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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LRRK2 Gene

protein-coding GIFtS: 66
GCID: GC12P040590

leucine-rich repeat kinase 2

(Previous name: Parkinson disease (autosomal dominant) 8 )
(Previous symbol: PARK8)

Explore 31 diseases affiliated with
LRRK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucine-Rich Repeat Kinase 2¹ ²		AURA17²
PARK8¹ ² ³ ⁵		DARDARIN²
RIPK7¹ ²		Augmented In Rheumatoid Arthritis 17²
ROCO2¹ ²		Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2²
DKFZp434H2111¹		Dardarin³
FLJ45829¹		EC 2.7.11.1³
Parkinson Disease (Autosomal Dominant) 8¹

External Ids:	HGNC: 18618¹	Entrez Gene: 120892²	Ensembl: ENSG00000188906⁷	OMIM: 609007⁵	UniProtKB: Q5S007³

Export aliases for LRRK2 gene to outside databases

Previous GC identifers: GC00U914055 GC12P038908 GC12P037646

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LRRK2:

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a

leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain,

and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer

membrane. Mutations in this gene have been associated with Parkinson disease-8. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LRRK2_HUMAN, Q5S007

Function: May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May

also have GTPase activity. Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK

signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors,

increase in lysosomal pH, and calcium release from lysosomes

summary for LRRK2:

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin, is a large multidomain protein kinase that

includes leucine-rich repeats and a GTPase domain. LRRK2 is encoded by the PARK8 gene. Autosomal dominant

missense mutations in LRRK2 are commonly associated with late-onset Parkinson's disease (PD); they are also

evident in a smaller percentage of familial Parkinson's disease cases, of which they are the most common

cause. The discovery of LRRK2 mutations helped strengthen a genetic link to Parkinson's disease, which had

previously been obscured by unusual inheritance patterns - in particular, incomplete/decreased penetrance

and variable age of onset. Mutations associated with PD have been isolated within the enzymatic domains of

LRRK2, namely its kinase and GTPase domains. The most frequent mutation is a substitution of the Gly2019

residue in the kinase domain with a serine residue, resulting in a kinase that exhibits 2- to 3-fold greater

catalytic activity. Pathogenic mutations within the Roc (Ras of complex) GTPase domain and COR

(carboxy-terminal of Roc) sequence have been shown to decrease GTPase activity, which is thought to

counteract LRRK2 activity and restore it to basal levels. Inhibitors of LRRK2 kinase activity have therefore

been of therapeutic interest in the treatment of LRRK2-linked PD. LRRK2 also contains protein-protein

interaction domains. Proteins thought to interact with LRRK2 include dishevelled proteins, MAPK kinase 6

(MKK6) and 14-3-3 proteins. Studies have shown that certain members of the 14-3-3 family bind and influence

the cytoplasmic localization of LRRK2. PD-associated mutants and a truncated form of LRRK2 show a decreased

ability to bind 14-3-3, suggesting that this interaction is important in the pathogenesis of PD.

Gene Wiki entry for LRRK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LRRK2 gene promoter:
STAT5B AP-1 Nkx2-2 ATF-2 Ik-3 Meis-1b c-Jun Meis-1a GCNF-2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRRK2 promoter sequence

Search SABiosciences Chromatin IP Primers for LRRK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q12 HGNC cytogenetic band: 12q12

LRRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRK2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P040590: view genomic region (about GC identifiers)

Start:	40,590,546 bp from pter	End:	40,763,087 bp from pter
Size:	172,542 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LRRK2_HUMAN, Q5S007 (See protein sequence)

Recommended Name: Leucine-rich repeat serine/threonine-protein kinase 2

Size: 2527 amino acids; 286103 Da

Subunit: Homodimer. Interacts with PARK2. Interacts with PRDX3. Interacts with TPCN2

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Mitochondrion. Note=Localized in the cytoplasm

and associated with cellular membrane structures. Associates with the mitochondrial outer membrane

2 PDB 3D structures from and Proteopedia for LRRK2:

2ZEJ (3D)

3D6T (3D)

Secondary accessions: A6NJU2 Q6ZS50 Q8NCX9

Explore the universe of human proteins at neXtProt for LRRK2: NX_Q5S007

Post-translational modifications:

Autophosphorylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5S007

LRRK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_940980.3

ENSEMBL proteins:

ENSP00000398726 ENSP00000341930 ENSP00000298910 ENSP00000410821

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant LRRK2 Protein
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	Novus Biologicals LRRK2 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LRRK2

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IDA	16352719
GO:0005739	mitochondrion	IDA	--
GO:0005802	trans-Golgi network	IEA	--
GO:0005886	plasma membrane	IEA	--

LRRK2 for ontologies About GeneDecksing

LRRK2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LRRK2
	R&D Systems Antibodies for LRRK2
	Cell Signaling Technology (CST) Antibodies for LRRK2
	OriGene Antibodies (see all 3): LRRK2 OriGene Custom Antibody Services for LRRK2
	GenScript Custom Superior Antibodies Services for LRRK2
	Novus Biologicals LRRK2 Antibodies
	Abcam antibodies for LRRK2
	Uscn Antibodies for LRRK2
	ThermoFisher Antibody for LRRK2

Assay Products for LRRK2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LRRK2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LRRK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LRRK2 for domains About GeneDecksing

5/17 InterPro domains/families (see all 17):

IPR017441 Protein_kinase_ATP_BS

IPR011989 ARM-like

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

IPR013684 MIRO-like

Graphical View of Domain Structure for InterPro Entry Q5S007

ProtoNet protein and cluster: Q5S007

2 Blocks protein families:

IPB000408 Regulator of chromosome condensation

IPB013684 Miro-like

UniProtKB/Swiss-Prot: LRRK2_HUMAN, Q5S007

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family

Similarity: Contains 12 LRR (leucine-rich) repeats

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 Roc domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LRRK2_HUMAN, Q5S007

Function: May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May

also have GTPase activity. Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK

signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors,

increase in lysosomal pH, and calcium release from lysosomes

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1¹

miRNA Products:		OriGene 3'-UTR Clone: LRRK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRK2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRK2 (see all 17):
		hsa-miR-607 hsa-miR-181c hsa-miR-301a hsa-miR-130b hsa-miR-181b hsa-miR-301b hsa-miR-205 hsa-miR-181a

		SwitchGear 3'UTR luciferase reporter plasmid: LRRK2 3' UTR sequence

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LRRK2

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		GenScript: all cDNA clones in your preferred vector: LRRK2 (NM_198578)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LRRK2
		Search LifeMap BioReagents cell lines for LRRK2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRK2

Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IDA	--
GO:0004672	protein kinase activity	IDA	--
GO:0004674	protein serine/threonine kinase activity	IDA	--
GO:0004708	MAP kinase kinase activity	IDA	19302196
GO:0005096	GTPase activator activity	IDA	17442267

LRRK2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for LRRK2:

Decreased viability with pacli

Upregulation of Wnt/beta-caten

Animal Models:
     Mouse knock-outs for LRRK2: Lrrk2^tm1Mjfa Lrrk2^tm1.1Cai Lrrk2^tm1Tmd Lrrk2^tm2.1Shn Lrrk2^tm1.1Mjff Lrrk2^tm1.1Npa
                                               Lrrk2^tm1Arte Lrrk2^tm3.1Shn
     14 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Lrrk2):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	integument	mortality/aging	nervous system
no phenotypic analysis	pigmentation	renal/urinary system	respiratory system

LRRK2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Neuroscience

Neuroscience

1.00

MAPK signaling pathway

MAPK signaling pathway

1.00

Parkinsons Disease Pathway

Parkinsons Disease Pathway

1.00

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Parkinson's disease

0.61

Wnt Signaling Pathway

Wnt Signaling Pathway and Pluripotency

0.55

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for LRRK2

Neuroscience

3 BioSystems Pathways for LRRK2

	MAPK signaling pathway
	Wnt Signaling Pathway and Pluripotency
	Parkinsons Disease Pathway

1 Kegg Pathway (Kegg details for LRRK2):

Parkinson's disease

LRRK2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LRRK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/67 Interacting proteins for LRRK2 (Q5S007^{1, 2, 3} ENSP00000298910⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 67)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARK2	O60260¹^,³, ENSP00000355865⁴	EBI-5323863,EBI-716346 I2D: score=1 STRING: ENSP00000355865
AKT1	P31749²^,³, ENSP00000270202⁴	MINT-8177975 MINT-8177865 MINT-8177888 MINT-8177907 MINT-8177924 MINT-8177954 I2D: score=1 STRING: ENSP00000270202
CALM1	P62158³	I2D: score=1
CALM2	P62158³	I2D: score=1
CALM3	P62158³	I2D: score=1

About this table

Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	IDA	17200152
GO:0000186	activation of MAPKK activity	IDA	19302196
GO:0000187	activation of MAPK activity	IDA	19302196
GO:0001934	positive regulation of protein phosphorylation	IMP	--
GO:0006184	GTP catabolic process	IDA	--

LRRK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LRRK2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for LRRK2 available from Tocris Bioscience About this table

Compound	Action	CAS #
LRRK2-IN-1	Potent and selective LRRK2 inhibitor	[1234480-84-2]

3 HMDB Compounds for LRRK2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

4 Novoseek chemical compound relationships for LRRK2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
levodopa	35.6	2	17614947 (1), 17427941 (1)
gtp	35.3	13	17260967 (4), 17706965 (2), 16980962 (1), 19712061 (1) (see all 5)
dopamine	26.1	6	19625511 (2), 17625107 (1), 19726410 (1), 18272292 (1) (see all 5)
lipid	1.83	7	17341485 (4)

Search CenterWatch for drugs/clinical trials and news about LRRK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LRRK2 gene:

NM_198578.3

Unigene Cluster for LRRK2:

Leucine-rich repeat kinase 2

Hs.187636 [show with all ESTs]

Unigene Representative Sequence: NM_198578

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000416796 ENST00000343742(uc001rmh.1) ENST00000298910(uc001rmg.4)

ENST00000474202 ENST00000430804(uc009zjw.3) ENST00000479187(uc001rmi.3)

ENST00000481256

miRNA Products:		OriGene 3'-UTR Clone: LRRK2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRK2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRK2 (see all 17):
		hsa-miR-607 hsa-miR-181c hsa-miR-301a hsa-miR-130b hsa-miR-181b hsa-miR-301b hsa-miR-205 hsa-miR-181a

		SwitchGear 3'UTR luciferase reporter plasmid: LRRK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: LRRK2 (NM_198578)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRK2

Additional cDNA sequence:

AK026776.1 AK122640.1 AK127729.1 AK131537.1 AL832453.2 AL834529.1 AY792511.1 BC117180.1

BX640975.1 EF212257.1

8 DOTS entries:

DT.92042415 DT.301521 DT.91844472 DT.95116671 DT.91980049 DT.408537 DT.95338047 DT.65285196

24/53 AceView cDNA sequences (see all 53):

AL834529 AA827621 AK122640 BF942699 AA906444 BX119871 AW772282 AK131537

AA741317 AW237822 AK127729 BU634341 BF331667 BM280361 BX640975 AK026776

AV705213 CA406939 AW118991 AA278300 BQ437477 BX499147 BG546973 AL832453

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LRRK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

LRRK2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human kidney epithelial cell spheroids (Kidney spheroids for...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LRRK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRK2

SOURCE GeneReport for Unigene cluster: Hs.187636

UniProtKB/Swiss-Prot: LRRK2_HUMAN, Q5S007

Tissue specificity: Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed

in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex,

medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain

dopaminoceptive areas

SABiosciences Expression via Pathway-Focused PCR Array including LRRK2:

Parkinson's Disease in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRK2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LRRK2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC427844¹	leucine-rich repeat serine/threonine-protein kinase more	73.19(n) 72.81(a)		427844 XM_003640340.1 XP_003640388.1
lizard (Anolis carolinensis)	Reptilia	LRRK2⁶	--	72(a)	1 ↔ 1	5(98166841-98263943)
zebrafish (Danio rerio)	Actinopterygii	lrrk2¹	leucine-rich repeat kinase 2	55.38(n) 49.4(a)		559366 NM_001201456.1 NP_001188385.1
fruit fly (Drosophila melanogaster)	Insecta	Lrrk⁶	Leucine-rich repeat kinase	17(a)	possible ortholog	3R(16461910-16469856)
worm (Caenorhabditis elegans)	Secernentea	lrk-1⁶	Leucine-rich repeat serine/threonine-protein kinas...	15(a)	possible ortholog	I(10879759-10894230)

ENSEMBL Gene Tree for LRRK2 (if available)
TreeFam Gene Tree for LRRK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LRRK2 gene

LRRK1²

3 SIMAP similar genes for LRRK2 using alignment to 5 protein entries: LRRK2_HUMAN (see all proteins):

DKFZp686E15222 AURA17 STK11

LRRK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34594498^1,2	C,F,	pathogenic	37674515(+)	`ATCTGC/TGAATG`	2	A V	mis¹		4		EA NA	5242
rs34410987^1,2	C,F,	pathogenic	37705347(+)	`CAGTCC/TCAAAT`	2	P L	mis¹		3		EA NA	188
rs35808389^1,2	C	pathogenic	37719923(+)	`ATTTTA/GGAAGG`	2	L	syn¹		2		NA	4550
rs34805604^1,2	C	pathogenic	37720560(+)	`CAGGGA/GTATGC`	2	I V	mis¹		2		NA	4
rs74163686^1,2	C	pathogenic	37730660(+)	`TCTTCA/CATATA`	2	N H	mis¹		0	--	--	--	--
rs33939927^1,2	C	pathogenic	37731869(+)	`AGGCTC/G/TGCGCT`	3	R G C	mis¹		2		NA	4
rs34995376^1,2	C	pathogenic	37731870(+)	`GGCTCG/ACGCTT`	2	/H /R	mis¹		2		NA	4
rs33949390^1,2	C,F,	pathogenic	37741479(+)	`TTCGCA/C/GTAGAG`	3	H P R	mis¹		3		NA	4156
rs35801418^1,2	C	pathogenic	37742550(+)	`GCCTTA/GTTTTC`	2	Y C	mis¹		1		NA	2
rs34637584^1,2	C,F,	pathogenic	37761838(+)	`ACTACG/AGCATT`	2	/S /G	mis¹		4		NA EU	5875
rs35870237^1,2	C	pathogenic	37761842(+)	`CGGCAT/CTGCTC`	2	/T /I	mis¹		2		NA	4
rs72546335^1,2	C	unknown	37647171(+)	`AGCCTC/TCAAGT`	2	S F	mis¹		0	--	--	--	--
rs75054132^1,2	C,F,	unknown	37647241(+)	`GTCGCG/AAGTGT`	2	/A	syn¹		1		NA	4540
rs33995463^1,2	C,F,	unknown	37657252(+)	`GATTCT/CTAAAA`	2	/P /L	mis¹		3		NA EU	5865
rs41286468^1,2	C,F	unknown	37657260(+)	`AAATGC/TTAACA`	2	L	syn¹		1		NA	4546
rs35517158^1,2	C	unknown	37659693(+)	`TGCAAA/GGCTTT`	2	K	syn¹		0	--	--	--	--
rs112794616^1,2	C,	unknown	37662158(+)	`AAGTGC/TGTTAA`	2	A V	mis¹		1		NA	4536
rs56108242^1,2	C	unknown	37662209(+)	`GCATTC/GTTTAC`	2	S C	mis¹		0	--	--	--	--
rs28365216^1,2	C,H,	unknown	37665188(+)	`CAATAA/TTGTGG`	2	N I	mis¹		4		NS EA	414
rs72546315^1,2	C,F	unknown	37665300(+)	`CTCCAA/C/TAGGCT`	3	Q H	mis¹ syn¹		1		NA	4548
rs17490713^1,2	C,F,H,	unknown	37671385(+)	`TTAAAC/TGAAGT`	2	N	syn¹ ese³		8		NS EA WA NA	5124
rs41286466^1,2	C,F,	unknown	37671454(+)	`TCAGCG/TCTCAG`	2	A	syn¹		2		NA EU	5865
rs78501232^1,2	C,F,	unknown	37672804(+)	`AGAATG/AAGAAT`	2	/K /E	mis¹		2		NA EU	4961
rs72546336^1,2	C	unknown	37672892(+)	`AAAGAA/GCAAGC`	2	N S	mis¹		0	--	--	--	--
rs113065049^1,2	C	unknown	37672900(+)	`AGCACA/GTGCAG`	2	M V	mis¹		0	--	--	--	--
rs35847451^1,2	C	unknown	37678873(+)	`GAAAGT/CGGCTG`	2	/S	syn¹		3		NA EU	1327
rs75711334^1,2	C	unknown	37681056(+)	`ATACTA/TACAGT`	2	L	syn¹		0	--	--	--	--
rs202009639^1,2	C	unknown	37681109(+)	`GCTTCG/AAGCTA`	2	/Q /R	mis¹		1		EU	1323
rs35328937^1,2	C	unknown	37685337(+)	`AATCCA/GGGGAG`	2	R G	mis¹		1		EU	1315
rs79996249^1,2	C	unknown	37685406(+)	`TTCACA/GAACTG`	2	K E	mis¹		0	--	--	--	--
rs7308720^1,2	C,F,H,	unknown	37685429(+)	`TTGAAC/GAGGGT`	2	N K	mis¹		30		EA NA NS WA CSA EU	8793
rs77424631^1,2	C	unknown	37696019(+)	`CCTGGA/GATTCA`	2	G	syn¹		0	--	--	--	--
rs78154388^1,2	C	unknown	37699352(+)	`CTTTTC/TCTAAG`	2	P S	mis¹		0	--	--	--	--
rs72546319^1,2	C,F,	unknown	37699387(+)	`TTAGTA/CATATT`	2	V	syn¹		2		CSA NA	4534
rs199566791^1,2	C	unknown	37699573(+)	`ATGTGA/GTGCTA`	2	M V	mis¹		0	--	--	--	--
rs10878307^1,2	C,F,H,	unknown	37699606(+)	`ACAGCA/GTCATG`	2	I V	mis¹ ese³		21		EA NA NS EU	7995
rs35173587^1,2	C,F,	unknown	37705461(+)	`AAGGAG/TGCTGG`	2	R M	mis¹		3		NA	4554
rs72546337^1,2	C	unknown	37705511(+)	`TTTGTA/GTAGGA`	2	I V	mis¹		0	--	--	--	--
rs76890302^1,2	C	unknown	37705564(+)	`ACTTCC/TAATTT`	2	S	syn¹		0	--	--	--	--
rs58559150^1,2	C	unknown	37715071(+)	`TTACAC/GCGTTG`	2	H Q	mis¹		0	--	--	--	--
rs17519916^1,2	C,F,H	unknown	37716301(+)	`ATGAAG/TATTTA`	2	D Y	mis¹		11		NS EA NA	1466
rs7966550^1,2	C,F,A,H,	unknown	37716328(+)	`AAATAT/CTATCT`	2	/L	syn¹		20		NS EA NA EU	7595
rs75148313^1,2	C	unknown	37716901(+)	`AGACAA/GCATTT`	2	N S	mis¹		0	--	--	--	--
rs113217062^1,2	C	unknown	37717001(+)	`TGTATA/GAGNGT`	2	I M	mis¹		0	--	--	--	--
rs55783828^1,2	C	unknown	37717004(+)	`ATAAGC/TGTTCA`	2	S	syn¹		0	--	--	--	--
rs111341148^1,2	C	unknown	37719781(+)	`CTCTCA/GAAATG`	2	Q R	mis¹		0	--	--	--	--
rs76535406^1,2	C	unknown	37719868(+)	`GCTGTC/GTTTTG`	2	S C	mis¹		0	--	--	--	--
rs78365431^1,2	C,	unknown	37719914(+)	`GAGCAG/TCTCAT`	2	Q H	mis¹		1		NA	4548
rs74985840^1,2	C	unknown	37720647(+)	`TTGAGG/ACTTGT`	2	/T /A	mis¹		1		NA	4550
rs72546324^1,2	C	unknown	37725439(+)	`CGCACA/GCTGGA`	2	H R	mis¹		0	--	--	--	--
rs60185966^1,2	C	unknown	37725475(+)	`ATTTAC/G/TCCATA`	3	T S I	mis¹		1		NA	4544
rs4640000^1,2	C,F,H,	unknown	37727226(+)	`TTCCTC/GCTGAG`	2	P A	mis¹ ese³		10		NS EA NA	5064
rs77018758^1,2	C,	unknown	37729902(+)	`ACTAGC/G/TTTTCT`	3	S R	mis¹		0	--	--	--	--
rs72546338^1,2	C,F	unknown	37729916(+)	`ACAGCG/AATTAA`	2	/Q /R	mis¹		1		NA	3886
rs17466213^1,2	C,F,H,	unknown	37730053(+)	`TTGGCA/GTAGAT`	2	I V	mis¹		9		NS EA NA EU	6339
rs28365226^1,2	C,F,H	unknown	37730067(+)	`AAAGAC/ATGGCC`	2	/E /D	mis¹ ese³		6		NS EA NA	420
rs7133914^1,2	C,F,A,H,	unknown	37730544(+)	`AGGTCG/ATGAGG`	2	/H /R	mis¹ ese³		27		NS EA NA CSA WA EU	8749
rs72546327^1,2	C,F,	unknown	37730580(+)	`TATGAC/TGCAGC`	2	T M	mis¹		1		NA	4546
rs113589830^1,2	C	unknown	37730609(+)	`TCTATA/GACCTC`	2	N D	mis¹		0	--	--	--	--
rs11175964^1,2	C,F,H,	unknown	37730620(+)	`AGCAAG/AGGACA`	2	/K	syn¹		22		NA NS EA EU	8225
rs111435410^1,2	C	unknown	37730641(+)	`GATGCC/TATGAA`	2	A	syn¹		0	--	--	--	--
rs112998035^1,2	C	unknown	37731871(+)	`GCTNNC/TGCTTC`	2	R	syn¹		0	--	--	--	--
rs74681492^1,2	C,	unknown	37731885(+)	`TTCCCC/TTGTGA`	2	P L	mis¹		0	--	--	--	--
rs111501952^1,2	C,	unknown	37731896(+)	`TTCTCG/ATTGGC`	2	/I /V	mis¹		1		NA	4550
rs113431708^1,2	C	unknown	37731996(+)	`CATACA/GAGATT`	2	Q R	mis¹		0	--	--	--	--
rs35507033^1,2	C,F,	unknown	37735412(+)	`GATCCG/AAGATC`	2	/Q /R	mis¹		5		NA EU	5723
rs33958906^1,2	C,F,	unknown	37735495(+)	`ATGTGC/TCAATT`	2	P S	mis¹		5		NA EU	5954
rs17491187^1,2	C	unknown	37735537(+)	`TACAAA/CTAGTG`	2	I L	mis¹ ese³		0	--	--	--	--
rs721710^1,2	C,H	unknown	37736702(+)	`CTTTGT/AGGAAC`	2	/E /V	mis¹ ese³		7		NA NS EA	504
rs1427263^1,2	C,F,O,A,H,	unknown	37741468(-)	`ATAATT/GCCCTT`	2	/G	syn¹		31		NA NS EA WA CSA EU	7905
rs11176013^1,2	C,F,A,H,	unknown	37741507(+)	`TCAAAG/AAAAAG`	2	/K	syn¹ trp³		26		NS EA NA WA CSA EU	7601
rs35303786^1,2	C,F,	unknown	37741533(+)	`CTACAT/CGTCAC`	2	/T /M	mis¹		4		NA EU	5269
rs11564148^1,2	C,F,H,	unknown	37741535(+)	`ACATGA/TCACAG`	2	T S	mis¹ ese³		27		EA NA NS WA EU	6984
rs111503579^1,2	C,	unknown	37741555(+)	`CTCCTA/GGAAAA`	2	L	syn¹		0	--	--	--	--
rs79909111^1,2	C,F,	unknown	37742617(+)	`CTTTCA/C/GGGGAG`	3	S	syn¹		1		NA	4510
rs11564176^1,2	C,F,H	unknown	37743474(+)	`TAGAAA/C/TGAGCA`	3	R *	syn¹ stg¹		10		NS EA NA	1132
rs72547979^1,2	C	unknown	37743475(+)	`AGAACG/AAGCAC`	2	/Q /R	mis¹		2		CA	520
rs145364431^1,2	C	unknown	37743484(+)	`ACTTCA/G/TCCCAA`	3	H R L	mis¹		0	--	--	--	--
rs111910483^1,2	C	unknown	37743823(+)	`GGGTTA/G/TCTGGA`	3	L F	syn¹ mis¹		0	--	--	--	--
rs10878371^1,2	C,F,A,H,	unknown	37743895(+)	`GATGGC/TGAAGA`	2	G	syn¹		29		NA NS EA WA CSA EU	8365
rs72547980^1,2	C,F	unknown	37743905(+)	`AACATC/AAAAAA`	2	/K /Q	mis¹		3		CA EU	1841
rs35602796^1,2	C,	unknown	37744693(+)	`TATTAT/CGTTGA`	2	/T /M	mis¹		3		NA	124
rs77428810^1,2	C	unknown	37756469(+)	`GATTCA/GTCCCC`	2	H R	mis¹		0	--	--	--	--
rs34015634^1,2	C	unknown	37761818(+)	`CATCAT/CTGCAA`	2	/T /I	mis¹		1		NA	2
rs78029637^1,2	C	unknown	37761874(+)	`TAAAAA/TCATCA`	2	T S	mis¹		0	--	--	--	--
rs111739194^1,2	C	unknown	37768267(+)	`TACTA-/CTCTA TGACA`	2	* LY	fra¹		0	--	--	--	--
rs33995883^1,2	C,F,	unknown	37768321(+)	`TTCCAA/GATGAG`	2	N D	mis¹		6		NS NA EU	5917
rs12423862^1,2	C,F,H	unknown	37769922(+)	`AAATCC/TTCAAG`	2	P L	mis¹ ese³		11		NS EA NA	1208
rs112048985^1,2	C	unknown	37773010(+)	`TAGTCA/TGTCTG`	2	S C	mis¹		0	--	--	--	--
rs111691891^1,2	C	unknown	37773017(+)	`TCTGAC/TGAGAC`	2	T M	mis¹		1		CSA	2
rs201271001^1,2	C	unknown	37773023(+)	`GAGACA/GCATTT`	2	H R	mis¹		0	--	--	--	--
rs34869625^1,2	C,F	unknown	37773105(+)	`CTGGGC/ATGTGG`	2	/G	syn¹		2		NA EU	5873
rs72547981^1,2	C	unknown	37773118(+)	`ACACCA/C/GACAGA`	3	N H D	mis¹		2		CA	520
rs35658131^1,2	C,	unknown	37773161(+)	`AGGATA/GCACTT`	2	Y C	mis¹		1		NA	4540
rs12581902^1,2	C,H	unknown	37777525(+)	`AAAAAA/TTTTTC`	2	N I	mis¹		5		NS EA NA	420
rs113511708^1,2	C	unknown	37784831(+)	`CATAAC/TAGTGG`	2	T I	mis¹		1		NA	4530
rs33962975^1,2	C,F,	unknown	37784919(+)	`TGTGGA/GCTAAT`	2	G	syn¹		7		NS NA CSA EU	6050
rs79546190^1,2	C	unknown	37784932(+)	`ACTGCG/ATGCAC`	2	/M /V	mis¹		1		NA	4528
rs78964014^1,2	C	unknown	37786234(+)	`CTAGGA/GAGGTA`	2	K E	mis¹		0	--	--	--	--
rs3761863^1,2	C,F,A,H,	unknown	37786241(-)	`TTACCG/ATTACC`	2	/T /M	mis¹		32		EA NS NA WA CSA EU	9908
rs60545352^1,2	C	unknown	37786275(+)	`AAAATA/GTCTTA`	2	I M	mis¹		0	--	--	--	--
rs55633591^1,2	C	unknown	37788441(+)	`GGAAAA/GATACT`	2	N D	mis¹		0	--	--	--	--
rs34778348^1,2	C,	other	37784917(+)	`TCTGTG/AGACTA`	2	/R /G	mis¹		3		NA	4540
rs17490599^1,2	C,F,H,	--	37644726(+)	`GGAGGT/AAGGTT`	1	--	us2k¹ tfbs³		5		NS EA WA	536
rs7294619^1,2	C,F,A,H,	--	37645013(+)	`AATTAT/CCAATT`	1	--	us2k¹		13		NS EA NA WA	1076
rs12304648^1,2	C,F,	--	37645032(+)	`GTTATC/TGTTAT`	1	--	us2k¹		1		WA	118
rs7136502^1,2	C,F,H,	--	37645042(+)	`TCTCTA/GTCTCC`	1	--	us2k¹		4		NS NA	242
rs1472115^1,2	C,F,H,	--	37645432(-)	`TCAATC/ACTGAT`	1	--	us2k¹		5		MN NS EA	600
rs10878226^1,2	C,F,H,	--	37645503(+)	`TCTTTG/CTAAGT`	1	--	us2k¹		12		NS EA NA WA	792
rs80033778^1,2	C,	--	37645571(+)	`ACAATA/GTTCTT`	1	--	us2k¹		0	--	--	--	--
rs111797474^1,2		--	37645599(+)	`AAAAAC/TACATT`	1	--	us2k¹		2		CSA WA	120
rs73276850^1,2	C,	--	37645667(+)	`TTGGGG/ATTATA`	1	--	us2k¹		1		WA	2
rs1491945^1,2	C,H,	--	37646223(-)	`CAGTGC/TGCAGC`	1	--	us2k¹		0	--	--	--	--
rs58621298^1,2	C,	--	37646497(+)	`CGTTTC/TTGGGG`	1	--	us2k¹		1		WA	2
rs112643657^1,2	C,	--	37646621(+)	`CGCGGG/CGAGCG`	1	--	us2k¹		1		WA	2
rs41286472^1,2	C	--	37646692(+)	`TTCCCA/TGAGCA`	1	--	ut5¹		0	--	--	--	--
rs41286470^1,2	C	--	37646724(+)	`GCGGCA/GGGTTG`	1	--	ut5¹		0	--	--	--	--
rs142399623^1,2	C	--	37646789(+)	`GAAACT/CCTGAA`	2	/T	syn¹		1		NA	4546
rs77507662^1,2	C,	--	37646874(+)	`TGCTGG/TTGTTC`	2	V L	mis¹		0	--	--	--	--
rs80220210^1,2	F,	--	37646995(+)	`CAAACC/ACGGAC`	1	--	int¹		1		EA	120
rs77259873^1,2	C,	--	37647117(+)	`GAGGGG/TGTGCT`	1	--	int¹		0	--	--	--	--
rs150422099^1,2	C,F	--	37647193(+)	`AAAAAT/AATCCA`	2	/K /N	mis¹		2		NA EU	5859
rs17465723^1,2	F,H	--	37647399(+)	`GGAATA/GTTGTT`	1	--	int¹		4		NS EA	416
rs1491944^1,2	C,F,H,	--	37647492(-)	`ATCCAT/CACTGT`	1	--	int¹		7		NS EA NA WA	540
rs17465730^1,2	C,H,	--	37647523(+)	`AATGGG/ATTCGG`	1	--	int¹		4		NS EA	418
rs17465737^1,2	C,F,H,	--	37647568(+)	`GTGTTT/CAGACT`	1	--	int¹		4		NS EA	418
rs28365208^1,2	F,H	--	37647637(+)	`AGTTTG/TGAAAA`	1	--	int¹ trp³		4		NS EA	416
rs28365209^1,2	H	--	37647753(+)	`CCTTGT/AAGTAT`	1	--	int¹		4		NS EA	416
rs17465744^1,2	C,F,H,	--	37647818(+)	`AAATGC/GATGTA`	1	--	int¹		4		NS EA	414
rs17490613^1,2	H	--	37648166(+)	`ATGTTT/GATCTC`	1	--	int¹		4		NS EA	410
rs17490620^1,2	C,F,H,	--	37648208(+)	`ATCTAG/ACTTCT`	1	--	int¹		5		NS EA WA	534
rs17490627^1,2	H	--	37648219(+)	`TTGATA/GTGAGG`	1	--	int¹		4		NS EA	404
rs28365210^1,2	F,H	--	37648225(+)	`TGAGGA/GCATTT`	1	--	int¹		4		NS EA	402
rs28365211^1,2	F,H	--	37648226(+)	`GAGGAC/AATTTA`	1	--	int¹		4		NS EA	412
rs17443380^1,2	F,H	--	37648317(+)	`AAACCA/GAACCA`	1	--	int¹		3		EA NS	298
rs17443387^1,2	C,F,H,	--	37648446(+)	`ACGTCA/TTCCCT`	1	--	int¹		4		NS EA	416
rs17465751^1,2	C,F,H,	--	37648692(+)	`TTGTCC/TGGAGT`	1	--	int¹		4		NS EA NA	406
rs76292542^1,2	C,	--	37649098(+)	`TGGTAA/CCCACC`	1	--	int¹		0	--	--	--	--
rs11175645^1,2	F,H,	--	37649703(+)	`TTTGGA/GTATAT`	1	--	int¹		6		NS EA WA NA	656
rs60351253^1,2	C	--	37650352(+)	`TCTGAG/AATGTA`	1	--	int¹		1		NA	2
rs77924679^1,2	C,F,	--	37650409(+)	`TGGATC/TTAGTT`	1	--	int¹		1		EA	120
rs113396001^1,2		--	37650481(+)	`TTACCG/AGATGT`	1	--	int¹		1		CSA	2
rs75931141^1,2	C,	--	37650493(+)	`TTACTG/TTCATA`	1	--	int¹		0	--	--	--	--
rs78583245^1,2	C,F,	--	37650616(+)	`GAATTC/TGCAAG`	1	--	int¹		1		NA	120
rs11175655^1,2	C,F,H,	--	37651539(+)	`TGTAGG/ATACAG`	1	--	int¹		15		NS EA NA WA	1890
rs11175657^1,2	H	--	37651606(+)	`CACCAG/AAAGCT`	1	--	int¹		4		NS EA	418
rs1352875^1,2	A	--	37651617(-)	`ACCTTC/TTGAAC`	1	--	int¹		2		NA	4
rs60243515^1,2	C,	--	37651651(+)	`AAAGTC/TTTGAT`	1	--	int¹		2		WA	120
rs74883359^1,2	C,F,	--	37651711(+)	`TCAACG/ATCTGT`	1	--	int¹		1		NA	120
rs1352874^1,2	F,H	--	37651774(-)	`AATTTC/TTGATA`	1	--	int¹		1		NS	112
rs73106332^1,2	C,	--	37651896(+)	`TAATCA/TTTTTT`	1	--	int¹		0	--	--	--	--
rs79751724^1,2	C,	--	37652045(+)	`TATCCA/CAAAAT`	1	--	int¹		0	--	--	--	--
rs11175658^1,2	C,F,H,	--	37652123(+)	`ATACAA/GTCTGG`	1	--	int¹		7		NS EA NA WA	658
rs79123781^1,2	C,	--	37652301(+)	`TTTTTG/TACCAT`	1	--	int¹		0	--	--	--	--
rs7974320^1,2	C,F,H,	--	37652652(+)	`TCTTTC/TTCTTT`	1	--	int¹ trp³		7		NS EA NA WA	540
rs78076305^1,2	C,	--	37652731(+)	`TTACTG/TGGGGA`	1	--	int¹		0	--	--	--	--
rs74324737^1,2	C,	--	37652894(+)	`CAGGTG/ACAGAG`	1	--	int¹		3		NA WA	240
rs9705559^1,2	A	--	37653192(+)	`acaaaA/Cccaaa`	1	--	int¹		0	--	--	--	--
rs11175659^1,2		--	37653220(+)	`GAAAAA/GAAAAG`	1	--	int¹ trp³		0	--	--	--	--
rs112395350^1,2	C	--	37653846(+)	`GCTCTG/ATTAAC`	1	--	int¹		2		CSA	3
rs141177841^1,2	C	--	37653974(+)	`TTGGAA/GATGAT`	2	N D	mis¹		1		NA	4552
rs201439315^1,2	C	--	37653999(+)	`TGTTCA/CCCAGT`	2	H P	mis¹		1		EU	1321
rs1352877^1,2	C,F,H,	--	37654195(-)	`AATGTT/ATGCTT`	1	--	int¹		14		NS EA NA	1536
rs75524445^1,2	F,	--	37654386(+)	`TCTGTA/GAGTAG`	1	--	int¹		1		EA	120
rs78645544^1,2	C,	--	37654586(+)	`TTCTTA/TGATGA`	1	--	int¹		0	--	--	--	--
rs79895559^1,2	C,F,	--	37655247(+)	`GGAATT/GACTCA`	1	--	int¹		1		WA	118
rs11175663^1,2	C,F,H,	--	37655305(+)	`GGGTGA/GTAATT`	1	--	int¹		5		NS EA WA	536
rs75275684^1,2	C,F,	--	37655321(+)	`GAAGTC/ACAAAG`	1	--	int¹		1		EA	120
rs112641618^1,2		--	37655386(+)	`CTGTAC/TAAACC`	1	--	int¹		2		CSA WA	120
rs17484093^1,2	F,H	--	37655469(+)	`ACTTTG/TTTCAT`	1	--	int¹		4		NS EA	416
rs11175666^1,2	C,F,H,	--	37656249(+)	`ctcggC/Tgtccc`	1	--	int¹		4		EA NS NA	300
rs113574761^1,2	C,	--	37656283(+)	`AGCAAC/TGGCCA`	1	--	int¹		0	--	--	--	--
rs112766989^1,2	C,F	--	37657240(+)	`TAACTA/CCAGAT`	1	--	int¹		2		CSA	5
rs74076179^1,2	C,F	--	37657413(+)	`TGTGTG/TTTTTT`	1	--	int¹		2		WA	4
rs11564154^1,2	C,F,H,	--	37657453(+)	`GTAGCT/ATGATT`	1	--	int¹		12		NS EA NA WA	1418
rs28365212^1,2	H	--	37657732(+)	`GCCCTT/CGCCAT`	1	--	int¹		6		NS EA NA	422
rs74700091^1,2	C,F,	--	37658414(+)	`ACCATG/ATTGTA`	1	--	int¹		1		WA	118
rs74076180^1,2	C,	--	37658792(+)	`TGTGCG/AGAAGG`	1	--	int¹		2		WA	120
rs10878244^1,2	C,F,H,	--	37659425(+)	`CTAGGG/ACAGTT`	1	--	int¹		28		NS EA NA WA	3014
rs10878246^1,2	C,F,H,	--	37659912(+)	`TTCATT/GCGTGG`	1	--	int¹		20		NA NS EA WA	2278
rs17519531^1,2	C,F,H,	--	37660574(+)	`TAAAGC/TTAGAT`	1	--	int¹		5		NS EA WA	534
rs12814962^1,2	H	--	37660994(+)	`AATTAG/CGATAA`	1	--	int¹		4		NS EA	416
rs17519552^1,2	C,F,H,	--	37661131(+)	`CTGGAG/AGTAGA`	1	--	int¹		6		NS EA CSA WA	506
rs73106342^1,2	C,F,	--	37661227(+)	`AATTTC/TTGATT`	1	--	int¹		1		WA	118
rs17490678^1,2	C,F,H,	--	37661388(+)	`TATTAT/CAGGGA`	1	--	int¹		4		NS EA	416
rs11564187^1,2	C,F,H,	--	37662016(+)	`CAACTA/GTAATG`	1	--	int¹		18		NA NS EA WA	2104
rs17484141^1,2	C,F,H,	--	37662287(+)	`TATATC/ATCATT`	1	--	int¹		4		NS EA	416
rs28365215^1,2	C,	--	37662289(+)	`TATCTA/CATTCT`	1	--	int¹		0	--	--	--	--
rs11564210^1,2	C,F,H,	--	37662632(+)	`TGTGAC/TCTGAA`	1	--	int¹		14		NS EA NA	1372
rs17490692^1,2	C,F,H,	--	37662669(+)	`GCAGTG/TGGCAT`	1	--	int¹		4		NS EA	418
rs13328957^1,2	C,F,H,	--	37662728(+)	`AGACAA/GAAGTA`	1	--	int¹		11		NS EA NA CSA WA	1304
rs17519566^1,2	C,F,H,	--	37662764(+)	`GTGTGC/TGTGCA`	1	--	int¹		5		NS EA WA	534
rs11564153^1,2	C,F,H,	--	37662804(+)	`ATCCCC/TAAATA`	1	--	int¹		9		NA NS EA	680
rs17519573^1,2	C,F,H,	--	37663169(+)	`CTACAG/AGATAT`	1	--	int¹		7		NS EA NA WA	658
rs73106345^1,2	C,	--	37663206(+)	`TCATCC/TTCACA`	1	--	int¹		1		NA	120
rs79623608^1,2		--	37663805(+)	`AAGTCT/CATTGT`	1	--	int¹		1		WA	118
rs12814307^1,2	H	--	37664357(+)	`cctccA/Ccaatg`	1	--	int¹		4		NS EA	418
rs17519580^1,2	C,F,H,	--	37664993(+)	`AGTCCT/CACACC`	1	--	int¹		5		NS EA WA	534
rs73106346^1,2	C,F,	--	37665124(+)	`GTATGC/TATATT`	1	--	int¹		1		WA	118
rs113160214^1,2		--	37665490(+)	`CAAACT/CGTTCT`	1	--	int¹		2		CSA WA	120
rs76645388^1,2	C,F,	--	37665853(+)	`TTCATG/ATTTCT`	1	--	int¹		1		WA	118
rs12425063^1,2	H	--	37666391(+)	`ggataG/Acattg`	1	--	int¹		4		NS EA	414
rs17461637^1,2	F,H	--	37666842(+)	`GTTTGT/GTAAAC`	1	--	int¹		3		NS EA	292
rs1388599^1,2	C,F,O,H,	--	37667990(-)	`ATCTAA/GTAAAT`	1	--	int¹		9		NA NS EA	556
rs73106349^1,2	C,F,	--	37668188(+)	`TCTAAA/GCCAAC`	1	--	int¹		1		WA	118
rs73276871^1,2	C,	--	37668987(+)	`GATAAC/TGTTTT`	1	--	int¹		1		WA	2
rs74076186^1,2	C,	--	37669463(+)	`CAAGAT/ATATGT`	1	--	int¹		2		WA	120
rs74076187^1,2	C,	--	37669617(+)	`TGTACA/GAAGTG`	1	--	int¹		2		WA	120
rs28365217^1,2	H	--	37669624(+)	`AGTGGC/GTGATA`	1	--	int¹		2		NS	224
rs10450777^1,2	C,F,H,	--	37670141(+)	`ACCTCA/CAGTAA`	1	--	int¹		7		NS EA NA WA	532
rs79166784^1,2		--	37670431(+)	`TGTGGA/CGAATT`	1	--	int¹		0	--	--	--	--
rs73106354^1,2	C,F,	--	37670800(+)	`GGTATA/GAAAAG`	1	--	int¹		1		NA	120
rs12321951^1,2	C,F,H,	--	37671799(+)	`GGGTGG/AATCAC`	1	--	int¹		6		NS EA NA	420
rs17519594^1,2	F,H	--	37671827(+)	`ACCAGC/TCTGGC`	1	--	int¹		1		NS	120
rs17443421^1,2	H	--	37672514(+)	`AATAAT/GCCTCC`	1	--	int¹ trp³		4		NS EA	414
rs146562427^1,2	C	--	37672868(+)	`TTACAA/GAGCAT`	2	K R	mis¹		1		NA	4518
rs144975499^1,2	C,F	--	37672899(+)	`AAGCAC/TGTGCA`	2	H	syn¹		1		NA	4508
rs199611108^1,2	C	--	37672993(+)	`TAATCC/TAGGAG`	1	--	int¹		1		EU	863
rs73106357^1,2	C,	--	37673319(+)	`ATTCAC/TGAATC`	1	--	int¹		0	--	--	--	--
rs77011528^1,2		--	37673597(+)	`ACATCA/TTAAGA`	1	--	int¹		0	--	--	--	--
rs11564186^1,2	C,F,H,	--	37673967(+)	`TTAGGG/ATAAGG`	1	--	int¹		9		NA NS EA WA	798
rs12422796^1,2	C,F,H,	--	37674263(+)	`GTTAGG/AATTTA`	1	--	int¹		5		NS EA NA	424
rs11612852^1,2	H	--	37674891(+)	`TTCTCA/CCATTA`	1	--	int¹		4		NS EA	414
rs17519615^1,2	C,F,H,	--	37674978(+)	`GTACCA/GTGATC`	1	--	int¹		4		NS EA	412
rs1491937^1,2	H,	--	37675203(-)	`GGGCCG/AGGCAC`	1	--	int¹		4		NS EA	418
rs1463717^1,2	C,F,A,H,	--	37675374(-)	`GGAACC/AATGTA`	1	--	int¹		5		NS EA NA	536
rs11564130^1,2	H	--	37675405(+)	`TTCATA/GGAAAT`	1	--	int¹		4		NS EA	418
rs17465807^1,2	F,H	--	37676372(+)	`TTTTGT/AATTGT`	1	--	int¹		4		NS EA	412
rs2708447^1,2	C,F,H,	--	37676863(+)	`TAAGAC/TCTGCA`	1	--	int¹		7		NS EA NA	542
rs17519629^1,2	H	--	37677454(+)	`TATGTG/AATTTC`	1	--	int¹		3		NS EA	296
rs17490762^1,2	H	--	37677543(+)	`ATGTTT/CCTTTT`	1	--	int¹ trp³		4		NS EA	402
rs17490769^1,2	F,H	--	37677544(+)	`TGTTTC/TTTTTT`	1	--	int¹ trp³		4		NS EA	418
rs1907633^1,2	C,F,H,	--	37678080(-)	`NNNNAG/AATATG`	1	--	int¹		7		NS EA NA WA	658
rs17484169^1,2	F,H	--	37678121(+)	`AATAAC/ATGTAA`	1	--	int¹		3		EA NS	280
rs1491936^1,2	C,F,O,H,	--	37678178(-)	`TCTATA/GTATGC`	1	--	int¹		10		NA NS EA WA	790
rs1907632^1,2	C,F,O,H,	--	37678231(-)	`GCCTTC/TAGCTG`	1	--	int¹		20		NA NS EA WA	2280
rs11564185^1,2	C,F,H,	--	37678446(+)	`GGAGAC/TCATTA`	1	--	int¹		8		NA NS EA	678
rs11564209^1,2	C,F,H,	--	37678604(+)	`ATGACA/TTGTGT`	1	--	int¹		9		NA NS EA	678
rs41286456^1,2	C	--	37678747(+)	`CTTTCA/GTATCT`	1	--	int¹		0	--	--	--	--
rs79656150^1,2	C,	--	37678879(+)	`GGCTGG/TAAAAT`	2	W C	mis¹		0	--	--	--	--
rs11564272^1,2	H	--	37678977(+)	`TCAAGC/TATATT`	1	--	int¹		4		NS EA	418
rs10506149^1,2	C,F,H,	--	37678980(+)	`AGCATA/GTTTCT`	1	--	int¹		15		NS NA EA WA	788
rs76603654^1,2	C,F,	--	37679037(+)	`CATTTT/CGCAAT`	1	--	int¹		1		WA	118
rs17465849^1,2	H	--	37679217(+)	`ATTGTG/TTGTGT`	1	--	int¹		4		NS EA	390
rs11564208^1,2	C,F,H,	--	37679275(+)	`CACAAC/TGAATA`	1	--	int¹		7		NS EA CSA WA NA	658
rs17461664^1,2	C,	--	37679701(+)	`GATTAG/TGATAA`	1	--	int¹		3		NA	124
rs28365220^1,2	H	--	37679915(+)	`TTTTTG/AAACAC`	1	--	int¹		3		NS EA	298
rs17519657^1,2	C,F,H,	--	37680074(+)	`TCTTAC/TGTAAA`	1	--	int¹		5		NS EA WA	534
rs2046928^1,2	C,F,H,	--	37680123(+)	`CTGACA/GGTGTG`	1	--	int¹		11		MN NS EA NA CSA WA	847
rs73276887^1,2	C,	--	37680547(+)	`TACCTC/TATAAG`	1	--	int¹		1		WA	2
rs17443497^1,2	F,H	--	37680572(+)	`TAATCT/GGGAAG`	1	--	int¹		4		NS EA	416
rs76709504^1,2	C,F,	--	37680725(+)	`AATAAC/TACCTA`	1	--	int¹		1		WA	118
rs73276892^1,2	C,	--	37680805(+)	`ATTCCC/TGGATT`	1	--	int¹		1		WA	2
rs17443504^1,2	C,F,H	--	37680967(+)	`ATTGAA/C/GTCAGA`	1	--	int¹		4		NS EA	416
rs28903073^1,2	C,F,	--	37681239(+)	`TTTCTA/GTCGAC`	1	--	int¹		4		EU NA	126
rs17443511^1,2	H	--	37681396(+)	`TAAGGA/TGGGTG`	1	--	int¹		4		NS EA	404
rs17443518^1,2	H	--	37681398(+)	`AGGAGG/CGTGTT`	1	--	int¹		4		NS EA	418
rs73108321^1,2	C,F,	--	37681418(+)	`TAATTC/ATTTTC`	1	--	int¹		1		WA	118
rs17490796^1,2	C,F,H,	--	37681604(+)	`ACCCAC/TCTTTA`	1	--	int¹		5		NS EA WA	536
rs73276895^1,2	C,	--	37681637(+)	`ACCTTG/ATTTGT`	1	--	int¹		1		WA	2
rs17465877^1,2	C,F,H,	--	37681700(+)	`TAAGTG/ACTTCT`	1	--	int¹		3		NS EA	282
rs17490810^1,2	C,F,H,	--	37682009(+)	`CGGGGG/ATGAGT`	1	--	int¹		5		NS EA WA	534
rs17484176^1,2	F,H	--	37682102(+)	`CAGTGC/TTAAAA`	1	--	int¹		3		NS EA	294
rs113752270^1,2	C,	--	37682139(+)	`CAACCC/TAAGTT`	1	--	int¹		2		CSA WA	120
rs78255436^1,2	C,F,	--	37682487(+)	`AGTTAT/CATAGG`	1	--	int¹		1		WA	118
rs76140903^1,2	F,	--	37682545(+)	`CAAGGA/GCAGAG`	1	--	int¹		1		EA	120
rs17465891^1,2	H	--	37682564(+)	`AGTCAT/ATTTTT`	1	--	int¹		2		EA NS	178
rs11564152^1,2	C,F,H,	--	37682602(+)	`ATTCAA/GTCAGT`	1	--	int¹		8		NA NS EA	444
rs11175766^1,2	C,F,H,	--	37682745(+)	`AACAAT/CAAAAA`	1	--	int¹		8		NS EA NA CSA WA	660
rs11564121^1,2	C,F,H,	--	37682974(+)	`TATGGG/ATGCCC`	1	--	int¹		13		NA NS EA	1280
rs17443539^1,2	H	--	37683031(+)	`TTTATA/GAGCAT`	1	--	int¹		4		NS EA	404
rs17443546^1,2	F,H	--	37683415(+)	`TCTTTC/AAATCT`	1	--	int¹		3		NS EA	280
rs17519671^1,2	C,F,H,	--	37683838(+)	`TCTAAC/TAGCAC`	1	--	int¹		7		NS EA NA WA	536
rs73276896^1,2	C,	--	37684377(+)	`TGATAC/TACAGA`	1	--	int¹		1		WA	2
rs17443552^1,2	C,F,H,	--	37684406(+)	`CCAGAC/ACACAC`	1	--	int¹		10		NS EA NA WA	774
rs11564113^1,2	C,F,H,	--	37685597(+)	`AGTGAA/CANNNN`	1	--	int¹		8		NS EA NA	676
rs80119436^1,2		--	37685603(+)	`AAGATA/GTGTAC`	1	--	int¹		2		CSA WA	120
rs17465939^1,2	H	--	37685755(+)	`TGCTGG/AGTACT`	1	--	int¹		3		NS EA	296
rs17465946^1,2	C,	--	37685884(+)	`CAGTGA/GCCCAC`	1	--	int¹		0	--	--	--	--
rs7974037^1,2	C,	--	37685933(+)	`GATCAC/TGAGGT`	1	--	int¹		2		NA	4
rs17461692^1,2	C,	--	37686145(+)	`GACTTA/C/TGTCTC`	1	--	int¹		1		CSA	2
rs17519713^1,2	C,	--	37686146(+)	`ACTTCG/ATCTCA`	1	--	int¹		2		WA	120
rs17443594^1,2	C,H,	--	37686220(+)	`TCATTG/CTTCTC`	1	--	int¹		4		NS EA	412
rs17443600^1,2	C,F,H,	--	37686596(+)	`TTAAAA/TATTCA`	1	--	int¹		5		NS EA NA	418
rs17443607^1,2	C,F,H,	--	37686693(+)	`GGCAAG/TAATTT`	1	--	int¹		9		NS EA NA	532
rs75895732^1,2	C,	--	37686778(+)	`TTAGAC/AGATAA`	1	--	int¹		1		NA	2
rs11175780^1,2	C,F,H,	--	37686825(+)	`TAAGCC/TGNNNN`	1	--	int¹		17		NS EA NA CSA WA	2220
rs112290054^1,2	C,	--	37686826(+)	`AAGCCG/AGTTGT`	1	--	int¹		1		WA	2
rs17465960^1,2	H	--	37686854(+)	`CCTTGG/TTTCTT`	1	--	int¹		2		NS	240
rs17519720^1,2	H	--	37686928(+)	`AAGAAT/AATTTT`	1	--	int¹		4		NS EA	414
rs73263847^1,2	C,	--	37687007(+)	`GACAGC/TGTAAA`	1	--	int¹		1		WA	2
rs73263851^1,2	C,	--	37687168(+)	`TAAGTG/ATCTGA`	1	--	int¹		1		WA	2
rs17490858^1,2	C,	--	37687337(+)	`GAGATA/GTAGGC`	1	--	int¹		0	--	--	--	--
rs7313276^1,2	C,H,	--	37687378(+)	`atgccG/Tcatat`	1	--	int¹		3		NS NA	116
rs11175786^1,2	C,H,	--	37687598(+)	`TAAGCA/TATACT`	1	--	int¹		6		NS EA NA	420
rs17490872^1,2	C,	--	37687636(+)	`TTCATA/GTCTAA`	1	--	int¹		0	--	--	--	--
rs111341533^1,2	C	--	37688355(+)	`GAACAG/ATGAGA`	1	--	int¹		1		WA	2
rs73263859^1,2	C,	--	37688816(+)	`AGTACG/ATAGAG`	1	--	int¹		1		WA	2
rs17519762^1,2	C,F,H,	--	37688939(+)	`AGAAGC/TCTAAG`	1	--	int¹		6		NS EA WA	536
rs79833858^1,2	C,F,	--	37688966(+)	`CAGTCG/AGGAGC`	1	--	int¹		1		WA	118
rs17466002^1,2	F,H	--	37689366(+)	`AGTTCC/AAAATA`	1	--	int¹		4		NS EA	408
rs73108336^1,2	C,	--	37691426(+)	`GCACCC/TTGGAC`	1	--	int¹		2		CSA WA	120
rs76705175^1,2	F,	--	37691976(+)	`TGAAGT/CGTTTG`	1	--	int¹

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LRRK2 Gene

leucine-rich repeat kinase 2

Aliases
for LRRK2 gene

Summaries
for LRRK2 gene

Genomic Views
for LRRK2 gene

Proteins
for LRRK2 gene

Protein Domains /
Families
for LRRK2 gene

Function
for LRRK2 gene

Pathways & Interactions
for LRRK2 gene

Drugs & Compounds
for LRRK2 gene

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for LRRK2 gene

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for LRRK2 gene

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for LRRK2 gene

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for LRRK2 gene

Genomic Variants
for LRRK2 gene

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Export list of displayed genes

LRRK2 Gene

leucine-rich repeat kinase 2

Aliasesfor LRRK2 gene

Summariesfor LRRK2 gene

Genomic Viewsfor LRRK2 gene

Proteinsfor LRRK2 gene

Protein Domains /Familiesfor LRRK2 gene

Functionfor LRRK2 gene

Pathways & Interactionsfor LRRK2 gene

Drugs & Compoundsfor LRRK2 gene

Transcriptsfor LRRK2 gene

Expression for LRRK2 gene

Orthologsfor LRRK2 gene

Paralogsfor LRRK2 gene

Genomic Variantsfor LRRK2 gene

Aliases
for LRRK2 gene

Summaries
for LRRK2 gene

Genomic Views
for LRRK2 gene

Proteins
for LRRK2 gene

Protein Domains /
Families
for LRRK2 gene

Function
for LRRK2 gene

Pathways & Interactions
for LRRK2 gene

Drugs & Compounds
for LRRK2 gene

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for LRRK2 gene

Expression
for LRRK2 gene

Orthologs
for LRRK2 gene

Paralogs
for LRRK2 gene

Genomic Variants
for LRRK2 gene