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Aliases for LSM1 Gene

Aliases for LSM1 Gene

  • LSM1, U6 Small Nuclear RNA Associated 2 3
  • Small Nuclear Ribonuclear CaSm 3 4
  • CASM 3 4
  • LSM1 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae) 2
  • LSM1 Homolog, U6 Small Nuclear RNA Associated 3
  • U6 SnRNA-Associated Sm-Like Protein LSm1 3
  • Cancer-Associated Sm-Like Protein 3
  • Cancer-Associated Sm-Like 4
  • YJL124C 3

External Ids for LSM1 Gene

Summaries for LSM1 Gene

Entrez Gene Summary for LSM1 Gene

  • This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

GeneCards Summary for LSM1 Gene

LSM1 (LSM1, U6 Small Nuclear RNA Associated) is a Protein Coding gene. Diseases associated with LSM1 include lung cancer and breast cancer. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for LSM1 Gene

  • Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3-terminal U-tract of U6 snRNA.

Gene Wiki entry for LSM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LSM1 Gene

Genomics for LSM1 Gene

Genomic Location for LSM1 Gene

38,163,321 bp from pter
38,176,730 bp from pter
13,410 bases
Minus strand

Genomic View for LSM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LSM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LSM1 Gene

Regulatory Elements for LSM1 Gene

Proteins for LSM1 Gene

  • Protein details for LSM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U6 snRNA-associated Sm-like protein LSm1
    Protein Accession:
    Secondary Accessions:
    • B2R5E6

    Protein attributes for LSM1 Gene

    133 amino acids
    Molecular mass:
    15179 Da
    Quaternary structure:
    • Interacts with SLBP. Interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a doughnut shape.

neXtProt entry for LSM1 Gene

Proteomics data for LSM1 Gene at MOPED

Post-translational modifications for LSM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LSM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LSM1 Gene

Domains for LSM1 Gene


  • Belongs to the snRNP Sm proteins family.:
    • O15116
genes like me logo Genes that share domains with LSM1: view

No data available for Gene Families for LSM1 Gene

Function for LSM1 Gene

Molecular function for LSM1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3-terminal U-tract of U6 snRNA.

Gene Ontology (GO) - Molecular Function for LSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding IBA --
GO:0005515 protein binding IPI 15231747
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with LSM1: view

miRNA for LSM1 Gene

miRTarBase miRNAs that target LSM1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LSM1 Gene

Localization for LSM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LSM1 Gene

Subcellular locations from

Jensen Localization Image for LSM1 Gene COMPARTMENTS Subcellular localization image for LSM1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for LSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IBA --
GO:0005634 nucleus IDA 18559850
GO:0005737 cytoplasm IDA 18559850
GO:0005829 cytosol TAS --
GO:0030529 ribonucleoprotein complex --
genes like me logo Genes that share ontologies with LSM1: view

Pathways for LSM1 Gene

genes like me logo Genes that share pathways with LSM1: view

Pathways by source for LSM1 Gene

1 KEGG pathway for LSM1 Gene

Gene Ontology (GO) - Biological Process for LSM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA --
GO:0000375 RNA splicing, via transesterification reactions TAS 10369684
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS 10369684
genes like me logo Genes that share ontologies with LSM1: view

Transcripts for LSM1 Gene

Unigene Clusters for LSM1 Gene

LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LSM1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP2: - -
SP3: -
SP4: - -

Relevant External Links for LSM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LSM1 Gene

mRNA expression in normal human tissues for LSM1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LSM1 Gene

SOURCE GeneReport for Unigene cluster for LSM1 Gene Hs.425311

mRNA Expression by UniProt/SwissProt for LSM1 Gene

Tissue specificity: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines
genes like me logo Genes that share expressions with LSM1: view

Orthologs for LSM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LSM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LSM1 36
  • 99.5 (n)
  • 100 (a)
LSM1 37
  • 100 (a)
(Bos Taurus)
Mammalia LSM1 36
  • 94.24 (n)
  • 99.25 (a)
LSM1 37
  • 99 (a)
(Canis familiaris)
Mammalia LSM1 36
  • 93.73 (n)
  • 100 (a)
LSM1 37
  • 100 (a)
(Mus musculus)
Mammalia Lsm1 36
  • 90.23 (n)
  • 97.74 (a)
Lsm1 16
Lsm1 37
  • 98 (a)
(Monodelphis domestica)
Mammalia LSM1 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia LSM1 37
  • 97 (a)
(Rattus norvegicus)
Mammalia Lsm1 36
  • 90.48 (n)
  • 97.74 (a)
(Gallus gallus)
Aves LSM1 36
  • 75.19 (n)
  • 93.23 (a)
LSM1 37
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lsm1 36
  • 78.95 (n)
  • 95.49 (a)
Str.15407 36
(Danio rerio)
Actinopterygii Dr.14834 36
lsm1 36
  • 75.44 (n)
  • 85.71 (a)
lsm1 37
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001686 36
  • 59.6 (n)
  • 58.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta LSm1 36
  • 62.37 (n)
  • 63.71 (a)
LSm1 37
  • 58 (a)
CG4279 38
  • 63 (a)
(Caenorhabditis elegans)
Secernentea lsm-1 36
  • 58.61 (n)
  • 59.34 (a)
lsm-1 37
  • 49 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL212C 36
  • 54.78 (n)
  • 49.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSM1 36
  • 61.32 (n)
  • 56.79 (a)
LSM1 37
  • 29 (a)
LSM1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15159g 36
  • 56.43 (n)
  • 47.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G14080 36
  • 53.67 (n)
  • 54 (a)
(Oryza sativa)
Liliopsida Os04g0445800 36
  • 56.09 (n)
  • 50 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lsm1 36
  • 54.24 (n)
  • 48.31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10250 36
Species with no ortholog for LSM1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LSM1 Gene

Gene Tree for LSM1 (if available)
Gene Tree for LSM1 (if available)

Paralogs for LSM1 Gene

Selected SIMAP similar genes for LSM1 Gene using alignment to 3 proteins: Pseudogenes for LSM1 Gene

genes like me logo Genes that share paralogs with LSM1: view

No data available for Paralogs for LSM1 Gene

Variants for LSM1 Gene

Sequence variations from dbSNP and Humsavar for LSM1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1845 -- 38,163,495(+) TTATT(A/T)AAAAA utr-variant-3-prime, nc-transcript-variant
rs2720051 -- 38,174,530(+) AGAGG(A/G)CCAAA intron-variant
rs2843726 -- 38,162,896(-) TGCGG(A/T)GAGCC downstream-variant-500B
rs2843738 -- 38,172,190(-) ATCCG(C/G)GTTGC intron-variant
rs2843739 -- 38,171,208(-) CTTCA(A/G)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LSM1 Gene

Variant ID Type Subtype PubMed ID
nsv397579 CNV Loss 16902084

Relevant External Links for LSM1 Gene

HapMap Linkage Disequilibrium report

Disorders for LSM1 Gene

Relevant External Links for LSM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LSM1: view

No data available for UniProtKB/Swiss-Prot for LSM1 Gene

Publications for LSM1 Gene

  1. CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes. (PMID: 18218995) Watson P.M. … Boylan A.M. (Am. J. Respir. Cell Mol. Biol. 2008) 3 23
  2. CaSm: an Sm-like protein that contributes to the transformed state in cancer cells. (PMID: 9230209) Schweinfest C.W. … Watson D.K. (Cancer Res. 1997) 3 4
  3. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. (PMID: 10369684) Salgado-Garrido J. … Seraphin B. (EMBO J. 1999) 3 4
  4. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PMID: 12515382) Ingelfinger D. … Achsel T. (RNA 2002) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for LSM1 Gene

Sources for LSM1 Gene

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