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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LSM5 Gene

protein-coding   GIFtS: 59
GCID: GC07M032524

LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
 Explore 3 diseases affiliated with
LSM5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LSM5    

Aliases
for LSM5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
LSM5 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)1 2
YER146W1 2
U6 SnRNA-Associated Sm-Like Protein LSm52

External Ids:    HGNC: 171621   Entrez Gene: 236582   Ensembl: ENSG000001063557   OMIM: 6072855   UniProtKB: Q9Y4Y93   

Export aliases for LSM5 gene to outside databases

Previous GC identifers: GC07M032167 GC07M032233 GC07M032267 GC07M032298 GC07M032491 GC07M032402


Summaries
for LSM5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LSM5:
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see
SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker
of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in
tri-snRNP particles, which are important for pre-mRNA splicing.(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: LSM5_HUMAN, Q9Y4Y9
Function: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating
formation of the spliceosomal U4/U6 duplex formation in vitro

Gene Wiki entry for LSM5


Genomic Views
for LSM5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LSM5 gene promoter:
         AML1a   FOXF2   FOXJ2 (long isoform)   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LSM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for LSM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LSM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

LSM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LSM5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M032524:  view genomic region     (about GC identifiers)

Start:
 32,524,945 bp from pter      End:
 32,534,895 bp from pter
Size:
 9,951 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 32,570,144-32,580,067     

Proteins
for LSM5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LSM5_HUMAN, Q9Y4Y9 (See protein sequence)
Recommended Name: U6 snRNA-associated Sm-like protein LSm5  
Size: 91 amino acids; 9937 Da
Subunit: LSm subunits form a heteromer with a doughnut shape (By similarity)
Subcellular location: Nucleus (By similarity)
Alternative splicing: 2 isoforms:  Q9Y4Y9-1   Q9Y4Y9-2   

Explore the universe of human proteins at neXtProt for LSM5: NX_Q9Y4Y9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y4Y9

    • LSM5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124182.1  NP_001132971.1  NP_036454.1  

    ENSEMBL proteins: 
     ENSP00000410758   ENSP00000386363   ENSP00000386814   ENSP00000386707   ENSP00000386275  
     ENSP00000223084   ENSP00000387109   ENSP00000387126  
    Reactome Protein details: Q9Y4Y9
    Human Recombinant Protein Products: 
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    Novus Biologicals LSM5 Protein
    Novus Biologicals LSM5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LSM5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0030529ribonucleoprotein complex IEA--


    LSM5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LSM5

    Protein Domains /
    Families
    for LSM5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LSM5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001163 Ribonucl_LSM
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4Y9

    ProtoNet protein and cluster: Q9Y4Y9

    2 Blocks protein families:
    IPB001163 Small nuclear ribonucleoprotein (Sm protein)
    IPB010920 Like-Sm ribonucleoprotein-related


    UniProtKB/Swiss-Prot: LSM5_HUMAN, Q9Y4Y9
    Similarity: Belongs to the snRNP Sm proteins family


    Function
    for LSM5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LSM5_HUMAN, Q9Y4Y9
    Function: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating
    formation of the spliceosomal U4/U6 duplex formation in vitro

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LSM5
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    hsa-miR-3128 hsa-miR-623 hsa-miR-4251 hsa-miR-539 hsa-miR-520d-5p hsa-miR-4263 hsa-miR-501-3p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: LSM5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LSM5 (see all 7)
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LSM5

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM5 

    Cell Line
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    Search LifeMap BioReagents cell lines for LSM5

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI15231747


    LSM5 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for LSM5:
     Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 


    Pathways & Interactions
    for LSM5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay1.00
    		mRNA Decay by 5' to 3' Exoribonuclease0.31
    		RNA degradation0.50
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Generic Transcription Pathway
    		Gene Expression0.46
    4mRNA Splicing - Major Pathway
    		Spliceosome0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for LSM5
        Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression
    mRNA Decay by 5' to 3' Exoribonuclease


    2         Kegg Pathways  (Kegg details for LSM5):
        RNA degradation
    Spliceosome


    LSM5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LSM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for LSM5 (Q9Y4Y91, 2, 3 ENSP000004107584) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSM7Q9UK451, 2, 3, ENSP000002526224EBI-373007,EBI-348372 MINT-8336342 I2D: score=6 STRING: ENSP00000252622
    LSM6P623121, 2, 3, ENSP000002965814EBI-373007,EBI-373310 MINT-8336331 I2D: score=4 STRING: ENSP00000296581
    LSM3P623101, 3, ENSP000003021604EBI-373007,EBI-348239 I2D: score=4 STRING: ENSP00000302160
    SNRPFP623062, 3, ENSP000002667354MINT-8332844 I2D: score=9 STRING: ENSP00000266735
    SMN2Q166373, ENSP000003701194I2D: score=1 STRING: ENSP00000370119
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--


    LSM5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LSM5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LSM5
    Search CenterWatch for drugs/clinical trials and news about LSM5 

    Transcripts
    for LSM5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LSM5 gene (3 alternative transcripts): 
    NM_001130710.1  NM_001139499.1  NM_012322.2  

    Unigene Cluster for LSM5:

    LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
    Hs.424908  [show with all ESTs]
    Unigene Representative Sequence: NR_024466
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450169(uc003tct.2 uc003tcu.2 uc011kag.1 uc011kah.1)
    ENST00000409909 ENST00000409292 ENST00000468872 ENST00000410044 ENST00000409987
    ENST00000223084 ENST00000409782 ENST00000409952 ENST00000480956

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LSM5
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate LSM5 (see all 20):
    hsa-miR-3128 hsa-miR-623 hsa-miR-4251 hsa-miR-539 hsa-miR-520d-5p hsa-miR-4263 hsa-miR-501-3p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: LSM5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LSM5 (see all 7)
    OriGene shRNA RFP: LSM5
    OriGene siRNA: LSM5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LSM5
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LSM5

    Additional cDNA sequence: 

    AF182291.1 AJ238097.1 AK022772.1 AK024217.1 BC005938.1 BC040717.1 NR_024466.1 

    9 DOTS entries:

    DT.453711  DT.100754880  DT.121066242  DT.100754879  DT.121066245  DT.100740988  DT.100800144  DT.92474402 
    DT.97805682 

    24/184 AceView cDNA sequences (see all 184):

    BM820373 AI523338 CD251698 AA662797 AW955662 BQ082201 AW166713 BG319582 
    CR600225 CA310476 H88391 AI458124 BF059004 CR607727 H25564 AI276769 
    BC040717 CB243219 BE890993 AA835397 AA453373 AK024217 AI860953 AA224216 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LSM5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for LSM5

    Expression
    for LSM5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LSM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTATCCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LSM5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LSM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LSM5

    SOURCE GeneReport for Unigene cluster: Hs.424908
        SABiosciences Custom PCR Arrays for LSM5
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM5

    Orthologs
    for LSM5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LSM5 gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Lsm51 , 5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)1, 5 90.11(n)1
    100(a)1    		   6 (27.72 cM)5
    663731  NM_025520.31  NP_079796.11 
     567010635 
    chicken
    (Gallus gallus)    		 Aves LSM51 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 86.45(n)
    98.9(a)    		   420751  XM_418849.3  XP_418849.3 
    lizard
    (Anolis carolinensis)    		 Reptilia LSM56
    		 --
    		 93(a)
    		 1 ↔ 1
    		 AAWZ02041982(111-2941)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AW644135.12   -- 80.82(n)    AW644135.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1719591 zgc:171959 79.12(n)
    94.51(a)    		   563948  NM_001100438.1  NP_001093908.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG66101 , 3 mRNA splicing3
    CG66101    		 85(a)3
    72.02(n)1
    85.19(a)1    		   65A53
    386931  NM_139765.31  NP_648022.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea lsm-51 Protein LSM-5 64.47(n)
    73.63(a)    		   180047  NM_074469.4  NP_506870.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SAD11 U6 snRNA-associated Sm-like protein LSm5 70.89(n)
    77.22(a)    		   834945  NM_124264.4  NP_199698.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.265742 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72(n)    AK059190.1 


    ENSEMBL Gene Tree for LSM5 (if available)
    TreeFam Gene Tree for LSM5 (if available) 

    Paralogs
    for LSM5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LSM5 gene
    1 SIMAP similar gene for LSM5 using alignment to 3 protein entries:     LSM5_HUMAN (see all proteins):
    SNRPE

    LSM5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for LSM5
    PGOHUM00000233138 PGOHUM00000236768


    Genomic Variants
    for LSM5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/181 NCBI SNPs in LSM5 are shown (see all 181)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1478865221,2
    		--32524454(+) AACTCC/TTGGCC 4 -- int10--------
    rs1841526911,2
    		--32524487(+) CCACCC/TACAAT 4 -- int10--------
    rs1489463371,2
    		--32524532(+) CTGGCC/TTAACT 4 -- int10--------
    rs102683481,2
    		C,F,H,--32524580(+) TAGCTC/TCCCTG 4 -- int116Minor allele frequency- T:0.21NS EA NA WA 1344
    rs21226321,2
    		C,F,O,A,H,--32524686(-) TAACTC/TTTGGG 4 -- int136Minor allele frequency- T:0.31NA EA NS WA 3590
    rs1437223761,2
    		--32524790(+) TAGCTG/TGAAAT 4 -- int10--------
    rs1869747441,2
    		--32524799(+) ATTAGA/CCAAGG 4 -- int10--------
    rs1914885801,2
    		--32524811(+) AGTAGC/TACTGA 4 -- int10--------
    rs1510773971,2
    		--32524831(+) AATCAA/GAGAAA 4 -- int10--------
    rs21672741,2
    		C,F,H,--32524844(-) ACTGAT/CTTGTA 4 -- int121Minor allele frequency- C:0.31NS EA NA WA 2348

    HapMap Linkage Disequilibrium report for LSM5 (32524945 - 32534895 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LSM5: --

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    Disorders / Diseases
    for LSM5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LSM5 for disorders           About GeneDecksing

    OMIM gene information: 607285    OMIM disorders: --

    3 diseases for LSM5:    About MalaCards
    spinal muscular atrophy    muscular atrophy    malaria


    Export disorders for LSM5 gene to outside databases

    Publications
    for LSM5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LSM5 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with LSM5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PubMed id 10369684)1, 2, 3 Salgado-Garrido J.... Seraphin B. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 3 Ingelfinger D....Achsel T. (2002)
    4. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PubMed id 10523320)1, 2 Achsel T....Luhrmann R. (1999)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for LSM5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing LSM5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23658 HGNC: 17162 AceView: LSM5 Ensembl:ENSG00000106355 euGenes: HUgn23658
    ECgene: LSM5 Kegg: 23658 H-InvDB: LSM5

    Other Databases showing LSM5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LSM5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LSM5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LSM5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LSM5 gene:
    Search GeneIP for patents involving LSM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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