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LSM3 Gene

protein-coding   GIFtS: 61
GCID: GC03P014219

LSM3 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LSM3 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)1 2
SMX42
USS22
YLR438C2
U6 SnRNA-Associated Sm-Like Protein LSm32

External Ids:    HGNC: 178741   Entrez Gene: 272582   Ensembl: ENSG000001708607   OMIM: 6072835   UniProtKB: P623103   

Export aliases for LSM3 gene to outside databases

Previous GC identifers: GC03P014149 GC03P014195 GC03P014155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LSM3 Gene:
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family
(see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated
by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer
present in tri-snRNP particles, which are important for pre-mRNA splicing.(supplied by OMIM, Apr 2004)

GeneCards Summary for LSM3 Gene:
LSM3 (LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)) is a protein-coding gene. Diseases associated with LSM3 include spinal muscular atrophy, and brain cancer. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: LSM3_HUMAN, P62310
Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA

Gene Wiki entry for LSM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the LSM3 gene promoter:
         Nkx3-1   SRF   Nkx3-1 v4   Brachyury   SRF (504 AA)   p300   LUN-1   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLSM3 promoter sequence
   Search Chromatin IP Primers for LSM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LSM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

LSM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LSM3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P014219:  view genomic region     (about GC identifiers)

Start:
14,219,858 bp from pter      End:
14,242,619 bp from pter
Size:
22,762 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LSM3_HUMAN, P62310 (See protein sequence)
Recommended Name: U6 snRNA-associated Sm-like protein LSm3  
Size: 102 amino acids; 11845 Da
Subunit: LSm subunits form a heteromer with a doughnut shape. Identified in the spliceosome C complex
Secondary accessions: Q6IAH0 Q9Y4Z1

Explore the universe of human proteins at neXtProt for LSM3: NX_P62310

Explore proteomics data for LSM3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LSM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055278.1  
    ENSEMBL proteins: 
     ENSP00000302160  
    Reactome Protein details: P62310

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom

    Graphical View of Domain Structure for InterPro Entry P62310

    ProtoNet protein and cluster: P62310

    1 Blocks protein domain: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: LSM3_HUMAN, P62310
    Similarity: Belongs to the snRNP Sm proteins family


    LSM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LSM3_HUMAN, P62310
    Function: Binds specifically to the 3'-terminal U-tract of U6 snRNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI14667819
    GO:0044822poly(A) RNA binding IDA--
         
    LSM3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LSM3:
     Decreased p24 protein expressi  Large nuclei  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LSM3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LSM3

    miRNA
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    miRTarBase miRNAs that target LSM3:
    hsa-mir-26b-5p (MIRT030252), hsa-mir-196a-5p (MIRT048272), hsa-mir-128-3p (MIRT045864), hsa-mir-155-5p (MIRT021014)

    Block miRNA regulation of human, mouse, rat LSM3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LSM3
    SwitchGear 3'UTR luciferase reporter plasmidLSM3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LSM3

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LSM3_HUMAN, P62310: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10369684
    GO:0005829cytosol TAS--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    LSM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LSM3 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for LSM3
        mRNA decay by 5' to 3' exoribonuclease


    2 Kegg Pathways  (Kegg details for LSM3):
        RNA degradation
    Spliceosome


    LSM3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LSM3
    Interactions:

        Search GeneGlobe Interaction Network for LSM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LSM3 (P623101, 2, 3 ENSP000003021604) via UniProtKB, MINT, STRING, and/or I2D (see all 204)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224979Q9Y3331, 2, 3, ENSP000004140064EBI-348239,EBI-347416 MINT-62591 MINT-8336166 MINT-62765 MINT-68452 MINT-63961 MINT-62689 I2D: score=9 STRING: ENSP00000414006
    ENSG00000236826Q9Y3331, 2, 3, ENSP000004146344EBI-348239,EBI-347416 MINT-62591 MINT-8336166 MINT-62765 MINT-68452 MINT-63961 MINT-62689 I2D: score=9 STRING: ENSP00000414634
    LSM2Q9Y3331, 2, 3, ENSP000003648134EBI-348239,EBI-347416 MINT-62591 MINT-8336166 MINT-62765 MINT-68452 MINT-63961 MINT-62689 I2D: score=9 STRING: ENSP00000364813
    ENSG00000172850Q9Y3331, 2, 3EBI-348239,EBI-347416 MINT-62591 MINT-8336166 MINT-62765 MINT-68452 MINT-63961 MINT-62689 I2D: score=9 
    ENSG00000225998Q9Y3331, 2, 3EBI-348239,EBI-347416 MINT-62591 MINT-8336166 MINT-62765 MINT-68452 MINT-63961 MINT-62689 I2D: score=9 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006397mRNA processing TAS10369684
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    LSM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LSM3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LSM3 gene: 
    NM_014463.2  

    Unigene Cluster for LSM3:

    LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
    Hs.111632  [show with all ESTs]
    Unigene Representative Sequence: BG329333
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306024(uc003byn.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat LSM3 using miScript Target Protectors
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LSM3
      QuantiTect SYBR Green Assays in human, mouse, rat LSM3
      QuantiFast Probe-based Assays in human, mouse, rat LSM3

    Additional mRNA sequence: 

    AF182289.1 AF182418.1 AJ238095.1 AK312189.1 BC007055.1 CR457185.1 

    14 DOTS entries:

    DT.100821302  DT.120920058  DT.100799074  DT.316970  DT.92328070  DT.121011972  DT.91991003  DT.95193911 
    DT.100046091  DT.100658480  DT.100718286  DT.91947897  DT.91989288  DT.99933766 

    Selected AceView cDNA sequences (see all 270):

    AF182418 BM746849 BQ011590 CD108858 CA942843 BM828185 AI523164 AA746014 
    BI495715 BM712300 BI492640 CD678797 CB136876 AI244193 AA461413 AA287365 
    BM670966 CD675354 BF513997 AI953296 BX115936 CB109603 BF094578 AJ238095 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LSM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATGATCA
    LSM3 Expression
    About this image


    LSM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
    LSM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LSM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111632
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LSM3 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lsm31 , 5 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)1, 5 90.85(n)1
    100(a)1
      6 (40.58 cM)5
    676781  NM_026309.21  NP_080585.11 
     915159285 
    chicken
    (Gallus gallus)
    Aves LSM31 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 84.31(n)
    99.02(a)
      416040  NM_001277862.1  NP_001264791.1 
    lizard
    (Anolis carolinensis)
    Reptilia LSM36
    LSM3 homolog, U6 small nuclear RNA associated (S. ...
    99(a)
    1 ↔ 1
    2(169455727-169460685)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60802 Xenopus laevis transcribed sequence with strong similarity more 79.87(n)    48036382 
    zebrafish
    (Danio rerio)
    Actinopterygii cldng2 claudin g 79.75(n)   81586  BC044441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LSm31 LSm3 66.34(n)
    77.45(a)
      42842  NM_001170236.2  NP_001163707.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lsm-31 lsm-3 62.75(n)
    69.61(a)
      178303  NM_070178.4  NP_502579.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSM3(YLR438C-A)4 Lsm (Like Sm) protein; part of heteroheptameric complexes more   --   12(1014178-1013909) 851159  NP_013543.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G768601 AT1G76860 68.89(n)
    80(a)
      844021  NM_106337.2  NP_177812.1 
    rice
    (Oryza sativa)
    Liliopsida Os.89932 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.82(n)    AK099337.1 


    ENSEMBL Gene Tree for LSM3 (if available)
    TreeFam Gene Tree for LSM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LSM3 gene
    1 SIMAP similar gene for LSM3 using alignment to 1 protein entry:     LSM3_HUMAN:
    SNRPD2

    LSM3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for LSM3
    PGOHUM00000239897 PGOHUM00000249176 PGOHUM00000237099 PGOHUM00000240121 PGOHUM00000246090


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LSM3 (see all 363)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155525661,2
    F--14222180(+) CAGAAA/GGAAGG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1906320181,2
    --14222288(+) ACCCGA/GACTGC 1 -- int10--------
    rs2008414911,2
    --14222320(+) GCTTG-/CCTTTT 1 -- int10--------
    rs26077381,2
    C--14222321(+) CTTGCC/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.50WA 2
    rs130924251,2
    C--14222322(+) TTGCCC/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.50NA 2
    rs341273861,2
    C--14222367(+) AAAAA-/A/AAA 
            
    GACAA
    1 -- int11NA 2
    rs1817358201,2
    --14222441(+) CACCTC/TGCCAG 1 -- int10--------
    rs1855553641,2
    --14222442(+) ACCTCA/GCCAGG 1 -- int10--------
    rs1164560171,2
    F--14222513(+) TGCCCG/AGCTAA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs26077391,2
    C,F,A,H--14222571(+) TCTTAC/TTCACC 1 -- int129Minor allele frequency- T:0.32NS EA NA WA CSA 2780

    HapMap Linkage Disequilibrium report for LSM3 (14219858 - 14242619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LSM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724945CNV Deletion23290073
    nsv876550CNV Loss21882294
    esv34163CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LSM3
    DNA2.0 Custom Variant and Variant Library Synthesis for LSM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607283    OMIM disorders: --

    4 diseases for LSM3:    
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    spinal muscular atrophy    brain cancer    muscular atrophy    hiv-1


    LSM3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LSM3
    Human Genome Epidemiology (HuGE) Navigator: LSM3 (1 document)

    Export disorders for LSM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LSM3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with LSM3)
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    1. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PubMed id 10369684)1, 2, 3 Salgado-Garrido J.... Seraphin B. (EMBO J. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    4. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. (PubMed id 10523320)1, 2 Achsel T.... Luehrmann R. (EMBO J. 1999)
    5. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27258 HGNC: 17874 AceView: LSM3 Ensembl:ENSG00000170860 euGenes: HUgn27258
    ECgene: LSM3 Kegg: 27258 H-InvDB: LSM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LSM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LSM3 gene:
    Search GeneIP for patents involving LSM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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