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Aliases for LRRTM2 Gene

Aliases for LRRTM2 Gene

  • Leucine Rich Repeat Transmembrane Neuronal 2 2 3
  • KIAA0416 4 6
  • Leucine-Rich Repeat Neuronal 2 Protein 4
  • LRRN2 4

External Ids for LRRTM2 Gene

Summaries for LRRTM2 Gene

GeneCards Summary for LRRTM2 Gene

LRRTM2 (Leucine Rich Repeat Transmembrane Neuronal 2) is a Protein Coding gene. GO annotations related to this gene include neurexin family protein binding. An important paralog of this gene is IGFALS.

UniProtKB/Swiss-Prot for LRRTM2 Gene

  • Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRTM2 Gene

Genomics for LRRTM2 Gene

Genomic Location for LRRTM2 Gene

Start:
138,868,923 bp from pter
End:
138,875,368 bp from pter
Size:
6,446 bases
Orientation:
Minus strand

Genomic View for LRRTM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRTM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRTM2 Gene

Regulatory Elements for LRRTM2 Gene

Proteins for LRRTM2 Gene

  • Protein details for LRRTM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43300-LRRT2_HUMAN
    Recommended name:
    Leucine-rich repeat transmembrane neuronal protein 2
    Protein Accession:
    O43300
    Secondary Accessions:
    • A0AVL3
    • A8K4U9
    • B7ZLN8
    • Q7L770

    Protein attributes for LRRTM2 Gene

    Size:
    516 amino acids
    Molecular mass:
    59076 Da
    Quaternary structure:
    • Interacts with DLG4 and NRXN1.
    SequenceCaution:
    • Sequence=BAA24846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LRRTM2 Gene

Proteomics data for LRRTM2 Gene at MOPED

Post-translational modifications for LRRTM2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn57, Asn126, Asn243, and Asn362

Other Protein References for LRRTM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRTM2 Gene

Domains for LRRTM2 Gene

UniProtKB/Swiss-Prot:

LRRT2_HUMAN
Domain:
  • Synaptogenic effects are mediated by the extracellular LRR region.:
    • O43300
  • Contains 1 LRRCT domain.:
    • O43300
  • Contains 1 LRRNT domain.:
    • O43300
Family:
  • Belongs to the LRRTM family.:
    • O43300
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.:
    • O43300
genes like me logo Genes that share domains with LRRTM2: view

No data available for Gene Families for LRRTM2 Gene

Function for LRRTM2 Gene

Molecular function for LRRTM2 Gene

UniProtKB/Swiss-Prot Function: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

Gene Ontology (GO) - Molecular Function for LRRTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042043 neurexin family protein binding IEA --
genes like me logo Genes that share ontologies with LRRTM2: view

Phenotypes for LRRTM2 Gene

GenomeRNAi human phenotypes for LRRTM2:
genes like me logo Genes that share phenotypes with LRRTM2: view

miRNA for LRRTM2 Gene

miRTarBase miRNAs that target LRRTM2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRRTM2 Gene

Localization for LRRTM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRTM2 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Note=Localized to excitatory synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRTM2 Gene COMPARTMENTS Subcellular localization image for LRRTM2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LRRTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IEA --
GO:0060076 excitatory synapse IEA --
genes like me logo Genes that share ontologies with LRRTM2: view

Pathways for LRRTM2 Gene

SuperPathways for LRRTM2 Gene

No Data Available

Interacting Proteins for LRRTM2 Gene

Gene Ontology (GO) - Biological Process for LRRTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002091 negative regulation of receptor internalization IEA --
GO:0050808 synapse organization IEA --
GO:0060291 long-term synaptic potentiation IEA --
genes like me logo Genes that share ontologies with LRRTM2: view

No data available for Pathways by source for LRRTM2 Gene

Transcripts for LRRTM2 Gene

mRNA/cDNA for LRRTM2 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for LRRTM2 Gene

No ASD Table

Relevant External Links for LRRTM2 Gene

GeneLoc Exon Structure for
LRRTM2
ECgene alternative splicing isoforms for
LRRTM2

Expression for LRRTM2 Gene

mRNA expression in normal human tissues for LRRTM2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRRTM2 Gene

mRNA Expression by UniProt/SwissProt for LRRTM2 Gene

O43300-LRRT2_HUMAN
Tissue specificity: Expressed in neuronal tissues.
genes like me logo Genes that share expressions with LRRTM2: view

Orthologs for LRRTM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRTM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRTM2 36
  • 99.94 (n)
  • 100 (a)
LRRTM2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRRTM2 36
  • 96.71 (n)
  • 99.03 (a)
LRRTM2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRTM2 36
  • 97.29 (n)
  • 99.22 (a)
LRRTM2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrtm2 36
  • 95.28 (n)
  • 98.25 (a)
Lrrtm2 16
Lrrtm2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRTM2 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrtm2 36
  • 95.53 (n)
  • 98.25 (a)
chicken
(Gallus gallus)
Aves LRRTM2 36
  • 85.7 (n)
  • 91.07 (a)
LRRTM2 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRTM2 37
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101884631 36
  • 63.31 (n)
  • 65.5 (a)
lrrtm2 37
  • 62 (a)
OneToMany
lrrtm2 37
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta haf 37
  • 9 (a)
OneToMany
Species with no ortholog for LRRTM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRTM2 Gene

ENSEMBL:
Gene Tree for LRRTM2 (if available)
TreeFam:
Gene Tree for LRRTM2 (if available)

Paralogs for LRRTM2 Gene

Paralogs for LRRTM2 Gene

Selected SIMAP similar genes for LRRTM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRRTM2: view

Variants for LRRTM2 Gene

Relevant External Links for LRRTM2 Gene

HapMap Linkage Disequilibrium report
LRRTM2

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for LRRTM2 Gene

Disorders for LRRTM2 Gene

Relevant External Links for LRRTM2

Genetic Association Database (GAD)
LRRTM2
Human Genome Epidemiology (HuGE) Navigator
LRRTM2
genes like me logo Genes that share disorders with LRRTM2: view

No data available for UniProtKB/Swiss-Prot for LRRTM2 Gene

Publications for LRRTM2 Gene

  1. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. (PMID: 12676565) Lauren J. … Timmusk T.T. (Genomics 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3 49
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LRRTM2 Gene

Sources for LRRTM2 Gene

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