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Aliases for LRRN1 Gene

Aliases for LRRN1 Gene

  • Leucine Rich Repeat Neuronal 1 2 3
  • Neuronal Leucine-Rich Repeat Protein 1 3 4
  • NLRR-1 3 4
  • Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domains 3 3
  • Immunoglobulin And Leucine Rich Repeat Domains 3 2
  • Leucine-Rich Repeat Neuronal Protein 1 3
  • Fibronectin Type III 2
  • KIAA1497 4
  • FIGLER3 3

External Ids for LRRN1 Gene

Summaries for LRRN1 Gene

GeneCards Summary for LRRN1 Gene

LRRN1 (Leucine Rich Repeat Neuronal 1) is a Protein Coding gene. Diseases associated with LRRN1 include atrioventricular septal defect. An important paralog of this gene is LINGO1.

Gene Wiki entry for LRRN1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN1 Gene

Genomics for LRRN1 Gene

Genomic Location for LRRN1 Gene

Start:
3,799,437 bp from pter
End:
3,848,024 bp from pter
Size:
48,588 bases
Orientation:
Plus strand

Genomic View for LRRN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN1 Gene

Regulatory Elements for LRRN1 Gene

Proteins for LRRN1 Gene

  • Protein details for LRRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXK5-LRRN1_HUMAN
    Recommended name:
    Leucine-rich repeat neuronal protein 1
    Protein Accession:
    Q6UXK5
    Secondary Accessions:
    • Q3LID5
    • Q8IYV5
    • Q9H8V1
    • Q9P231

    Protein attributes for LRRN1 Gene

    Size:
    716 amino acids
    Molecular mass:
    80716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96021.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14500.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRN1 Gene

Proteomics data for LRRN1 Gene at MOPED

Post-translational modifications for LRRN1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn96, Asn117, Asn385, Asn517, and Thr571

Other Protein References for LRRN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRN1 Gene

Domains for LRRN1 Gene

Gene Families for LRRN1 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for LRRN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXK5

UniProtKB/Swiss-Prot:

LRRN1_HUMAN
Domain:
  • Contains 1 fibronectin type-III domain.:
    • Q6UXK5
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q6UXK5
  • Contains 1 LRRCT domain.:
    • Q6UXK5
  • Contains 1 LRRNT domain.:
    • Q6UXK5
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.:
    • Q6UXK5
genes like me logo Genes that share domains with LRRN1: view

Function for LRRN1 Gene

Gene Ontology (GO) - Molecular Function for LRRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRN1: view

Phenotypes for LRRN1 Gene

MGI mutant phenotypes for LRRN1:
inferred from 1 alleles
GenomeRNAi human phenotypes for LRRN1:
genes like me logo Genes that share phenotypes with LRRN1: view

Animal Models for LRRN1 Gene

MGI Knock Outs for LRRN1:

miRNA for LRRN1 Gene

miRTarBase miRNAs that target LRRN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LRRN1 Gene

Localization for LRRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRN1 Gene COMPARTMENTS Subcellular localization image for LRRN1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN1: view

Pathways for LRRN1 Gene

SuperPathways for LRRN1 Gene

No Data Available

Interacting Proteins for LRRN1 Gene

Gene Ontology (GO) - Biological Process for LRRN1 Gene

None

No data available for Pathways by source for LRRN1 Gene

Transcripts for LRRN1 Gene

mRNA/cDNA for LRRN1 Gene

Unigene Clusters for LRRN1 Gene

Leucine rich repeat neuronal 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN1 Gene

No ASD Table

Relevant External Links for LRRN1 Gene

GeneLoc Exon Structure for
LRRN1
ECgene alternative splicing isoforms for
LRRN1

Expression for LRRN1 Gene

mRNA expression in normal human tissues for LRRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRN1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (5.2), Brain - Nucleus accumbens (basal ganglia) (5.0), and Brain - Putamen (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRN1 Gene

SOURCE GeneReport for Unigene cluster for LRRN1 Gene Hs.163244

genes like me logo Genes that share expressions with LRRN1: view

No data available for mRNA Expression by UniProt/SwissProt for LRRN1 Gene

Orthologs for LRRN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRN1 35
  • 99.53 (n)
  • 99.72 (a)
LRRN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRRN1 35
  • 91.81 (n)
  • 96.23 (a)
LRRN1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRN1 35
  • 91.85 (n)
  • 97.35 (a)
LRRN1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrn1 35
  • 87.52 (n)
  • 95.53 (a)
Lrrn1 16
Lrrn1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRN1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRN1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrn1 35
  • 87.85 (n)
  • 95.53 (a)
chicken
(Gallus gallus)
Aves LRRN1 35
  • 80.49 (n)
  • 92.74 (a)
LRRN1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRN1 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68797 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492182 35
  • 72.11 (n)
  • 80.59 (a)
Str.5362 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29044 35
lrrn1 35
  • 71.55 (n)
  • 80.31 (a)
lrrn1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta caps 36
  • 24 (a)
ManyToMany
CG14762 36
  • 22 (a)
ManyToMany
Fili 36
  • 18 (a)
ManyToMany
trn 36
  • 21 (a)
ManyToMany
CG6860 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea lron-11 36
  • 21 (a)
OneToMany
Species with no ortholog for LRRN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRN1 Gene

ENSEMBL:
Gene Tree for LRRN1 (if available)
TreeFam:
Gene Tree for LRRN1 (if available)

Paralogs for LRRN1 Gene

Selected SIMAP similar genes for LRRN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRN1: view

Variants for LRRN1 Gene

Sequence variations from dbSNP and Humsavar for LRRN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_049896 -
VAR_049897 -

Structural Variations from Database of Genomic Variants (DGV) for LRRN1 Gene

Variant ID Type Subtype PubMed ID
nsv876408 CNV Loss 21882294
esv2752001 CNV Gain 17911159
esv2724816 CNV Deletion 23290073
esv2724818 CNV Deletion 23290073
esv1006927 CNV Deletion 20482838
esv1787606 CNV Deletion 17803354
esv2724819 CNV Deletion 23290073
nsv236590 CNV Loss 16902084
esv2724820 CNV Deletion 23290073
esv3608 CNV Deletion 18987735
esv6311 CNV Loss 19470904
esv1213048 CNV Deletion 17803354

Relevant External Links for LRRN1 Gene

HapMap Linkage Disequilibrium report
LRRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN1 Gene

Disorders for LRRN1 Gene

(1) University of Copenhagen DISEASES for LRRN1 Gene

Relevant External Links for LRRN1

Genetic Association Database (GAD)
LRRN1
Human Genome Epidemiology (HuGE) Navigator
LRRN1
genes like me logo Genes that share disorders with LRRN1: view

No data available for UniProtKB/Swiss-Prot for LRRN1 Gene

Publications for LRRN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. (PMID: 18591937) Hossain M.S. … Nakagawara A. (Oncogene 2008) 3 23
  3. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for LRRN1 Gene

Sources for LRRN1 Gene

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