Aliases for LRRC8E Gene
External Ids for LRRC8E Gene
Previous GeneCards Identifiers for LRRC8E Gene
This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
GeneCards Summary for LRRC8E Gene
LRRC8E (Leucine Rich Repeat Containing 8 Family Member E) is a Protein Coding gene. An important paralog of this gene is LRRC8C.
UniProtKB/Swiss-Prot for LRRC8E Gene
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.