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Aliases for LRRN4CL Gene

Aliases for LRRN4CL Gene

  • LRRN4 C-Terminal Like 2 3 5

External Ids for LRRN4CL Gene

Previous GeneCards Identifiers for LRRN4CL Gene

  • GC11M062211
  • GC11M062454
  • GC11M058782
  • GC11M062456
  • GC11M062470
  • GC11M062476
  • GC11M062488

Summaries for LRRN4CL Gene

GeneCards Summary for LRRN4CL Gene

LRRN4CL (LRRN4 C-Terminal Like) is a Protein Coding gene. An important paralog of this gene is LRRN4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN4CL Gene

Genomics for LRRN4CL Gene

Regulatory Elements for LRRN4CL Gene

Enhancers for LRRN4CL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G062041 1.4 ENCODE dbSUPER 23.1 +644.5 644472 8.1 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC METTL12 INTS5 SNHG1 NXF1 TMEM138 MTA2 STX5 LOC105369332 TAF6L VPS37C
GH11G062838 1.5 ENCODE dbSUPER 18.9 -150.9 -150947 4.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 UBXN1 METTL12 TAF6L SNHG1 NXF1 INTS5 LRRN4CL MTA2 B3GAT3 EML3
GH11G061960 1.8 FANTOM5 ENCODE dbSUPER 9.7 +721.0 720976 16.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 UBXN1 INTS5 MTA2 TMEM138 EML3 STX5 NXF1 BEST1 TMEM179B RAB3IL1
GH11G062830 1.4 ENCODE dbSUPER 11 -142.6 -142553 4.6 CREB3L1 AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SNHG1 METTL12 NXF1 TAF6L UBXN1 INTS5 IMMP1LP1 LOC105369332 STX5 MTA2
GH11G062438 1.1 ENCODE dbSUPER 13 +251.0 250952 1.3 ELF3 FOXA2 MLX ZFP64 DMAP1 RAD21 RARA YY1 EGR1 CREM ENSG00000267811 LRRN4CL SCGB1A1 ENSG00000255126 ASRGL1 ENSG00000250659 ENSG00000257058 AHNAK GNG3 EEF1G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRN4CL on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRN4CL Gene

62,686,402 bp from pter
62,689,899 bp from pter
3,498 bases
Minus strand

Genomic View for LRRN4CL Gene

Genes around LRRN4CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN4CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN4CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN4CL Gene

Proteins for LRRN4CL Gene

  • Protein details for LRRN4CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LRRN4 C-terminal-like protein
    Protein Accession:
    Secondary Accessions:
    • A8K5L9

    Protein attributes for LRRN4CL Gene

    238 amino acids
    Molecular mass:
    25262 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN4CL Gene

Post-translational modifications for LRRN4CL Gene

Other Protein References for LRRN4CL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRN4CL Gene

Domains & Families for LRRN4CL Gene

Gene Families for LRRN4CL Gene

Protein Domains for LRRN4CL Gene


Suggested Antigen Peptide Sequences for LRRN4CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRN4CL: view

No data available for UniProtKB/Swiss-Prot for LRRN4CL Gene

Function for LRRN4CL Gene

Phenotypes for LRRN4CL Gene

GenomeRNAi human phenotypes for LRRN4CL:
genes like me logo Genes that share phenotypes with LRRN4CL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRN4CL

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRN4CL Gene

Localization for LRRN4CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN4CL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRN4CL gene
Compartment Confidence
plasma membrane 3
extracellular 3

Gene Ontology (GO) - Cellular Components for LRRN4CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN4CL: view

Pathways & Interactions for LRRN4CL Gene

SuperPathways for LRRN4CL Gene

No Data Available

Interacting Proteins for LRRN4CL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8ND94-LRN4L_HUMAN ENSP00000325808 for LRRN4CL Gene via IID STRING

Gene Ontology (GO) - Biological Process for LRRN4CL Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRN4CL Gene

Drugs & Compounds for LRRN4CL Gene

No Compound Related Data Available

Transcripts for LRRN4CL Gene

mRNA/cDNA for LRRN4CL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(521) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRN4CL Gene

LRRN4 C-terminal like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN4CL Gene

No ASD Table

Relevant External Links for LRRN4CL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRN4CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRN4CL Gene

Protein differential expression in normal tissues from HIPED for LRRN4CL Gene

This gene is overexpressed in Cerebral cortex (25.7), Uterus (12.5), Ovary (9.1), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRN4CL Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRN4CL Gene:


SOURCE GeneReport for Unigene cluster for LRRN4CL Gene:


Evidence on tissue expression from TISSUES for LRRN4CL Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with LRRN4CL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRN4CL Gene

Orthologs for LRRN4CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRN4CL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRN4CL 35 34
  • 99.16 (n)
(Canis familiaris)
Mammalia LRRN4CL 35 34
  • 80.43 (n)
(Bos Taurus)
Mammalia LRRN4CL 34 35
  • 79.37 (n)
(Mus musculus)
Mammalia Lrrn4cl 34 16 35
  • 72.27 (n)
(Rattus norvegicus)
Mammalia Lrrn4cl 34
  • 71.09 (n)
(Monodelphis domestica)
Mammalia LRRN4CL 35
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia LRRN4CL 35
  • 52 (a)
(Anolis carolinensis)
Reptilia LRRN4CL 35
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494823 34
  • 51.44 (n)
(Danio rerio)
Actinopterygii FP245511.1 35
  • 26 (a)
CU984579.1 35
  • 25 (a)
Species where no ortholog for LRRN4CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRN4CL Gene

Gene Tree for LRRN4CL (if available)
Gene Tree for LRRN4CL (if available)

Paralogs for LRRN4CL Gene

Paralogs for LRRN4CL Gene

genes like me logo Genes that share paralogs with LRRN4CL: view

Variants for LRRN4CL Gene

Sequence variations from dbSNP and Humsavar for LRRN4CL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs137852974 Pathogenic 62,691,132(-) ACATC(C/T)GAAAA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, stop-gained
rs587777606 Pathogenic 62,691,300(+) GTGTC(A/G)GGGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs749890533 Pathogenic 62,691,310(+) AGATG(-/C)CCCCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs766061024 Pathogenic 62,691,423(+) GTATC(C/G/T)GAGGC intron-variant, upstream-variant-2KB, splice-acceptor-variant
rs786205073 Pathogenic 62,691,424(-) TGCCT(C/G)AGATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRRN4CL Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for LRRN4CL Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRN4CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN4CL Gene

Disorders for LRRN4CL Gene

Relevant External Links for LRRN4CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRN4CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN4CL Gene

Publications for LRRN4CL Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3 64
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for LRRN4CL Gene

Sources for LRRN4CL Gene

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