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Aliases for LRRD1 Gene

Aliases for LRRD1 Gene

  • Leucine-Rich Repeats And Death Domain Containing 1 2 3

External Ids for LRRD1 Gene

Previous GeneCards Identifiers for LRRD1 Gene

  • GC07M091743

Summaries for LRRD1 Gene

GeneCards Summary for LRRD1 Gene

LRRD1 (Leucine-Rich Repeats And Death Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is MFHAS1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRD1 Gene

Genomics for LRRD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRRD1 Gene

92,112,159 bp from pter
92,179,531 bp from pter
67,373 bases
Minus strand

Genomic View for LRRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRD1 Gene

No data available for Regulatory Elements for LRRD1 Gene

Proteins for LRRD1 Gene

  • Protein details for LRRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat and death domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B7ZMM9
    • Q49AT9

    Protein attributes for LRRD1 Gene

    860 amino acids
    Molecular mass:
    98035 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAL24153.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRD1 Gene


neXtProt entry for LRRD1 Gene

Proteomics data for LRRD1 Gene at MOPED

Post-translational modifications for LRRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRD1 Gene

No data available for DME Specific Peptides for LRRD1 Gene

Domains & Families for LRRD1 Gene

Protein Domains for LRRD1 Gene

Suggested Antigen Peptide Sequences for LRRD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 death domain.
  • Contains 27 LRR (leucine-rich) repeats.
  • Contains 1 death domain.
  • Contains 27 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRD1: view

No data available for Gene Families for LRRD1 Gene

Function for LRRD1 Gene

Gene Ontology (GO) - Molecular Function for LRRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRD1: view

Phenotypes for LRRD1 Gene

GenomeRNAi human phenotypes for LRRD1:
genes like me logo Genes that share phenotypes with LRRD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRD1 Gene

Localization for LRRD1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LRRD1 Gene

Pathways & Interactions for LRRD1 Gene

SuperPathways for LRRD1 Gene

No Data Available

Interacting Proteins for LRRD1 Gene

Gene Ontology (GO) - Biological Process for LRRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with LRRD1: view

No data available for Pathways by source and SIGNOR curated interactions for LRRD1 Gene

Drugs & Compounds for LRRD1 Gene

No Compound Related Data Available

Transcripts for LRRD1 Gene

mRNA/cDNA for LRRD1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRD1 Gene

Leucine-rich repeats and death domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRD1 Gene

No ASD Table

Relevant External Links for LRRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRD1 Gene

mRNA expression in normal human tissues for LRRD1 Gene

mRNA differential expression in normal tissues according to GTEx for LRRD1 Gene

This gene is overexpressed in Testis (x33.0).

Protein differential expression in normal tissues from HIPED for LRRD1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRD1 Gene

SOURCE GeneReport for Unigene cluster for LRRD1 Gene Hs.671729

genes like me logo Genes that share expression patterns with LRRD1: view

Protein tissue co-expression partners for LRRD1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LRRD1 Gene

Orthologs for LRRD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRD1 35
  • 87.29 (n)
  • 78.71 (a)
LRRD1 36
  • 78 (a)
(Canis familiaris)
Mammalia LRRD1 35
  • 86.76 (n)
  • 79.67 (a)
LRRD1 36
  • 78 (a)
(Mus musculus)
Mammalia Lrrd1 35
  • 77.56 (n)
  • 67.67 (a)
Lrrd1 16
Lrrd1 36
  • 66 (a)
(Pan troglodytes)
Mammalia LRRD1 35
  • 99.22 (n)
  • 98.6 (a)
LRRD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lrrd1 35
  • 76.86 (n)
  • 67.63 (a)
(Monodelphis domestica)
Mammalia LRRD1 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia LRRD1 36
  • 43 (a)
(Anolis carolinensis)
Reptilia LRRD1 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrd1 35
  • 55.42 (n)
  • 45.94 (a)
(Oryza sativa)
Liliopsida Os05g0170300 35
  • 37.07 (n)
  • 30.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3983 36
  • 24 (a)
Species with no ortholog for LRRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRD1 Gene

Gene Tree for LRRD1 (if available)
Gene Tree for LRRD1 (if available)

Paralogs for LRRD1 Gene

(12) SIMAP similar genes for LRRD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRRD1: view

Variants for LRRD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRD1 Gene

Variant ID Type Subtype PubMed ID
nsv888734 CNV Loss 21882294
nsv5839 CNV Insertion 18451855
nsv888735 CNV Loss 21882294

Variation tolerance for LRRD1 Gene

Gene Damage Index Score: 10.89; 91.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for LRRD1 Gene

Disorders for LRRD1 Gene

Relevant External Links for LRRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LRRD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRD1 Gene

Publications for LRRD1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 67
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for LRRD1 Gene

Sources for LRRD1 Gene

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