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Aliases for LRRN4CL Gene

Aliases for LRRN4CL Gene

  • LRRN4 C-Terminal Like 2 3 5

External Ids for LRRN4CL Gene

Previous GeneCards Identifiers for LRRN4CL Gene

  • GC11M062211
  • GC11M062454
  • GC11M058782
  • GC11M062456
  • GC11M062470
  • GC11M062476
  • GC11M062488

Summaries for LRRN4CL Gene

GeneCards Summary for LRRN4CL Gene

LRRN4CL (LRRN4 C-Terminal Like) is a Protein Coding gene. An important paralog of this gene is LRRN4.

Additional gene information for LRRN4CL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN4CL Gene

Genomics for LRRN4CL Gene

Regulatory Elements for LRRN4CL Gene

Enhancers for LRRN4CL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H062838 1.5 ENCODE dbSUPER 46 -150.9 -150947 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC UBXN1 METTL12 WDR74 NXF1 SNHG1 INTS5 LOC105369332 STX5 MTA2 GANAB
GH11H061960 1.8 FANTOM5 ENCODE dbSUPER 17.8 +721.0 720976 16 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D UBXN1 LOC105369332 WDR74 INTS5 MTA2 CPSF7 TMEM138 NXF1 EML3 STX5
GH11H062032 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +656.0 656025 1 BCOR HDAC1 LEF1 SAP130 ARNT ZMYM3 MAX RARA CTBP1 POLR2A WDR74 METTL12 INTS5 VPS37C CPSF7 LRRN4CL UBXN1 TUT1 TAF6L RAB3IL1
GH11H061916 1.6 Ensembl ENCODE dbSUPER 10.7 +771.3 771342 4 HDGF PKNOX1 ATF1 SIN3A ZBTB7B TCF12 ELK1 GATA2 ATF7 SP3 RAB3IL1 METTL12 CPSF7 TUT1 TAF6L WDR74 GANAB SNHG1 FADS3 BEST1
GH11H062852 1.7 FANTOM5 ENCODE dbSUPER 9.8 -165.9 -165939 5 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SNHG1 METTL12 NXF1 MTA2 GANAB INTS5 UBXN1 EML3 STX5 LOC105369332
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRN4CL on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRN4CL Gene

Chromosome:
11
Start:
62,686,402 bp from pter
End:
62,689,899 bp from pter
Size:
3,498 bases
Orientation:
Minus strand

Genomic View for LRRN4CL Gene

Genes around LRRN4CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN4CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN4CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN4CL Gene

Proteins for LRRN4CL Gene

  • Protein details for LRRN4CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND94-LRN4L_HUMAN
    Recommended name:
    LRRN4 C-terminal-like protein
    Protein Accession:
    Q8ND94
    Secondary Accessions:
    • A8K5L9

    Protein attributes for LRRN4CL Gene

    Size:
    238 amino acids
    Molecular mass:
    25262 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN4CL Gene

Post-translational modifications for LRRN4CL Gene

Other Protein References for LRRN4CL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRN4CL Gene

Domains & Families for LRRN4CL Gene

Gene Families for LRRN4CL Gene

Protein Domains for LRRN4CL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRN4CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRN4CL: view

No data available for UniProtKB/Swiss-Prot for LRRN4CL Gene

Function for LRRN4CL Gene

Phenotypes From GWAS Catalog for LRRN4CL Gene

Phenotypes for LRRN4CL Gene

GenomeRNAi human phenotypes for LRRN4CL:
genes like me logo Genes that share phenotypes with LRRN4CL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRN4CL

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRN4CL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRN4CL Gene

Localization for LRRN4CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN4CL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRN4CL gene
Compartment Confidence
plasma membrane 3
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRN4CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN4CL: view

Pathways & Interactions for LRRN4CL Gene

SuperPathways for LRRN4CL Gene

No Data Available

Interacting Proteins for LRRN4CL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325808%0d%0a9606.ENSP00000377262%0d%0a9606.ENSP00000358739%0d%0a
Selected Interacting proteins: Q8ND94-LRN4L_HUMAN ENSP00000325808 for LRRN4CL Gene via IID STRING

Gene Ontology (GO) - Biological Process for LRRN4CL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRN4CL Gene

Drugs & Compounds for LRRN4CL Gene

No Compound Related Data Available

Transcripts for LRRN4CL Gene

mRNA/cDNA for LRRN4CL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(521) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRN4CL Gene

LRRN4 C-terminal like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRN4CL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN4CL Gene

No ASD Table

Relevant External Links for LRRN4CL Gene

GeneLoc Exon Structure for
LRRN4CL
ECgene alternative splicing isoforms for
LRRN4CL

Expression for LRRN4CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRN4CL Gene

Protein differential expression in normal tissues from HIPED for LRRN4CL Gene

This gene is overexpressed in Cerebral cortex (25.7), Uterus (12.5), Ovary (9.1), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRN4CL Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRN4CL Gene:

LRRN4CL

SOURCE GeneReport for Unigene cluster for LRRN4CL Gene:

Hs.427449

Evidence on tissue expression from TISSUES for LRRN4CL Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with LRRN4CL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRN4CL Gene

Orthologs for LRRN4CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRN4CL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRN4CL 33 34
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia LRRN4CL 33 34
  • 80.43 (n)
cow
(Bos Taurus)
Mammalia LRRN4CL 33 34
  • 79.37 (n)
mouse
(Mus musculus)
Mammalia Lrrn4cl 33 16 34
  • 72.27 (n)
rat
(Rattus norvegicus)
Mammalia Lrrn4cl 33
  • 71.09 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRN4CL 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRN4CL 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRN4CL 34
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494823 33
  • 51.44 (n)
zebrafish
(Danio rerio)
Actinopterygii FP245511.1 34
  • 26 (a)
ManyToMany
CU984579.1 34
  • 25 (a)
ManyToMany
Species where no ortholog for LRRN4CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRN4CL Gene

ENSEMBL:
Gene Tree for LRRN4CL (if available)
TreeFam:
Gene Tree for LRRN4CL (if available)

Paralogs for LRRN4CL Gene

Paralogs for LRRN4CL Gene

genes like me logo Genes that share paralogs with LRRN4CL: view

Variants for LRRN4CL Gene

Sequence variations from dbSNP and Humsavar for LRRN4CL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs137852974 Pathogenic 62,691,132(-) ACATC(C/T)GAAAA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, stop-gained
rs587777606 Pathogenic 62,691,300(+) GTGTC(A/G)GGGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs749890533 Pathogenic 62,691,310(+) AGATG(-/C)CCCCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs766061024 Pathogenic 62,691,423(+) GTATC(C/G/T)GAGGC intron-variant, upstream-variant-2KB, splice-acceptor-variant
rs786205073 Pathogenic 62,691,424(-) TGCCT(C/G)AGATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRRN4CL Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for LRRN4CL Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRN4CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRN4CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN4CL Gene

Disorders for LRRN4CL Gene

Relevant External Links for LRRN4CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRN4CL

No disorders were found for LRRN4CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN4CL Gene

Publications for LRRN4CL Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 60
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for LRRN4CL Gene

Sources for LRRN4CL Gene

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