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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRRN1 Gene

protein-coding   GIFtS: 56
GCID: GC03P003816

Leucine Rich Repeat Neuronal 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine Rich Repeat Neuronal 11 2     FIGLER32
Neuronal Leucine-Rich Repeat Protein 12 3     Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domains 32
NLRR-12 3     Leucine-Rich Repeat Neuronal Protein 12
Fibronectin Type III1     KIAA14973
Immunoglobulin And Leucine Rich Repeat Domains 31     

External Ids:    HGNC: 209801   Entrez Gene: 576332   Ensembl: ENSG000001759287   UniProtKB: Q6UXK53   

Export aliases for LRRN1 gene to outside databases

Previous GC identifers: GC07M098704 GC03P003833


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRRN1 Gene: 
LRRN1 (leucine rich repeat neuronal 1) is a protein-coding gene. Diseases associated with LRRN1 include atrioventricular septal defect, and neuronitis. An important paralog of this gene is LRFN3.

Gene Wiki entry for LRRN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRRN1 gene promoter:
         GR   AML1a   Pax-6   GR-beta   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRRN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26.2   Ensembl cytogenetic band:  3p26.2   HGNC cytogenetic band: 3p26.2

LRRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRN1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P003816:  view genomic region     (about GC identifiers)

Start:
3,841,121 bp from pter      End:
3,889,387 bp from pter
Size:
48,267 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRRN1_HUMAN, Q6UXK5 (See protein sequence)
Recommended Name: Leucine-rich repeat neuronal protein 1 precursor  
Size: 716 amino acids; 80716 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=BAA96021.1; Type=Erroneous initiation; Sequence=BAB14500.1; Type=Erroneous initiation;
Secondary accessions: Q3LID5 Q8IYV5 Q9H8V1 Q9P231

Explore the universe of human proteins at neXtProt for LRRN1: NX_Q6UXK5

Explore proteomics data for LRRN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UXK5

  • LRRN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRRN1 Protein Expression
    REFSEQ proteins: NP_065924.3  
    ENSEMBL proteins: 
     ENSP00000314901  

    Human Recombinant Protein Products for LRRN1: 
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    Novus Biologicals LRRN1 Protein
    Novus Biologicals LRRN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRRN1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    LRRN1 for ontologies           About GeneDecksing



    LRRN1 Antibody Products: 
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    Abcam antibodies for LRRN1
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    LSBio Antibodies in human, mouse, rat for LRRN1 

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    Cloud-Clone Corp. ELISAs for LRRN1 
    Cloud-Clone Corp. CLIAs for LRRN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/9 InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6UXK5

    ProtoNet protein and cluster: Q6UXK5

    5/6 Blocks protein domains (see all 6):
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: LRRN1_HUMAN, Q6UXK5
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    LRRN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    LRRN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRN1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lrrn1):
     behavior/neurological 

    LRRN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lrrn1tm1Lex for LRRN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRRN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRRN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRN1 

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRN1 (see all 26):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-148b* hsa-miR-181c hsa-miR-507 hsa-miR-218 hsa-miR-298 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidLRRN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRRN1
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for LRRN1 (see all 7)
    OriGene ORF clones in mouse, rat for LRRN1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRN1
    Sirion Biotech Customized lentivirus for stable overexpression of LRRN1 
                         Customized lentivirus expression plasmids for stable overexpression of LRRN1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LRRN1
    LifeMap BioReagents: cell line associated with LRRN1: PureStem 4D20.8, NCr-fac Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for LRRN1 (ENSP000003149014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIENSP000002303214STRING: ENSP00000230321
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRRN1

    Search CenterWatch for drugs/clinical trials and news about LRRN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRRN1 gene: 
    NM_020873.5  

    Unigene Cluster for LRRN1:

    Leucine rich repeat neuronal 1
    Hs.163244  [show with all ESTs]
    Unigene Representative Sequence: NM_020873
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319331(uc003bpt.4) ENST00000472075 ENST00000496115
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRN1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRN1 (see all 26):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-148b* hsa-miR-181c hsa-miR-507 hsa-miR-218 hsa-miR-298 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidLRRN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRRN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRN1
    Clone
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    OriGene clones in human, mouse for LRRN1 (see all 7)
    OriGene ORF clones in mouse, rat for LRRN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRN1 (NM_020873)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRN1
    Sirion Biotech Customized lentivirus for stable overexpression of LRRN1 
                         Customized lentivirus expression plasmids for stable overexpression of LRRN1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRRN1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRN1

    Additional mRNA sequence: 

    AB074161.1 AK022707.1 AK023273.1 AK291717.1 AY358312.1 BC034947.2 

    7 DOTS entries:

    DT.312004  DT.95262247  DT.65285539  DT.120874473  DT.120874462  DT.302711  DT.95204221 

    24/65 AceView cDNA sequences (see all 65):

    AW022367 F07005 AY358312 AI143877 BM704901 BF725066 AU132929 AI553952 
    AW296461 AA179088 BG717896 AW005806 AI569657 CD653169 AK022707 AA954155 
    BF531021 BU736857 BM677421 BQ575867 CD675583 AA780917 BI768561 AK023273 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRRN1 expression in normal human tissues (normalized intensities)      LRRN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATTGTTA
    LRRN1 Expression
    About this image


    LRRN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 11 entries
             hIPS1
             ESI-017   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   
     
     Epithelium
             Human Iris Pigment Epithelial Cells (HIPEpiC)   

    See LRRN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRRN1

    SOURCE GeneReport for Unigene cluster: Hs.163244
        SABiosciences Custom PCR Arrays for LRRN1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LRRN1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrn11 , 5 leucine rich repeat protein 1, neuronal1, 5 87.52(n)1
    95.53(a)1
      6 (49.71 cM)5
    169791  NM_008516.41  NP_032542.11 
     1075297265 
    chicken
    (Gallus gallus)
    Aves LRRN11 leucine rich repeat neuronal 1 80.49(n)
    92.74(a)
      771599  NM_001097539.1  NP_001091008.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRN16
    --
    Uncharacterized protein
    93(a)
    49(a)
    1 ↔ 1
    possible ortholog
    2(173939108-173941258)
    2(68468965-68471514)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687972 hypothetical protein MGC68797 75.52(n)    BC061939.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290442 Transcribed sequence with weak similarity to protein more 75.49(n)    AL731097.1 


    ENSEMBL Gene Tree for LRRN1 (if available)
    TreeFam Gene Tree for LRRN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRRN1 gene
    LRFN32  LRRN32  LINGO12  LRRC42  LRFN42  LINGO22  LRRC4B2  LRFN52  
    LRFN22  LRRC4C2  LRFN12  LINGO32  LRRN22  LINGO42  
    2 SIMAP similar genes for LRRN1 using alignment to 1 protein entry:     LRRN1_HUMAN:
    LRRN3    LRRN2

    LRRN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1219 SNPs in LRRN1 are shown (see all 1219)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797298621,2
    F--3839133(+) TAGTGC/TCTTTG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1507030781,2
    --3839153(+) GTCACA/GTGCGG 1 -- us2k10--------
    rs1849678811,2
    --3839183(+) TGAATC/TGATGT 1 -- us2k10--------
    rs1894775591,2
    --3839242(+) TGTCGC/TTGAAT 1 -- us2k10--------
    rs731290771,2
    C,F--3839277(+) CTAAGC/GATTTT 1 -- us2k13Minor allele frequency- G:0.07WA CSA 122
    rs1821244461,2
    --3839433(+) AAGCAG/TTGTTG 1 -- us2k10--------
    rs1851344591,2
    --3839466(+) TTGGTA/CCCTGA 1 -- us2k10--------
    rs1896402981,2
    --3839511(+) TGGAGC/GCTGTT 1 -- us2k10--------
    rs13869711,2
    C,F,A,H--3839711(+) ATTTCC/TGTACT 1 -- us2k1105Minor allele frequency- T:0.19NS MN EA NA PA EU CA WA 8062
    rs117066841,2
    C,F,H--3839719(+) ACTTCC/TACCAG 1 -- us2k11Minor allele frequency- T:0.06NA 120

    HapMap Linkage Disequilibrium report for LRRN1 (3841121 - 3889387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for LRRN1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724819CNV Deletion23290073
    esv1213048CNV Deletion17803354
    esv2724820CNV Deletion23290073
    esv1787606CNV Deletion17803354
    esv2724816CNV Deletion23290073
    esv3608CNV Deletion18987735
    esv1006927CNV Deletion20482838
    esv2724818CNV Deletion23290073
    nsv236590CNV Loss16902084
    esv6311CNV Loss19470904

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRN1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for LRRN1:    About MalaCards
    atrioventricular septal defect    neuronitis    autism spectrum disorder    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for LRRN1:
    Atrioventricular septal defect

    LRRN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRRN1
    Human Genome Epidemiology (HuGE) Navigator: LRRN1 (1 document)

    Export disorders for LRRN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRRN1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with LRRN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. (PubMed id 18591937)1, 9 Hossain M.S....Nakagawara A. (2008)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Polymorphisms in leucine-rich repeat genes are associ ated with autism spectrum disorder susceptibility in populations of European an cestry. (PubMed id 20678249)1 Sousa I....Monaco A.P. (2010)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57633 HGNC: 20980 AceView: LRRN1 Ensembl:ENSG00000175928 euGenes: HUgn57633
    ECgene: LRRN1 H-InvDB: LRRN1

    (According to HUGE)
    About This Section
    HUGE: KIAA1497

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRRN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRRN1 gene:
    Search GeneIP for patents involving LRRN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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