Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LSM3 Gene

Aliases for LSM3 Gene

  • LSM3 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2 3
  • U6 SnRNA-Associated Sm-Like Protein LSm3 3
  • YLR438C 3
  • SMX4 3
  • USS2 3

External Ids for LSM3 Gene

Summaries for LSM3 Gene

Entrez Gene Summary for LSM3 Gene

  • Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

GeneCards Summary for LSM3 Gene

LSM3 (LSM3 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for LSM3 Gene

  • Binds specifically to the 3-terminal U-tract of U6 snRNA

Gene Wiki entry for LSM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM3 Gene

Genomics for LSM3 Gene

Genomic Location for LSM3 Gene

Start:
14,178,358 bp from pter
End:
14,201,119 bp from pter
Size:
22,762 bases
Orientation:
Plus strand

Genomic View for LSM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LSM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM3 Gene

Regulatory Elements for LSM3 Gene

Proteins for LSM3 Gene

  • Protein details for LSM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62310-LSM3_HUMAN
    Recommended name:
    U6 snRNA-associated Sm-like protein LSm3
    Protein Accession:
    P62310
    Secondary Accessions:
    • Q6IAH0
    • Q9Y4Z1

    Protein attributes for LSM3 Gene

    Size:
    102 amino acids
    Molecular mass:
    11845 Da
    Quaternary structure:
    • LSm subunits form a heteromer with a doughnut shape. Identified in the spliceosome C complex.

neXtProt entry for LSM3 Gene

Proteomics data for LSM3 Gene at MOPED

Post-translational modifications for LSM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LSM3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LSM3 Gene

Domains for LSM3 Gene

Protein Domains for LSM3 Gene

UniProtKB/Swiss-Prot:

LSM3_HUMAN
Family:
  • Belongs to the snRNP Sm proteins family.:
    • P62310
genes like me logo Genes that share domains with LSM3: view

No data available for Gene Families for LSM3 Gene

Function for LSM3 Gene

Molecular function for LSM3 Gene

UniProtKB/Swiss-Prot Function: Binds specifically to the 3-terminal U-tract of U6 snRNA

Gene Ontology (GO) - Molecular Function for LSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14667819
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LSM3: view

Phenotypes for LSM3 Gene

genes like me logo Genes that share phenotypes with LSM3: view

miRNA for LSM3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LSM3 Gene

Localization for LSM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LSM3 Gene COMPARTMENTS Subcellular localization image for LSM3 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for LSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10369684
GO:0005829 cytosol TAS --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with LSM3: view

Pathways for LSM3 Gene

genes like me logo Genes that share pathways with LSM3: view

Pathways by source for LSM3 Gene

Gene Ontology (GO) - Biological Process for LSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006397 mRNA processing TAS 10369684
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
genes like me logo Genes that share ontologies with LSM3: view

Transcripts for LSM3 Gene

mRNA/cDNA for LSM3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(270) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LSM3 Gene

LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LSM3 Gene

No ASD Table

Relevant External Links for LSM3 Gene

GeneLoc Exon Structure for
LSM3
ECgene alternative splicing isoforms for
LSM3

Expression for LSM3 Gene

mRNA expression in normal human tissues for LSM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LSM3 Gene

SOURCE GeneReport for Unigene cluster for LSM3 Gene Hs.111632

genes like me logo Genes that share expressions with LSM3: view

Orthologs for LSM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LSM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSM3 36
  • 100 (n)
  • 100 (a)
LSM3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LSM3 36
  • 90.2 (n)
  • 100 (a)
LSM3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LSM3 36
  • 94.44 (n)
  • 100 (a)
LSM3 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lsm3 36
  • 90.85 (n)
  • 100 (a)
Lsm3 16
Lsm3 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LSM3 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LSM3 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lsm3 36
  • 90.52 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LSM3 36
  • 84.31 (n)
  • 99.02 (a)
lizard
(Anolis carolinensis)
Reptilia LSM3 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6080 36
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm3 36
  • 80.39 (n)
  • 98.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2463 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01028296.1 37
  • 97 (a)
OneToOne
cldng 36
LOC100535720 36
  • 79.08 (n)
  • 97.06 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013519 36
  • 70.1 (n)
  • 78.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta LSm3 36
  • 66.34 (n)
  • 77.45 (a)
LSm3 37
  • 76 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lsm-3 36
  • 62.75 (n)
  • 69.61 (a)
lsm-3 37
  • 70 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSM3 37
  • 39 (a)
OneToOne
LSM3 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.956 36
soybean
(Glycine max)
eudicotyledons Gma.12513 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G76860 36
  • 68.89 (n)
  • 80 (a)
corn
(Zea mays)
Liliopsida Zm.3271 36
rice
(Oryza sativa)
Liliopsida Os.8993 36
Os01g0866700 36
  • 69.63 (n)
  • 81.11 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1658 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.644 37
  • 83 (a)
OneToOne
Species with no ortholog for LSM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LSM3 Gene

ENSEMBL:
Gene Tree for LSM3 (if available)
TreeFam:
Gene Tree for LSM3 (if available)

Paralogs for LSM3 Gene

Selected SIMAP similar genes for LSM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LSM3: view

No data available for Paralogs for LSM3 Gene

Variants for LSM3 Gene

Sequence variations from dbSNP and Humsavar for LSM3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2470354 -- 14,189,837(+) TTGCC(A/G)TTGCT intron-variant
rs2470457 -- 14,190,291(-) ATATG(A/G)AACCA intron-variant
rs2607738 -- 14,180,821(+) CTTGC(C/T)TTTTT intron-variant
rs2607739 -- 14,181,071(+) TCTTA(C/T)TCACC intron-variant
rs2607743 -- 14,194,776(-) aaaaa(A/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSM3 Gene

Variant ID Type Subtype PubMed ID
nsv876550 CNV Loss 21882294
esv34163 CNV Loss 18971310
esv2724945 CNV Deletion 23290073

Relevant External Links for LSM3 Gene

HapMap Linkage Disequilibrium report
LSM3
Human Gene Mutation Database (HGMD)
LSM3

Disorders for LSM3 Gene

Relevant External Links for LSM3

Genetic Association Database (GAD)
LSM3
Human Genome Epidemiology (HuGE) Navigator
LSM3
genes like me logo Genes that share disorders with LSM3: view

No data available for UniProtKB/Swiss-Prot for LSM3 Gene

Publications for LSM3 Gene

  1. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PMID: 10369684) Salgado-Garrido J. … Seraphin B. (EMBO J. 1999) 2 3 4
  2. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PMID: 10523320) Achsel T. … Luehrmann R. (EMBO J. 1999) 3 4
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for LSM3 Gene

Sources for LSM3 Gene

Back to Top

Content