Aliases for LRWD1 Gene
External Ids for LRWD1 Gene
GeneCards Summary for LRWD1 Gene
LRWD1 (Leucine-Rich Repeats And WD Repeat Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and methyl-CpG binding.
UniProtKB/Swiss-Prot for LRWD1 Gene
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.