Aliases for LRRC8E Gene
External Ids for LRRC8E Gene
This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
GeneCards Summary for LRRC8E Gene
LRRC8E (Leucine Rich Repeat Containing 8 Family, Member E) is a Protein Coding gene. An important paralog of this gene is MFHAS1.
UniProtKB/Swiss-Prot for LRRC8E Gene
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity).