Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LRWD1 Gene

protein-coding   GIFtS: 47
GCID: GC07P102105

Leucine-Rich Repeats And WD Repeat Domain Containing 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Leucine-Rich Repeats And WD Repeat Domain Containing 11 2     CENP-332 3
Centromere Protein 331 2 3     ORC-Associated Protein2 3
ORCA2 3 5     Leucine-Rich Repeat And WD Repeat-Containing Protein 12
Origin Recognition Complex Associated1 2     CENP333
Origin Recognition Complex-Associated Protein2 3     

External Ids:    HGNC: 217691   Entrez Gene: 2222292   Ensembl: ENSG000001610367   OMIM: 6151675   UniProtKB: Q9UFC03   

Export aliases for LRWD1 gene to outside databases

Previous GC identifers: GC07P101893 GC07P096695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for LRWD1 Gene:
LRWD1 (leucine-rich repeats and WD repeat domain containing 1) is a protein-coding gene. GO annotations related to this gene include chromatin binding and methyl-CpG binding.

UniProtKB/Swiss-Prot: LRWD1_HUMAN, Q9UFC0
Function: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto
chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated
cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3
and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required
for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRWD1 gene promoter:
         p53   SRF (504 AA)   GCNF   Lmo2   GATA-2   HEN1   FAC1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRWD1 promoter sequence
   Search Chromatin IP Primers for LRWD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRWD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

LRWD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRWD1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102105:  view genomic region     (about GC identifiers)

Start:
102,105,376 bp from pter      End:
102,113,615 bp from pter
Size:
8,240 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 101,465,691-101,473,913     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LRWD1_HUMAN, Q9UFC0 (See protein sequence)
Recommended Name: Leucine-rich repeat and WD repeat-containing protein 1  
Size: 647 amino acids; 70861 Da
Subunit: Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2
only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these
interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during
G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1
phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis.
Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex
is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination
Developmental stage: Regulated in a cell-cycle dependent manner. Highest expression in G1 phase. Expression
decreases during S phase, rises again during G2 and drops during mitosis (at protein level). In contrast to
protein levels, transcript levels do not show any significant variation during different stages of the cell cycle
(PubMed:22935713)
Secondary accessions: A8K4K2 B2R9G2 Q8N0T9 Q8WV43 Q96GJ2

Explore the universe of human proteins at neXtProt for LRWD1: NX_Q9UFC0

Explore proteomics data for LRWD1 at MOPED

Post-translational modifications: 

  • Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Ubiquitination
    occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3
    ubiquitin-protein ligase complex and other E3 ligases1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LRWD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_690852.1  
    ENSEMBL proteins: 
     ENSP00000292616   ENSP00000420650   ENSP00000418204   ENSP00000417913   ENSP00000420729  
     ENSP00000420373  

    LRWD1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LRWD1
    OriGene Protein Over-expression Lysate for LRWD1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LRWD1
    GenScript Custom Purified and Recombinant Proteins Services for LRWD1
    Novus Biologicals LRWD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRWD1

     
    Search eBioscience for Proteins for LRWD1 

     
    antibodies-online proteins for LRWD1 (2 products) 

     
    antibodies-online peptides for LRWD1

    LRWD1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LRWD1
    Novus Biologicals LRWD1 Antibodies
    Search for Antibodies for LRWD1 at Abcam
    Cloud-Clone Corp. Antibodies for LRWD1
    ThermoFisher Antibodies for LRWD1
    antibodies-online antibodies for LRWD1 (11 products) 

    LRWD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRWD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LRWD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRWD1
    Cloud-Clone Corp. CLIAs for LRWD1
    Search eBioscience for ELISAs for LRWD1 
    antibodies-online kits for LRWD1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UFC0

    ProtoNet protein and cluster: Q9UFC0

    UniProtKB/Swiss-Prot: LRWD1_HUMAN, Q9UFC0
    Domain: The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for
    association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3
    Similarity: Belongs to the LRWD1 family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 5 WD repeats


    Find genes that share domains with LRWD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRWD1_HUMAN, Q9UFC0
    Function: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto
    chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated
    cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3
    and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required
    for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI--
    GO:0008327methyl-CpG binding IDA--
    GO:0035064methylated histone residue binding IDA--
         
    Find genes that share ontologies with LRWD1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LRWD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRWD1:
    hsa-mir-1 (MIRT023895)

    Block miRNA regulation of human, mouse, rat LRWD1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate LRWD1:
    hsa-miR-548c-3p hsa-miR-3657
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRWD1
    Predesigned siRNA for gene silencing in human, mouse, rat LRWD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRWD1

    Clone
    Products:
         
    OriGene clones in human, mouse for LRWD1 (see all 6)
    OriGene ORF clones in mouse, rat for LRWD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRWD1 (NM_152892)
    Sino Biological Human cDNA Clone for LRWD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRWD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRWD1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRWD1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LRWD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRWD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LRWD1_HUMAN, Q9UFC0: Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule
    organizing center, centrosome (By similarity). Note=Localizes to heterochromatin during G1 phase. Restricted to
    centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres.
    Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005664nuclear origin of replication recognition complex IDA--
    GO:0005721centromeric heterochromatin IDA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--

    Find genes that share ontologies with LRWD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRWD1
    Interactions:

        Search GeneGlobe Interaction Network for LRWD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for LRWD1 (Q9UFC02 ENSP000002926164) via UniProtKB, MINT, STRING, and/or I2D (see all 786)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    ORC2Q134162, ENSP000002342964MINT-7945693 MINT-7947479 STRING: ENSP00000234296
    ORC3Q9UBD52, ENSP000002577894MINT-7945693 MINT-7947479 STRING: ENSP00000257789
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006270DNA replication initiation TAS--
    GO:0006325chromatin organization IMP--
    GO:0016568chromatin modification IEA--
    GO:0071169establishment of protein localization to chromatin IDA--

    Find genes that share ontologies with LRWD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRWD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LRWD1 gene: 
    NM_152892.1  

    Unigene Cluster for LRWD1:

    Leucine-rich repeats and WD repeat domain containing 1
    Hs.274135  [show with all ESTs]
    Unigene Representative Sequence: AB209379
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292616(uc003uzn.3) ENST00000463739 ENST00000464107 ENST00000473880
    ENST00000476270 ENST00000485808 ENST00000485417 ENST00000468175
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRWD1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate LRWD1:
    hsa-miR-548c-3p hsa-miR-3657
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRWD1
    Predesigned siRNA for gene silencing in human, mouse, rat LRWD1
    Clone
    Products:
         
    OriGene clones in human, mouse for LRWD1 (see all 6)
    OriGene ORF clones in mouse, rat for LRWD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRWD1 (NM_152892)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRWD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRWD1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRWD1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRWD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRWD1
      QuantiTect SYBR Green Assays in human, mouse, rat LRWD1
      QuantiFast Probe-based Assays in human, mouse, rat LRWD1

    Additional mRNA sequence: 

    AB209379.1 AK290967.1 AK313771.1 AL133057.1 BC009436.1 BC018769.1 BC030547.1 

    18 DOTS entries:

    DT.100824847  DT.100884207  DT.102840197  DT.111585  DT.91842362  DT.92055183  DT.100824851  DT.100884206 
    DT.92330191  DT.97864593  DT.100824852  DT.100833157  DT.95358806  DT.100824831  DT.100039328  DT.100824832 
    DT.100824842  DT.91954606 

    Selected AceView cDNA sequences (see all 243):

    BI827109 BM845875 BE905597 BM923521 NM_152892 BQ441213 BI831183 BX384723 
    BI819164 CR620752 AL528301 BC030547 BM926877 BI826121 BM763242 BM845853 
    AI693780 BQ687580 BI829020 CR598375 BI831009 BI225217 BM547405 BM848366 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LRWD1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                          -     -                             -                       -                                                     -               
    SP2:                                -                             -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for LRWD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LRWD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAACACAG
    LRWD1 Expression
    About this image

    LRWD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRWD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274135

    UniProtKB/Swiss-Prot: LRWD1_HUMAN, Q9UFC0
    Tissue specificity: Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only
    syndrome (SCOS)

        Custom PCR Arrays for LRWD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LRWD1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRWD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRWD1
    QuantiTect SYBR Green Assays in human, mouse, rat LRWD1
    QuantiFast Probe-based Assays in human, mouse, rat LRWD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRWD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for LRWD1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrwd11 , 5 leucine-rich repeats and WD repeat domain containing more1, 5 80.59(n)1
    78.42(a)1
      5 (75.80 cM)5
    717351  NM_027891.41  NP_082167.21 
     1361227725 
    chicken
    (Gallus gallus)
    Aves LRWD11 leucine-rich repeats and WD repeat domain containing more 55.24(n)
    49.69(a)
      417511  XM_415759.4  XP_415759.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.319912 Xenopus laevis transcribed sequence with weak similarity more 73.34(n)    BJ611774.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrwd11 leucine-rich repeats and WD repeat domain containing more 49.61(n)
    38.41(a)
      327124  XM_678221.6  XP_683313.4 


    ENSEMBL Gene Tree for LRWD1 (if available)
    TreeFam Gene Tree for LRWD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LRWD1 (see all 159)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172098061,2
    F--102107362(+) AGCTGG/AGGCTT 1 -- int11Minor allele frequency- A:0.02NA 120
    rs563081761,2
    C,F--102107371(+) TTTAGG/ACGCAT 1 -- int16Minor allele frequency- A:0.31NA WA EA 364
    rs1428469551,2
    --102107451(+) CTCCTA/GGCCTC 1 -- int10--------
    rs595226941,2
    C--102107536(+) TGTGT-/GTG   
       TGTGT
    AGGCA
    1 -- int11Minor allele frequency- GTGTGTGT:0.00NA 2
    rs711066871,2
    C--102107563(-) ACACA-/AC/CC 
            
    CCAGC
    1 -- int11NA 2
    rs674048111,2
    C--102107566(+) TGGGG-/GT/   
      GTGTGT
    TGTGT
    2 -- int1 cds10--------
    rs1473619151,2
    C--102107608(+) CTGGG-/GTGTGTG 1 -- int10--------
    rs117649251,2
    C,A,H--102107615(+) GTGTGG/TGGGGT 1 -- int10--------
    rs1129389971,2
    C--102107629(+) TGTGTA/GTGTGT 1 -- int10--------
    rs1387542131,2
    --102107655(+) TGTGT-/GTGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for LRWD1 (102105376 - 102113615 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRWD1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471450CNV Duplication19718026
    dgv7413n71CNV Loss21882294
    nsv888832CNV Loss21882294
    nsv831083CNV Loss17160897
    nsv5879CNV Loss18451855
    nsv464665CNV Loss19166990
    dgv7412n71CNV Loss21882294
    nsv482111CNV Gain20164927
    nsv464664CNV Gain19166990
    nsv428182CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRWD1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRWD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615167    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for LRWD1:
    Sertoli cell-only syndrome

    Find genes that share disorders with LRWD1           About GenesLikeMe


    Export disorders for LRWD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LRWD1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with LRWD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PubMed id 20850016)1, 2, 3 Vermeulen M....Mann M. (Cell 2010)
    2. A WD-repeat protein stabilizes ORC binding to chromatin. (PubMed id 20932478)1, 2, 3 Shen Z.... Prasanth S.G. (Mol. Cell 2010)
    3. Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. (PubMed id 22427655)1, 2 Chan K.M. and Zhang Z. (J. Biol. Chem. 2012)
    4. Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation. (PubMed id 22645314)1, 2 Shen Z....Prasanth S.G. (Mol. Cell. Biol. 2012)
    5. Orc2 protects ORCA from ubiquitin-mediated degradation. (PubMed id 22935713)1, 2 Shen Z. and Prasanth S.G. (Cell Cycle 2012)
    6. Expression of lrwd1 in mouse testis and its centrosomal localization. (PubMed id 20180869)1, 3 Teng Y.N....Kuo T.Y. (Int. J. Androl. 2010)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 222229 HGNC: 21769 AceView: DKFZp434K1815 Ensembl:ENSG00000161036 euGenes: HUgn222229
    ECgene: LRWD1 H-InvDB: LRWD1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LRWD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LRWD1 gene:
    Search GeneIP for patents involving LRWD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LRWD1  
     OriGene qPCR primer pairs and template standards for LRWD1   OriGene Protein Over-expression Lysate for LRWD1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LRWD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for LRWD1   OriGene Purified Protein for LRWD1  
     OriGene ORF clones in mouse, rat for LRWD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LRWD1   OriGene Custom Protein Services for LRWD1  

     
     
     Block miRNA regulation of human, mouse, rat LRWD1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LRWD1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRWD1 Predesigned siRNA for gene silencing in human, mouse, rat LRWD1
     QuantiFast Probe-based Assays in human, mouse, rat LRWD1 QuantiTect SYBR Green Assays in human, mouse, rat LRWD1
     Custom PCR Arrays for LRWD1 Search Chromatin IP Primers for LRWD1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRWD1  Search GeneGlobe Interaction Network for LRWD1
     Regulatory tfbs in LRWD1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LRWD1 GenScript cDNA clones with any tag delivered in your preferred vector for LRWD1
     GenScript Custom Assay Services for LRWD1 GenScript Custom overexpressing Cell Line Services for LRWD1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LRWD1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for LRWD1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LRWD1 antibodies
     LRWD1 lysates
     Search for Antibodies for LRWD1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for LRWD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LRWD1
     Antibodies for LRWD1
     ELISAs for LRWD1
     CLIAs for LRWD1



     Browse ESI BIO Cell Lines and PureStem Progenitors for LRWD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRWD1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for LRWD1
     SwitchGear Promoter luciferase reporter plasmids for LRWD1
     ThermoFisher Antibodies for LRWD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRWD1
     Browse compounds at ApexBio
     Search Addgene for plasmids for LRWD1
      Search eBioscience for proteins for LRWD1
      Search eBioscience for elisas for LRWD1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for LRWD1
     antibodies-online antibodies for LRWD1 (11 products)
     antibodies-online kits for LRWD1 (4 products)
     antibodies-online peptides for LRWD1
     antibodies-online proteins for LRWD1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LRWD1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4