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Aliases for LRRN2 Gene

Aliases for LRRN2 Gene

  • Leucine Rich Repeat Neuronal 2 2 3 5
  • Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domain 7 2 3
  • Glioma Amplified On Chromosome 1 Protein 3 4
  • Leucine-Rich Repeat Neuronal Protein 5 3 4
  • Leucine Rich And Ankyrin Repeats 1 2 3
  • Leucine Rich Repeat Neuronal 5 2 3
  • LRRN5 3 4
  • GAC1 3 4
  • Leucine-Rich Repeat Neuronal Protein 2 3
  • FIGLER7 3
  • LRANK1 3

External Ids for LRRN2 Gene

Previous HGNC Symbols for LRRN2 Gene

  • LRRN5

Previous GeneCards Identifiers for LRRN2 Gene

  • GC00U911621
  • GC01M202853
  • GC01M175751

Summaries for LRRN2 Gene

Entrez Gene Summary for LRRN2 Gene

  • The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRN2 Gene

LRRN2 (Leucine Rich Repeat Neuronal 2) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is LRRN1.

Gene Wiki entry for LRRN2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN2 Gene

Genomics for LRRN2 Gene

Regulatory Elements for LRRN2 Gene

Enhancers for LRRN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F204646 1.3 Ensembl ENCODE 17.5 +38.1 38093 1.3 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ELK1 FOS JUNB NCOA1 LRRN2 ENSG00000240710 RBBP5 LOC105371694 LOC105371691 PIR48924 GC01P204628
GH01F204578 1 Ensembl ENCODE 17.1 +106.7 106651 2.1 HDGF CTCF MXI1 EBF1 SCRT2 EED ETV6 CHD2 MAZ MTA2 LRRN2 ENSG00000240710 LOC105371691 MDM4 GC01M204562 LOC105371692 RNA5SP74
GH01F204637 0.8 Ensembl ENCODE 18.5 +47.5 47549 2.0 ZNF680 RAD51 SMARCA4 BHLHE40 HMBOX1 USF2 REST LRRN2 ENSG00000240710 MDM4 GC01P204628 PIR48924 LOC105371691
GH01F204460 1.5 FANTOM5 Ensembl ENCODE 9.6 +221.5 221469 7.5 ARID4B YY1 GATA2 DEK REST NFIL3 MEF2D SMARCA4 KDM1A CTCF PIK3C2B PPP1R15B LRRN2 SOX13 ZC3H11A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRN2 on UCSC Golden Path with GeneCards custom track

Promoters for LRRN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000551386 533 1201 ZNF76 KLF17 ZNF121 GLIS2 SCRT2 KLF7 EGR2 SP3 YY2 ZEB2

Genomic Location for LRRN2 Gene

204,617,170 bp from pter
204,685,733 bp from pter
68,564 bases
Minus strand

Genomic View for LRRN2 Gene

Genes around LRRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN2 Gene

Proteins for LRRN2 Gene

  • Protein details for LRRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat neuronal protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R624
    • Q5T0Y0
    • Q6UXM0
    • Q8N182

    Protein attributes for LRRN2 Gene

    713 amino acids
    Molecular mass:
    78859 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN2 Gene

Post-translational modifications for LRRN2 Gene

  • Glycosylation at Asn 94, Asn 381, Asn 555, and Asn 583
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRN2 Gene

No data available for DME Specific Peptides for LRRN2 Gene

Domains & Families for LRRN2 Gene

Gene Families for LRRN2 Gene

Suggested Antigen Peptide Sequences for LRRN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 12 LRR (leucine-rich) repeats.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRN2: view

Function for LRRN2 Gene

Gene Ontology (GO) - Molecular Function for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9662332
genes like me logo Genes that share ontologies with LRRN2: view
genes like me logo Genes that share phenotypes with LRRN2: view

Animal Models for LRRN2 Gene

MGI Knock Outs for LRRN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRN2

miRNA for LRRN2 Gene

miRTarBase miRNAs that target LRRN2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRN2 Gene

Localization for LRRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRN2 gene
Compartment Confidence
extracellular 4
plasma membrane 3
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN2: view

Pathways & Interactions for LRRN2 Gene

SuperPathways for LRRN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9662332
GO:0007165 signal transduction TAS 9662332
GO:0007409 NOT axonogenesis IBA --
genes like me logo Genes that share ontologies with LRRN2: view

No data available for Pathways by source and SIGNOR curated interactions for LRRN2 Gene

Transcripts for LRRN2 Gene

mRNA/cDNA for LRRN2 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRN2 Gene

Leucine rich repeat neuronal 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for LRRN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of LRRN2 Gene:


SOURCE GeneReport for Unigene cluster for LRRN2 Gene:


mRNA Expression by UniProt/SwissProt for LRRN2 Gene:

Tissue specificity: Overamplified in malignant gliomas.
genes like me logo Genes that share expression patterns with LRRN2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LRRN2 Gene

Orthologs for LRRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRN2 34 35
  • 99.08 (n)
(Canis familiaris)
Mammalia LRRN2 34 35
  • 90.68 (n)
(Mus musculus)
Mammalia Lrrn2 34 16 35
  • 87.27 (n)
(Rattus norvegicus)
Mammalia Lrrn2 34
  • 87.08 (n)
(Bos Taurus)
Mammalia LRRN5 35
  • 82 (a)
(Monodelphis domestica)
Mammalia LRRN2 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia LRRN2 35
  • 64 (a)
(Gallus gallus)
Aves LRRN2 34 35
  • 71.45 (n)
(Anolis carolinensis)
Reptilia LRRN2 35
  • 66 (a)
(Danio rerio)
Actinopterygii LOC100150431 34
  • 60.17 (n)
LRRN2 35
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011378 34
  • 49.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta trn 34 35
  • 44.29 (n)
caps 35
  • 25 (a)
CG14762 35
  • 22 (a)
Fili 35
  • 21 (a)
(Caenorhabditis elegans)
Secernentea lron-11 35
  • 23 (a)
Species where no ortholog for LRRN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LRRN2 Gene

Gene Tree for LRRN2 (if available)
Gene Tree for LRRN2 (if available)

Paralogs for LRRN2 Gene

(2) SIMAP similar genes for LRRN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRN2: view

Variants for LRRN2 Gene

Sequence variations from dbSNP and Humsavar for LRRN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10563355 -- 204,651,048(+) GTCAC(-/AT)GAGTC intron-variant
rs10581422 -- 204,637,716(+) GAGGG(-/TG)GTAGA intron-variant
rs10719120 -- 204,632,647(+) AAAAA(-/A)TTCGC intron-variant
rs10751423 -- 204,632,835(+) AGGCT(A/G)AGGCA intron-variant
rs10751424 -- 204,632,912(+) CTGGG(C/T)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRN2 Gene

Variant ID Type Subtype PubMed ID
esv3328620 CNV insertion 20981092
esv3336117 CNV insertion 20981092
esv3588622 CNV gain 21293372
nsv4154 CNV insertion 18451855

Variation tolerance for LRRN2 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.36; 94.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN2 Gene

Disorders for LRRN2 Gene

Relevant External Links for LRRN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN2 Gene

Publications for LRRN2 Gene

  1. GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas. (PMID: 9662332) Malfoy B. … Hanash S. (Oncogene 1998) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for LRRN2 Gene

Sources for LRRN2 Gene

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