Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LSM4 Gene

protein-coding   GIFtS: 62
GCID: GC19M018417

LSM4 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
LSM4 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)1 2
Glycine-Rich Protein2 3
GRP2 3
YER112W2
U6 SnRNA-Associated Sm-Like Protein LSm42

External Ids:    HGNC: 172591   Entrez Gene: 258042   Ensembl: ENSG000001305207   OMIM: 6072845   UniProtKB: Q9Y4Z03   

Export aliases for LSM4 gene to outside databases

Previous GC identifers: GC19M018911 GC19M018809 GC19M018262 GC19M018278 GC19M017981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LSM4 Gene:
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that
bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by
mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for LSM4 Gene:
LSM4 (LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: LSM4_HUMAN, Q9Y4Z0
Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA

summary for LSM4 Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor).

Gene Wiki entry for LSM4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the LSM4 gene promoter:
         NF-YA   SREBP-1c   SREBP-1b   GATA-1   NF-YB   CBF-A   SREBP-1a   CBF-B   CP1A   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLSM4 promoter sequence
   Search Chromatin IP Primers for LSM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LSM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

LSM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LSM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018417:  view genomic region     (about GC identifiers)

Start:
18,417,040 bp from pter      End:
18,434,084 bp from pter
Size:
17,045 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LSM4_HUMAN, Q9Y4Z0 (See protein sequence)
Recommended Name: U6 snRNA-associated Sm-like protein LSm4  
Size: 139 amino acids; 15350 Da
Subunit: LSm subunits form a heteromer with a doughnut shape

Explore the universe of human proteins at neXtProt for LSM4: NX_Q9Y4Z0

Explore proteomics data for LSM4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys80
  • Modification sites at PhosphoSitePlus

  • See LSM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239058.1  NP_036453.1  

    ENSEMBL proteins: 
     ENSP00000469468   ENSP00000475950   ENSP00000469028   ENSP00000477443   ENSP00000476184  
    Reactome Protein details: Q9Y4Z0

    LSM4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for LSM4
    OriGene Protein Over-expression Lysate for LSM4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LSM4
    GenScript Custom Purified and Recombinant Proteins Services for LSM4
    Novus Biologicals LSM4 Proteins
    Novus Biologicals LSM4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LSM4
    Cloud-Clone Corp. Proteins for LSM4

     
    Search eBioscience for Proteins for LSM4 

     
    antibodies-online proteins for LSM4 (10 products) 

     
    antibodies-online peptides for LSM4

    LSM4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LSM4
    Novus Biologicals LSM4 Antibodies
    Abcam antibodies for LSM4
    Cloud-Clone Corp. Antibodies for LSM4
    ThermoFisher Antibodies for LSM4
    antibodies-online antibodies for LSM4 (19 products) 

    LSM4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LSM4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LSM4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LSM4
    Cloud-Clone Corp. CLIAs for LSM4
    Search eBioscience for ELISAs for LSM4 
    antibodies-online kits for LSM4 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom
     IPR027141 LSm4/Sm_D1/D3

    Graphical View of Domain Structure for InterPro Entry Q9Y4Z0

    ProtoNet protein and cluster: Q9Y4Z0

    2 Blocks protein domains:
    IPB001163 Small nuclear ribonucleoprotein (Sm protein)
    IPB010920 Like-Sm ribonucleoprotein-related


    UniProtKB/Swiss-Prot: LSM4_HUMAN, Q9Y4Z0
    Similarity: Belongs to the snRNP Sm proteins family


    Find genes that share domains with LSM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LSM4_HUMAN, Q9Y4Z0
    Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI15231747
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with LSM4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LSM4:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lsm4):
     mortality/aging 

    Find genes that share phenotypes with LSM4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LSM4

    miRNA
    Products:
        
    miRTarBase miRNAs that target LSM4:
    hsa-mir-769-5p (MIRT039176), hsa-mir-423-3p (MIRT042595)

    Block miRNA regulation of human, mouse, rat LSM4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LSM4
    SwitchGear 3'UTR luciferase reporter plasmidLSM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LSM4
    Predesigned siRNA for gene silencing in human, mouse, rat LSM4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LSM4

    Clone
    Products:
         
    OriGene clones in human, mouse for LSM4 (see all 6)
    OriGene ORF clones in mouse, rat for LSM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LSM4 (NM_012321)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LSM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LSM4
    Browse ESI BIO Cell Lines and PureStem Progenitors for LSM4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LSM4_HUMAN, Q9Y4Z0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005681spliceosomal complex IEA--
    GO:0005688U6 snRNP TAS10369684
    GO:0005829cytosol TAS--
    GO:0030532small nuclear ribonucleoprotein complex TAS10369684

    Find genes that share ontologies with LSM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LSM4 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with LSM4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for LSM4
        mRNA decay by 5' to 3' exoribonuclease


    2 Kegg Pathways  (Kegg details for LSM4):
        RNA degradation
    Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LSM4
    Interactions:

        GeneGlobe Interaction Network for LSM4

    Selected Interacting proteins for LSM4 (Q9Y4Z01, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSM7Q9UK451, 2, 3EBI-372521,EBI-348372 MINT-8336298 I2D: score=3 
    CALCOCO2Q131372, 3MINT-66805 I2D: score=5 
    LSM8O957771, 3EBI-372521,EBI-347779 I2D: score=3 
    NAA38O957771, 3EBI-372521,EBI-347779 I2D: score=3 
    CSNK2BP678703I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    Find genes that share ontologies with LSM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for LSM4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

    2 Novoseek inferred chemical compound relationships for LSM4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 6.71 3 19351738 (1), 8742709 (1), 9722554 (1)
    calcium 0 6 8798781 (2), 18836183 (1)



    Find genes that share compounds with LSM4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LSM4 gene (2 alternative transcripts): 
    NM_001252129.1  NM_012321.4  

    Unigene Cluster for LSM4:

    LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
    Hs.515255  [show with all ESTs]
    Unigene Representative Sequence: NM_012321
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593829 ENST00000252816(uc002niq.3 uc021uqn.1) ENST00000600289
    ENST00000594828 ENST00000597776 ENST00000593564
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LSM4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LSM4
    SwitchGear 3'UTR luciferase reporter plasmidLSM4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LSM4
    Predesigned siRNA for gene silencing in human, mouse, rat LSM4
    Clone
    Products:
         
    OriGene clones in human, mouse for LSM4 (see all 6)
    OriGene ORF clones in mouse, rat for LSM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LSM4 (NM_012321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LSM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LSM4
    OriGene qSTAR qPCR primer pairs in human, mouse for LSM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LSM4
      QuantiTect SYBR Green Assays in human, mouse, rat LSM4
      QuantiFast Probe-based Assays in human, mouse, rat LSM4

    Additional mRNA sequence: 

    AF117235.1 AF182290.1 AF251218.1 AJ238096.1 BC000387.2 BC003652.2 BC022198.2 BC023665.2 

    13 DOTS entries:

    DT.449516  DT.92329544  DT.100781992  DT.99985293  DT.95370437  DT.95353255  DT.121499345  DT.121499349 
    DT.86821342  DT.95153212  DT.95370431  DT.91751791  DT.95370438 

    Selected AceView cDNA sequences (see all 633):

    AI381000 BI833782 AI143119 BG826318 BU539495 BC000387 BF591324 AI279639 
    AI188299 BU535691 BE220955 AI123077 BC023665 AA306476 BM696199 AI334113 
    AI656971 BM714059 BC003652 AI928543 BI759131 BC022198 BF478227 AI796521 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LSM4    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                            -                 -                     
    SP2:                                            -     -           -                     
    SP3:                                            -     -                                 
    SP4:                                -           -     -           -                     
    SP5:                                                                                    


    ECgene alternative splicing isoforms for LSM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LSM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGACTGA
    LSM4 Expression
    About this image


    LSM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Colon (Gastrointestinal Tract)
     
     Testis (Reproductive System)
     
     Adrenal Gland (Endocrine System)
     
     Kidney (Urinary System)
    LSM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LSM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515255
        Custom PCR Arrays for LSM4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LSM4
    OriGene qSTAR qPCR primer pairs in human, mouse for LSM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LSM4
    QuantiTect SYBR Green Assays in human, mouse, rat LSM4
    QuantiFast Probe-based Assays in human, mouse, rat LSM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LSM4 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lsm41 , 5 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)1, 5 88.41(n)1
    97.1(a)1
      8 (34.15 cM)5
    507831  NM_015816.41  NP_056631.21 
     706732485 
    chicken
    (Gallus gallus)
    Aves LSM41 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 79.23(n)
    90.58(a)
      420128  XM_418245.4  XP_418245.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33292 Xenopus laevis transcribed sequence with strong similarity more 75.47(n)    48046740 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730572 hypothetical protein MGC73057 77.81(n)   393669  BC059435.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG177686
    --
    62(a)
    1 ↔ 1
    2L(10403197-10405203)
    worm
    (Caenorhabditis elegans)
    Secernentea lsm-46
    Protein LSM-4 (lsm-4) mRNA, complete cds
    68(a)
    1 ↔ 1
    II(7252230-7253163) WBGene00003078
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSM46
    Lsm (Like Sm) protein; part of heteroheptameric co...
    24(a)
    1 ↔ 1
    V(387232-387795) YER112W
    soybean
    (Glycine max)
    eudicotyledons BQ786270.12   -- 76.35(n)    BQ786270.1 
    rice
    (Oryza sativa)
    Liliopsida Os.1972 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.28(n)    AK100819.1 


    ENSEMBL Gene Tree for LSM4 (if available)
    TreeFam Gene Tree for LSM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LSM4 gene
    3 SIMAP similar genes for LSM4 using alignment to 5 protein entries:     LSM4_HUMAN (see all proteins):
    LSM2    SNRPD3    SNRPD1

    Find genes that share paralogs with LSM4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LSM4 (see all 403)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs587731081,2
    C--17982289(+) GGGGG-/GG/GGG
            
    ACTAG
    2 -- int11NA 2
    rs1147282051,2
    C,F--18416574(+) TAGCCG/ATCTGT 2 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1468187421,2
    --18416772(+) CCGGTA/GCATCC 2 -- ds50010--------
    rs20590381,2
    C,F,A,H--18416930(+) GCGACA/TGCAGA 2 -- ds500115Minor allele frequency- T:0.16NS EA NA WA CSA 788
    rs48087811,2
    C,F,A,H--18416972(+) GGAGAG/ACATCC 2 -- ds500127Minor allele frequency- A:0.22NS EA NA WA CSA 2771
    rs1165177411,2
    C,F--18416986(+) GCGAGG/AACATT 2 -- ds50011Minor allele frequency- A:0.10WA 118
    rs1807617661,2
    --18417043(+) AAAAAA/GAGTTC 2 -- ut310--------
    rs1864905071,2
    --18417057(+) ACGGAC/TGGGAC 2 -- ut310--------
    rs793508141,2
    C,F--18417100(+) CCGAAC/TGAGGA 2 -- ut311Minor allele frequency- T:0.03NA 120
    rs1893107421,2
    --18417104(+) ACGAGC/GACCCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LSM4 (18417040 - 18434084 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LSM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3781n71CNV Loss21882294
    nsv911271CNV Loss21882294
    dgv3780n71CNV Loss21882294
    dgv3774n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LSM4
    DNA2.0 Custom Variant and Variant Library Synthesis for LSM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607284    OMIM disorders: --


    Find genes that share disorders with LSM4           About GenesLikeMe

    3 Novoseek inferred disease relationships for LSM4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 7.96 1 15379262 (1)
    autoimmune diseases 0 2 10784611 (2)
    rheumatoid arthritis 0 1 7490114 (1)

    Genetic Association Database (GAD): LSM4
    Human Genome Epidemiology (HuGE) Navigator: LSM4 (1 document)

    Export disorders for LSM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LSM4 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with LSM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PubMed id 10523320)1, 2, 3 Achsel T.... Luehrmann R. (EMBO J. 1999)
    2. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PubMed id 10369684)1, 2, 3 Salgado-Garrido J.... Seraphin B. (EMBO J. 1999)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    6. Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). (PubMed id 10851237)1, 9 Friesen W.J. and Dreyfuss G. (J. Biol. Chem. 2000)
    7. The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation. (PubMed id 24255165)1 Lyons S.M....Marzluff W.F. (RNA 2014)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 25804 HGNC: 17259 AceView: LSM4 Ensembl:ENSG00000130520 euGenes: HUgn25804
    ECgene: LSM4 Kegg: 25804 H-InvDB: LSM4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LSM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LSM4 gene:
    Search GeneIP for patents involving LSM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LSM4  
     OriGene qPCR primer pairs and template standards for LSM4   OriGene Protein Over-expression Lysate for LSM4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LSM4  
     OriGene qSTAR qPCR primer pairs in human, mouse for LSM4   OriGene Purified Protein for LSM4  
     OriGene ORF clones in mouse, rat for LSM4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LSM4   OriGene Custom Protein Services for LSM4  

     
     
     Block miRNA regulation of human, mouse, rat LSM4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LSM4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LSM4 Predesigned siRNA for gene silencing in human, mouse, rat LSM4
     QuantiFast Probe-based Assays in human, mouse, rat LSM4 QuantiTect SYBR Green Assays in human, mouse, rat LSM4
     Custom PCR Arrays for LSM4 Search Chromatin IP Primers for LSM4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LSM4  GeneGlobe Interaction Network for LSM4
     Regulatory tfbs in LSM4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LSM4 GenScript cDNA clones with any tag delivered in your preferred vector for LSM4
     GenScript Custom Assay Services for LSM4 GenScript Custom overexpressing Cell Line Services for LSM4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for LSM4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LSM4 antibodies
     LSM4 proteins
     LSM4 lysates
     Antibodies for LSM4
     See all of Abcam's Antibodies, Kits and Proteins for LSM4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for LSM4
     Proteins for LSM4
     Antibodies for LSM4
     ELISAs for LSM4
     CLIAs for LSM4



     Browse ESI BIO Cell Lines and PureStem Progenitors for LSM4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM4
     SwitchGear 3'UTR luciferase reporter plasmids for LSM4
     SwitchGear Promoter luciferase reporter plasmids for LSM4
     ThermoFisher Antibodies for LSM4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM4
     Browse compounds at ApexBio
     Search Addgene for plasmids for LSM4
      Search eBioscience for proteins for LSM4
      Search eBioscience for elisas for LSM4
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for LSM4
     antibodies-online antibodies for LSM4 (19 products)
     antibodies-online kits for LSM4 (6 products)
     antibodies-online peptides for LSM4
     antibodies-online proteins for LSM4 (10 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LSM4 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4