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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRRK1 Gene

protein-coding   GIFtS: 57
GCID: GC15P101459

Leucine-Rich Repeat Kinase 1

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine-Rich Repeat Kinase 11 2
RIPK62
Roco12
Leucine-Rich Repeat Serine/Threonine-Protein Kinase 12
EC 2.7.11.13
KIAA17903

External Ids:    HGNC: 186081   Entrez Gene: 797052   Ensembl: ENSG000001542377   OMIM: 6109865   UniProtKB: Q38SD23   

Export aliases for LRRK1 gene to outside databases

Previous GC identifers: GC15P099297 GC15P099380 GC15P077581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRRK1 Gene: 
LRRK1 (leucine-rich repeat kinase 1) is a protein-coding gene. Diseases associated with LRRK1 include parkinson's disease. GO annotations related to this gene include protein serine/threonine kinase activity and GTP binding. An important paralog of this gene is LRRK2.

Gene Wiki entry for LRRK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRRK1 gene promoter:
         AML1a   p300   LCR-F1   Tal-1beta   MEF-2A   Pax-3   HOXA5   aMEF-2   TGIF   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for LRRK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

LRRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRK1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P101459:  view genomic region     (about GC identifiers)

Start:
101,459,420 bp from pter      End:
101,610,317 bp from pter
Size:
150,898 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRRK1_HUMAN, Q38SD2 (See protein sequence)
Recommended Name: Leucine-rich repeat serine/threonine-protein kinase 1  
Size: 2015 amino acids; 225393 Da
Cofactor: Magnesium or manganese
Subunit: Homodimer
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAY67799.1; Type=Miscellaneous discrepancy; Note=The cDNA contains a duplication of
exon 3; Sequence=BAB15547.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC85472.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6NVH5 Q6NYC0 Q6ZNL9 Q6ZNM9 Q96JN5 Q9H5S3
Alternative splicing: 2 isoforms:  Q38SD2-1   Q38SD2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRRK1: NX_Q38SD2

Explore proteomics data for LRRK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q38SD2

  • LRRK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRRK1 Protein Expression
    REFSEQ proteins: NP_078928.3  
    ENSEMBL proteins: 
     ENSP00000373600   ENSP00000435148   ENSP00000433268   ENSP00000433069   ENSP00000431668  
     ENSP00000436672   ENSP00000284395  

    Human Recombinant Protein Products for LRRK1: 
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    Novus Biologicals LRRK1 Proteins
    Novus Biologicals LRRK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRRK1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    LRRK1 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for LRRK1 

    Assay Products for LRRK1: 
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    Cloud-Clone Corp. CLIAs for LRRK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: leucine-rich repeat kinase 1 
    Leucine-rich repeat kinase (LRRK) family

    5/10 InterPro protein domains (see all 10):
     IPR001611 Leu-rich_rpt
     IPR027417 P-loop_NTPase
     IPR020859 ROC_GTPase
     IPR013684 MIRO-like
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q38SD2

    ProtoNet protein and cluster: Q38SD2

    1 Blocks protein domain: IPB013684 Miro-like

    UniProtKB/Swiss-Prot: LRRK1_HUMAN, Q38SD2
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily
    Similarity: Contains 4 ANK repeats
    Similarity: Contains 13 LRR (leucine-rich) repeats
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Roc domain


    LRRK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRRK1_HUMAN, Q38SD2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Binding of GTP stimulates kinase activity

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI19712061
    GO:0005524ATP binding IEA--
         
    LRRK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRK1:
     Increased colony dispersion (i 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lrrk1):
     mortality/aging 

    LRRK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lrrk1tm1.1Mjff for LRRK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRRK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRRK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRK1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRK1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRK1 (see all 16):
    hsa-miR-374b* hsa-miR-495 hsa-miR-1298 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-4267 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidLRRK1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/14 Interacting proteins for LRRK1 (Q38SD21, 3 ENSP000003736004) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C9orf163Q8N9P63, ENSP000003463454I2D: score=2 STRING: ENSP00000346345
    LYZP616263, ENSP000002612674I2D: score=2 STRING: ENSP00000261267
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007264small GTPase mediated signal transduction IEA--

    LRRK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRRK1

    5 HMDB Compounds for LRRK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    Search CenterWatch for drugs/clinical trials and news about LRRK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRRK1 gene: 
    NM_024652.3  

    Unigene Cluster for LRRK1:

    Leucine-rich repeat kinase 1
    Hs.407918  [show with all ESTs]
    Unigene Representative Sequence: NM_024652
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388948(uc002bwr.3 uc010usb.2 uc010usc.2) ENST00000534045
    ENST00000527698 ENST00000532029(uc002bwq.1) ENST00000525284 ENST00000531270
    ENST00000525617 ENST00000538064 ENST00000526457(uc002bws.3) ENST00000525395
    ENST00000532145 ENST00000284395

    miRNA
    Products:
         
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRK1 (see all 16):
    hsa-miR-374b* hsa-miR-495 hsa-miR-1298 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-4267 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidLRRK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRK1

    Additional mRNA sequence: 

    AB058693.1 AK026772.1 AK054662.1 AK058028.1 AK094556.1 AK130975.1 AK131075.1 AK225575.1 
    BC005408.1 BC018934.1 BC020379.1 BC066655.1 BC068080.1 BC110293.1 BC144705.1 BC146769.1 
    BC171802.1 DQ013130.1 

    10 DOTS entries:

    DT.100751216  DT.100751215  DT.99929164  DT.113762  DT.40128487  DT.95370489  DT.99999678  DT.308471 
    DT.91829562  DT.97779662 

    24/96 AceView cDNA sequences (see all 96):

    BQ187037 NM_024652 AA430539 AK058028 BM469840 CK820079 AK026772 BU428994 
    AK054662 BM354115 BX097196 BE907578 BU166882 BE463770 AA280028 CF529459 
    BU624641 AW500039 AW241403 AA282790 AI962086 W60132 BF056767 AW590768 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LRRK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22
    SP1:                                                                                                              -     -                       -         
    SP2:                                                                                                              -     -                                 
    SP3:                                                                                                              -                                       
    SP4:                                                                                                                    -                       -         


    ECgene alternative splicing isoforms for LRRK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGCAGTGA
    LRRK1 Expression
    About this image


    See LRRK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRRK1

    SOURCE GeneReport for Unigene cluster: Hs.407918
        SABiosciences Custom PCR Arrays for LRRK1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRRK1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrk11 , 5 leucine-rich repeat kinase 11, 5 85.37(n)1
    88.88(a)1
      7 (35.57 cM)5
    2333281  NM_146191.31  NP_666303.31 
     662269125 
    chicken
    (Gallus gallus)
    Aves LRRK11 leucine-rich repeat kinase 1 74.7(n)
    78(a)
      415520  XM_003641822.1  XP_003641870.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRK16
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343332.1(28519-84291)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.133622 Transcribed sequences 78.96(n)    BX729885.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrrk11 leucine-rich repeat kinase 1 63.34(n)
    60.38(a)
      100332050  XM_002667430.2  XP_002667476.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lrrk6
    Leucine-rich repeat kinase
    17(a)
    1 → many
    3R(16461910-16469856)
    worm
    (Caenorhabditis elegans)
    Secernentea lrk-16
    Leucine-rich repeat serine/threonine-protein kinas...
    18(a)
    1 → many
    I(10879766-10894237)


    ENSEMBL Gene Tree for LRRK1 (if available)
    TreeFam Gene Tree for LRRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRRK1 gene
    LRRK22  
    6 SIMAP similar genes for LRRK1 using alignment to 8 protein entries:     LRRK1_HUMAN (see all proteins):
    NEK9    PRKCH    MAP3K11    BRAF    MARK4    STK25

    LRRK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3994 SNPs in LRRK1 are shown (see all 3994)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406774
    ----see VAR_0406772 D G mis40--------
    VAR_0406754
    ----see VAR_0406752 L F mis40--------
    VAR_0406744
    ----see VAR_0406742 A T mis40--------
    VAR_0406764
    ----see VAR_0406762 S N mis40--------
    rs38351221,2
    C--77726167(+) AAAAA-/A/AA  
            
    CAGGT
    1 -- int1 trp32NA 4
    rs782128671,2
    C--101457481(+) TCTCTC/TGTAAC 1 -- us2k12Minor allele frequency- T:0.11CSA WA 120
    rs1179319371,2
    C,F--101457532(+) AGACAT/ACCCAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs46466911,2
    C--101457572(+) TAGGAG/AAAGGA 1 -- us2k13Minor allele frequency- A:0.01NA EA 124
    rs1925630541,2
    --101457606(+) GGAACA/GTGACT 1 -- us2k10--------
    rs1850417861,2
    --101457657(+) TATGCA/GTGTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRRK1 (101459420 - 101610317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for LRRK1 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750172CNV Deletion23290073
    esv2668881CNV Deletion23128226
    esv2750170CNV Deletion23290073
    esv1932382CNV Deletion18987734
    esv2750171CNV Deletion23290073
    nsv95032CNV Insertion16902084
    esv1015225CNV Insertion17803354
    nsv516426CNV Loss19592680
    esv33120CNV Loss17666407
    nsv904595CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610986    OMIM disorders: --

    2 diseases for LRRK1:    About MalaCards
    parkinson's disease    

    1 disease from the University of Copenhagen DISEASES database for LRRK1:
    Parkinson's disease

    LRRK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for LRRK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease, autosomal dominant 87.2 1 17225181 (1)
    parkinson disease 67.9 5 17225181 (2), 17394548 (1), 16243488 (1), 17324517 (1)
    parkinsonism 56.6 4 16243488 (1), 17324517 (1)

    Genetic Association Database (GAD): LRRK1
    Human Genome Epidemiology (HuGE) Navigator: LRRK1 (3 documents)

    Export disorders for LRRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRRK1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with LRRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. (PubMed id 16243488)1, 2, 9 Korr D.... Weiss B. (2006)
    3. Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway. (PubMed id 17324517)1, 4, 9 Haugarvoll K....Farrer M.J. (2007)
    4. Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. (PubMed id 22952686)1, 2 Civiero L.... Taymans J.M. (2012)
    5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Roc, a Ras/GTPase domain in complex proteins. (PubMed id 14654223)1, 3 Bosgraaf L. and Van Haastert P.J. (2003)
    9. Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. (PubMed id 17225181)1, 9 Taylor J.P....Farrer M.J. (2007)
    10. Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. (PubMed id 17394548)1, 9 Greggio E....Cookson M.R. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79705 HGNC: 18608 AceView: LRRK1 Ensembl:ENSG00000154237 euGenes: HUgn79705
    ECgene: LRRK1 H-InvDB: LRRK1

    (According to HUGE)
    About This Section
    HUGE: KIAA1790

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRRK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRRK1 gene:
    Search GeneIP for patents involving LRRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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