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Aliases for LRRN4 Gene

Aliases for LRRN4 Gene

  • Leucine Rich Repeat Neuronal 4 2 3 5
  • Neuronal Leucine-Rich Repeat Protein 4 3 4
  • C20orf75 3 4
  • NLRR-4 3 4
  • Leucine-Rich Repeat Neuronal Protein 4 3
  • Chromosome 20 Open Reading Frame 75 2
  • DJ1056H1.1 3
  • NLRR4 3

External Ids for LRRN4 Gene

Previous HGNC Symbols for LRRN4 Gene

  • C20orf75

Previous GeneCards Identifiers for LRRN4 Gene

  • GC07M099767
  • GC07M099781
  • GC20M005972
  • GC20M006021

Summaries for LRRN4 Gene

GeneCards Summary for LRRN4 Gene

LRRN4 (Leucine Rich Repeat Neuronal 4) is a Protein Coding gene. An important paralog of this gene is LRRN4CL.

UniProtKB/Swiss-Prot for LRRN4 Gene

  • May play an important role in hippocampus-dependent long-lasting memory.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN4 Gene

Genomics for LRRN4 Gene

Regulatory Elements for LRRN4 Gene

Enhancers for LRRN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F006051 1.4 FANTOM5 Ensembl ENCODE 11.8 +1.0 1042 3.2 HDAC1 PKNOX1 TBL1XR1 ZNF366 ETV6 CEBPB NCOA1 ZEB2 REST POLR2H CRLS1 LRRN4 MCM8 GC20M006038
GH20F006058 0.5 ENCODE 0.8 -4.9 -4854 0.8 PRDM10 CRLS1 LRRN4 ENSG00000278192
GH20F006055 0.4 ENCODE 0.8 -1.3 -1310 0.2 POLR2H LEF1 PKNOX1 NR2F1 IKZF1 TCF7 NR2F6 GABPA CRLS1 LRRN4 ENSG00000278192
GH20F006067 0.2 ENCODE 0.4 -13.8 -13808 1.3 ATF3 ZMYM3 CEBPB FERMT1 MCM8 TRMT6 ENSG00000278192 LRRN4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRRN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRN4 Gene

6,039,745 bp from pter
6,054,080 bp from pter
14,336 bases
Minus strand

Genomic View for LRRN4 Gene

Genes around LRRN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN4 Gene

Proteins for LRRN4 Gene

  • Protein details for LRRN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat neuronal protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K258
    • Q5JWV6
    • Q9H419

    Protein attributes for LRRN4 Gene

    740 amino acids
    Molecular mass:
    78843 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN4 Gene

Post-translational modifications for LRRN4 Gene

  • Glycosylation at Asn 42, Asn 176, Asn 289, Asn 379, Ser 423, Asn 442, and Asn 622
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRN4 Gene

Domains & Families for LRRN4 Gene

Gene Families for LRRN4 Gene

Protein Domains for LRRN4 Gene

Suggested Antigen Peptide Sequences for LRRN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibronectin type-III domain.
  • Contains 10 LRR (leucine-rich) repeats.
  • Contains 1 fibronectin type-III domain.
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRN4: view

Function for LRRN4 Gene

Molecular function for LRRN4 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in hippocampus-dependent long-lasting memory.
genes like me logo Genes that share phenotypes with LRRN4: view

Animal Models for LRRN4 Gene

MGI Knock Outs for LRRN4:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRN4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LRRN4 Gene

Localization for LRRN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LRRN4 Gene COMPARTMENTS Subcellular localization image for LRRN4 gene
Compartment Confidence
extracellular 5
plasma membrane 4
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LRRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with LRRN4: view

Pathways & Interactions for LRRN4 Gene

SuperPathways for LRRN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007616 long-term memory IEA,IBA --
GO:0008542 visual learning IEA --
genes like me logo Genes that share ontologies with LRRN4: view

No data available for Pathways by source and SIGNOR curated interactions for LRRN4 Gene

Transcripts for LRRN4 Gene

mRNA/cDNA for LRRN4 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRN4 Gene

Leucine rich repeat neuronal 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN4 Gene

No ASD Table

Relevant External Links for LRRN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRN4 Gene

mRNA expression in normal human tissues for LRRN4 Gene

mRNA differential expression in normal tissues according to GTEx for LRRN4 Gene

This gene is overexpressed in Lung (x15.5), Adipose - Visceral (Omentum) (x14.2), and Kidney - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for LRRN4 Gene

This gene is overexpressed in Urine (40.4) and Serum (23.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRN4 Gene

Protein tissue co-expression partners for LRRN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRN4 Gene:


SOURCE GeneReport for Unigene cluster for LRRN4 Gene:

genes like me logo Genes that share expression patterns with LRRN4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LRRN4 Gene

Orthologs for LRRN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRN4 34 35
  • 99.19 (n)
(Bos Taurus)
Mammalia LRRN4 34 35
  • 76.79 (n)
(Mus musculus)
Mammalia Lrrn4 34 16 35
  • 74.88 (n)
(Rattus norvegicus)
Mammalia Lrrn4 34
  • 73.79 (n)
(Canis familiaris)
Mammalia LRRN4 35
  • 67 (a)
(Monodelphis domestica)
Mammalia LRRN4 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia LRRN4 35
  • 45 (a)
(Gallus gallus)
Aves LRRN4 34 35
  • 53.21 (n)
(Anolis carolinensis)
Reptilia LRRN4 35
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrn4 34
  • 47.11 (n)
(Danio rerio)
Actinopterygii CU984579.1 35
  • 25 (a)
FP245511.1 35
  • 25 (a)
Species where no ortholog for LRRN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRN4 Gene

Gene Tree for LRRN4 (if available)
Gene Tree for LRRN4 (if available)

Paralogs for LRRN4 Gene

Paralogs for LRRN4 Gene

genes like me logo Genes that share paralogs with LRRN4: view

Variants for LRRN4 Gene

Sequence variations from dbSNP and Humsavar for LRRN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1040565 -- 6,045,914(+) gctca(A/G)ttgct intron-variant, upstream-variant-2KB
rs11087709 -- 6,053,176(+) CCTTT(A/G)TTGCT intron-variant
rs111520444 -- 6,047,426(+) CACAT(-/ACAC)ACACA intron-variant
rs111859521 -- 6,045,074(+) CACCG(C/T)TGAGT intron-variant, upstream-variant-2KB
rs111904568 -- 6,049,678(+) TATTT(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRN4 Gene

Variant ID Type Subtype PubMed ID
dgv112n73 CNV deletion 24416366
dgv694n67 CNV loss 20364138
dgv7450n54 CNV loss 21841781
dgv7451n54 CNV loss 21841781
esv26522 CNV loss 19812545
esv2663613 CNV deletion 23128226
esv2722145 CNV deletion 23290073
esv3556784 CNV deletion 23714750
esv3575356 CNV gain 25503493
esv3645113 CNV loss 21293372
esv9591 CNV loss 19470904
nsv1153139 CNV deletion 26484159
nsv585337 CNV loss 21841781
nsv585342 CNV loss 21841781

Variation tolerance for LRRN4 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.94; 93.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN4 Gene

Disorders for LRRN4 Gene

Relevant External Links for LRRN4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN4 Gene

Publications for LRRN4 Gene

  1. Loci at chromosomes 13, 19 and 20 influence age at natural menopause. (PMID: 19448619) Stolk L. … Uitterlinden A.G. (Nat. Genet. 2009) 3 46 64
  2. Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory. (PMID: 15870286) Bando T. … Miyajima A. (Mol. Cell. Biol. 2005) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64

Products for LRRN4 Gene

Sources for LRRN4 Gene

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