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Aliases for LRRN2 Gene

Aliases for LRRN2 Gene

  • Leucine Rich Repeat Neuronal 2 2 3
  • Glioma Amplified On Chromosome 1 Protein 3 4
  • Leucine-Rich Repeat Neuronal Protein 5 3 4
  • Leucine Rich And Ankyrin Repeats 1 2 3
  • Leucine Rich Repeat Neuronal 5 2 3
  • LRRN5 3 4
  • GAC1 3 4
  • Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domain 7 3
  • Immunoglobulin And Leucine Rich Repeat Domain 7 2
  • Fibronectin Type III 2
  • FIGLER7 3
  • LRANK1 3

External Ids for LRRN2 Gene

Previous HGNC Symbols for LRRN2 Gene

  • LRRN5

Previous GeneCards Identifiers for LRRN2 Gene

  • GC00U911621
  • GC01M202853
  • GC01M175751

Summaries for LRRN2 Gene

Entrez Gene Summary for LRRN2 Gene

  • The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRN2 Gene

LRRN2 (Leucine Rich Repeat Neuronal 2) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is LINGO1.

Gene Wiki entry for LRRN2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN2 Gene

Genomics for LRRN2 Gene

Regulatory Elements for LRRN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRRN2 Gene

Chromosome:
1
Start:
204,617,170 bp from pter
End:
204,685,733 bp from pter
Size:
68,564 bases
Orientation:
Minus strand

Genomic View for LRRN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN2 Gene

Proteins for LRRN2 Gene

  • Protein details for LRRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75325-LRRN2_HUMAN
    Recommended name:
    Leucine-rich repeat neuronal protein 2
    Protein Accession:
    O75325
    Secondary Accessions:
    • B2R624
    • Q5T0Y0
    • Q6UXM0
    • Q8N182

    Protein attributes for LRRN2 Gene

    Size:
    713 amino acids
    Molecular mass:
    78859 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN2 Gene

Proteomics data for LRRN2 Gene at MOPED

Post-translational modifications for LRRN2 Gene

  • Glycosylation at Asn 94, Asn 381, Asn 555, and Asn 583
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRN2 Gene

No data available for DME Specific Peptides for LRRN2 Gene

Domains & Families for LRRN2 Gene

Gene Families for LRRN2 Gene

Suggested Antigen Peptide Sequences for LRRN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75325

UniProtKB/Swiss-Prot:

LRRN2_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 12 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRN2: view

Function for LRRN2 Gene

Gene Ontology (GO) - Molecular Function for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9662332
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRN2: view
genes like me logo Genes that share phenotypes with LRRN2: view

Animal Models for LRRN2 Gene

MGI Knock Outs for LRRN2:

Animal Model Products

miRNA for LRRN2 Gene

miRTarBase miRNAs that target LRRN2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LRRN2 Gene

Localization for LRRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN2 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN2: view

No data available for Subcellular locations from COMPARTMENTS for LRRN2 Gene

Pathways & Interactions for LRRN2 Gene

SuperPathways for LRRN2 Gene

No Data Available

Interacting Proteins for LRRN2 Gene

Gene Ontology (GO) - Biological Process for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9662332
GO:0007165 signal transduction TAS 9662332
GO:0007409 NOT axonogenesis IBA --
genes like me logo Genes that share ontologies with LRRN2: view

No data available for Pathways by source and SIGNOR curated interactions for LRRN2 Gene

Drugs & Compounds for LRRN2 Gene

No Compound Related Data Available

Transcripts for LRRN2 Gene

mRNA/cDNA for LRRN2 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRN2 Gene

Leucine rich repeat neuronal 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for LRRN2 Gene

GeneLoc Exon Structure for
LRRN2
ECgene alternative splicing isoforms for
LRRN2

Expression for LRRN2 Gene

mRNA expression in normal human tissues for LRRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for LRRN2 Gene Hs.26312

mRNA Expression by UniProt/SwissProt for LRRN2 Gene

O75325-LRRN2_HUMAN
Tissue specificity: Overamplified in malignant gliomas
genes like me logo Genes that share expression patterns with LRRN2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LRRN2 Gene

Orthologs for LRRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRN2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LRRN2 35
  • 90.68 (n)
  • 94.8 (a)
LRRN2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrn2 35
  • 87.27 (n)
  • 91.03 (a)
Lrrn2 16
Lrrn2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRN2 35
  • 99.08 (n)
  • 99.13 (a)
LRRN2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrn2 35
  • 87.08 (n)
  • 90.31 (a)
cow
(Bos Taurus)
Mammalia LRRN5 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRN2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRN2 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRN2 35
  • 71.45 (n)
  • 70.12 (a)
LRRN2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRN2 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100150431 35
  • 60.17 (n)
  • 60.5 (a)
LRRN2 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011378 35
  • 49.26 (n)
  • 35.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta trn 35
  • 44.29 (n)
  • 32.32 (a)
caps 36
  • 25 (a)
ManyToMany
CG14762 36
  • 22 (a)
ManyToMany
Fili 36
  • 21 (a)
ManyToMany
trn 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lron-11 36
  • 23 (a)
OneToMany
Species with no ortholog for LRRN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LRRN2 Gene

ENSEMBL:
Gene Tree for LRRN2 (if available)
TreeFam:
Gene Tree for LRRN2 (if available)

Paralogs for LRRN2 Gene

(2) SIMAP similar genes for LRRN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRN2: view

Variants for LRRN2 Gene

Sequence variations from dbSNP and Humsavar for LRRN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs869871 -- 204,683,495(+) ACAGG(A/G)AAAAT intron-variant
rs875092 -- 204,631,821(-) CCCAC(A/G)GGGAG intron-variant, upstream-variant-2KB
rs875093 -- 204,631,591(-) CTACA(C/T)GAGGT intron-variant, upstream-variant-2KB
rs875094 -- 204,630,721(+) TGCCC(C/T)TCCCC intron-variant
rs880497 -- 204,653,086(+) tccca(C/G)agcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRN2 Gene

Variant ID Type Subtype PubMed ID
nsv4154 CNV Insertion 18451855
esv271419 CNV Insertion 20981092

Variation tolerance for LRRN2 Gene

Residual Variation Intolerance Score: 35.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.36; 94.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRN2 Gene

HapMap Linkage Disequilibrium report
LRRN2

PCR Panel Products

  • Copy Number PCR Panels: for LRRN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN2 Gene

Disorders for LRRN2 Gene

Relevant External Links for LRRN2

Genetic Association Database (GAD)
LRRN2
Human Genome Epidemiology (HuGE) Navigator
LRRN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRN2
genes like me logo Genes that share disorders with LRRN2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN2 Gene

Publications for LRRN2 Gene

  1. GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas. (PMID: 9662332) Malfoy B. … Hanash S. (Oncogene 1998) 2 23 67
  2. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  3. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. (PMID: 23722424) Rietveld C.A. … Koellinger P.D. (Science 2013) 67
  4. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. (PMID: 23535733) Garcia-Closas M. … Kraft P. (Nat. Genet. 2013) 67
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 67

Products for LRRN2 Gene

Sources for LRRN2 Gene

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