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LSM7 Gene

protein-coding   GIFtS: 59
GCID: GC19M002321

LSM7 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LSM7 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)1 2
YNL147W2
U6 SnRNA-Associated Sm-Like Protein LSm72

External Ids:    HGNC: 204701   Entrez Gene: 516902   Ensembl: ENSG000001303327   OMIM: 6072875   UniProtKB: Q9UK453   

Export aliases for LSM7 gene to outside databases

Previous GC identifers: GC19M002384 GC19M002261 GC19M002272 GC19M002092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LSM7 Gene:
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family
(see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated
by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer
present in tri-snRNP particles, which are important for pre-mRNA splicing.(supplied by OMIM, Apr 2004)

GeneCards Summary for LSM7 Gene:
LSM7 (LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)) is a protein-coding gene. Diseases associated with LSM7 include spinal muscular atrophy, and muscular atrophy. GO annotations related to this gene include U6 snRNA binding.

UniProtKB/Swiss-Prot: LSM7_HUMAN, Q9UK45
Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome

Gene Wiki entry for LSM7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the LSM7 gene promoter:
         GR   USF1   Sp1   USF2   USF-1:USF-2   STAT5A   FOXJ2 (long isoform)   USF-1   FOXJ2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLSM7 promoter sequence
   Search Chromatin IP Primers for LSM7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LSM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

LSM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LSM7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002321:  view genomic region     (about GC identifiers)

Start:
2,321,516 bp from pter      End:
2,328,619 bp from pter
Size:
7,104 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LSM7_HUMAN, Q9UK45 (See protein sequence)
Recommended Name: U6 snRNA-associated Sm-like protein LSm7  
Size: 103 amino acids; 11602 Da
Subunit: LSm subunits form a heteromer with a doughnut shape. Also interacts with TACC1

Explore the universe of human proteins at neXtProt for LSM7: NX_Q9UK45

Explore proteomics data for LSM7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17, Lys21
  • Modification sites at PhosphoSitePlus

  • See LSM7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057283.1  
    ENSEMBL proteins: 
     ENSP00000252622   ENSP00000466556   ENSP00000467145  
    Reactome Protein details: Q9UK45

    LSM7 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for LSM7

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    Cloud-Clone Corp. CLIAs for LSM7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom
     IPR017132 U6_snRNA_Lsm7

    Graphical View of Domain Structure for InterPro Entry Q9UK45

    ProtoNet protein and cluster: Q9UK45

    2 Blocks protein domains:
    IPB001163 Small nuclear ribonucleoprotein (Sm protein)
    IPB010920 Like-Sm ribonucleoprotein-related


    UniProtKB/Swiss-Prot: LSM7_HUMAN, Q9UK45
    Similarity: Belongs to the snRNP Sm proteins family


    LSM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LSM7_HUMAN, Q9UK45
    Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12165861
    GO:0017070U6 snRNA binding NAS10523320
         
    LSM7 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for LSM7:
     Decreased homologous recombina  Decreased viability of wild-ty  Decreased viability with pacli  Increased circadian period len 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LSM7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LSM7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LSM7

    miRNA
    Products:
        
    miRTarBase miRNAs that target LSM7:
    hsa-mir-92a-3p (MIRT049616)

    Block miRNA regulation of human, mouse, rat LSM7 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LSM7:
    hsa-miR-3658 hsa-miR-590-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidLSM7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LSM7
    Predesigned siRNA for gene silencing in human, mouse, rat LSM7

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LSM7

    Clone
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    GenScript: all cDNA clones in your preferred vector: LSM7 (NM_016199)
    Sino Biological Human cDNA Clone for LSM7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LSM7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LSM7_HUMAN, Q9UK45: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005681spliceosomal complex IEA--
    GO:0005829cytosol TAS--

    LSM7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LSM7 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2mRNA Splicing - Major Pathway
    mRNA processing0.44
    3Gene Expression
    Gene Expression0.40
    4Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LSM7
        mRNA processing


    1 Reactome Pathway for LSM7
        mRNA decay by 5' to 3' exoribonuclease


    2 Kegg Pathways  (Kegg details for LSM7):
        RNA degradation
    Spliceosome


    LSM7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LSM7
    Interactions:

        Search GeneGlobe Interaction Network for LSM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LSM7 (Q9UK451, 2, 3 ENSP000002526224) via UniProtKB, MINT, STRING, and/or I2D (see all 178)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236826Q9Y3331, 2, 3, ENSP000004146344EBI-348372,EBI-347416 MINT-62690 MINT-62766 MINT-62592 MINT-8336188 I2D: score=6 STRING: ENSP00000414634
    LSM2Q9Y3331, 2, 3, ENSP000003648134EBI-348372,EBI-347416 MINT-62690 MINT-62766 MINT-62592 MINT-8336188 I2D: score=6 STRING: ENSP00000364813
    ENSG00000172850Q9Y3331, 2, 3EBI-348372,EBI-347416 MINT-62690 MINT-62766 MINT-62592 MINT-8336188 I2D: score=6 
    ENSG00000225998Q9Y3331, 2, 3EBI-348372,EBI-347416 MINT-62690 MINT-62766 MINT-62592 MINT-8336188 I2D: score=6 
    ENSG00000231502Q9Y3331, 2, 3EBI-348372,EBI-347416 MINT-62690 MINT-62766 MINT-62592 MINT-8336188 I2D: score=6 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000398mRNA splicing, via spliceosome ----
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0010467gene expression TAS--

    LSM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LSM7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LSM7 gene: 
    NM_016199.2  

    Unigene Cluster for LSM7:

    LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
    Hs.512610  [show with all ESTs]
    Unigene Representative Sequence: AK127573
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252622(uc002lvp.4) ENST00000589532 ENST00000585395 ENST00000587502
    ENST00000585409 ENST00000591515 ENST00000591745
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LSM7 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LSM7:
    hsa-miR-3658 hsa-miR-590-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidLSM7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LSM7
    Predesigned siRNA for gene silencing in human, mouse, rat LSM7
    Clone
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    OriGene clones in human, mouse for LSM7 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LSM7 (NM_016199)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LSM7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM7
    Primer
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    OriGene qPCR primer pairs and template standards for LSM7
    OriGene qSTAR qPCR primer pairs in human, mouse for LSM7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LSM7
      QuantiTect SYBR Green Assays in human, mouse, rat LSM7
      QuantiFast Probe-based Assays in human, mouse, rat LSM7

    Additional mRNA sequence: 

    AF182293.1 AK127573.1 BC018621.1 

    9 DOTS entries:

    DT.446022  DT.100768058  DT.121414335  DT.91749168  DT.99997695  DT.121414515  DT.121414562  DT.95268954 
    DT.99979042 

    Selected AceView cDNA sequences (see all 164):

    AA481033 AA358257 BE644879 AA595320 BM473112 BU732767 BQ548745 BC018621 
    BU856494 AI369407 BM546845 BU146987 BU728481 AA588197 BM663115 AI620598 
    BM023323 BX279582 AA609823 AA722938 AI081256 BM790300 BM991504 AI097314 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LSM7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                          -     -                           
    SP2:                          -     -                           
    SP3:                                -                           
    SP4:                          -     -                           
    SP5:                                                            


    ECgene alternative splicing isoforms for LSM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LSM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCCATCC
    LSM7 Expression
    About this image


    LSM7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Stomach (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    LSM7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LSM7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512610
        Custom PCR Arrays for LSM7
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat LSM7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LSM7 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lsm71 , 5 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)1, 5 87.06(n)1
    97.09(a)1
      10 (39.72 cM)5
    660941  NM_025349.21  NP_079625.11 
     808528255 
    chicken
    (Gallus gallus)
    Aves LSM71 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 77.99(n)
    96.12(a)
      420055  NM_001006337.2  NP_001006337.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lsm71 LSM7 homolog, U6 small nuclear RNA associated 76.05(n)
    95.15(a)
      100127774  NM_001171662.1  NP_001165133.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj64g012 wufj64g01 80.53(n)   336340  BC055642.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LSm71 LSm7 70.1(n)
    77.32(a)
      35003  NM_001259116.2  NP_001246045.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lsm-71 lsm-7 56.33(n)
    57(a)
      177988  NM_069633.4  NP_502034.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSM7(YNL147W)4
    LSM71
    Lsm (Like Sm) protein; part of heteroheptameric complexes more4
    LSM71
    49.81(n)1
    49.44(a)1
      14(350940-351383)4
    8555751, 4  NP_014252.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G038701 AT2G03870 58.87(n)
    55.32(a)
      814913  NM_179600.2  NP_849931.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01777001 Os08g0177700 61.48(n)
    56.67(a)
      4344803  NM_001067659.1  NP_001061124.1 


    ENSEMBL Gene Tree for LSM7 (if available)
    TreeFam Gene Tree for LSM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LSM7 gene
    2 SIMAP similar genes for LSM7 using alignment to 3 protein entries:     LSM7_HUMAN (see all proteins):
    SNRPG    LSM8

    LSM7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LSM7 (see all 166)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104137791,2
    C--2321067(+) GCCTCT/CTGATG 1 -- int12Minor allele frequency- C:0.00NA 4
    rs1477437311,2
    --2321073(+) TGATGA/CACCCC 1 -- int10--------
    rs1150008861,2
    F--2321076(+) TGCACC/TCCGGC 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1422414291,2
    C--2321099(+) CAGCC-/TCCTGAT
    GCACCCCAGG
    TCCTG
    1 -- int10--------
    rs286738591,2
    C--2321114(+) ACCCCA/GGCTCC 1 -- int10--------
    rs287330431,2
    --2321116(+) CCCGGC/GTCCTG 1 -- int10--------
    rs285670131,2
    C--2321124(+) CTGATG/TCACCC 1 -- int10--------
    rs729874531,2
    C,F--2321148(+) ACCCAG/TCTCCT 1 -- int15Minor allele frequency- T:0.19CSA WA NA EA 362
    rs1498185811,2
    --2321197(+) GCACCC/TCGGCT 1 -- int10--------
    rs729874551,2
    C--2321198(+) CACCCC/TGGCTC 1 -- int15Minor allele frequency- T:0.19CSA WA NA EA 361

    HapMap Linkage Disequilibrium report for LSM7 (2321516 - 2328619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LSM7 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910651CNV Loss21882294
    dgv3631n71CNV Loss21882294
    dgv3630n71CNV Loss21882294
    dgv3614n71CNV Loss21882294
    dgv3635n71CNV Loss21882294
    dgv3622n71CNV Loss21882294
    dgv3633n71CNV Loss21882294
    nsv910643CNV Loss21882294
    nsv910623CNV Loss21882294
    nsv833707CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607287    OMIM disorders: --

    4 diseases for LSM7:    
    About MalaCards
    spinal muscular atrophy    muscular atrophy    malaria    breast cancer


    LSM7 for disorders           About GeneDecksing


    Export disorders for LSM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LSM7 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with LSM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PubMed id 10523320)1, 2, 3 Achsel T.... Luehrmann R. (EMBO J. 1999)
    2. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PubMed id 12165861)1, 2, 9 Conte N.... Birnbaum D. (Oncogene 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 3 Ingelfinger D.... Achsel T. (RNA 2002)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51690 HGNC: 20470 AceView: LSM7 Ensembl:ENSG00000130332 euGenes: HUgn51690
    ECgene: LSM7 Kegg: 51690 H-InvDB: LSM7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LSM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LSM7 gene:
    Search GeneIP for patents involving LSM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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