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Aliases for LSM12 Gene

Aliases for LSM12 Gene

  • LSM12 Homolog 2 3 5
  • LSM12 Homolog (S. Cerevisiae) 2
  • Protein LSM12 Homolog 3
  • PNAS-135 3

External Ids for LSM12 Gene

Previous GeneCards Identifiers for LSM12 Gene

  • GC17M039468
  • GC17M042112
  • GC17M037876

Summaries for LSM12 Gene

GeneCards Summary for LSM12 Gene

LSM12 (LSM12 Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM12 Gene

Genomics for LSM12 Gene

Regulatory Elements for LSM12 Gene

Enhancers for LSM12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F044024 0.3 FANTOM5 25.1 +43.2 43155 0.4 HDAC1 ARID4B SIN3A DMAP1 ZNF2 RAD21 RARA ZNF143 CREM THAP11 C17orf105 LSM12 NAGS CD300LG ENSG00000221044 TMEM101 PYY
GH17F043926 1.1 FANTOM5 ENCODE 24.4 +139.4 139412 2.8 SOX13 GATAD2A SOX5 TFAP4 NRF1 FEZF1 HMG20A OSR2 ZNF121 TCF7 LSM12 C17orf105 MPP2 NAGS PYY ENSG00000221044 CD300LG LOC102724183 LINC01976
GH17F044094 1.5 FANTOM5 Ensembl ENCODE 12.4 -29.3 -29282 4.2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF263 SP3 SP5 ASB16 G6PC3 TMEM101 ASB16-AS1 LSM12 RNU6-131P C17orf53 HDAC5 ENSG00000221044 PYY
GH17F044101 1 Ensembl ENCODE 11.9 -40.0 -40036 12.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ASB16-AS1 DHX8 HMGN1P29 LINC00910 ASB16 NAGS G6PC3 C17orf53 ENSG00000267002 ENSG00000267340
GH17F044042 0.9 Ensembl ENCODE 11.5 +23.9 23929 1.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 ZNF143 LSM12 G6PC3 PPY GC17P044038
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LSM12 on UCSC Golden Path with GeneCards custom track

Promoters for LSM12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for LSM12 Gene

44,034,635 bp from pter
44,067,619 bp from pter
32,985 bases
Minus strand

Genomic View for LSM12 Gene

Genes around LSM12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSM12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM12 Gene

Proteins for LSM12 Gene

  • Protein details for LSM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein LSM12 homolog
    Protein Accession:
    Secondary Accessions:
    • Q86YB1
    • Q96NL5

    Protein attributes for LSM12 Gene

    195 amino acids
    Molecular mass:
    21701 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LSM12 Gene


neXtProt entry for LSM12 Gene

Post-translational modifications for LSM12 Gene

  • Ubiquitination at Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for LSM12 Gene

No data available for DME Specific Peptides for LSM12 Gene

Domains & Families for LSM12 Gene

Protein Domains for LSM12 Gene


Suggested Antigen Peptide Sequences for LSM12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LSM12 family.
  • Belongs to the LSM12 family.
genes like me logo Genes that share domains with LSM12: view

No data available for Gene Families for LSM12 Gene

Function for LSM12 Gene

genes like me logo Genes that share phenotypes with LSM12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LSM12 Gene

Localization for LSM12 Gene

Subcellular locations from

Jensen Localization Image for LSM12 Gene COMPARTMENTS Subcellular localization image for LSM12 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LSM12 Gene

Pathways & Interactions for LSM12 Gene

SuperPathways for LSM12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LSM12 Gene


No data available for Pathways by source and SIGNOR curated interactions for LSM12 Gene

Transcripts for LSM12 Gene

Unigene Clusters for LSM12 Gene

LSM12 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LSM12 Gene

No ASD Table

Relevant External Links for LSM12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LSM12 Gene

mRNA expression in normal human tissues for LSM12 Gene

Protein differential expression in normal tissues from HIPED for LSM12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.4) and Lung (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LSM12 Gene

Protein tissue co-expression partners for LSM12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LSM12 Gene:


SOURCE GeneReport for Unigene cluster for LSM12 Gene:

genes like me logo Genes that share expression patterns with LSM12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LSM12 Gene

Orthologs for LSM12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LSM12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LSM12 34 35
  • 99.83 (n)
(Canis familiaris)
Mammalia LSM12 34 35
  • 98.63 (n)
(Bos Taurus)
Mammalia LSM12 34 35
  • 98.29 (n)
(Mus musculus)
Mammalia Lsm12 34 16 35
  • 97.09 (n)
(Rattus norvegicus)
Mammalia Lsm12 34
  • 97.09 (n)
(Ornithorhynchus anatinus)
Mammalia LSM12 35
  • 91 (a)
(Gallus gallus)
Aves LSM12 35
  • 94 (a)
TMEM101 34
  • 85.84 (n)
(Anolis carolinensis)
Reptilia LSM12 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394627 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25564 34
(Danio rerio)
Actinopterygii lsm12b 34 35
  • 78.8 (n)
lsm12a 35
  • 77 (a)
wufe01f11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10493 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002167 34
  • 51.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15735 34 35
  • 46.09 (n)
CG14164 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSM12 35 37
  • 24 (a)
Species where no ortholog for LSM12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LSM12 Gene

Gene Tree for LSM12 (if available)
Gene Tree for LSM12 (if available)

Paralogs for LSM12 Gene Pseudogenes for LSM12 Gene

genes like me logo Genes that share paralogs with LSM12: view

No data available for Paralogs for LSM12 Gene

Variants for LSM12 Gene

Sequence variations from dbSNP and Humsavar for LSM12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11079942 -- 44,042,058(+) GAGGC(A/G)GGCGG intron-variant
rs111239849 -- 44,067,258(+) TGTGC(-/CA)CACTG intron-variant, upstream-variant-2KB
rs111303263 -- 44,067,663(+) AGGTT(G/T)AAATG upstream-variant-2KB
rs111395649 -- 44,054,194(+) CATGC(A/G)CTATA intron-variant
rs111558559 -- 44,050,034(+) TCATC(C/G)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSM12 Gene

Variant ID Type Subtype PubMed ID
esv2662976 CNV deletion 23128226
esv3640641 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv833454 CNV loss 17160897

Variation tolerance for LSM12 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSM12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM12 Gene

Disorders for LSM12 Gene

Relevant External Links for LSM12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LSM12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSM12 Gene

Publications for LSM12 Gene

  1. Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. (PMID: 15225602) Albrecht M. … Lengauer T. (FEBS Lett. 2004) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for LSM12 Gene

Sources for LSM12 Gene

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