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Aliases for LSM14A Gene

Aliases for LSM14A Gene

  • LSM14A, SCD6 Homolog A (S. Cerevisiae) 2 3
  • Family With Sequence Similarity 61, Member A 2 3
  • Putative Alpha-Synuclein-Binding Protein 3 4
  • RNA-Associated Protein 55A 3 4
  • Protein SCD6 Homolog 3 4
  • AlphaSNBP 3 4
  • C19orf13 3 4
  • HRAP55A 3 4
  • FAM61A 3 4
  • RAP55A 3 4
  • HRAP55 3 4
  • RAP55 3 4
  • LSM14 Homolog A (SCD6, S. Cerevisiae) 2
  • Chromosome 19 Open Reading Frame 13 2
  • RNA-Associated Protein 55 3
  • Protein LSM14 Homolog A 3
  • LSM14 Homolog A 3
  • Protein FAM61A 4

External Ids for LSM14A Gene

Previous HGNC Symbols for LSM14A Gene

  • C19orf13
  • FAM61A

Previous GeneCards Identifiers for LSM14A Gene

  • GC19P039359
  • GC19P034663
  • GC19P031161

Summaries for LSM14A Gene

Entrez Gene Summary for LSM14A Gene

  • Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

GeneCards Summary for LSM14A Gene

LSM14A (LSM14A, SCD6 Homolog A (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include double-stranded DNA binding and single-stranded RNA binding. An important paralog of this gene is LSM14B.

UniProtKB/Swiss-Prot for LSM14A Gene

  • Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM14A Gene

Genomics for LSM14A Gene

Regulatory Elements for LSM14A Gene

Genomic Location for LSM14A Gene

Start:
34,172,447 bp from pter
End:
34,229,515 bp from pter
Size:
57,069 bases
Orientation:
Plus strand

Genomic View for LSM14A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LSM14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM14A Gene

Proteins for LSM14A Gene

  • Protein details for LSM14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND56-LS14A_HUMAN
    Recommended name:
    Protein LSM14 homolog A
    Protein Accession:
    Q8ND56
    Secondary Accessions:
    • B4DTG6
    • Q76LX7
    • Q96AR3
    • Q96K73
    • Q96SN5
    • Q9UFR3

    Protein attributes for LSM14A Gene

    Size:
    463 amino acids
    Molecular mass:
    50530 Da
    Quaternary structure:
    • Component of a ribonucleoprotein (RNP) complex.
    SequenceCaution:
    • Sequence=BAB55066.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LSM14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LSM14A Gene

Proteomics data for LSM14A Gene at MOPED

Post-translational modifications for LSM14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LSM14A Gene

No data available for DME Specific Peptides for LSM14A Gene

Domains for LSM14A Gene

Protein Domains for LSM14A Gene

Suggested Antigen Peptide Sequences for LSM14A Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND56

UniProtKB/Swiss-Prot:

LS14A_HUMAN :
  • Q8ND56
Domain:
  • The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
  • Contains 1 DFDF domain.
Family:
  • Belongs to the LSM14 family.
genes like me logo Genes that share domains with LSM14A: view

No data available for Gene Families for LSM14A Gene

Function for LSM14A Gene

Molecular function for LSM14A Gene

UniProtKB/Swiss-Prot Function: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.

Gene Ontology (GO) - Molecular Function for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0003725 double-stranded RNA binding IEA --
GO:0003727 single-stranded RNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LSM14A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSM14A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LSM14A Gene

Localization for LSM14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM14A Gene

Cytoplasm. Cytoplasm, P-body. Note=Targeted to stress granules (SGs) in response to cellular stress.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LSM14A Gene COMPARTMENTS Subcellular localization image for LSM14A gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 16484376
GO:0005737 cytoplasm IDA --
GO:0010494 cytoplasmic stress granule IDA 16484376
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with LSM14A: view

Pathways for LSM14A Gene

SuperPathways for LSM14A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LSM14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organismal development IEA --
GO:0033962 cytoplasmic mRNA processing body assembly IMP 17074753
GO:0039529 RIG-I signaling pathway IEA --
GO:0051607 defense response to virus --
genes like me logo Genes that share ontologies with LSM14A: view

No data available for Pathways by source for LSM14A Gene

Transcripts for LSM14A Gene

Unigene Clusters for LSM14A Gene

LSM14A, SCD6 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LSM14A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSM14A Gene

No ASD Table

Relevant External Links for LSM14A Gene

GeneLoc Exon Structure for
LSM14A
ECgene alternative splicing isoforms for
LSM14A

Expression for LSM14A Gene

mRNA expression in normal human tissues for LSM14A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LSM14A Gene

SOURCE GeneReport for Unigene cluster for LSM14A Gene Hs.744009

genes like me logo Genes that share expressions with LSM14A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LSM14A Gene

Orthologs for LSM14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LSM14A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSM14A 35
  • 99.64 (n)
  • 99.57 (a)
LSM14A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LSM14A 35
  • 93.3 (n)
  • 95.9 (a)
LSM14A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LSM14A 35
  • 94 (n)
  • 96.73 (a)
LSM14A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lsm14a 35
  • 90.5 (n)
  • 94.74 (a)
Lsm14a 16
Lsm14a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LSM14A 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LSM14A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lsm14a 35
  • 90.5 (n)
  • 94.74 (a)
chicken
(Gallus gallus)
Aves LSM14A 35
  • 84.13 (n)
  • 91.3 (a)
LSM14A 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LSM14A 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53350 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm14a 35
  • 76.24 (n)
  • 82.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2043 35
zebrafish
(Danio rerio)
Actinopterygii lsm14aa 35
  • 65.48 (n)
  • 72.75 (a)
lsm14aa 36
  • 70 (a)
OneToMany
lsm14ab 36
  • 68 (a)
OneToMany
wufa10g11 35
fruit fly
(Drosophila melanogaster)
Insecta tral 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea car-1 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCD6 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10167 36
  • 43 (a)
OneToMany
Species with no ortholog for LSM14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LSM14A Gene

ENSEMBL:
Gene Tree for LSM14A (if available)
TreeFam:
Gene Tree for LSM14A (if available)

Paralogs for LSM14A Gene

Paralogs for LSM14A Gene

Selected SIMAP similar genes for LSM14A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for LSM14A Gene

genes like me logo Genes that share paralogs with LSM14A: view

Variants for LSM14A Gene

Sequence variations from dbSNP and Humsavar for LSM14A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs16427 -- 34,228,569(-) TCATC(-/CAT)AGGCC cds-indel
rs475850 -- 34,226,365(+) TCCCC(A/C)TCTCT intron-variant
rs479036 -- 34,229,537(-) TGGCT(C/T)AATCT downstream-variant-500B
rs481218 -- 34,220,348(+) ATACT(C/T)TTGTT intron-variant
rs502810 -- 34,227,008(-) CAACA(C/T)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSM14A Gene

Variant ID Type Subtype PubMed ID
nsv2467 CNV Insertion 18451855
nsv509737 CNV Insertion 20534489

Relevant External Links for LSM14A Gene

HapMap Linkage Disequilibrium report
LSM14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM14A Gene

Disorders for LSM14A Gene

(1) University of Copenhagen DISEASES for LSM14A Gene

genes like me logo Genes that share disorders with LSM14A: view

No data available for UniProtKB/Swiss-Prot for LSM14A Gene

Publications for LSM14A Gene

  1. RAP55: insights into an evolutionarily conserved protein family. (PMID: 18723115) Marnef A. … Ladomery M.R. (Int. J. Biochem. Cell Biol. 2009) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. (PMID: 16484376) Yang W.H. … Bloch D.B. (RNA 2006) 3 4

Products for LSM14A Gene

Sources for LSM14A Gene

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