LRRD1 Gene
protein-coding GIFtS: 32
GCID: GC07M091743
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leucine-rich repeats and death domain containing 1
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Aliases
for LRRD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine-Rich Repeats And Death Domain Containing 11 2 | | IMAGE:47989711 | | Leucine-Rich Repeat And Death Domain-Containing Protein 12 | | Leucine-Rich Repeat And Death Domain-Containing Protein LOC4013872 |
Export aliases for LRRD1 gene to outside databases |
Summaries
for LRRD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LRRD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for LRRD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.2 Ensembl cytogenetic band: 7q21.2 HGNC cytogenetic band: 7q21.2LRRD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M091743: view genomic region
(about GC identifiers)
Start:
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91,741,473 bp from pter |
End:
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91,808,845 bp from pter |
Size:
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67,373 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 91,103,440-91,123,828 |
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Proteins
for LRRD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRRD1_HUMAN, A4D1F6 (See
protein sequence)Recommended Name: Leucine-rich repeat and death domain-containing protein 1 Size: 860 amino acids; 98035 Da
Sequence caution: Sequence=EAL24153.1; Type=Erroneous gene model prediction;
Secondary accessions: B7ZMM9 Q49AT9Alternative splicing: 2 isoforms: A4D1F6-1 A4D1F6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LRRD1: NX_A4D1F6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A4D1F6
LRRD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001155000.1
ENSEMBL proteins: ENSP00000339642 ENSP00000405987 ENSP00000387628 ENSP00000411568 ENSP00000392112
Human Recombinant Protein Products:
LRRD1 Antibody Products:
Assay Products for LRRD1: |
Protein
Domains /
Families
for LRRD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRD1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A4D1F6ProtoNet protein and cluster: A4D1F6 UniProtKB/Swiss-Prot: LRRD1_HUMAN, A4D1F6Similarity: Contains 1 death domainSimilarity: Contains 27 LRR (leucine-rich) repeats |
Function
for LRRD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for LRRD1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRD1 |
|
Pathways & Interactions
for LRRD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRD1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- |
LRRD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for LRRD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRD1
Search CenterWatch for drugs/clinical trials and news about LRRD1
|
Transcripts
for LRRD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRD1 gene (2 alternative transcripts): NM_001045475.2 NM_001161528.1 Unigene Cluster for LRRD1: Leucine-rich repeats and death domain containing 1 Hs.671729 [show with all ESTs]Unigene Representative Sequence: NM_0011615286 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000422722(uc003uln.4) ENST00000343318(uc011kho.2) ENST00000458448
ENST00000437357 ENST00000430130(uc011khp.1) ENST00000454089
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for LRRD1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRD1 |
Additional cDNA sequence: BC026112.1 BC144674.1 BC144678.1 1 DOTS entry: DT.101955507 1 AceView cDNA sequence: BU567656
GeneLoc Exon Structure
|
Expression
for LRRD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LRRD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRD1
SOURCE GeneReport for Unigene cluster: Hs.671729
SABiosciences Custom PCR Arrays for LRRD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRD1 |
Orthologs
for LRRD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LRRD1 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for LRRD1 (if available)
TreeFam Gene Tree for LRRD1 (if available) |
Paralogs
for LRRD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRD1 gene
- LRRC72 LRRC22 ERBB2IP2 MFHAS12 LRRC182 LRRC302 LRRC12 PIDD2
- LRRIQ42 SCRIB2 SHOC22 LRRC10B2 LRRC392 LRRC402 LRRC102
12 SIMAP similar genes for LRRD1 using alignment to 3 protein entries: LRRD1_HUMAN (see all proteins):ERBB2IP LRFN5 LRRC8C LRRC28 LRCH1 LRRC57
LRCH3 LRRC1 SCRIB LRRC63 RSU1 FLII
LRRD1 for paralogs About GeneDecksing
|
Genomic Variants
for LRRD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRD1 (91741473 - 91808845 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LRRD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRD1 |
|
Disorders
/ Diseases
for LRRD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for LRRD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for LRRD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LRRD1 gene:
Search GeneIP for patents involving LRRD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRD1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LRRD1 | | OriGene Custom Protein Services for LRRD1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRD1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRD1 |
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| | | | Search Tocris compounds for LRRD1 |
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 | | | LRRD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for LRRD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRD1 |
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