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LSM5 Gene

protein-coding   GIFtS: 59
GCID: GC07M032524

LSM5 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LSM5 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)1 2
YER146W2
U6 SnRNA-Associated Sm-Like Protein LSm52

External Ids:    HGNC: 171621   Entrez Gene: 236582   Ensembl: ENSG000001063557   OMIM: 6072855   UniProtKB: Q9Y4Y93   

Export aliases for LSM5 gene to outside databases

Previous GC identifers: GC07M032167 GC07M032233 GC07M032267 GC07M032298 GC07M032491 GC07M032402


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LSM5 Gene:
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family
(see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated
by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer
present in tri-snRNP particles, which are important for pre-mRNA splicing.(supplied by OMIM, Apr 2004)

GeneCards Summary for LSM5 Gene:
LSM5 (LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)) is a protein-coding gene. Diseases associated with LSM5 include spinal muscular atrophy, and muscular atrophy. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: LSM5_HUMAN, Q9Y4Y9
Function: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating
formation of the spliceosomal U4/U6 duplex formation in vitro

Gene Wiki entry for LSM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the LSM5 gene promoter:
         AML1a   FOXF2   FOXJ2 (long isoform)   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LSM5 promoter sequence
   Search Chromatin IP Primers for LSM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LSM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

LSM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LSM5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M032524:  view genomic region     (about GC identifiers)

Start:
32,524,945 bp from pter      End:
32,534,895 bp from pter
Size:
9,951 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 32,570,144-32,580,067     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LSM5_HUMAN, Q9Y4Y9 (See protein sequence)
Recommended Name: U6 snRNA-associated Sm-like protein LSm5  
Size: 91 amino acids; 9937 Da
Subunit: LSm subunits form a heteromer with a doughnut shape (By similarity)
Alternative splicing: 2 isoforms:  Q9Y4Y9-1   Q9Y4Y9-2   

Explore the universe of human proteins at neXtProt for LSM5: NX_Q9Y4Y9

Explore proteomics data for LSM5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20
  • Modification sites at PhosphoSitePlus

  • See LSM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124182.1  NP_001132971.1  NP_036454.1  

    ENSEMBL proteins: 
     ENSP00000410758   ENSP00000386363   ENSP00000386814   ENSP00000386707   ENSP00000386275  
     ENSP00000223084   ENSP00000387109   ENSP00000387126  
    Reactome Protein details: Q9Y4Y9

    LSM5 Human Recombinant Protein Products:

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    Novus Biologicals LSM5 Proteins
    Novus Biologicals LSM5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LSM5

    LSM5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for LSM5

    LSM5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LSM5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LSM5
    Cloud-Clone Corp. CLIAs for LSM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4Y9

    ProtoNet protein and cluster: Q9Y4Y9

    2 Blocks protein domains:
    IPB001163 Small nuclear ribonucleoprotein (Sm protein)
    IPB010920 Like-Sm ribonucleoprotein-related


    UniProtKB/Swiss-Prot: LSM5_HUMAN, Q9Y4Y9
    Similarity: Belongs to the snRNP Sm proteins family


    LSM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LSM5_HUMAN, Q9Y4Y9
    Function: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating
    formation of the spliceosomal U4/U6 duplex formation in vitro

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI15231747
         
    LSM5 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for LSM5:
     Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LSM5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LSM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LSM5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LSM5

    miRNA
    Products:
        
    miRTarBase miRNAs that target LSM5:
    hsa-mir-16-5p (MIRT051127)

    Block miRNA regulation of human, mouse, rat LSM5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LSM5 (see all 20):
    hsa-miR-3128 hsa-miR-623 hsa-miR-4251 hsa-miR-539 hsa-miR-520d-5p hsa-miR-4263 hsa-miR-501-3p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidLSM5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LSM5
    Predesigned siRNA for gene silencing in human, mouse, rat LSM5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LSM5

    Clone
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    OriGene clones in human, mouse for LSM5 (see all 18)
    OriGene ORF clones in mouse, rat for LSM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LSM5 (NM_001130710)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LSM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LSM5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LSM5_HUMAN, Q9Y4Y9: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10369684
    GO:0005681spliceosomal complex IEA--
    GO:0005829cytosol TAS--

    LSM5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LSM5 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for LSM5
        mRNA decay by 5' to 3' exoribonuclease


    2 Kegg Pathways  (Kegg details for LSM5):
        RNA degradation
    Spliceosome


    LSM5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LSM5
    Interactions:

        Search GeneGlobe Interaction Network for LSM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LSM5 (Q9Y4Y91, 2, 3 ENSP000004107584) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPFP623062, 3, ENSP000002667354MINT-8332844 I2D: score=9 STRING: ENSP00000266735
    LSM3P623101, 3, ENSP000003021604EBI-373007,EBI-348239 I2D: score=4 STRING: ENSP00000302160
    LSM2Q9Y3333, ENSP000003648134I2D: score=3 STRING: ENSP00000364813
    ENSG00000172850Q9Y3333I2D: score=3 
    ENSG00000224979Q9Y3333I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    LSM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LSM5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LSM5 gene (3 alternative transcripts): 
    NM_001130710.1  NM_001139499.1  NM_012322.2  

    Unigene Cluster for LSM5:

    LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
    Hs.424908  [show with all ESTs]
    Unigene Representative Sequence: NR_024466
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450169(uc003tct.2 uc003tcu.2 uc011kag.1 uc011kah.1)
    ENST00000409909 ENST00000409292 ENST00000468872 ENST00000410044 ENST00000409987
    ENST00000223084 ENST00000409782 ENST00000409952 ENST00000480956
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LSM5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LSM5 (see all 20):
    hsa-miR-3128 hsa-miR-623 hsa-miR-4251 hsa-miR-539 hsa-miR-520d-5p hsa-miR-4263 hsa-miR-501-3p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidLSM5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LSM5
    Predesigned siRNA for gene silencing in human, mouse, rat LSM5
    Clone
    Products:
         
    OriGene clones in human, mouse for LSM5 (see all 18)
    OriGene ORF clones in mouse, rat for LSM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LSM5 (NM_001130710)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LSM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LSM5
    OriGene qSTAR qPCR primer pairs in human, mouse for LSM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LSM5
      QuantiTect SYBR Green Assays in human, mouse, rat LSM5
      QuantiFast Probe-based Assays in human, mouse, rat LSM5

    Additional mRNA sequence: 

    AF182291.1 AJ238097.1 AK022772.1 AK024217.1 BC005938.1 BC040717.1 NR_024466.1 

    9 DOTS entries:

    DT.453711  DT.100754880  DT.121066242  DT.100754879  DT.121066245  DT.100740988  DT.100800144  DT.92474402 
    DT.97805682 

    Selected AceView cDNA sequences (see all 184):

    CB243219 AA662797 CR600225 BC040717 BM820373 CA310476 AI458124 AI276769 
    BQ082201 AA835397 AW166713 H88391 BE890993 AI523338 CR607727 AW955662 
    CD251698 BF059004 AA453373 BG319582 H25564 AL550414 AU123026 CB160296 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LSM5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for LSM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LSM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATCCTGG
    LSM5 Expression
    About this image

    LSM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LSM5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.424908
        Custom PCR Arrays for LSM5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LSM5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LSM5 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lsm51 , 5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)1, 5 90.11(n)1
    100(a)1
      6 (27.72 cM)5
    663731  NM_025520.31  NP_079796.11 
     567010635 
    chicken
    (Gallus gallus)
    Aves LSM51 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 86.45(n)
    98.9(a)
      420751  XM_418849.4  XP_418849.3 
    lizard
    (Anolis carolinensis)
    Reptilia LSM56
    LSM5 homolog, U6 small nuclear RNA associated (S. ...
    93(a)
    1 ↔ 1
    AAWZ02041982(111-2941)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW644135.12   -- 80.82(n)    AW644135.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1719591 zgc:171959 79.12(n)
    94.51(a)
      563948  NM_001100438.1  NP_001093908.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66101 , 3 mRNA splicing3
    CG66101
    85(a)3
    70.16(n)1
    81.4(a)1
      65A53
    386931  NM_001274532.11  NP_001261461.11 
    worm
    (Caenorhabditis elegans)
    Secernentea lsm-51 lsm-5 64.47(n)
    73.63(a)
      180047  NM_074469.5  NP_506870.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSM5(YER146W)4 Lsm (Like Sm) protein; part of heteroheptameric complexes more   --   5(462585-462866) 856889  NP_011073.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SAD11 SAD1 70.37(n)
    75.31(a)
      834945  NM_124264.4  NP_199698.1 
    rice
    (Oryza sativa)
    Liliopsida Os.265742 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72(n)    AK059190.1 


    ENSEMBL Gene Tree for LSM5 (if available)
    TreeFam Gene Tree for LSM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LSM5 gene
    1 SIMAP similar gene for LSM5 using alignment to 3 protein entries:     LSM5_HUMAN (see all proteins):
    SNRPE

    LSM5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for LSM5
    PGOHUM00000233138 PGOHUM00000236768


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LSM5 (see all 218)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478865221,2
    --32524454(+) AACTCC/TTGGCC 4 -- int10--------
    rs1841526911,2
    --32524487(+) CCACCC/TACAAT 4 -- int10--------
    rs1489463371,2
    --32524532(+) CTGGCC/TTAACT 4 -- int10--------
    rs102683481,2
    C,F,H--32524580(+) TAGCTC/TCCCTG 4 -- int116Minor allele frequency- T:0.21NS EA NA WA 1344
    rs21226321,2
    C,F,O,A,H--32524686(-) TAACTC/TTTGGG 4 -- int136Minor allele frequency- T:0.31NA EA NS WA 3590
    rs1437223761,2
    --32524790(+) TAGCTG/TGAAAT 4 -- int10--------
    rs1869747441,2
    --32524799(+) ATTAGA/CCAAGG 4 -- int10--------
    rs1914885801,2
    --32524811(+) AGTAGC/TACTGA 4 -- int10--------
    rs1510773971,2
    C--32524831(+) AATCAA/GAGAAA 4 -- int10--------
    rs21672741,2
    C,F,H--32524844(-) ACTGAT/CTTGTA 4 -- int121Minor allele frequency- C:0.31NS EA NA WA 2348

    HapMap Linkage Disequilibrium report for LSM5 (32524945 - 32534895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LSM5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436557CNV Deletion17901297
    nsv887922CNV Gain21882294
    nsv887921CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607285    OMIM disorders: --

    3 diseases for LSM5:    
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    spinal muscular atrophy    muscular atrophy    malaria


    LSM5 for disorders           About GeneDecksing


    Export disorders for LSM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LSM5 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with LSM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PubMed id 10369684)1, 2, 3 Salgado-Garrido J.... Seraphin B. (EMBO J. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 3 Ingelfinger D.... Achsel T. (RNA 2002)
    4. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PubMed id 10523320)1, 2 Achsel T.... Luehrmann R. (EMBO J. 1999)
    5. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)
    6. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    7. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23658 HGNC: 17162 AceView: LSM5 Ensembl:ENSG00000106355 euGenes: HUgn23658
    ECgene: LSM5 Kegg: 23658 H-InvDB: LSM5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LSM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LSM5 gene:
    Search GeneIP for patents involving LSM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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