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Aliases for LSM11 Gene

Aliases for LSM11 Gene

  • LSM11, U7 Small Nuclear RNA Associated 2 3 5
  • LSM11 Homolog, U7 Small Nuclear RNA Associated (S. Cerevisiae) 2

External Ids for LSM11 Gene

Previous GeneCards Identifiers for LSM11 Gene

  • GC05P157151
  • GC05P157103
  • GC05P157171
  • GC05P152259

Summaries for LSM11 Gene

GeneCards Summary for LSM11 Gene

LSM11 (LSM11, U7 Small Nuclear RNA Associated) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include U7 snRNA binding.

UniProtKB/Swiss-Prot for LSM11 Gene

  • Component of the U7 snRNP complex that is involved in the histone 3-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM11 Gene

Genomics for LSM11 Gene

Regulatory Elements for LSM11 Gene

Promoters for LSM11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LSM11 on UCSC Golden Path with GeneCards custom track

Genomic Location for LSM11 Gene

Chromosome:
5
Start:
157,743,695 bp from pter
End:
157,760,709 bp from pter
Size:
17,015 bases
Orientation:
Plus strand

Genomic View for LSM11 Gene

Genes around LSM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LSM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LSM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM11 Gene

Proteins for LSM11 Gene

  • Protein details for LSM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83369-LSM11_HUMAN
    Recommended name:
    U7 snRNA-associated Sm-like protein LSm11
    Protein Accession:
    P83369
    Secondary Accessions:
    • A0AVQ1
    • Q7Z7P0
    • Q8N975

    Protein attributes for LSM11 Gene

    Size:
    360 amino acids
    Molecular mass:
    39500 Da
    Quaternary structure:
    • Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with LSM10, SMN, SNRPB and ZNF473. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts (via the Sm domains) with CLNS1A. Interacts with PRMT5 and WDR77 (By similarity).

neXtProt entry for LSM11 Gene

Proteomics data for LSM11 Gene at MOPED

Post-translational modifications for LSM11 Gene

Other Protein References for LSM11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for LSM11

No data available for DME Specific Peptides for LSM11 Gene

Domains & Families for LSM11 Gene

Protein Domains for LSM11 Gene

Suggested Antigen Peptide Sequences for LSM11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P83369

UniProtKB/Swiss-Prot:

LSM11_HUMAN :
  • The C-terminal SM 1 domain is both necessary for the binding to the Sm-binding site of U7 snRNA and U7 snRNP assembly (By similarity). The N-terminal domain is essential for histone pre-mRNA cleavage. Amino acids 63-82 are sufficient to interact with ZNF473.
  • Belongs to the snRNP Sm proteins family.
Domain:
  • The C-terminal SM 1 domain is both necessary for the binding to the Sm-binding site of U7 snRNA and U7 snRNP assembly (By similarity). The N-terminal domain is essential for histone pre-mRNA cleavage. Amino acids 63-82 are sufficient to interact with ZNF473.
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with LSM11: view

No data available for Gene Families for LSM11 Gene

Function for LSM11 Gene

Molecular function for LSM11 Gene

UniProtKB/Swiss-Prot Function:
Component of the U7 snRNP complex that is involved in the histone 3-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.

Phenotypes for LSM11 Gene

genes like me logo Genes that share phenotypes with LSM11: view

Animal Models for LSM11 Gene

MGI Knock Outs for LSM11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LSM11 Gene

Localization for LSM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LSM11 Gene COMPARTMENTS Subcellular localization image for LSM11 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for LSM11 Gene

Pathways & Interactions for LSM11 Gene

genes like me logo Genes that share pathways with LSM11: view

Gene Ontology (GO) - Biological Process for LSM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with LSM11: view

No data available for SIGNOR curated interactions for LSM11 Gene

Drugs & Compounds for LSM11 Gene

No Compound Related Data Available

Transcripts for LSM11 Gene

mRNA/cDNA for LSM11 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(104) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LSM11 Gene

LSM11, U7 small nuclear RNA associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LSM11 Gene

No ASD Table

Relevant External Links for LSM11 Gene

GeneLoc Exon Structure for
LSM11
ECgene alternative splicing isoforms for
LSM11

Expression for LSM11 Gene

mRNA expression in normal human tissues for LSM11 Gene

Protein differential expression in normal tissues from HIPED for LSM11 Gene

This gene is overexpressed in Breast (28.0), Lung (13.4), and Plasma (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LSM11 Gene



SOURCE GeneReport for Unigene cluster for LSM11 Gene Hs.631954

genes like me logo Genes that share expression patterns with LSM11: view

Protein tissue co-expression partners for LSM11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LSM11 Gene

Orthologs for LSM11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LSM11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LSM11 35
  • 99.44 (n)
  • 99.72 (a)
LSM11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LSM11 35
  • 90.53 (n)
  • 91.62 (a)
LSM11 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lsm11 36
  • 88 (a)
OneToOne
Lsm11 16
Lsm11 35
  • 85.05 (n)
  • 88.58 (a)
oppossum
(Monodelphis domestica)
Mammalia LSM11 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LSM11 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lsm11 35
  • 85.38 (n)
  • 88.55 (a)
chicken
(Gallus gallus)
Aves LSM11 36
  • 59 (a)
OneToOne
LSM11 35
  • 65.91 (n)
  • 65.81 (a)
lizard
(Anolis carolinensis)
Reptilia LSM11 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LSM11 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm11 35
  • 60 (n)
  • 57.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13176 35
zebrafish
(Danio rerio)
Actinopterygii lsm11 36
  • 48 (a)
OneToMany
lsm11 36
  • 47 (a)
OneToMany
Dr.15509 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for LSM11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LSM11 Gene

ENSEMBL:
Gene Tree for LSM11 (if available)
TreeFam:
Gene Tree for LSM11 (if available)

Paralogs for LSM11 Gene

No data available for Paralogs for LSM11 Gene

Variants for LSM11 Gene

Sequence variations from dbSNP and Humsavar for LSM11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs924442 -- 157,751,964(-) CTAAA(A/C)CGATA intron-variant
rs873343 -- 157,747,112(+) AGAGA(C/T)GGTAA intron-variant
rs2015909 -- 157,752,571(-) accgc(A/G)tgcag intron-variant
rs1546250 -- 157,749,588(-) GTGTG(C/T)GCGCG intron-variant
rs2242404 -- 157,759,559(-) TCATT(C/G)ACAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LSM11 Gene

Variant ID Type Subtype PubMed ID
dgv1868e1 CNV Complex 17122850
nsv5090 CNV Insertion 18451855

Variation tolerance for LSM11 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LSM11 Gene

HapMap Linkage Disequilibrium report
LSM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LSM11 Gene

Disorders for LSM11 Gene

Relevant External Links for LSM11

Genetic Association Database (GAD)
LSM11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LSM11

No disorders were found for LSM11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LSM11 Gene

Publications for LSM11 Gene

  1. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. (PMID: 12975319) Pillai R.S. … Schuemperli D. (Genes Dev. 2003) 2 3 4 23 67
  2. ZFP100, a component of the active U7 snRNP limiting for histone pre- mRNA processing, is required for entry into S phase. (PMID: 16914750) Wagner E.J. … Marzluff W.F. (Mol. Cell. Biol. 2006) 3 23
  3. A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing. (PMID: 23071092) Yang X.C. … Dominski Z. (Mol. Cell. Biol. 2013) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. The SMN interactome includes Myb-binding protein 1a. (PMID: 19928837) Fuller H.R. … Morris G.E. (J. Proteome Res. 2010) 3

Products for LSM11 Gene

Sources for LSM11 Gene

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