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Aliases for LRRTM2 Gene

Aliases for LRRTM2 Gene

  • Leucine Rich Repeat Transmembrane Neuronal 2 2 3
  • Leucine-Rich Repeat Neuronal 2 Protein 4
  • KIAA0416 4
  • LRRN2 4

External Ids for LRRTM2 Gene

Previous GeneCards Identifiers for LRRTM2 Gene

  • GC05M138235
  • GC05M138281
  • GC05U900490
  • GC05M133394
  • GC05M138205

Summaries for LRRTM2 Gene

GeneCards Summary for LRRTM2 Gene

LRRTM2 (Leucine Rich Repeat Transmembrane Neuronal 2) is a Protein Coding gene. GO annotations related to this gene include neurexin family protein binding. An important paralog of this gene is IGFALS.

UniProtKB/Swiss-Prot for LRRTM2 Gene

  • Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRTM2 Gene

Genomics for LRRTM2 Gene

Regulatory Elements for LRRTM2 Gene

Genomic Location for LRRTM2 Gene

Chromosome:
5
Start:
138,868,923 bp from pter
End:
138,875,368 bp from pter
Size:
6,446 bases
Orientation:
Minus strand

Genomic View for LRRTM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRTM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRTM2 Gene

Proteins for LRRTM2 Gene

  • Protein details for LRRTM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43300-LRRT2_HUMAN
    Recommended name:
    Leucine-rich repeat transmembrane neuronal protein 2
    Protein Accession:
    O43300
    Secondary Accessions:
    • A0AVL3
    • A8K4U9
    • B7ZLN8
    • Q7L770

    Protein attributes for LRRTM2 Gene

    Size:
    516 amino acids
    Molecular mass:
    59076 Da
    Quaternary structure:
    • Interacts with DLG4 and NRXN1.
    SequenceCaution:
    • Sequence=BAA24846.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LRRTM2 Gene

Proteomics data for LRRTM2 Gene at MOPED

Post-translational modifications for LRRTM2 Gene

  • Glycosylation at Asn 57, Asn 126, Asn 243, and Asn 362
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRTM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for LRRTM2

No data available for DME Specific Peptides for LRRTM2 Gene

Domains & Families for LRRTM2 Gene

Suggested Antigen Peptide Sequences for LRRTM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43300

UniProtKB/Swiss-Prot:

LRRT2_HUMAN :
  • Synaptogenic effects are mediated by the extracellular LRR region.
  • Belongs to the LRRTM family.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Synaptogenic effects are mediated by the extracellular LRR region.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the LRRTM family.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRTM2: view

No data available for Gene Families for LRRTM2 Gene

Function for LRRTM2 Gene

Molecular function for LRRTM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

Gene Ontology (GO) - Molecular Function for LRRTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042043 neurexin family protein binding IEA --
genes like me logo Genes that share ontologies with LRRTM2: view
genes like me logo Genes that share phenotypes with LRRTM2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRTM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRTM2 Gene

Localization for LRRTM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRTM2 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Note=Localized to excitatory synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRTM2 Gene COMPARTMENTS Subcellular localization image for LRRTM2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for LRRTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IEA --
GO:0060076 excitatory synapse IEA --
genes like me logo Genes that share ontologies with LRRTM2: view

Pathways & Interactions for LRRTM2 Gene

SuperPathways for LRRTM2 Gene

No Data Available

Interacting Proteins for LRRTM2 Gene

Gene Ontology (GO) - Biological Process for LRRTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002091 negative regulation of receptor internalization IEA --
GO:0050808 synapse organization IEA --
GO:0051965 positive regulation of synapse assembly IEA --
GO:0060291 long-term synaptic potentiation IEA --
genes like me logo Genes that share ontologies with LRRTM2: view

No data available for Pathways by source and SIGNOR curated interactions for LRRTM2 Gene

Drugs & Compounds for LRRTM2 Gene

No Compound Related Data Available

Transcripts for LRRTM2 Gene

mRNA/cDNA for LRRTM2 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRTM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRTM2 Gene

No ASD Table

Relevant External Links for LRRTM2 Gene

GeneLoc Exon Structure for
LRRTM2
ECgene alternative splicing isoforms for
LRRTM2

Expression for LRRTM2 Gene

mRNA expression in normal human tissues for LRRTM2 Gene

Protein differential expression in normal tissues from HIPED for LRRTM2 Gene

This gene is overexpressed in Platelet (57.7) and Frontal cortex (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRTM2 Gene



mRNA Expression by UniProt/SwissProt for LRRTM2 Gene

O43300-LRRT2_HUMAN
Tissue specificity: Expressed in neuronal tissues.
genes like me logo Genes that share expression patterns with LRRTM2: view

Protein tissue co-expression partners for LRRTM2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LRRTM2 Gene

Orthologs for LRRTM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRTM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRTM2 35
  • 96.71 (n)
  • 99.03 (a)
LRRTM2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRTM2 35
  • 97.29 (n)
  • 99.22 (a)
LRRTM2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrtm2 35
  • 95.28 (n)
  • 98.25 (a)
Lrrtm2 16
Lrrtm2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRTM2 35
  • 99.94 (n)
  • 100 (a)
LRRTM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrtm2 35
  • 95.53 (n)
  • 98.25 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRTM2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRTM2 35
  • 85.7 (n)
  • 91.07 (a)
LRRTM2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRTM2 36
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101884631 35
  • 63.31 (n)
  • 65.5 (a)
lrrtm2 36
  • 62 (a)
OneToMany
lrrtm2 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta haf 36
  • 9 (a)
OneToMany
Species with no ortholog for LRRTM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRTM2 Gene

ENSEMBL:
Gene Tree for LRRTM2 (if available)
TreeFam:
Gene Tree for LRRTM2 (if available)

Paralogs for LRRTM2 Gene

Paralogs for LRRTM2 Gene

(4) SIMAP similar genes for LRRTM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRRTM2: view

Variants for LRRTM2 Gene

Variation tolerance for LRRTM2 Gene

Residual Variation Intolerance Score: 20.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRTM2 Gene

HapMap Linkage Disequilibrium report
LRRTM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for LRRTM2 Gene

Disorders for LRRTM2 Gene

Relevant External Links for LRRTM2

Genetic Association Database (GAD)
LRRTM2
Human Genome Epidemiology (HuGE) Navigator
LRRTM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRTM2
genes like me logo Genes that share disorders with LRRTM2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRTM2 Gene

Publications for LRRTM2 Gene

  1. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. (PMID: 20519524) Siddiqui T.J. … Craig A.M. (J. Neurosci. 2010) 23 67
  2. LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. (PMID: 20064387) Ko J. … SA1dhof T.C. (Neuron 2009) 23 67
  3. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. (PMID: 12676565) Lauren J. … Timmusk T.T. (Genomics 2003) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms. (PMID: 21708131) Kask M. … Timmusk T. (Biochem. Biophys. Res. Commun. 2011) 67

Products for LRRTM2 Gene

Sources for LRRTM2 Gene

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