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LRRN1 Gene

protein-coding   GIFtS: 57
GCID: GC03P003816

Leucine Rich Repeat Neuronal 1

  See LRRN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Neuronal 11 2     FIGLER32
Neuronal Leucine-Rich Repeat Protein 12 3     Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domains 32
NLRR-12 3     Leucine-Rich Repeat Neuronal Protein 12
Fibronectin Type III1     KIAA14973
Immunoglobulin And Leucine Rich Repeat Domains 31     

External Ids:    HGNC: 209801   Entrez Gene: 576332   Ensembl: ENSG000001759287   UniProtKB: Q6UXK53   

Export aliases for LRRN1 gene to outside databases

Previous GC identifers: GC07M098704 GC03P003833


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRRN1 Gene:
LRRN1 (leucine rich repeat neuronal 1) is a protein-coding gene. Diseases associated with LRRN1 include atrioventricular septal defect. An important paralog of this gene is LRFN3.

Gene Wiki entry for LRRN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRN1 gene promoter:
         GR   AML1a   Pax-6   GR-beta   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRN1 promoter sequence
   Search Chromatin IP Primers for LRRN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26.2   Ensembl cytogenetic band:  3p26.2   HGNC cytogenetic band: 3p26.2

LRRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRN1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P003816:  view genomic region     (about GC identifiers)

Start:
3,841,121 bp from pter      End:
3,889,387 bp from pter
Size:
48,267 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRRN1_HUMAN, Q6UXK5 (See protein sequence)
Recommended Name: Leucine-rich repeat neuronal protein 1 precursor  
Size: 716 amino acids; 80716 Da
Sequence caution: Sequence=BAA96021.1; Type=Erroneous initiation; Sequence=BAB14500.1; Type=Erroneous initiation;
Secondary accessions: Q3LID5 Q8IYV5 Q9H8V1 Q9P231

Explore the universe of human proteins at neXtProt for LRRN1: NX_Q6UXK5

Explore proteomics data for LRRN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn96, Asn117, Asn385, Asn517, Thr571
  • Modification sites at PhosphoSitePlus

  • See LRRN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065924.3  
    ENSEMBL proteins: 
     ENSP00000314901  

    LRRN1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for LRRN1
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    Search eBioscience for ELISAs for LRRN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6UXK5

    ProtoNet protein and cluster: Q6UXK5

    Selected Blocks protein domains (see all 6):
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: LRRN1_HUMAN, Q6UXK5
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with LRRN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRRN1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRN1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lrrn1):
     behavior/neurological 

    Find genes that share phenotypes with LRRN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lrrn1tm1Lex for LRRN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRN1
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    miRNA
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    miRTarBase miRNAs that target LRRN1:
    hsa-mir-30a-5p (MIRT049961), hsa-mir-124-3p (MIRT023145), hsa-mir-335-5p (MIRT019163)

    Block miRNA regulation of human, mouse, rat LRRN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRN1 (see all 26):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-148b* hsa-miR-181c hsa-miR-507 hsa-miR-218 hsa-miR-298 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidLRRN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRRN1
    Predesigned siRNA for gene silencing in human, mouse, rat LRRN1

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for LRRN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRN1 (NM_020873)
    Sino Biological Human cDNA Clone for LRRN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRN1

    Cell Line
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    ESI BIO PureStem Progenitor for LRRN1: 
    PureStem 4D20.8, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRRN1_HUMAN, Q6UXK5: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    endoplasmic reticulum1
    endosome1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LRRN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRN1
    Interactions:

        Search GeneGlobe Interaction Network for LRRN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for LRRN1 (ENSP000003149014) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO1ENSP000003382074STRING: ENSP00000338207
    LRRC4CENSP000002781984STRING: ENSP00000278198
    LHX2ENSP000003627174STRING: ENSP00000362717
    LHX9ENSP000003563574STRING: ENSP00000356357
    LRRC4ENSP000002493634STRING: ENSP00000249363
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRRN1 gene: 
    NM_020873.5  

    Unigene Cluster for LRRN1:

    Leucine rich repeat neuronal 1
    Hs.163244  [show with all ESTs]
    Unigene Representative Sequence: NM_020873
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319331(uc003bpt.4) ENST00000472075 ENST00000496115
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRRN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRN1 (see all 26):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-148b* hsa-miR-181c hsa-miR-507 hsa-miR-218 hsa-miR-298 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidLRRN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRRN1
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    OriGene ORF clones in mouse, rat for LRRN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRN1 (NM_020873)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRN1
    Primer
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    OriGene qPCR primer pairs and template standards for LRRN1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRN1
      QuantiTect SYBR Green Assays in human, mouse, rat LRRN1
      QuantiFast Probe-based Assays in human, mouse, rat LRRN1

    Additional mRNA sequence: 

    AB074161.1 AK022707.1 AK023273.1 AK291717.1 AY358312.1 BC034947.2 

    7 DOTS entries:

    DT.312004  DT.95262247  DT.65285539  DT.120874473  DT.120874462  DT.302711  DT.95204221 

    Selected AceView cDNA sequences (see all 65):

    AI143877 BM704901 AU132929 F07005 AW022367 BF725066 AY358312 AI569657 
    BU734344 BG717896 BX116447 AA179088 BU685265 BU736857 AA780917 AI553952 
    AW005806 NM_020873 BQ575867 BI768561 CD653169 BM722959 AU154359 AB040930 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATTGTTA
    LRRN1 Expression
    About this image


    LRRN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             hIPS1
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebellum
             Oligodendrocyte-like cells
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Pre-Granulosa Cells Primordial Follicle
             Oviduct
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Vascular endothelial growth factor-induced cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    LRRN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.163244
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRRN1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrn11 , 5 leucine rich repeat protein 1, neuronal1, 5 87.52(n)1
    95.53(a)1
      6 (49.71 cM)5
    169791  NM_008516.41  NP_032542.11 
     1075297265 
    chicken
    (Gallus gallus)
    Aves LRRN11 leucine rich repeat neuronal 1 80.49(n)
    92.74(a)
      771599  NM_001097539.1  NP_001091008.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRN16
    leucine rich repeat neuronal 1
    93(a)
    1 ↔ 1
    2(173939108-173941258)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687972 hypothetical protein MGC68797 75.52(n)    BC061939.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290442 Transcribed sequence with weak similarity to protein more 75.49(n)    AL731097.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68603 RAS protein signal transduction 42(a)   36C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea lron-116
    Protein LRON-11 (lron-11) mRNA, complete cds
    21(a)
    1 → many
    I(2735345-2742508) WBGene00022129


    ENSEMBL Gene Tree for LRRN1 (if available)
    TreeFam Gene Tree for LRRN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRN1 gene
    LRFN32  LRRN32  LINGO12  LRRC42  LRFN42  LINGO22  LRRC4B2  LRFN52  
    LRFN22  LRRC4C2  LRFN12  LINGO32  LRRN22  LINGO42  
    2 SIMAP similar genes for LRRN1 using alignment to 1 protein entry:     LRRN1_HUMAN:
    LRRN3    LRRN2

    Find genes that share paralogs with LRRN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRN1 (see all 1219)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797298621,2
    F--3839133(+) TAGTGC/TCTTTG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1507030781,2
    --3839153(+) GTCACA/GTGCGG 1 -- us2k10--------
    rs1849678811,2
    --3839183(+) TGAATC/TGATGT 1 -- us2k10--------
    rs1894775591,2
    --3839242(+) TGTCGC/TTGAAT 1 -- us2k10--------
    rs731290771,2
    C,F--3839277(+) CTAAGC/GATTTT 1 -- us2k13Minor allele frequency- G:0.07WA CSA 122
    rs1821244461,2
    --3839433(+) AAGCAG/TTGTTG 1 -- us2k10--------
    rs1851344591,2
    --3839466(+) TTGGTA/CCCTGA 1 -- us2k10--------
    rs1896402981,2
    --3839511(+) TGGAGC/GCTGTT 1 -- us2k10--------
    rs13869711,2
    C,F,A,H--3839711(+) ATTTCC/TGTACT 1 -- us2k1105Minor allele frequency- T:0.19NS MN EA NA PA EU CA WA 8062
    rs117066841,2
    C,F,H--3839719(+) ACTTCC/TACCAG 1 -- us2k11Minor allele frequency- T:0.06NA 120

    HapMap Linkage Disequilibrium report for LRRN1 (3841121 - 3889387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRRN1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724819CNV Deletion23290073
    esv1213048CNV Deletion17803354
    esv2724820CNV Deletion23290073
    esv1787606CNV Deletion17803354
    esv2724816CNV Deletion23290073
    esv3608CNV Deletion18987735
    esv1006927CNV Deletion20482838
    esv2724818CNV Deletion23290073
    nsv236590CNV Loss16902084
    esv6311CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for LRRN1:    
    About MalaCards
    atrioventricular septal defect

    1 disease from the University of Copenhagen DISEASES database for LRRN1:
    Atrioventricular septal defect

    Find genes that share disorders with LRRN1           About GenesLikeMe

    Genetic Association Database (GAD): LRRN1
    Human Genome Epidemiology (HuGE) Navigator: LRRN1 (1 document)

    Export disorders for LRRN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRN1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with LRRN1)
        Utopia: connect your pdf to the dynamic
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    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (Cancer Lett. 2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. (PubMed id 18591937)1, 9 Hossain M.S....Nakagawara A. (Oncogene 2008)
    8. Genetics of callous-unemotional behavior in children. (PubMed id 23874384)1 Viding E....Plomin R. (PLoS ONE 2013)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. (PubMed id 20678249)1 Sousa I....Monaco A.P. (Mol Autism 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57633 HGNC: 20980 AceView: LRRN1 Ensembl:ENSG00000175928 euGenes: HUgn57633
    ECgene: LRRN1 H-InvDB: LRRN1

    (According to HUGE)
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    HUGE: KIAA1497

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRN1 gene:
    Search GeneIP for patents involving LRRN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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