Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LRRK1 Gene

protein-coding   GIFtS: 56
GCID: GC15P101459

Leucine-Rich Repeat Kinase 1

  See LRRK1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Leucine-Rich Repeat Kinase 11 2
RIPK62
Roco12
Leucine-Rich Repeat Serine/Threonine-Protein Kinase 12
EC 2.7.11.13
KIAA17903

External Ids:    HGNC: 186081   Entrez Gene: 797052   Ensembl: ENSG000001542377   OMIM: 6109865   UniProtKB: Q38SD23   

Export aliases for LRRK1 gene to outside databases

Previous GC identifers: GC15P099297 GC15P099380 GC15P077581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for LRRK1 Gene:
LRRK1 (leucine-rich repeat kinase 1) is a protein-coding gene. Diseases associated with LRRK1 include parkinson's disease. GO annotations related to this gene include protein serine/threonine kinase activity and identical protein binding. An important paralog of this gene is LRRK2.

Gene Wiki entry for LRRK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRK1 gene promoter:
         AML1a   p300   LCR-F1   Tal-1beta   MEF-2A   Pax-3   HOXA5   aMEF-2   TGIF   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for LRRK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

LRRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRK1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P101459:  view genomic region     (about GC identifiers)

Start:
101,459,420 bp from pter      End:
101,610,317 bp from pter
Size:
150,898 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LRRK1_HUMAN, Q38SD2 (See protein sequence)
Recommended Name: Leucine-rich repeat serine/threonine-protein kinase 1  
Size: 2015 amino acids; 225393 Da
Cofactor: Magnesium or manganese
Subunit: Homodimer
Sequence caution: Sequence=AAY67799.1; Type=Miscellaneous discrepancy; Note=The cDNA contains a duplication of
exon 3; Sequence=BAB15547.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC85472.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6NVH5 Q6NYC0 Q6ZNL9 Q6ZNM9 Q96JN5 Q9H5S3
Alternative splicing: 2 isoforms:  Q38SD2-1   Q38SD2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRRK1: NX_Q38SD2

Explore proteomics data for LRRK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LRRK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078928.3  
    ENSEMBL proteins: 
     ENSP00000373600   ENSP00000435148   ENSP00000433268   ENSP00000433069   ENSP00000431668  
     ENSP00000436672   ENSP00000284395  

    LRRK1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LRRK1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LRRK1
    GenScript Custom Purified and Recombinant Proteins Services for LRRK1
    Novus Biologicals LRRK1 Proteins
    Novus Biologicals LRRK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRRK1

     
    Search eBioscience for Proteins for LRRK1 

     
    antibodies-online proteins for LRRK1 (4 products) 

     
    antibodies-online peptides for LRRK1

    LRRK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LRRK1
    OriGene Custom Antibody Services for LRRK1
    Novus Biologicals LRRK1 Antibodies
    Abcam antibodies for LRRK1
    Cloud-Clone Corp. Antibodies for LRRK1
    ThermoFisher Antibodies for LRRK1
    antibodies-online antibodies for LRRK1 (23 products) 

    LRRK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRRK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LRRK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRRK1
    Cloud-Clone Corp. CLIAs for LRRK1
    Search eBioscience for ELISAs for LRRK1 
    antibodies-online kits for LRRK1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: leucine-rich repeat kinase 1
    Leucine-rich repeat kinase (LRRK) family

    Selected InterPro protein domains (see all 11):
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR027417 P-loop_NTPase
     IPR020859 ROC_GTPase
     IPR013684 MIRO-like

    Graphical View of Domain Structure for InterPro Entry Q38SD2

    ProtoNet protein and cluster: Q38SD2

    1 Blocks protein domain: IPB013684 Miro-like

    UniProtKB/Swiss-Prot: LRRK1_HUMAN, Q38SD2
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily
    Similarity: Contains 4 ANK repeats
    Similarity: Contains 13 LRR (leucine-rich) repeats
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Roc domain


    Find genes that share domains with LRRK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRRK1_HUMAN, Q38SD2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Binding of GTP stimulates kinase activity

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI19712061
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with LRRK1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRK1:
     Increased colony dispersion (i 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lrrk1):
     mortality/aging 

    Find genes that share phenotypes with LRRK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lrrk1tm1.1Mjff for LRRK1

       genOway: Develop your customized and physiologically relevant rodent model for LRRK1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LRRK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRK1 (see all 16):
    hsa-miR-374b* hsa-miR-495 hsa-miR-1298 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-4267 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidLRRK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRRK1
    Predesigned siRNA for gene silencing in human, mouse, rat LRRK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRRK1

    Clone
    Products:
         
    OriGene clones in human, mouse for LRRK1 (see all 7)
    OriGene ORF clones in mouse, rat for LRRK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRK1 (NM_024652)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRK1
    Addgene plasmids for LRRK1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRRK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LRRK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LRRK1_HUMAN, Q38SD2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol3
    nucleus2
    endosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with LRRK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRK1
    Interactions:

        Search GeneGlobe Interaction Network for LRRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LRRK1 (Q38SD21, 3 ENSP000003736004) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C9orf163Q8N9P63, ENSP000003463454I2D: score=2 STRING: ENSP00000346345
    LYZP616263, ENSP000002612674I2D: score=2 STRING: ENSP00000261267
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    BCRP112743, ENSP000003035074I2D: score=1 STRING: ENSP00000303507
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with LRRK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRK1

    5 HMDB Compounds for LRRK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LRRK1 gene: 
    NM_024652.3  

    Unigene Cluster for LRRK1:

    Leucine-rich repeat kinase 1
    Hs.407918  [show with all ESTs]
    Unigene Representative Sequence: NM_024652
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388948(uc002bwr.3 uc010usb.2 uc010usc.2) ENST00000534045
    ENST00000527698 ENST00000532029(uc002bwq.1) ENST00000525284 ENST00000531270
    ENST00000525617 ENST00000538064 ENST00000526457(uc002bws.3) ENST00000525395
    ENST00000532145 ENST00000284395
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRRK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRK1 (see all 16):
    hsa-miR-374b* hsa-miR-495 hsa-miR-1298 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-4267 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidLRRK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRRK1
    Predesigned siRNA for gene silencing in human, mouse, rat LRRK1
    Clone
    Products:
         
    OriGene clones in human, mouse for LRRK1 (see all 7)
    OriGene ORF clones in mouse, rat for LRRK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRK1 (NM_024652)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRK1
    Addgene plasmids for LRRK1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRK1
      QuantiTect SYBR Green Assays in human, mouse, rat LRRK1
      QuantiFast Probe-based Assays in human, mouse, rat LRRK1

    Additional mRNA sequence: 

    AB058693.1 AK026772.1 AK054662.1 AK058028.1 AK094556.1 AK130975.1 AK131075.1 AK225575.1 
    BC005408.1 BC018934.1 BC020379.1 BC066655.1 BC068080.1 BC110293.1 BC144705.1 BC146769.1 
    BC171802.1 DQ013130.1 

    10 DOTS entries:

    DT.100751216  DT.100751215  DT.99929164  DT.113762  DT.40128487  DT.95370489  DT.99999678  DT.308471 
    DT.91829562  DT.97779662 

    Selected AceView cDNA sequences (see all 96):

    BE463770 AA781948 CK300098 AK054662 BU428994 AK026772 AK094556 BU166882 
    CF529459 AA282790 AI962086 AK131075 BX097196 BU624641 AW590768 AA742267 
    CA308667 CF529669 BQ187037 AB058693 AW502995 CD742790 AI126719 W60132 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LRRK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22
    SP1:                                                                                                              -     -                       -         
    SP2:                                                                                                              -     -                                 
    SP3:                                                                                                              -                                       
    SP4:                                                                                                                    -                       -         


    ECgene alternative splicing isoforms for LRRK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LRRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGCAGTGA
    LRRK1 Expression
    About this image

    LRRK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407918
        Custom PCR Arrays for LRRK1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRK1
    QuantiTect SYBR Green Assays in human, mouse, rat LRRK1
    QuantiFast Probe-based Assays in human, mouse, rat LRRK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LRRK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrk11 , 5 leucine-rich repeat kinase 11, 5 85.37(n)1
    88.88(a)1
      7 (35.57 cM)5
    2333281  NM_146191.31  NP_666303.31 
     662269125 
    chicken
    (Gallus gallus)
    Aves LRRK11 leucine-rich repeat kinase 1 75.03(n)
    78.18(a)
      415520  XM_003641822.2  XP_003641870.2 
    lizard
    (Anolis carolinensis)
    Reptilia LRRK16
    leucine-rich repeat kinase 1
    76(a)
    1 ↔ 1
    GL343332.1(28519-84291)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.133622 Transcribed sequences 78.96(n)    BX729885.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrrk11 leucine-rich repeat kinase 1 63.15(n)
    60.12(a)
      100332050  XM_002667430.3  XP_002667476.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lrrk6
    Leucine-rich repeat kinase
    14(a)
    1 → many
    3R(16461910-16469856)
    worm
    (Caenorhabditis elegans)
    Secernentea lrk-16
    Protein LRK-1 (lrk-1) mRNA, complete cds
    17(a)
    1 → many
    I(10879766-10894237) WBGene00003068


    ENSEMBL Gene Tree for LRRK1 (if available)
    TreeFam Gene Tree for LRRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LRRK1 gene
    LRRK22  
    6 SIMAP similar genes for LRRK1 using alignment to 8 protein entries:     LRRK1_HUMAN (see all proteins):
    NEK9    PRKCH    MAP3K11    BRAF    MARK4    STK25

    Find genes that share paralogs with LRRK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LRRK1 (see all 3994)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38351221,2
    C--77726167(+) AAAAA-/A/AA  
            
    CAGGT
    1 -- int1 trp32NA 4
    rs782128671,2
    C--101457481(+) TCTCTC/TGTAAC 1 -- us2k12Minor allele frequency- T:0.11CSA WA 120
    rs1179319371,2
    C,F--101457532(+) AGACAT/ACCCAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs46466911,2
    C--101457572(+) TAGGAG/AAAGGA 1 -- us2k13Minor allele frequency- A:0.01NA EA 124
    rs1925630541,2
    --101457606(+) GGAACA/GTGACT 1 -- us2k10--------
    rs1850417861,2
    --101457657(+) TATGCA/GTGTGC 1 -- us2k10--------
    rs121488491,2
    C,F--101457805(+) TTGAAG/AGGGGA 1 -- us2k19Minor allele frequency- A:0.19NA WA CSA EA 370
    rs1890752821,2
    --101457845(+) GGAAGA/GCTGTC 1 -- us2k10--------
    rs1810660101,2
    --101457972(+) CCCACA/CCACCT 1 -- us2k10--------
    rs46466921,2
    C,F--101457974(+) CACCCG/ACCTCA 1 -- us2k113Minor allele frequency- A:0.39NA WA CSA EA 377

    HapMap Linkage Disequilibrium report for LRRK1 (101459420 - 101610317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRRK1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750172CNV Deletion23290073
    esv2668881CNV Deletion23128226
    esv2750170CNV Deletion23290073
    esv1932382CNV Deletion18987734
    esv2750171CNV Deletion23290073
    nsv95032CNV Insertion16902084
    esv1015225CNV Insertion17803354
    nsv516426CNV Loss19592680
    esv33120CNV Loss17666407
    nsv904595CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610986    OMIM disorders: --

    1 disease for LRRK1:    
    About MalaCards
    parkinson's disease

    1 disease from the University of Copenhagen DISEASES database for LRRK1:
    Parkinson's disease

    Find genes that share disorders with LRRK1           About GenesLikeMe

    3 Novoseek inferred disease relationships for LRRK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease, autosomal dominant 87.2 1 17225181 (1)
    parkinson disease 67.9 5 17225181 (2), 17394548 (1), 16243488 (1), 17324517 (1)
    parkinsonism 56.6 4 16243488 (1), 17324517 (1)

    Genetic Association Database (GAD): LRRK1
    Human Genome Epidemiology (HuGE) Navigator: LRRK1 (3 documents)

    Export disorders for LRRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LRRK1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with LRRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. (PubMed id 16243488)1, 2, 9 Korr D.... Weiss B. (Cell. Signal. 2006)
    3. Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway. (PubMed id 17324517)1, 4, 9 Haugarvoll K....Farrer M.J. (Neurosci. Lett. 2007)
    4. Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. (PubMed id 22952686)1, 2 Civiero L.... Taymans J.M. (PLoS ONE 2012)
    5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Roc, a Ras/GTPase domain in complex proteins. (PubMed id 14654223)1, 3 Bosgraaf L. and Van Haastert P.J. (Biochim. Biophys. Acta 2003)
    9. Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. (PubMed id 17225181)1, 9 Taylor J.P....Farrer M.J. (Neurogenetics 2007)
    10. Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. (PubMed id 17394548)1, 9 Greggio E....Cookson M.R. (J. Neurochem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79705 HGNC: 18608 AceView: LRRK1 Ensembl:ENSG00000154237 euGenes: HUgn79705
    ECgene: LRRK1 H-InvDB: LRRK1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1790

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LRRK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LRRK1 gene:
    Search GeneIP for patents involving LRRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LRRK1   OriGene RNAi products in human, mouse, rat for LRRK1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for LRRK1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LRRK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for LRRK1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LRRK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LRRK1   OriGene Custom Protein Services for LRRK1  

     
     
     Block miRNA regulation of human, mouse, rat LRRK1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LRRK1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRK1 Predesigned siRNA for gene silencing in human, mouse, rat LRRK1
     QuantiFast Probe-based Assays in human, mouse, rat LRRK1 QuantiTect SYBR Green Assays in human, mouse, rat LRRK1
     Custom PCR Arrays for LRRK1 Search Chromatin IP Primers for LRRK1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRK1  Search GeneGlobe Interaction Network for LRRK1
     Regulatory tfbs in LRRK1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LRRK1 GenScript cDNA clones with any tag delivered in your preferred vector for LRRK1
     GenScript Custom Assay Services for LRRK1 GenScript Custom overexpressing Cell Line Services for LRRK1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LRRK1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LRRK1 antibodies
     LRRK1 proteins
     LRRK1 lysates
     Antibodies for LRRK1
     See all of Abcam's Antibodies, Kits and Proteins for LRRK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LRRK1
     Antibodies for LRRK1
     ELISAs for LRRK1
     CLIAs for LRRK1



     Browse ESI BIO Cell Lines and PureStem Progenitors for LRRK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRK1
     SwitchGear 3'UTR luciferase reporter plasmids for LRRK1
     Browse SwitchGear Promoter luciferase reporter plasmids for LRRK1
     ThermoFisher Antibodies for LRRK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRK1
     Browse compounds at ApexBio
     Addgene plasmids for LRRK1
      Search eBioscience for proteins for LRRK1
      Search eBioscience for elisas for LRRK1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for LRRK1
     antibodies-online antibodies for LRRK1 (23 products)
     antibodies-online kits for LRRK1 (4 products)
     antibodies-online peptides for LRRK1
     antibodies-online proteins for LRRK1 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LRRK1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4