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Aliases for LSM14A Gene

Aliases for LSM14A Gene

  • LSM14A, MRNA Processing Body Assembly Factor 2 3 5
  • Family With Sequence Similarity 61, Member A 2 3
  • Putative Alpha-Synuclein-Binding Protein 3 4
  • RNA-Associated Protein 55A 3 4
  • RNA-Associated Protein 55 2 3
  • Protein SCD6 Homolog 3 4
  • AlphaSNBP 3 4
  • C19orf13 3 4
  • HRAP55A 3 4
  • FAM61A 3 4
  • RAP55A 3 4
  • HRAP55 3 4
  • RAP55 3 4
  • LSM14 Homolog A (SCD6, S. Cerevisiae) 2
  • Chromosome 19 Open Reading Frame 13 2
  • Protein LSM14 Homolog A 3
  • LSM14A, SCD6 Homolog A 3
  • LSM14 Homolog A 3
  • Protein FAM61A 4

External Ids for LSM14A Gene

Previous HGNC Symbols for LSM14A Gene

  • C19orf13
  • FAM61A

Previous GeneCards Identifiers for LSM14A Gene

  • GC19P039359
  • GC19P034663
  • GC19P031161

Summaries for LSM14A Gene

Entrez Gene Summary for LSM14A Gene

  • Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

GeneCards Summary for LSM14A Gene

LSM14A (LSM14A, MRNA Processing Body Assembly Factor) is a Protein Coding gene. Diseases associated with LSM14A include Autoimmune Disease Of Urogenital Tract. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is LSM14B.

UniProtKB/Swiss-Prot for LSM14A Gene

  • Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

Additional gene information for LSM14A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM14A Gene

Genomics for LSM14A Gene

Regulatory Elements for LSM14A Gene

Enhancers for LSM14A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H033273 1.9 FANTOM5 Ensembl ENCODE dbSUPER 116.4 -897.4 -897394 3 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF302 ZNF416 FOS ZNF548 GPATCH1 ZNF507 CEP89 LSM14A KIAA0355 PDCD5 WDR88 AKR1B1P7 LOC100996681 RPL21P131
GH19H033247 1.6 Ensembl ENCODE dbSUPER 126 -923.6 -923577 3 HDGF FOXA2 YBX1 ZNF2 ZBTB7B YY1 ZNF207 FOS ZNF548 REST GPATCH1 CEP89 ZNF507 LSM14A FAAP24 PDCD5 WDR88 AKR1B1P7 LOC100996681 RPL21P131
GH19H033819 1.9 FANTOM5 Ensembl ENCODE dbSUPER 102.5 -351.8 -351805 2 ZFP64 ARID4B SIN3A FEZF1 ZNF302 ZNF416 SP3 ZC3H11A REST SMARCA4 GPATCH1 CEP89 ZNF599 LSM14A KIAA0355 ZNF181 ENSG00000267219 WTIP FAAP24 ENSG00000271049
GH19H034994 2.1 FANTOM5 Ensembl ENCODE dbSUPER 91.7 +828.5 828485 13 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 ZC3H11A NFYC TMEM147-AS1 ZNF599 LSM14A HAUS5 KMT2B ZNF792 ZNF302 KIAA0355 PROSER3 RBM42
GH19H033370 1.4 ENCODE dbSUPER 134.3 -797.7 -797749 8 FOXA2 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 GPATCH1 LSM14A CEP89 KIAA0355 FAAP24 WDR88 PDCD5 ENSG00000267219 AKR1B1P7 LOC100996681
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LSM14A on UCSC Golden Path with GeneCards custom track

Promoters for LSM14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108857 553 2401 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Location for LSM14A Gene

Chromosome:
19
Start:
34,172,447 bp from pter
End:
34,229,515 bp from pter
Size:
57,069 bases
Orientation:
Plus strand

Genomic View for LSM14A Gene

Genes around LSM14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSM14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSM14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM14A Gene

Proteins for LSM14A Gene

  • Protein details for LSM14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND56-LS14A_HUMAN
    Recommended name:
    Protein LSM14 homolog A
    Protein Accession:
    Q8ND56
    Secondary Accessions:
    • B4DTG6
    • Q76LX7
    • Q96AR3
    • Q96K73
    • Q96SN5
    • Q9UFR3

    Protein attributes for LSM14A Gene

    Size:
    463 amino acids
    Molecular mass:
    50530 Da
    Quaternary structure:
    • Component of a ribonucleoprotein (RNP) complex.
    SequenceCaution:
    • Sequence=BAB55066.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LSM14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSM14A Gene

Post-translational modifications for LSM14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for LSM14A Gene

Domains & Families for LSM14A Gene

Gene Families for LSM14A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for LSM14A Gene

Suggested Antigen Peptide Sequences for LSM14A Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND56

UniProtKB/Swiss-Prot:

LS14A_HUMAN :
  • The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
  • Belongs to the LSM14 family.
Domain:
  • The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
Family:
  • Belongs to the LSM14 family.
genes like me logo Genes that share domains with LSM14A: view

Function for LSM14A Gene

Molecular function for LSM14A Gene

UniProtKB/Swiss-Prot Function:
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

Phenotypes From GWAS Catalog for LSM14A Gene

Gene Ontology (GO) - Molecular Function for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003725 double-stranded RNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
genes like me logo Genes that share ontologies with LSM14A: view
genes like me logo Genes that share phenotypes with LSM14A: view

Animal Models for LSM14A Gene

MGI Knock Outs for LSM14A:

Animal Model Products

CRISPR Products

miRNA for LSM14A Gene

miRTarBase miRNAs that target LSM14A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LSM14A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSM14A Gene

Localization for LSM14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM14A Gene

Cytoplasm. Cytoplasm, P-body. Note=Targeted to stress granules (SGs) in response to cellular stress. {ECO:0000269 PubMed:16484376}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LSM14A gene
Compartment Confidence
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 16484376
GO:0005737 cytoplasm IDA,IEA 16484376
GO:0005829 cytosol IDA --
GO:0010494 cytoplasmic stress granule IDA 16484376
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with LSM14A: view

Pathways & Interactions for LSM14A Gene

SuperPathways for LSM14A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organism development IEA --
GO:0033962 cytoplasmic mRNA processing body assembly IMP 17074753
GO:0039529 RIG-I signaling pathway IEA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with LSM14A: view

No data available for Pathways by source and SIGNOR curated interactions for LSM14A Gene

Drugs & Compounds for LSM14A Gene

No Compound Related Data Available

Transcripts for LSM14A Gene

Unigene Clusters for LSM14A Gene

LSM14A, SCD6 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LSM14A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LSM14A Gene

No ASD Table

Relevant External Links for LSM14A Gene

GeneLoc Exon Structure for
LSM14A
ECgene alternative splicing isoforms for
LSM14A

Expression for LSM14A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LSM14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LSM14A Gene

This gene is overexpressed in Pancreas (11.0), CD8 Tcells (10.0), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LSM14A Gene



Protein tissue co-expression partners for LSM14A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LSM14A Gene:

LSM14A

SOURCE GeneReport for Unigene cluster for LSM14A Gene:

Hs.744009

Evidence on tissue expression from TISSUES for LSM14A Gene

  • Blood(4)
  • Liver(4)
  • Pancreas(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with LSM14A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LSM14A Gene

Orthologs for LSM14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LSM14A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSM14A 34 33
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LSM14A 33 34
  • 94 (n)
oppossum
(Monodelphis domestica)
Mammalia LSM14A 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LSM14A 33 34
  • 93.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LSM14A 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lsm14a 16 34 33
  • 90.5 (n)
rat
(Rattus norvegicus)
Mammalia Lsm14a 33
  • 90.5 (n)
chicken
(Gallus gallus)
Aves LSM14A 33 34
  • 84.13 (n)
lizard
(Anolis carolinensis)
Reptilia LSM14A 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm14a 33
  • 76.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53350 33
zebrafish
(Danio rerio)
Actinopterygii lsm14ab 34
  • 68 (a)
OneToMany
lsm14aa 33 34
  • 65.48 (n)
wufa10g11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2043 33
fruit fly
(Drosophila melanogaster)
Insecta tral 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea car-1 34
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCD6 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10167 34
  • 43 (a)
OneToMany
Species where no ortholog for LSM14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LSM14A Gene

ENSEMBL:
Gene Tree for LSM14A (if available)
TreeFam:
Gene Tree for LSM14A (if available)

Paralogs for LSM14A Gene

Paralogs for LSM14A Gene

(1) SIMAP similar genes for LSM14A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LSM14A: view

Variants for LSM14A Gene

Sequence variations from dbSNP and Humsavar for LSM14A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2274896 --
rs36006556 --
rs369374116 -- 34,227,790(+) AAGGT(-/TTG)TGTGT utr-variant-3-prime
rs762529598 -- 34,226,375(+) TTCTC(-/T/TT)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSM14A Gene

Variant ID Type Subtype PubMed ID
dgv3515n100 CNV gain 25217958
nsv2467 CNV insertion 18451855
nsv474170 CNV novel sequence insertion 20440878
nsv509737 CNV insertion 20534489
nsv963038 CNV duplication 23825009

Variation tolerance for LSM14A Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSM14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LSM14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM14A Gene

Disorders for LSM14A Gene

MalaCards: The human disease database

(1) MalaCards diseases for LSM14A Gene - From: DISEASES

Disorder Aliases PubMed IDs
autoimmune disease of urogenital tract
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LSM14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSM14A
genes like me logo Genes that share disorders with LSM14A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LSM14A Gene

Publications for LSM14A Gene

  1. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. (PMID: 22745163) Li Y … Shu HB (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 60
  2. RAP55: insights into an evolutionarily conserved protein family. (PMID: 18723115) Marnef A … Ladomery MR (The international journal of biochemistry & cell biology 2009) 3 4 60
  3. RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. (PMID: 16484376) Yang WH … Bloch DB (RNA (New York, N.Y.) 2006) 3 4 60
  4. RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes. (PMID: 17074753) Tanaka KJ … Tsujimoto M (The Journal of biological chemistry 2006) 3 4 60
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60

Products for LSM14A Gene

Sources for LSM14A Gene

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