LSM12 Gene
protein-coding GIFtS: 45
GCID: GC17M042112
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LSM12 homolog (S. cerevisiae)
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Aliases
for LSM12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| LSM12 Homolog (S. Cerevisiae)1 2 | | FLJ306561 | | PNAS-1352 | | Protein LSM12 Homolog2 |
Export aliases for LSM12 gene to outside databasesPrevious GC identifers: GC17M039468 GC17M037876 |
Summaries
for LSM12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LSM12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LSM12 gene promoter:
SREBP-1c Nkx2-5 Nkx5-1 SREBP-1b PPAR-gamma1 SREBP-1a TFIID Zic1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for LSM12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LSM12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31LSM12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M042112: view genomic region
(about GC identifiers)
Start:
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42,112,003 bp from pter |
End:
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42,144,987 bp from pter |
Size:
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32,985 bases |
Orientation:
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minus strand |
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Proteins
for LSM12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LSM12_HUMAN, Q3MHD2 (See
protein sequence)Recommended Name: Protein LSM12 homolog Size: 195 amino acids; 21701 Da
Secondary accessions: Q86YB1 Q96NL5Alternative splicing: 2 isoforms: Q3MHD2-1 Q3MHD2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LSM12: NX_Q3MHD2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3MHD2
LSM12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689557.1
ENSEMBL proteins: ENSP00000466718 ENSP00000466074 ENSP00000293406
Human Recombinant Protein Products:
LSM12 Antibody Products:
Assay Products for LSM12: |
Protein
Domains /
Families
for LSM12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LSM12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q3MHD2ProtoNet protein and cluster: Q3MHD2 UniProtKB/Swiss-Prot: LSM12_HUMAN, Q3MHD2Similarity: Belongs to the LSM12 family |
Function
for LSM12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LSM12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LSM12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LSM12 (NM_152344) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LSM12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM12 |
1 GenomeRNAi human phenotype for LSM12:
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Pathways & Interactions
for LSM12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LSM12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/26 Interacting proteins for LSM12 (Q3MHD23 ENSP000002934064) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
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Drugs & Compounds
for LSM12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LSM12
Search CenterWatch for drugs/clinical trials and news about LSM12
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Transcripts
for LSM12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LSM12 gene: NM_152344.3 Unigene Cluster for LSM12: LSM12 homolog (S. cerevisiae) Hs.355570 [show with all ESTs]Unigene Representative Sequence: NM_1523444 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591247 ENST00000590563 ENST00000585388 ENST00000293406(uc010wit.2 uc002iev.3 uc002iew.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LSM12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LSM12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LSM12 (NM_152344) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LSM12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM12 |
Additional cDNA sequence: AF277193.1 AK055218.1 AK300637.1 AL832076.1 BC016791.2 BC044587.1 BC066298.1 BC105288.1 DQ786277.1 9 DOTS entries: DT.40110305 DT.92054731 DT.121477686 DT.100790336 DT.99950808 DT.96085399 DT.97816352 DT.100790334 DT.92467003 24/178 AceView cDNA sequences (see all 178): CB114266 CN480217 BG677691 BM905720 BM360861 BM796359 BM462936 AA422052 BX342471 BG108232 BF034776 AI862573 AI189640 AA758466 BC066298 AI380005 BE549995 CB989704 BG770934 AI217775 AI243538 AA699831 BE221885 BE327765
GeneLoc Exon Structure
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Expression
for LSM12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LSM12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTCTTTCC
About this image
See LSM12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LSM12
SOURCE GeneReport for Unigene cluster: Hs.355570
SABiosciences Custom PCR Arrays for LSM12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LSM12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LSM12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LSM12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LSM12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM12 |
Orthologs
for LSM12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for LSM12 gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for LSM12 (if available)
TreeFam Gene Tree for LSM12 (if available) |
Paralogs
for LSM12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LSM12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for LSM12 (42112003 - 42144987 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LSM12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LSM12 |
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Disorders
/ Diseases
for LSM12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LSM12 for disorders About GeneDecksing
OMIM gene information: 611793
OMIM disorders: --
2  diseases for LSM12: About MalaCardssertoli cell-only syndrome malaria
1 disease from the University of Copenhagen DISEASES database for LSM12:Sertoli cell-only syndrome Export disorders for LSM12 gene to outside databases
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Publications
for LSM12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LSM12 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with LSM12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. (PubMed id 15225602)1, 3 Albrecht M. and Lengauer T. (2004)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
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External Searches for LSM12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LSM12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing LSM12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LSM12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LSM12 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for LSM12 gene:
Search GeneIP for patents involving LSM12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LSM12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LSM12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LSM12 | | | OriGene Protein Over-expression Lysate for LSM12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for LSM12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LSM12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LSM12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LSM12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LSM12 | | OriGene Custom Protein Services for LSM12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LSM12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LSM12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LSM12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LSM12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LSM12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LSM12 |
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| | | | Search Tocris compounds for LSM12 |
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 | | | LSM12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LSM12 |
|  |  |  | | | | Search ThermoFisher Antibodies for LSM12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM12 |
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