Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LSM14A Gene

Aliases for LSM14A Gene

  • LSM14A MRNA Processing Body Assembly Factor 2 3 5
  • Family With Sequence Similarity 61, Member A 2 3
  • Putative Alpha-Synuclein-Binding Protein 3 4
  • RNA-Associated Protein 55A 3 4
  • RNA-Associated Protein 55 2 3
  • Protein SCD6 Homolog 3 4
  • AlphaSNBP 3 4
  • C19orf13 3 4
  • HRAP55A 3 4
  • FAM61A 3 4
  • RAP55A 3 4
  • HRAP55 3 4
  • RAP55 3 4
  • LSM14 Homolog A (SCD6, S. Cerevisiae) 2
  • Chromosome 19 Open Reading Frame 13 2
  • LSM14A, SCD6 Homolog A 3
  • LSM14 Homolog A 3
  • Protein FAM61A 4

External Ids for LSM14A Gene

Previous HGNC Symbols for LSM14A Gene

  • C19orf13
  • FAM61A

Previous GeneCards Identifiers for LSM14A Gene

  • GC19P039359
  • GC19P034663
  • GC19P031161

Summaries for LSM14A Gene

Entrez Gene Summary for LSM14A Gene

  • Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

GeneCards Summary for LSM14A Gene

LSM14A (LSM14A MRNA Processing Body Assembly Factor) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is LSM14B.

UniProtKB/Swiss-Prot for LSM14A Gene

  • Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM14A Gene

Genomics for LSM14A Gene

Regulatory Elements for LSM14A Gene

Promoters for LSM14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LSM14A on UCSC Golden Path with GeneCards custom track

Genomic Location for LSM14A Gene

Chromosome:
19
Start:
34,172,447 bp from pter
End:
34,229,515 bp from pter
Size:
57,069 bases
Orientation:
Plus strand

Genomic View for LSM14A Gene

Genes around LSM14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSM14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSM14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM14A Gene

Proteins for LSM14A Gene

  • Protein details for LSM14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND56-LS14A_HUMAN
    Recommended name:
    Protein LSM14 homolog A
    Protein Accession:
    Q8ND56
    Secondary Accessions:
    • B4DTG6
    • Q76LX7
    • Q96AR3
    • Q96K73
    • Q96SN5
    • Q9UFR3

    Protein attributes for LSM14A Gene

    Size:
    463 amino acids
    Molecular mass:
    50530 Da
    Quaternary structure:
    • Component of a ribonucleoprotein (RNP) complex.
    SequenceCaution:
    • Sequence=BAB55066.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LSM14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSM14A Gene

Proteomics data for LSM14A Gene at MOPED

Post-translational modifications for LSM14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LSM14A Gene

Antibody Products

No data available for DME Specific Peptides for LSM14A Gene

Domains & Families for LSM14A Gene

Protein Domains for LSM14A Gene

Suggested Antigen Peptide Sequences for LSM14A Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND56

UniProtKB/Swiss-Prot:

LS14A_HUMAN :
  • The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
  • Belongs to the LSM14 family.
Domain:
  • The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
  • Contains 1 DFDF domain.
Family:
  • Belongs to the LSM14 family.
genes like me logo Genes that share domains with LSM14A: view

No data available for Gene Families for LSM14A Gene

Function for LSM14A Gene

Molecular function for LSM14A Gene

UniProtKB/Swiss-Prot Function:
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

Gene Ontology (GO) - Molecular Function for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0003725 double-stranded RNA binding IEA --
genes like me logo Genes that share ontologies with LSM14A: view
genes like me logo Genes that share phenotypes with LSM14A: view

Animal Models for LSM14A Gene

MGI Knock Outs for LSM14A:

Animal Model Products

CRISPR Products

miRNA for LSM14A Gene

miRTarBase miRNAs that target LSM14A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSM14A Gene

Localization for LSM14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM14A Gene

Cytoplasm. Cytoplasm, P-body. Note=Targeted to stress granules (SGs) in response to cellular stress. {ECO:0000269 PubMed:16484376}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LSM14A Gene

Pathways & Interactions for LSM14A Gene

SuperPathways for LSM14A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with LSM14A: view

No data available for Pathways by source and SIGNOR curated interactions for LSM14A Gene

Drugs & Compounds for LSM14A Gene

No Compound Related Data Available

Transcripts for LSM14A Gene

Unigene Clusters for LSM14A Gene

LSM14A, SCD6 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LSM14A Gene

No ASD Table

Relevant External Links for LSM14A Gene

GeneLoc Exon Structure for
LSM14A
ECgene alternative splicing isoforms for
LSM14A

Expression for LSM14A Gene

mRNA expression in normal human tissues for LSM14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LSM14A Gene

This gene is overexpressed in Pancreas (11.0), CD8 Tcells (10.0), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LSM14A Gene



SOURCE GeneReport for Unigene cluster for LSM14A Gene Hs.744009

genes like me logo Genes that share expression patterns with LSM14A: view

Protein tissue co-expression partners for LSM14A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LSM14A Gene

Orthologs for LSM14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LSM14A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LSM14A 35
  • 93.3 (n)
  • 95.9 (a)
LSM14A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LSM14A 35
  • 94 (n)
  • 96.73 (a)
LSM14A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lsm14a 35
  • 90.5 (n)
  • 94.74 (a)
Lsm14a 16
Lsm14a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LSM14A 35
  • 99.64 (n)
  • 99.57 (a)
LSM14A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lsm14a 35
  • 90.5 (n)
  • 94.74 (a)
oppossum
(Monodelphis domestica)
Mammalia LSM14A 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LSM14A 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves LSM14A 35
  • 84.13 (n)
  • 91.3 (a)
LSM14A 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LSM14A 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm14a 35
  • 76.24 (n)
  • 82.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53350 35
zebrafish
(Danio rerio)
Actinopterygii lsm14aa 35
  • 65.48 (n)
  • 72.75 (a)
wufa10g11 35
lsm14aa 36
  • 70 (a)
OneToMany
lsm14ab 36
  • 68 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2043 35
fruit fly
(Drosophila melanogaster)
Insecta tral 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea car-1 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCD6 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10167 36
  • 43 (a)
OneToMany
Species with no ortholog for LSM14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LSM14A Gene

ENSEMBL:
Gene Tree for LSM14A (if available)
TreeFam:
Gene Tree for LSM14A (if available)

Paralogs for LSM14A Gene

Paralogs for LSM14A Gene

(1) SIMAP similar genes for LSM14A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for LSM14A Gene

genes like me logo Genes that share paralogs with LSM14A: view

Variants for LSM14A Gene

Sequence variations from dbSNP and Humsavar for LSM14A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_022884 -
VAR_057532 -
rs369374116 -- 34,227,790(+) AAGGT(-/TG)TGTGT utr-variant-3-prime
rs762529598 -- 34,226,375(+) TTCTC(-/T/TT)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSM14A Gene

Variant ID Type Subtype PubMed ID
nsv2467 CNV Insertion 18451855
nsv509737 CNV Insertion 20534489

Variation tolerance for LSM14A Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSM14A Gene

HapMap Linkage Disequilibrium report
LSM14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM14A Gene

Disorders for LSM14A Gene

Relevant External Links for LSM14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSM14A

No disorders were found for LSM14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSM14A Gene

Publications for LSM14A Gene

  1. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. (PMID: 22745163) Li Y. … Shu H.B. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 67
  2. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. (PMID: 15225602) Albrecht M. … Lengauer T. (FEBS Lett. 2004) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Autophagic degradation of the inhibitory p53 isoform I9133p53I+ as a regulatory mechanism for p53-mediated senescence. (PMID: 25144556) Horikawa I. … Harris C.C. (Nat Commun 2014) 3

Products for LSM14A Gene

Sources for LSM14A Gene

Back to Top

Content