LRRTM2 Gene
protein-coding GIFtS: 43
GCID: GC05M138205
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leucine rich repeat transmembrane neuronal 2
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Aliases
for LRRTM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Transmembrane Neuronal 21 2 | | KIAA04161 3 5 | | Leucine-Rich Repeat Neuronal 2 Protein2 3 | | Leucine-Rich Repeat Transmembrane Neuronal 2 Protein2 | | Leucine-Rich Repeat Transmembrane Neuronal Protein 22 | | LRRN23 |
Export aliases for LRRTM2 gene to outside databasesPrevious GC identifers: GC05M138235 GC05M138281 GC05U900490 GC05M133394 |
Summaries
for LRRTM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LRRT2_HUMAN, O43300Function: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulatessurface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as aligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity)
|
Genomic Views
for LRRTM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRTM2 gene promoter:
TBP USF1 NRSF form 1 Nkx2-5 AREB6 POU2F1 USF-1 POU2F1a Sox9 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRTM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRTM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31LRRTM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M138205: view genomic region
(about GC identifiers)
Start:
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138,205,079 bp from pter |
End:
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138,211,057 bp from pter |
Size:
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5,979 bases |
Orientation:
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minus strand |
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Proteins
for LRRTM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRRT2_HUMAN, O43300 (See
protein sequence)Recommended Name: Leucine-rich repeat transmembrane neuronal protein 2 precursor Size: 516 amino acids; 59076 Da
Subunit: Interacts with DLG4 and NRXN1 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cellmembrane; Single-pass type I membrane protein (By similarity). Note=Localized to excitatory synapses (By similarity)
Sequence caution: Sequence=BAA24846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A0AVL3 A8K4U9 B7ZLN8 Q7L770Explore the universe of human proteins at neXtProt for LRRTM2: NX_O43300
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43300
LRRTM2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056379.1
ENSEMBL proteins: ENSP00000430902 ENSP00000428398 ENSP00000274711
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
LRRTM2 for ontologies About GeneDecksing
LRRTM2 Antibody Products:
Assay Products for LRRTM2: |
Protein
Domains /
Families
for LRRTM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRTM2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43300ProtoNet protein and cluster: O43300 2 Blocks protein families: IPB000372 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: LRRT2_HUMAN, O43300Domain: Synaptogenic effects are mediated by the extracellular LRR region (By similarity)Similarity: Belongs to the LRRTM familySimilarity: Contains 10 LRR (leucine-rich) repeatsSimilarity: Contains 1 LRRCT domainSimilarity: Contains 1 LRRNT domain |
Function
for LRRTM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LRRT2_HUMAN, O43300Function: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulatessurface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as aligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRTM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRTM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LRRTM2 (NM_015564) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRTM2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRTM2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRTM2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042043 | neurexin family protein binding |
IEA | -- |
LRRTM2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for LRRTM2:
|
Pathways & Interactions
for LRRTM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRTM2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0050808 | synapse organization |
IEA | -- |
LRRTM2 for ontologies About GeneDecksing
|
Drugs & Compounds
for LRRTM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRTM2
Search CenterWatch for drugs/clinical trials and news about LRRTM2 / LRRT2
|
Transcripts
for LRRTM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRTM2 gene: NM_015564.2 4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000521094(uc010jez.2) ENST00000518785(uc011cza.1) ENST00000274711(uc011cyz.1)
ENST00000523537
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRTM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRTM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LRRTM2 (NM_015564) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRTM2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRTM2 |
GeneLoc Exon Structure
|
Expression
for LRRTM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRTM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LRRTM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRTM2
UniProtKB/Swiss-Prot: LRRT2_HUMAN, O43300Tissue specificity: Expressed in neuronal tissues
SABiosciences Custom PCR Arrays for LRRTM2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRTM2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRTM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRTM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRTM2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRTM2 |
Orthologs
for LRRTM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LRRTM2 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for LRRTM2 (if available)
TreeFam Gene Tree for LRRTM2 (if available) |
Paralogs
for LRRTM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRTM2 gene
- FLRT12 GP52 CPN22 LRRC152 LRRTM32 IGFALS2 LRIG12 FLRT22
- LRRTM12 LRIG32 LRRTM42 CHAD2 FLRT32 LRIG22 CHADL2 VASN2
4 SIMAP similar genes for LRRTM2 using alignment to 3 protein entries: LRRT2_HUMAN (see all proteins):LRRTM1 LRRTM3 LRRTM4 CHAD
LRRTM2 for paralogs About GeneDecksing
|
Genomic Variants
for LRRTM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRTM2 |
|
Disorders
/ Diseases
for LRRTM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LRRTM2 for disorders About GeneDecksing
OMIM gene information: 610868
OMIM disorders: --
2  diseases for LRRTM2: About MalaCardsneuronitis myelodysplastic syndrome
Human Genome Epidemiology (HuGE) Navigator: LRRTM2 (1 document)
Export disorders for LRRTM2 gene to outside databases
|
Publications
for LRRTM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRTM2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRTM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. (PubMed id 12676565)1, 2, 3 Lauren J.... Timmusk T.T. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
- Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms. (PubMed id 21708131)1 Kask M.... Timmusk T. (2011)
- Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)1 Graubert T.A....Walter M.J. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- LRRTMs and neuroligins bind neurexins with a differen tial code to cooperate in glutamate synapse development. (PubMed id 20519524)9 Siddiqui T.J....Craig A.M. (2010)
- LRRTM2 functions as a neurexin ligand in promoting ex citatory synapse formation. (PubMed id 20064387)9 Ko J....SA1dhof T.C. (2009)
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External Searches for LRRTM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LRRTM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRTM2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing LRRTM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRTM2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for LRRTM2 gene:
Search GeneIP for patents involving LRRTM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRTM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRRTM2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRTM2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRTM2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRTM2 | | OriGene 3'-UTR Clone for LRRTM2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRTM2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRTM2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRTM2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRTM2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRTM2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRTM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRTM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRTM2 |
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 | | | LRRTM2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRTM2 |
|  |  |  | | | | ThermoFisher Antibodies for LRRTM2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRTM2 |
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