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Aliases for LRRIQ1 Gene

Aliases for LRRIQ1 Gene

  • Leucine Rich Repeats And IQ Motif Containing 1 2 3 5
  • KIAA1801 4

External Ids for LRRIQ1 Gene

Previous GeneCards Identifiers for LRRIQ1 Gene

  • GC12P083934
  • GC12P085430
  • GC12P082487

Summaries for LRRIQ1 Gene

GeneCards Summary for LRRIQ1 Gene

LRRIQ1 (Leucine Rich Repeats And IQ Motif Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRIQ1 Gene

Genomics for LRRIQ1 Gene

Regulatory Elements for LRRIQ1 Gene

Enhancers for LRRIQ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G085035 0.9 ENCODE 0.7 +0.0 7 1.2 TBP PKNOX1 ARID4B SIN3A BMI1 RFX5 YY1 ZNF366 ZSCAN5C SCRT2 LRRIQ1 GC12M085041
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRIQ1 on UCSC Golden Path with GeneCards custom track

Promoters for LRRIQ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054773 187 999 TBP PKNOX1 SIN3A BMI1 RFX5 YY1 ZNF366 ZSCAN5C SCRT2 RCOR1

Genomic Location for LRRIQ1 Gene

Chromosome:
12
Start:
85,036,314 bp from pter
End:
85,272,867 bp from pter
Size:
236,554 bases
Orientation:
Plus strand

Genomic View for LRRIQ1 Gene

Genes around LRRIQ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRIQ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRIQ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRIQ1 Gene

Proteins for LRRIQ1 Gene

  • Protein details for LRRIQ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JM4-LRIQ1_HUMAN
    Recommended name:
    Leucine-rich repeat and IQ domain-containing protein 1
    Protein Accession:
    Q96JM4
    Secondary Accessions:
    • Q567P4
    • Q9BS17
    • Q9HA36

    Protein attributes for LRRIQ1 Gene

    Size:
    1722 amino acids
    Molecular mass:
    199300 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH93088.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB47430.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB47430.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRIQ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRIQ1 Gene

Post-translational modifications for LRRIQ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRIQ1 Gene

Domains & Families for LRRIQ1 Gene

Suggested Antigen Peptide Sequences for LRRIQ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRIQ1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LRRIQ1 Gene

Function for LRRIQ1 Gene

Phenotypes for LRRIQ1 Gene

genes like me logo Genes that share phenotypes with LRRIQ1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRIQ1 Gene

Localization for LRRIQ1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRIQ1 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRIQ1 Gene

Pathways & Interactions for LRRIQ1 Gene

SuperPathways for LRRIQ1 Gene

No Data Available

Interacting Proteins for LRRIQ1 Gene

Gene Ontology (GO) - Biological Process for LRRIQ1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRIQ1 Gene

Transcripts for LRRIQ1 Gene

Unigene Clusters for LRRIQ1 Gene

Leucine-rich repeats and IQ motif containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRIQ1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3:

Relevant External Links for LRRIQ1 Gene

GeneLoc Exon Structure for
LRRIQ1
ECgene alternative splicing isoforms for
LRRIQ1

Expression for LRRIQ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRIQ1 Gene

mRNA differential expression in normal tissues according to GTEx for LRRIQ1 Gene

This gene is overexpressed in Testis (x14.8).

Protein differential expression in normal tissues from HIPED for LRRIQ1 Gene

This gene is overexpressed in Plasma (25.9), Liver, secretome (20.0), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRIQ1 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRIQ1 Gene:

LRRIQ1

SOURCE GeneReport for Unigene cluster for LRRIQ1 Gene:

Hs.402200
genes like me logo Genes that share expression patterns with LRRIQ1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRIQ1 Gene

Orthologs for LRRIQ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRIQ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRIQ1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia LRRIQ1 34 35
  • 83.88 (n)
cow
(Bos Taurus)
Mammalia LRRIQ1 34 35
  • 83.1 (n)
mouse
(Mus musculus)
Mammalia Lrriq1 34 16 35
  • 72.76 (n)
rat
(Rattus norvegicus)
Mammalia Lrriq1 34
  • 72.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRIQ1 35
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRIQ1 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRIQ1 34 35
  • 60.24 (n)
lizard
(Anolis carolinensis)
Reptilia LRRIQ1 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lrriq1 34 35
  • 50.16 (n)
Species where no ortholog for LRRIQ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRIQ1 Gene

ENSEMBL:
Gene Tree for LRRIQ1 (if available)
TreeFam:
Gene Tree for LRRIQ1 (if available)

Paralogs for LRRIQ1 Gene

No data available for Paralogs for LRRIQ1 Gene

Variants for LRRIQ1 Gene

Sequence variations from dbSNP and Humsavar for LRRIQ1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000000145 -- 85,178,561(+) TCTTA(A/G)TTACT intron-variant
rs1000012926 -- 85,055,223(+) CCCTT(C/T)TGTTG intron-variant
rs1000013502 -- 85,228,317(+) TTGTA(A/T)AATTA intron-variant
rs1000018097 -- 85,105,915(+) CCTCA(C/G)CTTCC intron-variant
rs1000019008 -- 85,149,703(+) CTTGA(A/G)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRIQ1 Gene

Variant ID Type Subtype PubMed ID
dgv2764n54 CNV loss 21841781
dgv2765n54 CNV loss 21841781
dgv843n106 CNV deletion 24896259
esv2638439 CNV insertion 19546169
esv2761757 CNV gain 21179565
esv3306294 CNV mobile element insertion 20981092
esv3307254 CNV mobile element insertion 20981092
esv3331519 CNV insertion 20981092
esv3340126 CNV insertion 20981092
esv3355826 CNV insertion 20981092
esv3381252 CNV insertion 20981092
esv3630228 CNV gain 21293372
esv3630229 CNV gain 21293372
esv3630230 CNV gain 21293372
esv3630232 CNV gain 21293372
esv3630233 CNV gain 21293372
esv3892240 CNV gain 25118596
nsv1040452 CNV gain 25217958
nsv1052676 CNV gain 25217958
nsv1070119 CNV deletion 25765185
nsv1111075 CNV tandem duplication 24896259
nsv1111076 CNV tandem duplication 24896259
nsv1152183 CNV duplication 26484159
nsv510605 CNV deletion 20534489
nsv559653 CNV loss 21841781
nsv559654 CNV loss 21841781
nsv559655 CNV loss 21841781
nsv559661 CNV loss 21841781
nsv559662 CNV loss 21841781
nsv819416 CNV gain 19587683
nsv826466 CNV gain 20364138

Variation tolerance for LRRIQ1 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.72; 86.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRIQ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRIQ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRIQ1 Gene

Disorders for LRRIQ1 Gene

Relevant External Links for LRRIQ1

Genetic Association Database (GAD)
LRRIQ1
Human Genome Epidemiology (HuGE) Navigator
LRRIQ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRIQ1

No disorders were found for LRRIQ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRIQ1 Gene

Publications for LRRIQ1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for LRRIQ1 Gene

Sources for LRRIQ1 Gene

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