProtKB/Swiss-Prot: LSM8_HUMAN, O95777Function: Binds specifically to the 3'-terminal U-tract of U6 snRNAGene Wiki entry for LSM8 |
Genomic Location for LSM8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LSM8 gene 
Entrez Gene cytogenetic band: 7q31.1-q31.3 Ensembl cytogenetic band: 7q31.31 HGNC cytogenetic band: 7q31.1-q31.3LSM8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P117611:
(about GC identifiers)
Start:
|
117,611,322 bp from pter |
End:
|
117,620,116 bp from pter |
Size:
|
8,795 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 117,219,509-117,228,303 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079596.2
| Proteins for LSM8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LSM8_HUMAN, O95777 (See
protein sequence)Recommended Name: U6 snRNA-associated Sm-like protein LSm8 Size: 96 amino acids; 10403 Da
Subunit: LSm subunits form a heteromer with a donut shape
Subcellular location: Nucleus (Potential)Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057284.1
ENSEMBL proteins: ENSP00000249299
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- | | GO:0030529 | ribonucleoprotein complex |
IEA | -- | About this table
Antibodies for LSM8: Assays for LSM8: | Protein
Domains/ Families for LSM8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95777
ProtoNet protein and cluster: O95777 2 Blocks protein families: IPB001163 Small nuclear ribonucleoprotein (Sm protein) IPB010920 Like-Sm ribonucleoprotein-related
UniProtKB/Swiss-Prot: LSM8_HUMAN, O95777Similarity: Belongs to the snRNP Sm proteins family | Gene Function for LSM8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016200
Applied Biosystems Silencer® siRNAs for LSM8
Sigma-Aldrich siRNA for LSM8  Sigma-Aldrich shRNA for LSM8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016200                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016200                                  untagged cDNA clones in CMV expression vector (see all 2): BC002742 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016200
UniProtKB/Swiss-Prot: LSM8_HUMAN, O95777Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LSM8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/33 Interacting proteins for LSM8 (O957771, 2 ENSP000002492993) via UniProtKB, MINT, and/or STRING (see all 33
)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ENSG00000172850 | Q9Y3331, 2, ENSP000003728833 | EBI-347779, EBI-347416 MINT-62688 MINT-62590 MINT-62764 STRING (score=.744) | | LSM3 | P623101, ENSP000003021603 | EBI-347779, EBI-348239 STRING (score=.988) | | LSM6 | P623121, ENSP000002965813 | EBI-347779, EBI-373310 STRING (score=.987) | | LSM4 | Q9Y4Z01, ENSP000002528163 | EBI-347779, EBI-372521 STRING (score=.986) | | LSM7 | Q9UK451, ENSP000002526223 | EBI-347779, EBI-348372 STRING (score=.736) | | ENSG00000111987 | Q9Y3331, 2 | EBI-347779, EBI-347416 MINT-62688 MINT-62590 MINT-62764 | About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000398 | nuclear mRNA splicing, via spliceosome |
NAS | -- | | GO:0008380 | RNA splicing |
IEA | -- | About this table
|
Drugs & Compounds for LSM8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LSM8
|
Transcripts for LSM8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016200
Sigma-Aldrich siRNA for LSM8  Sigma-Aldrich shRNA for LSM8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016200 REFSEQ mRNAs for LSM8 gene: NM_016200.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016200               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016200                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016200                                  untagged cDNA clones in CMV expression vector (see all 2): BC002742  Additional cDNA sequence: AF182294.1 AK090561.1 AK311936.1 BC002742.2 BC022440.1 BX537999.1 8 DOTS entries: DT.115713 DT.100662478 DT.80100375 DT.95274095 DT.100667712 DT.121108915 DT.91762921 DT.120805871 24/189 AceView cDNA sequences (see all 189
):AA992175 BM546875 BX503520 AA953298 N32524 AA742187 AI358735 AI933638 Z44888 AA554299 BM023159 AL600056 AI243658 AA885244 BC053644 AA578593 BQ009177 Z40586 Z44780 AW078874 BF436500 F04945 BP380562 BU601738
highest scoring ESTs for LSM8:AI978701 AL046942 AA281594 AA588130 AA641763 AA700501 AA742187 AA761830 AF182294 AI354410 Unigene Cluster for LSM8: LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) Hs.709757 [show with all ESTs]Unigene Representative Sequence: BX537999
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for LSM8
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LSM8
1 Ensembl transcript including schematic representation: ENST00000249299
|
Expression for LSM8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LSM8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LSM8
1 / 2 / 3 4 probe-sets matching LSM8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACGAGTATT
SOURCE GeneReport for Unigene cluster: Hs.709757
|
Orthologs for LSM8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LSM8 gene from 5/17 species (see all 17
)
About this table Species with no ortholog for LSM8
ENSEMBL Gene Tree for LSM8 | Paralogs for LSM8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for LSM8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LSM8 (up to first 250kb)
|
Disorders & Mutations for LSM8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607288
|
Medical News for LSM8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LSM8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for LSM8 gene (see all 14
): |
Search for LSM8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LSM8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LSM8
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LSM8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LSM8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LSM8:

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| | Recombinant Proteins (LSM8) | | Antibodies (LSM8) |
| | | Search Tocris compounds for LSM8 |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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