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Aliases for LRRIQ1 Gene

Aliases for LRRIQ1 Gene

  • Leucine-Rich Repeats And IQ Motif Containing 1 2 3 5
  • KIAA1801 4

External Ids for LRRIQ1 Gene

Previous GeneCards Identifiers for LRRIQ1 Gene

  • GC12P083934
  • GC12P085430
  • GC12P082487

Summaries for LRRIQ1 Gene

GeneCards Summary for LRRIQ1 Gene

LRRIQ1 (Leucine-Rich Repeats And IQ Motif Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRIQ1 Gene

Genomics for LRRIQ1 Gene

Regulatory Elements for LRRIQ1 Gene

Enhancers for LRRIQ1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRRIQ1 on UCSC Golden Path with GeneCards custom track

Promoters for LRRIQ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRIQ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRIQ1 Gene

Chromosome:
12
Start:
85,036,314 bp from pter
End:
85,272,867 bp from pter
Size:
236,554 bases
Orientation:
Plus strand

Genomic View for LRRIQ1 Gene

Genes around LRRIQ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRIQ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRIQ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRIQ1 Gene

Proteins for LRRIQ1 Gene

  • Protein details for LRRIQ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JM4-LRIQ1_HUMAN
    Recommended name:
    Leucine-rich repeat and IQ domain-containing protein 1
    Protein Accession:
    Q96JM4
    Secondary Accessions:
    • Q567P4
    • Q9BS17
    • Q9HA36

    Protein attributes for LRRIQ1 Gene

    Size:
    1722 amino acids
    Molecular mass:
    199300 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH93088.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB47430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB47430.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRIQ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRIQ1 Gene

Proteomics data for LRRIQ1 Gene at MOPED

Post-translational modifications for LRRIQ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRIQ1 Gene

No data available for DME Specific Peptides for LRRIQ1 Gene

Domains & Families for LRRIQ1 Gene

Protein Domains for LRRIQ1 Gene

Suggested Antigen Peptide Sequences for LRRIQ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JM4

UniProtKB/Swiss-Prot:

LRIQ1_HUMAN :
  • Contains 3 IQ domains.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Contains 3 IQ domains.
  • Contains 1 LRRCT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRIQ1: view

No data available for Gene Families for LRRIQ1 Gene

Function for LRRIQ1 Gene

Phenotypes for LRRIQ1 Gene

genes like me logo Genes that share phenotypes with LRRIQ1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRIQ1 Gene

Localization for LRRIQ1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRIQ1 Gene COMPARTMENTS Subcellular localization image for LRRIQ1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRIQ1 Gene

Pathways & Interactions for LRRIQ1 Gene

SuperPathways for LRRIQ1 Gene

No Data Available

Interacting Proteins for LRRIQ1 Gene

Gene Ontology (GO) - Biological Process for LRRIQ1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRIQ1 Gene

Drugs & Compounds for LRRIQ1 Gene

No Compound Related Data Available

Transcripts for LRRIQ1 Gene

Unigene Clusters for LRRIQ1 Gene

Leucine-rich repeats and IQ motif containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRIQ1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3:

Relevant External Links for LRRIQ1 Gene

GeneLoc Exon Structure for
LRRIQ1
ECgene alternative splicing isoforms for
LRRIQ1

Expression for LRRIQ1 Gene

mRNA expression in normal human tissues for LRRIQ1 Gene

mRNA differential expression in normal tissues according to GTEx for LRRIQ1 Gene

This gene is overexpressed in Testis (x14.8).

Protein differential expression in normal tissues from HIPED for LRRIQ1 Gene

This gene is overexpressed in Plasma (25.9), Liver, secretome (20.0), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRIQ1 Gene



SOURCE GeneReport for Unigene cluster for LRRIQ1 Gene Hs.402200

genes like me logo Genes that share expression patterns with LRRIQ1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LRRIQ1 Gene

Orthologs for LRRIQ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRIQ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRIQ1 35
  • 83.1 (n)
  • 73.41 (a)
LRRIQ1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRIQ1 35
  • 83.88 (n)
  • 73.84 (a)
LRRIQ1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrriq1 35
  • 72.76 (n)
  • 59.87 (a)
Lrriq1 16
Lrriq1 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRIQ1 35
  • 99.52 (n)
  • 99.01 (a)
LRRIQ1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrriq1 35
  • 72.6 (n)
  • 56.93 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRIQ1 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRIQ1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRIQ1 35
  • 60.24 (n)
  • 44.25 (a)
LRRIQ1 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRIQ1 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lrriq1 35
  • 50.16 (n)
  • 39.71 (a)
lrriq1 36
  • 31 (a)
OneToOne
Species with no ortholog for LRRIQ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRIQ1 Gene

ENSEMBL:
Gene Tree for LRRIQ1 (if available)
TreeFam:
Gene Tree for LRRIQ1 (if available)

Paralogs for LRRIQ1 Gene

No data available for Paralogs for LRRIQ1 Gene

Variants for LRRIQ1 Gene

Sequence variations from dbSNP and Humsavar for LRRIQ1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_037672 -
rs3765044 - 85,044,721(-) AACTA(C/T)AGCCT nc-transcript-variant, reference, missense
rs17012533 - 85,072,945(+) ACAAT(A/G)CAGGG intron-variant, nc-transcript-variant, reference, missense
rs1961049 -- 85,201,122(-) caggc(A/G)tggtg intron-variant
rs1976270 -- 85,043,131(-) CTCTC(C/T)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRIQ1 Gene

Variant ID Type Subtype PubMed ID
nsv899377 CNV Loss 21882294
nsv510605 CNV Loss 20534489
nsv899387 CNV Loss 21882294
nsv899388 CNV Loss 21882294
nsv899389 CNV Loss 21882294
nsv899390 CNV Loss 21882294
esv2638439 CNV Insertion 19546169
esv271261 CNV Insertion 20981092
esv273028 CNV Insertion 20981092
nsv899391 CNV Loss 21882294
esv271530 CNV Insertion 20981092
nsv826466 CNV Gain 20364138
nsv819416 CNV Gain 19587683
esv270571 CNV Insertion 20981092
nsv899392 CNV Loss 21882294

Variation tolerance for LRRIQ1 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.72; 86.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRIQ1 Gene

HapMap Linkage Disequilibrium report
LRRIQ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRIQ1 Gene

Disorders for LRRIQ1 Gene

Relevant External Links for LRRIQ1

Genetic Association Database (GAD)
LRRIQ1
Human Genome Epidemiology (HuGE) Navigator
LRRIQ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRIQ1

No disorders were found for LRRIQ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRIQ1 Gene

Publications for LRRIQ1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for LRRIQ1 Gene

Sources for LRRIQ1 Gene

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