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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LRSAM1 Gene

protein-coding GIFtS: 54
GCID: GC09P130215

leucine rich repeat and sterile alpha motif containing 1

Explore 9 diseases affiliated with
LRSAM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucine Rich Repeat And Sterile Alpha Motif Containing 1¹ ²		CMT2P²
TAL² ³ ⁵		E3 Ubiquitin-Protein Ligase LRSAM1²
Tsg101-Associated Ligase² ³		EC 6.3.2.-³
RIFLE² ⁵		HTAL¹
FLJ31641¹		Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1³

External Ids:	HGNC: 25135¹	Entrez Gene: 90678²	Ensembl: ENSG00000148356⁷	OMIM: 610933⁵	UniProtKB: Q6UWE0³

Export aliases for LRSAM1 gene to outside databases

Previous GC identifers: GC09P125590 GC09P127293 GC09P129253 GC09P099831

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LRSAM1:

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways

and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis.

Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding

different isoforms have been identified for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: LRSM1_HUMAN, Q6UWE0

Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to

inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos

Gene Wiki entry for LRSAM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LRSAM1 gene promoter:
FAC1 E2F E2F-1 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRSAM1 promoter sequence

Search SABiosciences Chromatin IP Primers for LRSAM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRSAM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q34.13

LRSAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRSAM1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P130215: view genomic region (about GC identifiers)

Start:	130,213,765 bp from pter	End:	130,265,780 bp from pter
Size:	52,016 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LRSM1_HUMAN, Q6UWE0 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase LRSAM1

Size: 723 amino acids; 83594 Da

Subunit: Interacts with TSG101

Subcellular location: Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring

Secondary accessions: Q5VVV0 Q8NB40 Q96GT5 Q96MX5 Q96MZ7

Alternative splicing: 3 isoforms: Q6UWE0-1 Q6UWE0-2 Q6UWE0-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRSAM1: NX_Q6UWE0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UWE0

LRSAM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001005373.1 NP_001005374.1 NP_001177652.1 NP_612370.3

ENSEMBL proteins:

ENSP00000362421 ENSP00000322937 ENSP00000362419 ENSP00000300417

Reactome Protein details: Q6UWE0
Human Recombinant Protein Products for LRSAM1:

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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0044425	membrane part	IDA	15256501

LRSAM1 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LRSAM1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR001841 Znf_RING

IPR016179 Insulin-like

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q6UWE0

ProtoNet protein and cluster: Q6UWE0

4 Blocks protein families:

IPB001660 Sterile alpha motif SAM

IPB001841 Zn-finger

IPB004825 Insulin/IGF/relaxin

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: LRSM1_HUMAN, Q6UWE0

Domain: The coiled coil domains interact with the SB domain of TSG101

Domain: The PTAP motifs mediate the binding to UEV domains

Similarity: Contains 6 LRR (leucine-rich) repeats

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LRSM1_HUMAN, Q6UWE0

Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to

inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos

Enzyme Number (IUBMB): EC 6.3.2.-¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	15256501
GO:0005179	hormone activity	IEA	--
GO:0005515	protein binding	IPI	15256501
GO:0008270	zinc ion binding	IEA	--

LRSAM1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for LRSAM1:

Decreased viability with pacli

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LRSAM1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRSAM1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for LRSAM1

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

UniProtKB/Swiss-Prot: LRSM1_HUMAN, Q6UWE0

Pathway: Protein modification; protein ubiquitination

LRSAM1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LRSAM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/46 Interacting proteins for LRSAM1 (Q6UWE0^{2, 3} ENSP00000300417⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NINL	Q9Y2I6²^,³, ENSP00000278886⁴	MINT-64682 I2D: score=5 STRING: ENSP00000278886
TSG101	Q99816²^,³, ENSP00000251968⁴	MINT-66554 I2D: score=5 STRING: ENSP00000251968
PHF23	Q9BUL5²^,³, ENSP00000322579⁴	MINT-64687 I2D: score=4 STRING: ENSP00000322579
ATXN1	P54253²^,³, ENSP00000244769⁴	MINT-2877872 I2D: score=3 STRING: ENSP00000244769
KLC1	Q07866²^,³	MINT-64684 I2D: score=5

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	IDA	18077552
GO:0015031	protein transport	IEA	--
GO:0030163	protein catabolic process	IMP	18077552
GO:0045806	negative regulation of endocytosis	IMP	15256501
GO:0046755	non-lytic virus budding	IMP	15256501

LRSAM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LRSAM1

4 HMDB Compounds for LRSAM1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about LRSAM1 / LRSM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LRSAM1 gene (4 alternative transcripts):

NM_001005373.3 NM_001005374.3 NM_001190723.2 NM_138361.5

Unigene Cluster for LRSAM1:

Leucine rich repeat and sterile alpha motif containing 1

Hs.495188 [show with all ESTs]

Unigene Representative Sequence: NM_138361

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373324 ENST00000323301(uc004brc.2) ENST00000486587 ENST00000485704

ENST00000373322(uc004brd.2) ENST00000498513 ENST00000483302(uc004bre.2)

ENST00000472068 ENST00000461164 ENST00000472592(uc004brg.2) ENST00000476755

ENST00000479957 ENST00000300417(uc004brb.2 uc010mxk.2)

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		hsa-miR-432
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Additional cDNA sequence:

AF086398.1 AK056203.1 AK056305.1 AK091589.1 AK226106.1 AY358830.1 BC009239.2

17 DOTS entries:

DT.100684954 DT.97783250 DT.91666535 DT.40308302 DT.100833777 DT.40197366 DT.100788585 DT.100024672

DT.100001485 DT.100788582 DT.40124898 DT.100024671 DT.100788588 DT.121170802 DT.121170828 DT.92419781

DT.91923266

24/138 AceView cDNA sequences (see all 138):

BI915149 BQ129393 BM987675 NM_138361 W73962 BF916364 CR622763 BM722753

AK056203 BU607630 BG683320 BM728141 AF086398 BQ029522 CB145491 CA428739

BM010953 AA777476 BX372139 CB142288 BM676281 AK091589 BP341834 AX747077

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for LRSAM1 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^
SP1:					-				-		-												-																						-
SP2:					-				-		-												-																						-
SP3:									-		-												-																						-
SP4:											-												-																						-
SP5:																																													-

ExUns:	23	^	24a	·	24b	^	25a	·	25b	^	26	^	27	^	28	^	29
SP1:					-		-
SP2:	-				-		-
SP3:					-		-
SP4:					-		-
SP5:					-		-

ECgene alternative splicing isoforms for LRSAM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LRSAM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCTCGATC

About this image
See LRSAM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRSAM1

SOURCE GeneReport for Unigene cluster: Hs.495188

UniProtKB/Swiss-Prot: LRSM1_HUMAN, Q6UWE0

Tissue specificity: Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue

SABiosciences Expression via Pathway-Focused PCR Array including LRSAM1:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRSAM1 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LRSAM1¹	leucine rich repeat and sterile alpha motif containing more	73.08(n) 72.48(a)		417265 XM_415540.3 XP_415540.2
lizard (Anolis carolinensis)	Reptilia	LRSAM1⁶	--	65(a)	1 ↔ 1	GL344004.1(34737-73729)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19414²	Xenopus laevis transcribed sequence with weak similarity more	72.53(n)		BJ074206.1
zebrafish (Danio rerio)	Actinopterygii	lrsam1¹	leucine rich repeat and sterile alpha motif containing more	60.92(n) 58.62(a)		562066 NM_001100004.1 NP_001093474.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP005053¹	AGAP005053-PA	44.11(n) 30.93(a)		4576263 XM_001230956.2 XP_001230957.2
worm (Caenorhabditis elegans)	Secernentea	C14F11.2⁶	Protein C14F11.2	8(a)	possible ortholog	X(6208731-6213876)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G07910⁶ AT2G30105⁶	uncharacterized protein	18(a) 13(a)	possible ortholog possible ortholog	5(2521534-2524201) 2(12849766-12852092)
rice (Oryza sativa)	Liliopsida	-- --	ubiquitin family protein, putative, expressed	18(a) 12(a)	possible ortholog possible ortholog	3(5852906-5856465) 10(16594587-16602237)

ENSEMBL Gene Tree for LRSAM1 (if available)
TreeFam Gene Tree for LRSAM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LRSAM1 gene

RSU1² LRCH2² LRCH3² LRCH4² LRCH1²

LRSAM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79960557^1,2	F	--	99831911(+)	`GTCTCT/CAAGTT`	4	--	int¹		1		WA	118
rs117612613^1,2	C,F	--	99832206(+)	`TGAAAC/GTAGGA`	4	--	int¹		1		EA	120
rs78037809^1,2		--	99832610(+)	`CCTCCG/ATGGAA`	4	--	int¹		1		WA	118
rs75663017^1,2		--	99832974(+)	`TCCCCC/GACCCA`	4	--	int¹		1		NA	120
rs34459766^1,2	C	--	99834427(+)	`TATGCAA/-AAAAA`	4	--	int¹		1		NA	2
rs113472184^1,2		--	99834787(+)	`ACCACG/ACCCAG`	4	--	int¹		2		CSA WA	120
rs112336153^1,2		--	99835142(+)	`AAAAAA/TAAGAA`	4	--	int¹		2		CSA WA	119
rs113052336^1,2		--	99835446(+)	`TGACCC/TGCATC`	4	--	int¹		1		CSA	2
rs78192407^1,2	F	--	99836121(+)	`GAGGCC/TGGCAG`	4	--	int¹		1		WA	118
rs200075998^1,2	C	--	99836232(+)	`TCTTTC/TTTTTT`	4	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LRSAM1 (130213765 - 130265780 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LRSAM1
1 CNV: 6715
Human Gene Mutation Database (HGMD): LRSAM1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LRSAM1 for disorders About GeneDecksing

OMIM gene information: 610933 OMIM disorders: --

UniProtKB/Swiss-Prot: LRSM1_HUMAN, Q6UWE0

Defects in LRSAM1 are a cause of Charcot-Marie-Tooth disease type 2P (CMT2P) [MIM:614436]. CMT2P is an axonal

form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive

weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms.

Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and

histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and

primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal

degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and

progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced

9 diseases for LRSAM1: About MalaCards

charcot-marie-tooth disease tooth disease hemopneumothorax horner's syndrome

macular degeneration mixed malaria ataxia immunodeficiency

polyneuropathy

2 diseases from the University of Copenhagen DISEASES database for LRSAM1:

Kidney failure Mixed malaria

Export disorders for LRSAM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LRSAM1 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with LRSAM1)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding. (PubMed id 15256501)^{1, 2, 9} Amit I.... Yarden Y. (2004)
A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy. (PubMed id 22012984)^{1, 2} Weterman M.A.... Baas F. (2012)
Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease. (PubMed id 20865121)^{1, 2} Guernsey D.L....Samuels M.E. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regulation of Tsg101 Expression by the Steadiness Box: A Role of Tsg101-associated Ligase. (PubMed id 18077552)^{1, 9} McDonald B. and Martin-Serrano J. (2008)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90678	HGNC: 25135	AceView: LRSAM1	Ensembl:ENSG00000148356	euGenes: HUgn90678
ECgene: LRSAM1	H-InvDB: LRSAM1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LRSAM1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LRSAM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LRSAM1 gene:
Search GeneIP for patents involving LRSAM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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leucine rich repeat and sterile alpha motif containing 1

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LRSAM1 Gene

leucine rich repeat and sterile alpha motif containing 1

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