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Aliases for LRRN4CL Gene

Aliases for LRRN4CL Gene

  • LRRN4 C-Terminal Like 2 3 5

External Ids for LRRN4CL Gene

Previous GeneCards Identifiers for LRRN4CL Gene

  • GC11M062211
  • GC11M062454
  • GC11M058782
  • GC11M062456
  • GC11M062470
  • GC11M062476
  • GC11M062488

Summaries for LRRN4CL Gene

GeneCards Summary for LRRN4CL Gene

LRRN4CL (LRRN4 C-Terminal Like) is a Protein Coding gene. An important paralog of this gene is LRRN4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN4CL Gene

Genomics for LRRN4CL Gene

Regulatory Elements for LRRN4CL Gene

Promoters for LRRN4CL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRN4CL on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRN4CL Gene

Chromosome:
11
Start:
62,686,402 bp from pter
End:
62,689,899 bp from pter
Size:
3,498 bases
Orientation:
Minus strand

Genomic View for LRRN4CL Gene

Genes around LRRN4CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN4CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN4CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN4CL Gene

Proteins for LRRN4CL Gene

  • Protein details for LRRN4CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND94-LRN4L_HUMAN
    Recommended name:
    LRRN4 C-terminal-like protein
    Protein Accession:
    Q8ND94
    Secondary Accessions:
    • A8K5L9

    Protein attributes for LRRN4CL Gene

    Size:
    238 amino acids
    Molecular mass:
    25262 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN4CL Gene

Proteomics data for LRRN4CL Gene at MOPED

Post-translational modifications for LRRN4CL Gene

Other Protein References for LRRN4CL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRN4CL Gene

Domains & Families for LRRN4CL Gene

Gene Families for LRRN4CL Gene

Protein Domains for LRRN4CL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRN4CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8ND94

UniProtKB/Swiss-Prot:

LRN4L_HUMAN :
  • Contains 1 fibronectin type-III domain.
Domain:
  • Contains 1 fibronectin type-III domain.
genes like me logo Genes that share domains with LRRN4CL: view

Function for LRRN4CL Gene

Phenotypes for LRRN4CL Gene

GenomeRNAi human phenotypes for LRRN4CL:
genes like me logo Genes that share phenotypes with LRRN4CL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRN4CL

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRN4CL Gene

Localization for LRRN4CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN4CL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRN4CL Gene COMPARTMENTS Subcellular localization image for LRRN4CL gene
Compartment Confidence
extracellular 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for LRRN4CL Gene

Pathways & Interactions for LRRN4CL Gene

SuperPathways for LRRN4CL Gene

No Data Available

Interacting Proteins for LRRN4CL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325808%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: ENSP00000325808 for LRRN4CL Gene via STRING

Symbol External ID(s) Details
SRPK2

Gene Ontology (GO) - Biological Process for LRRN4CL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRN4CL Gene

Drugs & Compounds for LRRN4CL Gene

No Compound Related Data Available

Transcripts for LRRN4CL Gene

mRNA/cDNA for LRRN4CL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(521) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRN4CL Gene

LRRN4 C-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN4CL Gene

No ASD Table

Relevant External Links for LRRN4CL Gene

GeneLoc Exon Structure for
LRRN4CL
ECgene alternative splicing isoforms for
LRRN4CL

Expression for LRRN4CL Gene

mRNA expression in normal human tissues for LRRN4CL Gene

Protein differential expression in normal tissues from HIPED for LRRN4CL Gene

This gene is overexpressed in Cerebral cortex (25.7), Uterus (12.5), Ovary (9.1), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRN4CL Gene



SOURCE GeneReport for Unigene cluster for LRRN4CL Gene Hs.427449

genes like me logo Genes that share expression patterns with LRRN4CL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LRRN4CL Gene

Orthologs for LRRN4CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRN4CL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRN4CL 35
  • 79.37 (n)
  • 74.03 (a)
LRRN4CL 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRN4CL 35
  • 80.43 (n)
  • 78.26 (a)
LRRN4CL 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrn4cl 35
  • 72.27 (n)
  • 69.47 (a)
Lrrn4cl 16
Lrrn4cl 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRN4CL 35
  • 99.16 (n)
  • 98.32 (a)
LRRN4CL 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrn4cl 35
  • 71.09 (n)
  • 67.7 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRN4CL 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRN4CL 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRN4CL 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494823 35
  • 51.44 (n)
  • 49.14 (a)
zebrafish
(Danio rerio)
Actinopterygii CU984579.1 36
  • 25 (a)
ManyToMany
FP245511.1 36
  • 26 (a)
ManyToMany
Species with no ortholog for LRRN4CL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRN4CL Gene

ENSEMBL:
Gene Tree for LRRN4CL (if available)
TreeFam:
Gene Tree for LRRN4CL (if available)

Paralogs for LRRN4CL Gene

Paralogs for LRRN4CL Gene

genes like me logo Genes that share paralogs with LRRN4CL: view

Variants for LRRN4CL Gene

Sequence variations from dbSNP and Humsavar for LRRN4CL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs498800 -- 62,686,948(-) ctcac(A/G)cctgt utr-variant-3-prime
rs1787662 -- 62,687,296(-) TTTTG(G/T)TTTGG utr-variant-3-prime
rs2187108 -- 62,688,714(+) AAAAC(A/G)TGATC intron-variant
rs2512561 -- 62,686,480(-) GGAAT(C/T)TCCCC utr-variant-3-prime
rs2845673 -- 62,686,125(+) tggcc(A/C)acatg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LRRN4CL Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897
nsv897623 CNV Loss 21882294

Variation tolerance for LRRN4CL Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRN4CL Gene

HapMap Linkage Disequilibrium report
LRRN4CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN4CL Gene

Disorders for LRRN4CL Gene

Relevant External Links for LRRN4CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRN4CL

No disorders were found for LRRN4CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN4CL Gene

Publications for LRRN4CL Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 67
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LRRN4CL Gene

Sources for LRRN4CL Gene

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