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Aliases for LSM7 Gene

Aliases for LSM7 Gene

  • LSM7 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2 3
  • U6 SnRNA-Associated Sm-Like Protein LSm7 3
  • YNL147W 3

External Ids for LSM7 Gene

Previous GeneCards Identifiers for LSM7 Gene

  • GC19M002384
  • GC19M002261
  • GC19M002272
  • GC19M002092

Summaries for LSM7 Gene

Entrez Gene Summary for LSM7 Gene

  • Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

GeneCards Summary for LSM7 Gene

LSM7 (LSM7 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include U6 snRNA binding.

UniProtKB/Swiss-Prot for LSM7 Gene

  • Binds specifically to the 3-terminal U-tract of U6 snRNA and is probably a component of the spliceosome

Gene Wiki entry for LSM7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM7 Gene

Genomics for LSM7 Gene

Regulatory Elements for LSM7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LSM7 Gene

Start:
2,321,517 bp from pter
End:
2,328,620 bp from pter
Size:
7,104 bases
Orientation:
Minus strand

Genomic View for LSM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LSM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM7 Gene

Proteins for LSM7 Gene

  • Protein details for LSM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK45-LSM7_HUMAN
    Recommended name:
    U6 snRNA-associated Sm-like protein LSm7
    Protein Accession:
    Q9UK45
    Secondary Accessions:

    Protein attributes for LSM7 Gene

    Size:
    103 amino acids
    Molecular mass:
    11602 Da
    Quaternary structure:
    • LSm subunits form a heteromer with a doughnut shape. Also interacts with TACC1.

neXtProt entry for LSM7 Gene

Proteomics data for LSM7 Gene at MOPED

Post-translational modifications for LSM7 Gene

  • Ubiquitination at Lys17 and Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for LSM7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LSM7 Gene

Domains for LSM7 Gene

Suggested Antigen Peptide Sequences for LSM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK45

UniProtKB/Swiss-Prot:

LSM7_HUMAN :
  • Q9UK45
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with LSM7: view

No data available for Gene Families for LSM7 Gene

Function for LSM7 Gene

Molecular function for LSM7 Gene

UniProtKB/Swiss-Prot Function: Binds specifically to the 3-terminal U-tract of U6 snRNA and is probably a component of the spliceosome

Gene Ontology (GO) - Molecular Function for LSM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12165861
GO:0017070 U6 snRNA binding NAS 10523320
genes like me logo Genes that share ontologies with LSM7: view
genes like me logo Genes that share phenotypes with LSM7: view

Animal Model Products

CRISPR Products

miRNA for LSM7 Gene

miRTarBase miRNAs that target LSM7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSM7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LSM7 Gene

Localization for LSM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LSM7 Gene COMPARTMENTS Subcellular localization image for LSM7 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for LSM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IEA --
GO:0005732 small nucleolar ribonucleoprotein complex IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LSM7: view

Pathways for LSM7 Gene

genes like me logo Genes that share pathways with LSM7: view

Pathways by source for LSM7 Gene

1 BioSystems pathway for LSM7 Gene
2 KEGG pathways for LSM7 Gene

Gene Ontology (GO) - Biological Process for LSM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000398 mRNA splicing, via spliceosome IEA --
GO:0006397 mRNA processing --
GO:0008380 RNA splicing --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with LSM7: view

Transcripts for LSM7 Gene

Unigene Clusters for LSM7 Gene

LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSM7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSM7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for LSM7 Gene

GeneLoc Exon Structure for
LSM7
ECgene alternative splicing isoforms for
LSM7

Expression for LSM7 Gene

mRNA expression in normal human tissues for LSM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for LSM7 Gene

SOURCE GeneReport for Unigene cluster for LSM7 Gene Hs.512610

genes like me logo Genes that share expressions with LSM7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LSM7 Gene

Orthologs for LSM7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LSM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSM7 35
  • 100 (n)
  • 100 (a)
LSM7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LSM7 35
  • 90.94 (n)
  • 100 (a)
LSM7 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LSM7 35
  • 91.59 (n)
  • 99.03 (a)
LSM7 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10146 36
  • 97 (a)
OneToMany
Lsm7 35
  • 87.06 (n)
  • 97.09 (a)
Lsm7 16
Lsm7 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LSM7 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LSM7 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lsm7 35
  • 85.76 (n)
  • 98.06 (a)
chicken
(Gallus gallus)
Aves LSM7 35
  • 77.99 (n)
  • 96.12 (a)
LSM7 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm7 35
  • 76.05 (n)
  • 95.15 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8944 35
zebrafish
(Danio rerio)
Actinopterygii lsm7 35
  • 79.61 (n)
  • 95.15 (a)
lsm7 36
  • 95 (a)
OneToOne
wufj64g01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008122 35
  • 72.79 (n)
  • 80.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta LSm7 35
  • 70.1 (n)
  • 77.32 (a)
LSm7 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lsm-7 35
  • 56.33 (n)
  • 57 (a)
lsm-7 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR053C 35
  • 61.96 (n)
  • 51.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSM7 35
  • 49.81 (n)
  • 49.44 (a)
LSM7 36
  • 40 (a)
OneToOne
LSM7 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22881g 35
  • 51.69 (n)
  • 51.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G03870 35
  • 58.87 (n)
  • 55.32 (a)
rice
(Oryza sativa)
Liliopsida Os08g0177700 35
  • 61.48 (n)
  • 56.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lsm7 35
  • 52.08 (n)
  • 60.42 (a)
Species with no ortholog for LSM7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LSM7 Gene

ENSEMBL:
Gene Tree for LSM7 (if available)
TreeFam:
Gene Tree for LSM7 (if available)

Paralogs for LSM7 Gene

Selected SIMAP similar genes for LSM7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LSM7: view

No data available for Paralogs for LSM7 Gene

Variants for LSM7 Gene

Sequence variations from dbSNP and Humsavar for LSM7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs876692 -- 2,322,166(+) TGGCC(A/G)GCCAG intron-variant
rs886881 -- 2,321,855(+) AGGGA(C/G)CTCCA intron-variant
rs886882 -- 2,322,086(+) GGCCC(A/G)GGTGA intron-variant
rs1971004 -- 2,322,322(+) ATCAC(A/G)AGGTC intron-variant
rs1971005 -- 2,322,354(+) CTAAC(A/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSM7 Gene

Variant ID Type Subtype PubMed ID
dgv3614n71 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
nsv910623 CNV Loss 21882294
dgv3630n71 CNV Loss 21882294
dgv3631n71 CNV Loss 21882294
nsv833707 CNV Loss 17160897
dgv3633n71 CNV Loss 21882294
nsv910643 CNV Loss 21882294
dgv3635n71 CNV Loss 21882294
nsv910650 CNV Gain 21882294
nsv910651 CNV Loss 21882294

Relevant External Links for LSM7 Gene

HapMap Linkage Disequilibrium report
LSM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM7 Gene

Disorders for LSM7 Gene

No disorders were found for LSM7 Gene.

No data available for UniProtKB/Swiss-Prot for LSM7 Gene

Publications for LSM7 Gene

  1. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N. … Birnbaum D. (Oncogene 2002) 3 4 23
  2. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PMID: 10523320) Achsel T. … Luehrmann R. (EMBO J. 1999) 2 3 4
  3. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PMID: 12515382) Ingelfinger D. … Achsel T. (RNA 2002) 2 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for LSM7 Gene

Sources for LSM7 Gene

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