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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRWD1 Gene

protein-coding   GIFtS: 46
GCID: GC07P102105

Leucine-Rich Repeats And WD Repeat Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine-Rich Repeats And WD Repeat Domain Containing 11 2     ORCA2 3
Centromere Protein 331 2     ORC-Associated Protein2 3
Origin Recognition Complex Associated1 2     CENP-332
Origin Recognition Complex-Associated Protein2 3     Leucine-Rich Repeat And WD Repeat-Containing Protein 12

External Ids:    HGNC: 217691   Entrez Gene: 2222292   Ensembl: ENSG000001610367   OMIM: 6151675   UniProtKB: Q9UFC03   

Export aliases for LRWD1 gene to outside databases

Previous GC identifers: GC07P101893 GC07P096695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRWD1 Gene: 
LRWD1 (leucine-rich repeats and WD repeat domain containing 1) is a protein-coding gene. Diseases associated with LRWD1 include nocardiosis, and tooth erosion. GO annotations related to this gene include chromatin binding and methyl-CpG binding.

UniProtKB/Swiss-Prot: LRWD1_HUMAN, Q9UFC0
Function: Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC
complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish
pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA
and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks
H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recognizes
and binds these repressive marks by itself or needs additional factors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRWD1 gene promoter:
         p53   SRF (504 AA)   GCNF   Lmo2   GATA-2   HEN1   FAC1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRWD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRWD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRWD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

LRWD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRWD1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102105:  view genomic region     (about GC identifiers)

Start:
102,105,376 bp from pter      End:
102,113,615 bp from pter
Size:
8,240 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 101,465,691-101,473,913     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRWD1_HUMAN, Q9UFC0 (See protein sequence)
Recommended Name: Leucine-rich repeat and WD repeat-containing protein 1  
Size: 647 amino acids; 70861 Da
Subunit: Component of the ORC complex
Subcellular location: Nucleus. Chromosome, centromere. Chromosome, telomere. Note=Localizes to heterochromatin
during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter
mitosis, relocalizes to centromeres
Secondary accessions: A8K4K2 B2R9G2 Q8N0T9 Q8WV43 Q96GJ2

Explore the universe of human proteins at neXtProt for LRWD1: NX_Q9UFC0

Explore proteomics data for LRWD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UFC0

  • LRWD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRWD1 Protein Expression
    REFSEQ proteins: NP_690852.1  
    ENSEMBL proteins: 
     ENSP00000292616   ENSP00000420650   ENSP00000418204   ENSP00000417913   ENSP00000420729  
     ENSP00000420373  

    Human Recombinant Protein Products for LRWD1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRWD1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005664nuclear origin of replication recognition complex IDA--
    GO:0005721centromeric heterochromatin IDA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--

    LRWD1 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for LRWD1
    LSBio Antibodies in human, mouse, rat for LRWD1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UFC0

    ProtoNet protein and cluster: Q9UFC0

    UniProtKB/Swiss-Prot: LRWD1_HUMAN, Q9UFC0
    Domain: The WD repeats are required for the interaction with ORC components
    Similarity: Belongs to the LRWD1 family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 5 WD repeats


    LRWD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRWD1_HUMAN, Q9UFC0
    Function: Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC
    complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish
    pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA
    and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks
    H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recognizes
    and binds these repressive marks by itself or needs additional factors

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI--
    GO:0008327methyl-CpG binding IDA--
    GO:0035064methylated histone residue binding IDA--
         
    LRWD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRWD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRWD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRWD1 
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRWD1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LRWD1:
    hsa-miR-548c-3p hsa-miR-3657
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRWD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRWD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/785 Interacting proteins for LRWD1 (Q9UFC02 ENSP000002926164) via UniProtKB, MINT, STRING, and/or I2D (see all 785)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    ORC2Q134162, ENSP000002342964MINT-7945693 MINT-7947479 STRING: ENSP00000234296
    ORC3Q9UBD52, ENSP000002577894MINT-7945693 MINT-7947479 STRING: ENSP00000257789
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle ----
    GO:0006270DNA replication initiation TAS--
    GO:0006325chromatin organization IMP--
    GO:0016568chromatin modification IEA--
    GO:0071169establishment of protein localization to chromatin IDA--

    LRWD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRWD1

    Search CenterWatch for drugs/clinical trials and news about LRWD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRWD1 gene: 
    NM_152892.1  

    Unigene Cluster for LRWD1:

    Leucine-rich repeats and WD repeat domain containing 1
    Hs.274135  [show with all ESTs]
    Unigene Representative Sequence: AB209379
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292616(uc003uzn.3) ENST00000463739 ENST00000464107 ENST00000473880
    ENST00000476270 ENST00000485808 ENST00000485417 ENST00000468175
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRWD1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LRWD1:
    hsa-miR-548c-3p hsa-miR-3657
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRWD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRWD1
    Clone
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    OriGene clones in human, mouse for LRWD1 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: LRWD1 (NM_152892)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRWD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRWD1
    Sirion Biotech Customized lentivirus for stable overexpression of LRWD1 
                         Customized lentivirus expression plasmids for stable overexpression of LRWD1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRWD1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRWD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRWD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRWD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRWD1

    Additional mRNA sequence: 

    AB209379.1 AK290967.1 AK313771.1 AL133057.1 BC009436.1 BC018769.1 BC030547.1 

    18 DOTS entries:

    DT.100824847  DT.100884207  DT.102840197  DT.111585  DT.91842362  DT.92055183  DT.100824851  DT.100884206 
    DT.92330191  DT.97864593  DT.100824852  DT.100833157  DT.95358806  DT.100824831  DT.100039328  DT.100824832 
    DT.100824842  DT.91954606 

    24/243 AceView cDNA sequences (see all 243):

    CR620752 CD244224 BE397005 AL549792 BM835310 BM923521 BG331815 BM926877 
    BI829020 BX459355 AL561185 BQ083203 BQ687580 BE855868 BI831183 BG326896 
    BM544610 AL554650 BQ940501 BI225217 BM547405 BQ441213 BI826121 BM553138 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LRWD1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                          -     -                             -                       -                                                     -               
    SP2:                                -                             -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for LRWD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRWD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAACACAG
    LRWD1 Expression
    About this image


    See LRWD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRWD1

    SOURCE GeneReport for Unigene cluster: Hs.274135
        SABiosciences Custom PCR Arrays for LRWD1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRWD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LRWD1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrwd11 , 5 leucine-rich repeats and WD repeat domain containing more1, 5 80.59(n)1
    78.42(a)1
      5 (75.80 cM)5
    717351  NM_027891.41  NP_082167.21 
     1361227725 
    chicken
    (Gallus gallus)
    Aves LRWD11 leucine-rich repeats and WD repeat domain containing more 54.78(n)
    48.91(a)
      417511  XM_415759.3  XP_415759.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.319912 Xenopus laevis transcribed sequence with weak similarity more 73.34(n)    BJ611774.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrwd11 leucine-rich repeats and WD repeat domain containing more 49.56(n)
    38.41(a)
      327124  XM_678221.5  XP_683313.4 


    ENSEMBL Gene Tree for LRWD1 (if available)
    TreeFam Gene Tree for LRWD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/159 SNPs in LRWD1 are shown (see all 159)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172098061,2
    F--102107362(+) AGCTGG/AGGCTT 1 -- int11Minor allele frequency- A:0.02NA 120
    rs563081761,2
    C,F--102107371(+) TTTAGG/ACGCAT 1 -- int16Minor allele frequency- A:0.31NA WA EA 364
    rs1428469551,2
    --102107451(+) CTCCTA/GGCCTC 1 -- int10--------
    rs595226941,2
    C--102107536(+) TGTGT-/GTG   
       TGTGT
    AGGCA
    1 -- int11Minor allele frequency- GTGTGTGT:0.00NA 2
    rs711066871,2
    C--102107563(-) ACACA-/AC/CC 
            
    CCAGC
    1 -- int11NA 2
    rs674048111,2
    C--102107566(+) TGGGG-/GT/   
      GTGTGT
    TGTGT
    2 -- int1 cds10--------
    rs1473619151,2
    C--102107608(+) CTGGG-/GTGTGTG 1 -- int10--------
    rs117649251,2
    C,A,H--102107615(+) GTGTGG/TGGGGT 1 -- int10--------
    rs1129389971,2
    C--102107629(+) TGTGTA/GTGTGT 1 -- int10--------
    rs1387542131,2
    --102107655(+) TGTGT-/GTGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for LRWD1 (102105376 - 102113615 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for LRWD1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471450CNV Duplication19718026
    dgv7413n71CNV Loss21882294
    nsv888832CNV Loss21882294
    nsv831083CNV Loss17160897
    nsv5879CNV Loss18451855
    nsv464665CNV Loss19166990
    dgv7412n71CNV Loss21882294
    nsv482111CNV Gain20164927
    nsv464664CNV Gain19166990
    nsv428182CNV Gain18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615167    OMIM disorders: --

    6 diseases for LRWD1:    About MalaCards
    nocardiosis    tooth erosion    rosacea    sertoli cell-only syndrome
    dental caries    gastroenteritis

    1 disease from the University of Copenhagen DISEASES database for LRWD1:
    Sertoli cell-only syndrome

    LRWD1 for disorders           About GeneDecksing


    Export disorders for LRWD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRWD1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with LRWD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Quantitative interaction proteomics and genome-wide p rofiling of epigenetic histone marks and their readers. (PubMed id 20850016)1, 2, 3 Vermeulen M....Mann M. (2010)
    2. A WD-repeat protein stabilizes ORC binding to chromat in. (PubMed id 20932478)1, 2, 3 Shen Z....Prasanth S.G. (2010)
    3. Expression of lrwd1 in mouse testis and its centrosom al localization. (PubMed id 20180869)1, 3 Teng Y.N....Kuo T.Y. (2010)
    4. Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histon e H3 and maintains heterochromatin silencing. (PubMed id 22427655)1 Chan K.M. and Zhang Z. (2012)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Dynamic association of ORCA with prereplicative comple x components regulates DNA replication initiation. (PubMed id 22645314)1 Shen Z....Prasanth S.G. (2012)
    7. Orc2 protects ORCA from ubiquitin-mediated degradation . (PubMed id 22935713)1 Shen Z. and Prasanth S.G. (2012)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222229 HGNC: 21769 AceView: DKFZp434K1815 Ensembl:ENSG00000161036 euGenes: HUgn222229
    ECgene: LRWD1 H-InvDB: LRWD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRWD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRWD1 gene:
    Search GeneIP for patents involving LRWD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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