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Aliases for LRTM1 Gene

Aliases for LRTM1 Gene

  • Leucine-Rich Repeats And Transmembrane Domains 1 2 3
  • Leucine-Rich Repeat And Transmembrane Domain-Containing Protein 1 3
  • HT017 3

External Ids for LRTM1 Gene

Summaries for LRTM1 Gene

GeneCards Summary for LRTM1 Gene

LRTM1 (Leucine-Rich Repeats And Transmembrane Domains 1) is a Protein Coding gene. An important paralog of this gene is SLITRK3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRTM1 Gene

Genomics for LRTM1 Gene

Regulatory Elements for LRTM1 Gene

Genomic Location for LRTM1 Gene

54,918,237 bp from pter
54,967,088 bp from pter
48,852 bases
Minus strand

Genomic View for LRTM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRTM1 Gene

Proteins for LRTM1 Gene

  • Protein details for LRTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat and transmembrane domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IUU2

    Protein attributes for LRTM1 Gene

    345 amino acids
    Molecular mass:
    38171 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRTM1 Gene


neXtProt entry for LRTM1 Gene

Proteomics data for LRTM1 Gene at MOPED

Post-translational modifications for LRTM1 Gene

  • Glycosylation at Asn104 and Asn147
  • Modification sites at PhosphoSitePlus

Other Protein References for LRTM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRTM1 Gene

Domains for LRTM1 Gene

Suggested Antigen Peptide Sequences for LRTM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9HBL6
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRTM1: view

No data available for Gene Families for LRTM1 Gene

Function for LRTM1 Gene

Gene Ontology (GO) - Molecular Function for LRTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRTM1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LRTM1 Gene

Localization for LRTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRTM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LRTM1 Gene COMPARTMENTS Subcellular localization image for LRTM1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LRTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRTM1: view

Pathways for LRTM1 Gene

SuperPathways for LRTM1 Gene

No Data Available

Interacting Proteins for LRTM1 Gene

Gene Ontology (GO) - Biological Process for LRTM1 Gene


No data available for Pathways by source for LRTM1 Gene

Transcripts for LRTM1 Gene

mRNA/cDNA for LRTM1 Gene

Unigene Clusters for LRTM1 Gene

Leucine-rich repeats and transmembrane domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRTM1 Gene

No ASD Table

Relevant External Links for LRTM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRTM1 Gene

mRNA expression in normal human tissues for LRTM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRTM1 Gene

This gene is overexpressed in Spleen (40.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRTM1 Gene

SOURCE GeneReport for Unigene cluster for LRTM1 Gene Hs.591668

genes like me logo Genes that share expressions with LRTM1: view

No data available for mRNA Expression by UniProt/SwissProt for LRTM1 Gene

Orthologs for LRTM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRTM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRTM1 35
  • 96.81 (n)
  • 95.93 (a)
LRTM1 36
  • 97 (a)
(Bos Taurus)
Mammalia LRTM1 35
  • 82.56 (n)
  • 76.16 (a)
LRTM1 36
  • 71 (a)
(Canis familiaris)
Mammalia LRTM1 36
  • 80 (a)
(Mus musculus)
Mammalia Lrtm1 35
  • 72.48 (n)
  • 66.86 (a)
Lrtm1 16
Lrtm1 36
  • 65 (a)
(Monodelphis domestica)
Mammalia LRTM1 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia LRTM1 36
  • 57 (a)
(Rattus norvegicus)
Mammalia LOC102547963 35
  • 73.55 (n)
  • 67.44 (a)
(Gallus gallus)
Aves LRTM1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia LRTM1 36
  • 42 (a)
(Danio rerio)
Actinopterygii LOC101883439 35
  • 54.09 (n)
  • 46.11 (a)
LRTM1 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta kek1 36
  • 8 (a)
kek2 36
  • 9 (a)
kek3 36
  • 8 (a)
kek4 36
  • 11 (a)
kek5 36
  • 8 (a)
kek6 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
-- 36
  • 22 (a)
CSA.1672 36
  • 19 (a)
Species with no ortholog for LRTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRTM1 Gene

Gene Tree for LRTM1 (if available)
Gene Tree for LRTM1 (if available)

Paralogs for LRTM1 Gene

Selected SIMAP similar genes for LRTM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRTM1: view

Variants for LRTM1 Gene

Sequence variations from dbSNP and Humsavar for LRTM1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_051144 -
VAR_051145 -

Structural Variations from Database of Genomic Variants (DGV) for LRTM1 Gene

Variant ID Type Subtype PubMed ID
nsv517851 CNV Gain 19592680
nsv876812 CNV Gain 21882294

Relevant External Links for LRTM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRTM1 Gene

Disorders for LRTM1 Gene

(2) University of Copenhagen DISEASES for LRTM1 Gene

Relevant External Links for LRTM1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with LRTM1: view

No data available for UniProtKB/Swiss-Prot for LRTM1 Gene

Publications for LRTM1 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  5. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (PMID: 24315451) van der Valk R.J. … de Jongste J.C. (J. Allergy Clin. Immunol. 2014) 3

Products for LRTM1 Gene

Sources for LRTM1 Gene

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