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Aliases for LRRD1 Gene

Aliases for LRRD1 Gene

  • Leucine Rich Repeats And Death Domain Containing 1 2 3 5

External Ids for LRRD1 Gene

Previous GeneCards Identifiers for LRRD1 Gene

  • GC07M091743

Summaries for LRRD1 Gene

GeneCards Summary for LRRD1 Gene

LRRD1 (Leucine Rich Repeats And Death Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ERBIN.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRD1 Gene

Genomics for LRRD1 Gene

Regulatory Elements for LRRD1 Gene

Enhancers for LRRD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G092178 1 ENCODE 4.9 +0.3 322 1.5 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF143 ZNF263 KAT8 CYP51A1 ERVW-1 KRIT1 LRRD1
GH07G091892 0.8 ENCODE 5.3 +286.9 286899 1.1 BACH1 ZNF175 ZIC2 FOSL1 IRF9 FOXK2 FOS NFE2 EGR2 YY2 CYP51A1 AKAP9 LRRD1 GC07M091889
GH07G091695 0.4 FANTOM5 6.6 +483.7 483740 0.3 PKNOX1 HMBOX1 LRRD1 MTERF1 ENSG00000223665 GC07P091818
GH07G092418 0.5 FANTOM5 3.5 -239.5 -239504 0.1 CTCF ZNF654 GATAD1 IKZF1 ERVW-1 ANKIB1 KRIT1 LRRD1 TMBIM7P GC07P092389
GH07G092653 0.7 FANTOM5 dbSUPER 1.5 -473.7 -473657 0.4 SCRT1 SAMD9L KRIT1 GATAD1 SAMD9 LRRD1 GC07M092611 GC07M092702 RNU6-10P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRD1 on UCSC Golden Path with GeneCards custom track

Promoters for LRRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215077 331 801 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF143 FOS ZNF263

Genomic Location for LRRD1 Gene

92,112,159 bp from pter
92,179,531 bp from pter
67,373 bases
Minus strand

Genomic View for LRRD1 Gene

Genes around LRRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRD1 Gene

Proteins for LRRD1 Gene

  • Protein details for LRRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat and death domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B7ZMM9
    • Q49AT9

    Protein attributes for LRRD1 Gene

    860 amino acids
    Molecular mass:
    98035 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAL24153.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRD1 Gene


neXtProt entry for LRRD1 Gene

Post-translational modifications for LRRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRD1 Gene

No data available for DME Specific Peptides for LRRD1 Gene

Domains & Families for LRRD1 Gene

Suggested Antigen Peptide Sequences for LRRD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LRRD1 Gene

Function for LRRD1 Gene

Phenotypes for LRRD1 Gene

GenomeRNAi human phenotypes for LRRD1:
genes like me logo Genes that share phenotypes with LRRD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRD1 Gene

Localization for LRRD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRD1 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016323 basolateral plasma membrane IBA --
genes like me logo Genes that share ontologies with LRRD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRD1 Gene

Pathways & Interactions for LRRD1 Gene

SuperPathways for LRRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0045199 maintenance of epithelial cell apical/basal polarity IBA --
genes like me logo Genes that share ontologies with LRRD1: view

No data available for Pathways by source and SIGNOR curated interactions for LRRD1 Gene

Drugs & Compounds for LRRD1 Gene

No Compound Related Data Available

Transcripts for LRRD1 Gene

mRNA/cDNA for LRRD1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRD1 Gene

Leucine-rich repeats and death domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRD1 Gene

No ASD Table

Relevant External Links for LRRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRD1 Gene

mRNA differential expression in normal tissues according to GTEx for LRRD1 Gene

This gene is overexpressed in Testis (x33.0).

Protein differential expression in normal tissues from HIPED for LRRD1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRD1 Gene

Protein tissue co-expression partners for LRRD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRD1 Gene:


SOURCE GeneReport for Unigene cluster for LRRD1 Gene:


Evidence on tissue expression from TISSUES for LRRD1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LRRD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRD1 Gene

Orthologs for LRRD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRD1 35 34
  • 99.22 (n)
(Bos Taurus)
Mammalia LRRD1 35 34
  • 87.29 (n)
(Canis familiaris)
Mammalia LRRD1 35 34
  • 86.76 (n)
(Mus musculus)
Mammalia Lrrd1 16 35 34
  • 77.56 (n)
(Rattus norvegicus)
Mammalia Lrrd1 34
  • 76.86 (n)
(Monodelphis domestica)
Mammalia LRRD1 35
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia LRRD1 35
  • 43 (a)
(Anolis carolinensis)
Reptilia LRRD1 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrd1 34
  • 55.42 (n)
(Oryza sativa)
Liliopsida Os05g0170300 34
  • 37.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3983 35
  • 24 (a)
Species where no ortholog for LRRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRD1 Gene

Gene Tree for LRRD1 (if available)
Gene Tree for LRRD1 (if available)

Paralogs for LRRD1 Gene

(12) SIMAP similar genes for LRRD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRRD1: view

Variants for LRRD1 Gene

Sequence variations from dbSNP and Humsavar for LRRD1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000069436 -- 92,165,729(+) GGTAG(C/T)GGGCG intron-variant, upstream-variant-2KB
rs1000138814 -- 92,157,005(+) GGAAA(C/T)TGTAT intron-variant
rs1000344867 -- 92,158,055(+) AATTA(A/G)GGCTA intron-variant
rs1000460682 -- 92,159,922(+) GGCCC(C/T)ATTGC intron-variant
rs1000547888 -- 92,145,564(+) CCTCC(A/C/G)GAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRD1 Gene

Variant ID Type Subtype PubMed ID
esv3614136 CNV loss 21293372
nsv1114987 CNV deletion 24896259
nsv5839 CNV insertion 18451855

Variation tolerance for LRRD1 Gene

Gene Damage Index Score: 10.89; 91.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRD1 Gene

Disorders for LRRD1 Gene

Relevant External Links for LRRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRD1 Gene

Publications for LRRD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LRRD1 Gene

Sources for LRRD1 Gene

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