Aliases for LRWD1 Gene
External Ids for LRWD1 Gene
Previous GeneCards Identifiers for LRWD1 Gene
The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for LRWD1 Gene
LRWD1 (Leucine-Rich Repeats And WD Repeat Domain Containing 1) is a Protein Coding gene. Diseases associated with LRWD1 include Sertoli Cell-Only Syndrome. GO annotations related to this gene include chromatin binding and methyl-CpG binding.
UniProtKB/Swiss-Prot for LRWD1 Gene
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.