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LSM1 Gene

protein-coding   GIFtS: 61
GCID: GC08M038020

LSM1, U6 Small Nuclear RNA Associated

(Previous names: LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LSM1, U6 Small Nuclear RNA Associated1 2     Cancer-Associated Sm-Like Protein2
Small Nuclear Ribonuclear CaSm2 3     LSM1 Homolog, U6 Small Nuclear RNA Associated2
CASM2 3     U6 SnRNA-Associated Sm-Like Protein LSm12
LSM1 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae)1     Cancer-Associated Sm-Like3
YJL124C2     

External Ids:    HGNC: 204721   Entrez Gene: 272572   Ensembl: ENSG000001753247   OMIM: 6072815   UniProtKB: O151163   

Export aliases for LSM1 gene to outside databases

Previous GC identifers: GC08M037561 GC08M038149 GC08M037761 GC08M038038 GC08M038140 GC08M036555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LSM1 Gene:
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that
bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by
mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and
the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively
spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the
short arm of chromosome 9. (provided by RefSeq, Nov 2011)

GeneCards Summary for LSM1 Gene:
LSM1 (LSM1, U6 small nuclear RNA associated) is a protein-coding gene. Diseases associated with LSM1 include lung cancer, and spinal muscular atrophy. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: LSM1_HUMAN, O15116
Function: Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal
U-tract of U6 snRNA

Gene Wiki entry for LSM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LSM1 gene promoter:
         GR   GR-beta   ATF-2   GR-alpha   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLSM1 promoter sequence
   Search Chromatin IP Primers for LSM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LSM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p11.2

LSM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LSM1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M038020:  view genomic region     (about GC identifiers)

Start:
38,020,839 bp from pter      End:
38,034,248 bp from pter
Size:
13,410 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LSM1_HUMAN, O15116 (See protein sequence)
Recommended Name: U6 snRNA-associated Sm-like protein LSm1  
Size: 133 amino acids; 15179 Da
Subunit: Interacts with SLBP. Interaction with SLBP occurs when histone mRNA is being rapidly degraded during the
S phase. LSm subunits form a heteromer with a doughnut shape
Secondary accessions: B2R5E6

Explore the universe of human proteins at neXtProt for LSM1: NX_O15116

Explore proteomics data for LSM1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LSM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055277.1  
    ENSEMBL proteins: 
     ENSP00000310596   ENSP00000430021   ENSP00000428307  
    Reactome Protein details: O15116

    LSM1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom

    Graphical View of Domain Structure for InterPro Entry O15116

    ProtoNet protein and cluster: O15116

    2 Blocks protein domains:
    IPB001163 Small nuclear ribonucleoprotein (Sm protein)
    IPB010920 Like-Sm ribonucleoprotein-related


    UniProtKB/Swiss-Prot: LSM1_HUMAN, O15116
    Similarity: Belongs to the snRNP Sm proteins family


    LSM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LSM1_HUMAN, O15116
    Function: Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal
    U-tract of U6 snRNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI15231747
    GO:0044822poly(A) RNA binding IDA--
         
    LSM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Lsm1 (no phenotypes)

    LSM1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LSM1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LSM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LSM1

    miRNA
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    miRTarBase miRNAs that target LSM1:
    hsa-mir-26b-5p (MIRT030039), hsa-mir-30a-5p (MIRT028662)

    Block miRNA regulation of human, mouse, rat LSM1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LSM1:
    hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidLSM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LSM1
    Predesigned siRNA for gene silencing in human, mouse, rat LSM1

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    Sino Biological Human cDNA Clone for LSM1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LSM1_HUMAN, O15116: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18559850
    GO:0005737cytoplasm IDA18559850
    GO:0005829cytosol TAS--
    GO:0030529ribonucleoprotein complex IEA--

    LSM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LSM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for LSM1
        mRNA decay by 5' to 3' exoribonuclease


    1 Kegg Pathway  (Kegg details for LSM1):
        RNA degradation


    LSM1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LSM1
    Interactions:

        Search GeneGlobe Interaction Network for LSM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LSM1 (O151161, 2, 3 ENSP000003105964) via UniProtKB, MINT, STRING, and/or I2D (see all 281)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206394O002992, 3MINT-62597 MINT-62771 MINT-62695 I2D: score=5 
    ENSG00000223639O002992, 3MINT-62597 MINT-62771 MINT-62695 I2D: score=5 
    ENSG00000226248O002992, 3MINT-62597 MINT-62771 MINT-62695 I2D: score=5 
    ENSG00000226417O002992, 3MINT-62597 MINT-62771 MINT-62695 I2D: score=5 
    ENSG00000226651O002992, 3MINT-62597 MINT-62771 MINT-62695 I2D: score=5 
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    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000375RNA splicing, via transesterification reactions TAS10369684
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing TAS10369684
    GO:0010467gene expression TAS--

    LSM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LSM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LSM1 gene: 
    NM_014462.2  

    Unigene Cluster for LSM1:

    LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
    Hs.425311  [show with all ESTs]
    Unigene Representative Sequence: NM_014462
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311351(uc003xkx.3 uc003xkw.3 uc022atz.1) ENST00000520755
    ENST00000522515 ENST00000520286 ENST00000523511
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LSM1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LSM1:
    hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidLSM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LSM1
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    GenScript: all cDNA clones in your preferred vector (see all 2): LSM1 (NM_015578)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LSM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LSM1
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    OriGene qPCR primer pairs and template standards for LSM1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LSM1
      QuantiTect SYBR Green Assays in human, mouse, rat LSM1
      QuantiFast Probe-based Assays in human, mouse, rat LSM1

    Additional mRNA sequence: 

    AF000177.1 AF147348.1 AJ238094.1 AK312159.1 BC001767.1 NR_045492.1 NR_045493.1 

    12 DOTS entries:

    DT.100787766  DT.445391  DT.92427027  DT.120637226  DT.120637288  DT.40273676  DT.410810  DT.116154 
    DT.100787770  DT.100028229  DT.40121734  DT.91925459 

    Selected AceView cDNA sequences (see all 204):

    CA432148 AA384967 BM460122 BM835998 CR621829 BU521199 BE672501 BM854482 
    CA941955 BF477610 BU073292 BF446157 T55582 AW264714 AI038948 BQ646642 
    AI240951 BE785977 AA252501 BQ130632 AA542973 BU739068 BM821336 CD107263 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LSM1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                                                  
    SP2:                    -           -                                 
    SP3:                                -                                 
    SP4:                                -     -                           


    ECgene alternative splicing isoforms for LSM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LSM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAATCGT
    LSM1 Expression
    About this image

    LSM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LSM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.425311

    UniProtKB/Swiss-Prot: LSM1_HUMAN, O15116
    Tissue specificity: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines

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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LSM1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lsm11 , 5 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)1, 5 90.23(n)1
    97.74(a)1
      8 (14.17 cM)5
    672071  NM_026032.11  NP_080308.11 
     257855915 
    chicken
    (Gallus gallus)
    Aves LSM11 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) 75.19(n)
    93.23(a)
      426775  XM_424387.4  XP_424387.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154072 Transcribed sequence with strong similarity to protein more 79.25(n)    AL859723.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148342 Transcribed sequence with moderate similarity to protein more 76.33(n)    CK352774.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42793
    LSm11
    mRNA splicing3
    LSm11
    63(a)3
    62.37(n)1
    63.71(a)1
      57C73
    374131  NM_137715.31  NP_611559.11 
    worm
    (Caenorhabditis elegans)
    Secernentea lsm-11 lsm-1 58.61(n)
    59.34(a)
      174700  NM_063984.5  NP_496385.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LSM1(YJL124C)4
    LSM11
    Lsm (Like Sm) protein; forms heteroheptameric complex more4
    LSM11
    61.32(n)1
    56.79(a)1
      10(187644-187126)4
    8533181, 4  NP_012411.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G140801 AT3G14080 53.67(n)
    54(a)
      820624  NM_180249.3  NP_850580.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g04458001 Os04g0445800 56.09(n)
    50(a)
      4335963  NM_001059440.1  NP_001052905.1 


    ENSEMBL Gene Tree for LSM1 (if available)
    TreeFam Gene Tree for LSM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LSM1 gene
    1 SIMAP similar gene for LSM1 using alignment to 3 protein entries:     LSM1_HUMAN (see all proteins):
    LSM8

    LSM1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for LSM1
    PGOHUM00000235446 PGOHUM00000235974 PGOHUM00000241209


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LSM1 (see all 228)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017381371,2
    C--38020339(+) TTTATA/TTTTTT 3 -- ds50010--------
    rs557360521,2
    C--38020408(+) AATCTC/TGGCTC 3 -- ds50011Minor allele frequency- T:0.50NA 2
    rs28437261,2
    C,F,A,H--38020414(-) TGCGGT/AGAGCC 3 -- ds50014Minor allele frequency- A:0.50NA WA 8
    rs1450241061,2
    --38020488(+) CATGCA/GCCACC 3 -- ds50010--------
    rs1920816941,2
    --38020524(+) GTAGAC/GACAGG 3 -- ds50010--------
    rs774934081,2
    C--38020565(+) ACTCCC/TGACCT 3 -- ds50010--------
    rs1880338611,2
    --38020586(+) ACCCGC/TCTCGG 3 -- ds50010--------
    rs1913434401,2
    --38020636(+) CCTGCC/GGAACA 3 -- ds50010--------
    rs1388059271,2
    --38020867(+) AGATTC/TATATT 3 -- ut31 nc-transcript-variant0--------
    rs1823720641,2
    --38020880(+) ATTTAA/CAAGTA 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for LSM1 (38020839 - 38034248 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LSM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv397579CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607281    OMIM disorders: --

    11 diseases for LSM1:    
    About MalaCards
    lung cancer    spinal muscular atrophy    muscular atrophy    breast cancer
    pancreatic cancer    prostate cancer    prostatitis    malaria
    pancreatitis    schizophrenia    adenocarcinoma


    LSM1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LSM1
    Human Genome Epidemiology (HuGE) Navigator: LSM1 (2 documents)

    Export disorders for LSM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LSM1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with LSM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. (PubMed id 22037555)1, 4 Shi Y....He L. (Nat. Genet. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (Genes Dev. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 3 Ingelfinger D.... Achsel T. (RNA 2002)
    6. Down-regulation of Lsm1 is involved in human prostate cancer progression. (PubMed id 11953827)1, 3 Takahashi S....Shirai T. (Br. J. Cancer 2002)
    7. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PubMed id 10369684)1, 2 Salgado-Garrido J.... Seraphin B. (EMBO J. 1999)
    8. CaSm: an Sm-like protein that contributes to the transformed state in cancer cells. (PubMed id 9230209)1, 2 Schweinfest C.W....Watson D.K. (Cancer Res. 1997)
    9. CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes. (PubMed id 18218995)1, 9 Watson P.M....Boylan A.M. (Am. J. Respir. Cell Mol. Biol. 2008)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27257 HGNC: 20472 AceView: LSM1 Ensembl:ENSG00000175324 euGenes: HUgn27257
    ECgene: LSM1 Kegg: 27257 H-InvDB: LSM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LSM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LSM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LSM1 gene:
    Search GeneIP for patents involving LSM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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